DK1200386T3 - Fremgangsmåde til fremstilling af nitroxyalkylestere af naproxen - Google Patents

Fremgangsmåde til fremstilling af nitroxyalkylestere af naproxen

Info

Publication number
DK1200386T3
DK1200386T3 DK00951456T DK00951456T DK1200386T3 DK 1200386 T3 DK1200386 T3 DK 1200386T3 DK 00951456 T DK00951456 T DK 00951456T DK 00951456 T DK00951456 T DK 00951456T DK 1200386 T3 DK1200386 T3 DK 1200386T3
Authority
DK
Denmark
Prior art keywords
naproxen
preparation
nitroxyalkyl
esters
nitroxyalkyl esters
Prior art date
Application number
DK00951456T
Other languages
English (en)
Inventor
Francesca Benedini
Erminio Oldani
Graziano Castaldi
Antonio Tarquini
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Application granted granted Critical
Publication of DK1200386T3 publication Critical patent/DK1200386T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK00951456T 1999-08-04 2000-07-27 Fremgangsmåde til fremstilling af nitroxyalkylestere af naproxen DK1200386T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI001753A IT1313596B1 (it) 1999-08-04 1999-08-04 Processo per la preparazione di nitrossialchil esteri del naproxene
PCT/EP2000/007222 WO2001010814A1 (en) 1999-08-04 2000-07-27 Process for the preparation of naproxene nitroxyalkylesters

Publications (1)

Publication Number Publication Date
DK1200386T3 true DK1200386T3 (da) 2003-12-22

Family

ID=11383500

Family Applications (2)

Application Number Title Priority Date Filing Date
DK00951456T DK1200386T3 (da) 1999-08-04 2000-07-27 Fremgangsmåde til fremstilling af nitroxyalkylestere af naproxen
DK03102132T DK1384707T3 (da) 1999-08-04 2000-07-27 4-Nitroxybutylester af naproxen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK03102132T DK1384707T3 (da) 1999-08-04 2000-07-27 4-Nitroxybutylester af naproxen

Country Status (23)

Country Link
US (2) US6700011B1 (da)
EP (2) EP1384707B1 (da)
JP (2) JP4667691B2 (da)
KR (1) KR100687820B1 (da)
CN (1) CN1198786C (da)
AT (2) ATE297372T1 (da)
AU (1) AU778694B2 (da)
BR (1) BRPI0012915B1 (da)
CA (1) CA2380116C (da)
DE (2) DE60020753T2 (da)
DK (2) DK1200386T3 (da)
ES (2) ES2208390T3 (da)
HU (1) HU227109B1 (da)
IL (1) IL147639A0 (da)
IT (1) IT1313596B1 (da)
MX (1) MXPA02001256A (da)
NO (1) NO327669B1 (da)
PL (1) PL200165B1 (da)
PT (2) PT1200386E (da)
RU (1) RU2248348C2 (da)
TR (1) TR200200290T2 (da)
WO (1) WO2001010814A1 (da)
ZA (2) ZA200200478B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU763000B2 (en) 1998-10-30 2003-07-10 Nicox S.A. Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
US6706724B2 (en) 2000-12-21 2004-03-16 Nitromed, Inc. Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
WO2003045896A1 (en) * 2001-11-27 2003-06-05 Astrazeneca Ab New process
US7220749B2 (en) 2002-06-11 2007-05-22 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
JP2005539089A (ja) 2002-07-03 2005-12-22 ニトロメッド インコーポレーティッド ニトロソ化非ステロイド性抗炎症化合物、組成物および使用方法
CA2493156A1 (en) 2002-07-29 2004-02-05 Nitromed, Inc. Cyclooxygenase-2 selective inhibitors, compositions and methods of use
ITMI20021861A1 (it) * 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
ITMI20022409A1 (it) * 2002-11-14 2004-05-15 Dinamite Dipharma S P A Procedimento per la purificazione di 1, 4-butandiolo mononitrato.
PT1978947E (pt) * 2006-02-03 2014-11-03 Nicox Science Ireland Derivados nitro-óxido para utilização no tratamento de distrofias musculares
CN100427475C (zh) * 2006-11-30 2008-10-22 华南理工大学 萘普生-2-芳基吗啉乙酯及其制备方法与应用
CN101730676A (zh) * 2007-06-28 2010-06-09 尼科克斯公司 1,4-丁二醇单硝酸酯的制备方法
WO2009149053A2 (en) * 2008-06-02 2009-12-10 Dr. Reddy's Laboratories Ltd. Naproxcinod process and solid dispersion
ITRM20080325A1 (it) 2008-06-20 2009-12-21 Nicox Sa Metodo per purificare 4-(nitroosi)butil(2s)-2-(6-metossi-2-naftil) propanoato
TW201139337A (en) 2010-03-31 2011-11-16 Lonza Ag Process for the production of esters of nitric acid
TWI417276B (zh) 2011-03-01 2013-12-01 Everlight Chem Ind Corp ２-（ｓ）-（６-甲氧基-２-萘基）-丙酸之酸酐衍生物、其製法暨及其用途
CA2897571C (en) 2013-01-21 2018-12-18 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
US11660282B2 (en) 2020-02-10 2023-05-30 Nicox Sa Method for treating vaso occlusive crises associated with sickle cell disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57145841A (en) * 1981-03-05 1982-09-09 Nissan Chem Ind Ltd L-menthyl naphthylpropionate and its preparation
IT1243367B (it) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
US5700947A (en) 1993-10-06 1997-12-23 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
SI0759899T1 (en) * 1994-05-10 1999-12-31 Nicox S.A. Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
CN1144092A (zh) * 1995-08-25 1997-03-05 蔡雄 可释放一氧化氮的新型非类固醇类抗炎药、它们的制备方法和用途
WO1997013519A1 (en) * 1995-10-09 1997-04-17 Russinsky Limited Esters of cyclooxygenase inhibitors and terpene derivatives as pharmaceutical products
IT1276071B1 (it) * 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
FR2757159B1 (fr) * 1996-12-12 1999-12-17 Hoechst Marion Roussel Inc Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments

Also Published As

Publication number Publication date
BR0012915A (pt) 2002-06-04
DK1384707T3 (da) 2005-08-15
ES2208390T3 (es) 2004-06-16
KR20020013974A (ko) 2002-02-21
EP1384707A1 (en) 2004-01-28
TR200200290T2 (tr) 2002-05-21
EP1200386A1 (en) 2002-05-02
CN1367773A (zh) 2002-09-04
HU227109B1 (en) 2010-07-28
ITMI991753A1 (it) 2001-02-04
US7238829B2 (en) 2007-07-03
ES2243859T3 (es) 2005-12-01
IL147639A0 (en) 2002-08-14
RU2248348C2 (ru) 2005-03-20
DE60020753T2 (de) 2006-03-16
US6700011B1 (en) 2004-03-02
WO2001010814A1 (en) 2001-02-15
CA2380116C (en) 2011-07-05
NO20020515L (no) 2002-02-01
PT1200386E (pt) 2004-02-27
EP1384707B1 (en) 2005-06-08
ATE297372T1 (de) 2005-06-15
ZA200200478B (en) 2003-10-29
HUP0202435A3 (en) 2004-03-01
AU6438500A (en) 2001-03-05
EP1200386B1 (en) 2003-10-01
JP2003506425A (ja) 2003-02-18
NO20020515D0 (no) 2002-02-01
NO327669B1 (no) 2009-09-07
DE60005682T2 (de) 2004-09-16
ZA200304525B (en) 2004-04-28
CA2380116A1 (en) 2001-02-15
JP4667691B2 (ja) 2011-04-13
PL353092A1 (en) 2003-10-06
PT1384707E (pt) 2005-08-31
PL200165B1 (pl) 2008-12-31
KR100687820B1 (ko) 2007-02-28
US20050119339A1 (en) 2005-06-02
BRPI0012915B1 (pt) 2015-09-01
AU778694B2 (en) 2004-12-16
DE60005682D1 (de) 2003-11-06
IT1313596B1 (it) 2002-09-09
JP2011042690A (ja) 2011-03-03
CN1198786C (zh) 2005-04-27
ITMI991753A0 (it) 1999-08-04
DE60020753D1 (de) 2005-07-14
HUP0202435A2 (hu) 2002-11-28
ATE251109T1 (de) 2003-10-15
MXPA02001256A (es) 2005-06-06

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