ATE240299T1 - Diester prodrugs von decahydroischinoline-3- carbonsäure - Google Patents

Diester prodrugs von decahydroischinoline-3- carbonsäure

Info

Publication number
ATE240299T1
ATE240299T1 AT00941172T AT00941172T ATE240299T1 AT E240299 T1 ATE240299 T1 AT E240299T1 AT 00941172 T AT00941172 T AT 00941172T AT 00941172 T AT00941172 T AT 00941172T AT E240299 T1 ATE240299 T1 AT E240299T1
Authority
AT
Austria
Prior art keywords
carboxylic acid
decahydroischinoline
prodrugs
prodrug forms
decahydroisoquinoline
Prior art date
Application number
AT00941172T
Other languages
English (en)
Inventor
Thomas John Bleisch
Edward Louis Mattiuz
Paul Leslie Ornstein
Robert Eugene Junior Stratford
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE240299T1 publication Critical patent/ATE240299T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT00941172T 1999-07-06 2000-06-13 Diester prodrugs von decahydroischinoline-3- carbonsäure ATE240299T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14248499P 1999-07-06 1999-07-06
PCT/US2000/015030 WO2001002367A2 (en) 1999-07-06 2000-06-13 Diester prodrugs of a decahydroisoquinoline-3-carboxylic acid

Publications (1)

Publication Number Publication Date
ATE240299T1 true ATE240299T1 (de) 2003-05-15

Family

ID=22500022

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00941172T ATE240299T1 (de) 1999-07-06 2000-06-13 Diester prodrugs von decahydroischinoline-3- carbonsäure

Country Status (7)

Country Link
US (1) US6486175B1 (de)
EP (1) EP1208087B1 (de)
AT (1) ATE240299T1 (de)
AU (1) AU5591900A (de)
DE (1) DE60002733T2 (de)
ES (1) ES2198323T3 (de)
WO (1) WO2001002367A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1200073E (pt) 1999-07-06 2007-03-30 Lilly Co Eli Antagonistas selectivos do receptor de iglur5 para o tratamento de enxaqueca
AU2574801A (en) 1999-12-22 2001-07-03 Eli Lilly And Company Selective iGLUR5 receptor antagonists
US6924294B2 (en) 2001-01-05 2005-08-02 Eli Lilly And Company Excitatory amino acid receptor antagonists
AU2002227020A1 (en) 2001-01-05 2002-07-16 Eli Lilly And Company Pyrrolidinylmethyl- and piperidinyl substituted decahydroisoquinolines as excitatory amino acid receptor antagonists
AU2002228736A1 (en) 2001-01-05 2002-07-16 Eli Lilly And Company Pyrrolidinylmethyl substituted decahydroisoquinolines as excitatory amino acid receptor antagonists
US7205313B2 (en) 2001-01-05 2007-04-17 Eli Lilly And Company Excitatory amino acid receptor antagonists
WO2002058691A1 (en) * 2001-01-23 2002-08-01 Neurosearch A/S Use of non-competitive and selective glur5 antagonists as glutamate receptor modulating compounds
EP1511741B1 (de) * 2002-04-26 2012-12-26 Eli Lilly And Company Esterderivate einer decahydroisoquinolin-3-carbonsäure als analgetika
PL2083811T3 (pl) 2006-11-22 2017-05-31 Clinical Research Associates, Llc Sposoby leczenia zespołu downa, zespołu łamliwego chromosomu x oraz autyzmu
WO2011109398A2 (en) 2010-03-02 2011-09-09 President And Fellows Of Harvard College Methods and compositions for treatment of angelman syndrome and autism spectrum disorders
US20110294879A1 (en) 2010-05-28 2011-12-01 Xenoport, Inc. Method of treatment of fragile x syndrome, down's syndrome, autism and related disorders
WO2012009646A1 (en) 2010-07-15 2012-01-19 Xenoport, Inc. Methods of treating fragile x syndrome, down's syndrome, autism and related disorders
WO2012054724A1 (en) 2010-10-21 2012-04-26 Massachusetts Institute Of Technology Methods of treating seizure disorders
EP4175635B1 (de) 2020-07-02 2026-03-25 Sea Pharmaceuticals LLC Pharmazeutische zusammensetzungen aus 6-(2-(2h-tetrazol-5-yl)ethyl)-6-fluordecahydroisochinolin-3-carbonsäure und esterderivaten davon

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2252381B (en) 1990-12-14 1995-08-09 Charles Bickford Improved fixing
US5284957A (en) * 1992-09-03 1994-02-08 Eli Lilly And Company Excitatory amino acid receptor antagonists
US5446051A (en) * 1994-05-31 1995-08-29 Eli Lilly And Company Aryl-spaced decahydroisoquinoline-3-carboxylic acids as excitatory amino acid receptor antagonists
EA199900912A1 (ru) 1997-04-07 2000-04-24 Эли Лилли Энд Компани Фармацевтические средства

Also Published As

Publication number Publication date
ES2198323T3 (es) 2004-02-01
AU5591900A (en) 2001-01-22
DE60002733D1 (de) 2003-06-18
WO2001002367A2 (en) 2001-01-11
DE60002733T2 (de) 2004-03-18
EP1208087A2 (de) 2002-05-29
WO2001002367A3 (en) 2001-03-08
US6486175B1 (en) 2002-11-26
EP1208087B1 (de) 2003-05-14

Similar Documents

Publication Publication Date Title
FI970246A7 (fi) Dihydrobentsofuraanit
DE60131160D1 (de) Caspase-inhibitoren und ihre verwendungen
BR9900443A (pt) Esteres de ácido aril acrìlico.
ATE232873T1 (de) Phosphonsaürederivate als ptp-1b-inhibitoren
FI956119A0 (fi) Fenyyliheterosyklejä syklo-oksigenaasi-2-inhibiittoreina
DK1140918T3 (da) Thrombininhibitorer
IS4695A (is) (Metýlsúlfónýl)fenýl-2-(5H)-fúranón sem sýklóoxýgenasa-2 tálmar
TR200001435T2 (tr) Antimikrobiyal kuinolonlar, bunların bileşimleri ve kullanımları
DE69915004D1 (de) 5-Oxo-pyrrolidine-2-Carbonsäure-Hydroxamidderivate
FI924311A0 (fi) Nya 2-substituerade indan-2 -merkaptoacetylamidderivat anvaendbara som inhibitorer av enkefalinas och ace.
MEP24608A (en) Azetidine derivatives, preparation thereof and pharmaceutical compositions containing same
AP2001002217A0 (en) Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids.
ES2175624T3 (es) Derivados de pirazolo(4,3-d)pirimidina y composiciones farmaceuticas que los contienen.
IL159418A0 (en) Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
ATE240299T1 (de) Diester prodrugs von decahydroischinoline-3- carbonsäure
DE69732571D1 (de) Beta-sulfonyl-hydroxamsäuren als matrix-metalloproteinaseinhibitoren
DE60334773D1 (de) Formulierungen zur oralen verabreichung von wirkstoffen
EA200100516A1 (ru) Производные 3,3-биарилпиперидина и 2,2-биарилморфолина
ATE223376T1 (de) Bisarylcyclobutenderivate als cyclooxygenasehemmer
ES2147973T3 (es) Estirenos alquilatados como profarmacos de inhibidores de cox-2.
DE60041001D1 (de) Substituierte homopiperidylbenzimidazolanaloga als fundusrelaxantien
PL328225A1 (en) Diphenylstilbenes as pro-medications used to produce cox-2-inhibitors
TR200200494T2 (tr) Yağlı asit sintazı inhibitörleri.
GR3017348T3 (en) Novel isoindolinone derivative, preparation thereof, and pharmaceutical compositions containing same.
ES2183500T3 (es) Nuevos compuestos y composiciones farmaceuticas que los contienen.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties