JPS57145841A - L-menthyl naphthylpropionate and its preparation - Google Patents
L-menthyl naphthylpropionate and its preparationInfo
- Publication number
- JPS57145841A JPS57145841A JP3186181A JP3186181A JPS57145841A JP S57145841 A JPS57145841 A JP S57145841A JP 3186181 A JP3186181 A JP 3186181A JP 3186181 A JP3186181 A JP 3186181A JP S57145841 A JPS57145841 A JP S57145841A
- Authority
- JP
- Japan
- Prior art keywords
- methoxynaphth
- propionic acid
- menthyl
- naphthylpropionate
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:2-(4-Methoxynaphth-2-yl)propionic acid l-menthyl ester of formulaI.
USE: Intermediate of pharmaceuticals. It has antiphlogistic, analgesic and antipyretic activities.
PROCESS: The compound of fomulaIcan be prepared by (1) reacting 1mol of d-, l-, or dl-2-(6-methoxynaphth-2-yl)propionic acid of formula with 1W4mol of an acid-halogenating agent in a solvent such as benzene at about 30minWabout 18hr at about 15W80°C, and (2) condensing the resultant d-, l- or dl-2-(6-methoxynaphth-2-yl)propionic acid halide with somewhat excess l-methol in the presence of a base such as pyridine in an organic solvent such as THF under ice cooling or at room temperture.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3186181A JPS57145841A (en) | 1981-03-05 | 1981-03-05 | L-menthyl naphthylpropionate and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3186181A JPS57145841A (en) | 1981-03-05 | 1981-03-05 | L-menthyl naphthylpropionate and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57145841A true JPS57145841A (en) | 1982-09-09 |
Family
ID=12342826
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3186181A Pending JPS57145841A (en) | 1981-03-05 | 1981-03-05 | L-menthyl naphthylpropionate and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57145841A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997013519A1 (en) * | 1995-10-09 | 1997-04-17 | Russinsky Limited | Esters of cyclooxygenase inhibitors and terpene derivatives as pharmaceutical products |
JP2003506425A (en) * | 1999-08-04 | 2003-02-18 | ニコックス エス エイ | Method for producing nitroxyalkyl ester of naproxen |
-
1981
- 1981-03-05 JP JP3186181A patent/JPS57145841A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997013519A1 (en) * | 1995-10-09 | 1997-04-17 | Russinsky Limited | Esters of cyclooxygenase inhibitors and terpene derivatives as pharmaceutical products |
JP2003506425A (en) * | 1999-08-04 | 2003-02-18 | ニコックス エス エイ | Method for producing nitroxyalkyl ester of naproxen |
JP4667691B2 (en) * | 1999-08-04 | 2011-04-13 | ニコックス エス エイ | Process for the preparation of nitroxyalkyl esters of naproxen |
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