JPS57145841A - L-menthyl naphthylpropionate and its preparation - Google Patents

L-menthyl naphthylpropionate and its preparation

Info

Publication number
JPS57145841A
JPS57145841A JP3186181A JP3186181A JPS57145841A JP S57145841 A JPS57145841 A JP S57145841A JP 3186181 A JP3186181 A JP 3186181A JP 3186181 A JP3186181 A JP 3186181A JP S57145841 A JPS57145841 A JP S57145841A
Authority
JP
Japan
Prior art keywords
methoxynaphth
propionic acid
menthyl
naphthylpropionate
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3186181A
Other languages
Japanese (ja)
Inventor
Yoshio Obara
Kazutaka Arai
Yasuo Takakuwa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissan Chemical Corp
Original Assignee
Nissan Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Corp filed Critical Nissan Chemical Corp
Priority to JP3186181A priority Critical patent/JPS57145841A/en
Publication of JPS57145841A publication Critical patent/JPS57145841A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:2-(4-Methoxynaphth-2-yl)propionic acid l-menthyl ester of formulaI.
USE: Intermediate of pharmaceuticals. It has antiphlogistic, analgesic and antipyretic activities.
PROCESS: The compound of fomulaIcan be prepared by (1) reacting 1mol of d-, l-, or dl-2-(6-methoxynaphth-2-yl)propionic acid of formula with 1W4mol of an acid-halogenating agent in a solvent such as benzene at about 30minWabout 18hr at about 15W80°C, and (2) condensing the resultant d-, l- or dl-2-(6-methoxynaphth-2-yl)propionic acid halide with somewhat excess l-methol in the presence of a base such as pyridine in an organic solvent such as THF under ice cooling or at room temperture.
COPYRIGHT: (C)1982,JPO&Japio
JP3186181A 1981-03-05 1981-03-05 L-menthyl naphthylpropionate and its preparation Pending JPS57145841A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3186181A JPS57145841A (en) 1981-03-05 1981-03-05 L-menthyl naphthylpropionate and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3186181A JPS57145841A (en) 1981-03-05 1981-03-05 L-menthyl naphthylpropionate and its preparation

Publications (1)

Publication Number Publication Date
JPS57145841A true JPS57145841A (en) 1982-09-09

Family

ID=12342826

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3186181A Pending JPS57145841A (en) 1981-03-05 1981-03-05 L-menthyl naphthylpropionate and its preparation

Country Status (1)

Country Link
JP (1) JPS57145841A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997013519A1 (en) * 1995-10-09 1997-04-17 Russinsky Limited Esters of cyclooxygenase inhibitors and terpene derivatives as pharmaceutical products
JP2003506425A (en) * 1999-08-04 2003-02-18 ニコックス エス エイ Method for producing nitroxyalkyl ester of naproxen

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997013519A1 (en) * 1995-10-09 1997-04-17 Russinsky Limited Esters of cyclooxygenase inhibitors and terpene derivatives as pharmaceutical products
JP2003506425A (en) * 1999-08-04 2003-02-18 ニコックス エス エイ Method for producing nitroxyalkyl ester of naproxen
JP4667691B2 (en) * 1999-08-04 2011-04-13 ニコックス エス エイ Process for the preparation of nitroxyalkyl esters of naproxen

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