ES2159665T3 - Preparacion y utilizacion de enantiomeros puros de los acidos 8-halogeno-6-hidroxioctanoicos, sus esteres alquilicos y sus sales con los enantiomeros puros de alfa-metilbencilamina. - Google Patents

Preparacion y utilizacion de enantiomeros puros de los acidos 8-halogeno-6-hidroxioctanoicos, sus esteres alquilicos y sus sales con los enantiomeros puros de alfa-metilbencilamina.

Info

Publication number
ES2159665T3
ES2159665T3 ES96114418T ES96114418T ES2159665T3 ES 2159665 T3 ES2159665 T3 ES 2159665T3 ES 96114418 T ES96114418 T ES 96114418T ES 96114418 T ES96114418 T ES 96114418T ES 2159665 T3 ES2159665 T3 ES 2159665T3
Authority
ES
Spain
Prior art keywords
pure enantiomers
salts
acids
alkyl esters
methylbencilamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96114418T
Other languages
English (en)
Inventor
Rainer Dr Gewald
Gunter Dr Laban
Thomas Dr Beisswenger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asta Medica GmbH
Original Assignee
Asta Medica GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica GmbH filed Critical Asta Medica GmbH
Application granted granted Critical
Publication of ES2159665T3 publication Critical patent/ES2159665T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/115—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

SE DESCRIBE LA OBTENCION DE LOS ENANTIOMEROS PUROS DE LOS ACIDOS 8-HALO-6-HIDROXIOCTANOICO Y DE SUS ESTERES ALQUILICOS POR FORMACION DE LAS SALES DIAESTEREOMERICAS CON LOS ENANTIOMEROS DE LA {AL}-METIL-BENCILAMINA EN DISOLUCION.
ES96114418T 1995-09-13 1996-09-10 Preparacion y utilizacion de enantiomeros puros de los acidos 8-halogeno-6-hidroxioctanoicos, sus esteres alquilicos y sus sales con los enantiomeros puros de alfa-metilbencilamina. Expired - Lifetime ES2159665T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19533882A DE19533882A1 (de) 1995-09-13 1995-09-13 Herstellung und Verwendung der reinen Enantiomere der 8-Halogen-6-hydroxyoctansäuren, ihrer Alkylester und ihrer Salze mit reinen Enantiomeren des alpha-Methylbenzylamins

Publications (1)

Publication Number Publication Date
ES2159665T3 true ES2159665T3 (es) 2001-10-16

Family

ID=7772034

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96114418T Expired - Lifetime ES2159665T3 (es) 1995-09-13 1996-09-10 Preparacion y utilizacion de enantiomeros puros de los acidos 8-halogeno-6-hidroxioctanoicos, sus esteres alquilicos y sus sales con los enantiomeros puros de alfa-metilbencilamina.

Country Status (10)

Country Link
US (1) US5869713A (es)
EP (1) EP0763516B1 (es)
JP (1) JPH09169692A (es)
AT (1) ATE202332T1 (es)
DE (2) DE19533882A1 (es)
DK (1) DK0763516T3 (es)
ES (1) ES2159665T3 (es)
GR (1) GR3036631T3 (es)
PT (1) PT763516E (es)
RU (1) RU2175965C2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10137381A1 (de) 2001-07-31 2003-02-13 Viatris Gmbh Neue Modifikationen des Trometamolsalzes der R-Thioctsäure sowie Verfahren zu ihrer Herstellung
DE10152113C1 (de) * 2001-10-23 2003-03-06 Viatris Gmbh Verfahren zur Herstellung von (R)- und (S)-8-Chlor-6-hydroxy-octansäurealkylestern durch enzymatische Reduktion

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2980716A (en) * 1954-06-11 1961-04-18 Research Corp Method for preparing 6, 8-dihalooctanoic esters
US2975198A (en) * 1954-07-08 1961-03-14 Research Corp Lipoic acid intermediates
IE904034A1 (en) 1989-11-09 1991-05-22 Asta Medica Ag A medicament containing r-ó-lipoic acid or s-ó-lipoic acid¹as active substance
DE4037440A1 (de) 1990-11-24 1992-05-27 Basf Ag Verfahren zur herstellung von (6s)-6,8-dihydroxyoctansaeureestern
DE4137773A1 (de) * 1991-11-16 1993-05-19 Degussa Herstellung und verwendung von salzen der reinen enantiomere der (alpha)-liponsaeure

Also Published As

Publication number Publication date
EP0763516A1 (de) 1997-03-19
PT763516E (pt) 2001-11-30
RU2175965C2 (ru) 2001-11-20
US5869713A (en) 1999-02-09
DK0763516T3 (da) 2001-09-17
EP0763516B1 (de) 2001-06-20
JPH09169692A (ja) 1997-06-30
DE59607119D1 (de) 2001-07-26
GR3036631T3 (en) 2001-12-31
ATE202332T1 (de) 2001-07-15
DE19533882A1 (de) 1997-03-20

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