PT1384707E - Ester 4-nitroxibutilico de naproxeno - Google Patents

Ester 4-nitroxibutilico de naproxeno

Info

Publication number
PT1384707E
PT1384707E PT03102132T PT03102132T PT1384707E PT 1384707 E PT1384707 E PT 1384707E PT 03102132 T PT03102132 T PT 03102132T PT 03102132 T PT03102132 T PT 03102132T PT 1384707 E PT1384707 E PT 1384707E
Authority
PT
Portugal
Prior art keywords
ester
nitroxibutilic
naproxene
naphthyl
methoxy
Prior art date
Application number
PT03102132T
Other languages
English (en)
Portuguese (pt)
Inventor
Graziano Castaldi
Francesca Benedini
Erminio Oldani
Antonio Tarquini
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Publication of PT1384707E publication Critical patent/PT1384707E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PT03102132T 1999-08-04 2000-07-27 Ester 4-nitroxibutilico de naproxeno PT1384707E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999MI001753A IT1313596B1 (it) 1999-08-04 1999-08-04 Processo per la preparazione di nitrossialchil esteri del naproxene

Publications (1)

Publication Number Publication Date
PT1384707E true PT1384707E (pt) 2005-08-31

Family

ID=11383500

Family Applications (2)

Application Number Title Priority Date Filing Date
PT03102132T PT1384707E (pt) 1999-08-04 2000-07-27 Ester 4-nitroxibutilico de naproxeno
PT00951456T PT1200386E (pt) 1999-08-04 2000-07-27 Processo para a preparacao de esteres nitroxialquilicos de naproxeno

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT00951456T PT1200386E (pt) 1999-08-04 2000-07-27 Processo para a preparacao de esteres nitroxialquilicos de naproxeno

Country Status (23)

Country Link
US (2) US6700011B1 (https=)
EP (2) EP1200386B1 (https=)
JP (2) JP4667691B2 (https=)
KR (1) KR100687820B1 (https=)
CN (1) CN1198786C (https=)
AT (2) ATE251109T1 (https=)
AU (1) AU778694B2 (https=)
BR (1) BRPI0012915B1 (https=)
CA (1) CA2380116C (https=)
DE (2) DE60005682T2 (https=)
DK (2) DK1200386T3 (https=)
ES (2) ES2243859T3 (https=)
HU (1) HU227109B1 (https=)
IL (1) IL147639A0 (https=)
IT (1) IT1313596B1 (https=)
MX (1) MXPA02001256A (https=)
NO (1) NO327669B1 (https=)
PL (1) PL200165B1 (https=)
PT (2) PT1384707E (https=)
RU (1) RU2248348C2 (https=)
TR (1) TR200200290T2 (https=)
WO (1) WO2001010814A1 (https=)
ZA (2) ZA200200478B (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6297260B1 (en) 1998-10-30 2001-10-02 Nitromed, Inc. Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
AP2002002582A0 (en) 1999-12-23 2002-09-30 Nitromed Inc Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
DE60122939T2 (de) 2000-12-21 2007-01-11 Nitromed, Inc., Bedford Substituierte arylverbindungen als neue, cyclooxygenase-2-selektive inhibitoren, zusammensetzungen und verwendungsverfahren
AU2002365372A1 (en) * 2001-11-27 2003-06-10 Astrazeneca Ab New process
CA2487414A1 (en) 2002-06-11 2003-12-18 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
AU2003247792B2 (en) 2002-07-03 2009-09-24 Nicox S.A. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
US7244753B2 (en) 2002-07-29 2007-07-17 Nitromed, Inc. Cyclooxygenase-2 selective inhibitors, compositions and methods of use
ITMI20021861A1 (it) 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
ITMI20022409A1 (it) * 2002-11-14 2004-05-15 Dinamite Dipharma S P A Procedimento per la purificazione di 1, 4-butandiolo mononitrato.
NZ569396A (en) * 2006-02-03 2011-06-30 Nicox Sa Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
CN100427475C (zh) * 2006-11-30 2008-10-22 华南理工大学 萘普生-2-芳基吗啉乙酯及其制备方法与应用
JP2010531324A (ja) * 2007-06-28 2010-09-24 ニコックス エス エイ １，４−ブタンジオールモノナイトレートの製造方法
WO2009149053A2 (en) * 2008-06-02 2009-12-10 Dr. Reddy's Laboratories Ltd. Naproxcinod process and solid dispersion
ITRM20080325A1 (it) * 2008-06-20 2009-12-21 Nicox Sa Metodo per purificare 4-(nitroosi)butil(2s)-2-(6-metossi-2-naftil) propanoato
TW201139337A (en) 2010-03-31 2011-11-16 Lonza Ag Process for the production of esters of nitric acid
TWI417276B (zh) 2011-03-01 2013-12-01 Everlight Chem Ind Corp ２-（ｓ）-（６-甲氧基-２-萘基）-丙酸之酸酐衍生物、其製法暨及其用途
CA2897571C (en) 2013-01-21 2018-12-18 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
CA3167343A1 (en) 2020-02-10 2021-08-19 Brigitte DUQUESROIX-CHAKROUN Method for treating vaso occlusive crises associated with sickle cell disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57145841A (en) * 1981-03-05 1982-09-09 Nissan Chem Ind Ltd L-menthyl naphthylpropionate and its preparation
IT1243367B (it) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
EP0722434B1 (en) * 1993-10-06 1998-07-29 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
WO1995030641A1 (en) * 1994-05-10 1995-11-16 Nicox S.A. Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
CN1144092A (zh) * 1995-08-25 1997-03-05 蔡雄 可释放一氧化氮的新型非类固醇类抗炎药、它们的制备方法和用途
WO1997013519A1 (en) * 1995-10-09 1997-04-17 Russinsky Limited Esters of cyclooxygenase inhibitors and terpene derivatives as pharmaceutical products
IT1276071B1 (it) 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
FR2757159B1 (fr) 1996-12-12 1999-12-17 Hoechst Marion Roussel Inc Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments

Also Published As

Publication number Publication date
DE60020753T2 (de) 2006-03-16
JP2003506425A (ja) 2003-02-18
CA2380116C (en) 2011-07-05
CN1198786C (zh) 2005-04-27
MXPA02001256A (es) 2005-06-06
EP1384707A1 (en) 2004-01-28
DE60020753D1 (de) 2005-07-14
HUP0202435A2 (hu) 2002-11-28
EP1200386A1 (en) 2002-05-02
ATE251109T1 (de) 2003-10-15
PL200165B1 (pl) 2008-12-31
RU2248348C2 (ru) 2005-03-20
JP4667691B2 (ja) 2011-04-13
KR100687820B1 (ko) 2007-02-28
DE60005682T2 (de) 2004-09-16
CA2380116A1 (en) 2001-02-15
HU227109B1 (en) 2010-07-28
IT1313596B1 (it) 2002-09-09
WO2001010814A1 (en) 2001-02-15
US7238829B2 (en) 2007-07-03
NO20020515D0 (no) 2002-02-01
DE60005682D1 (de) 2003-11-06
ITMI991753A0 (it) 1999-08-04
CN1367773A (zh) 2002-09-04
ES2208390T3 (es) 2004-06-16
ES2243859T3 (es) 2005-12-01
NO327669B1 (no) 2009-09-07
HUP0202435A3 (en) 2004-03-01
ITMI991753A1 (it) 2001-02-04
IL147639A0 (en) 2002-08-14
EP1200386B1 (en) 2003-10-01
BR0012915A (pt) 2002-06-04
EP1384707B1 (en) 2005-06-08
JP2011042690A (ja) 2011-03-03
BRPI0012915B1 (pt) 2015-09-01
ZA200304525B (en) 2004-04-28
KR20020013974A (ko) 2002-02-21
DK1384707T3 (da) 2005-08-15
DK1200386T3 (da) 2003-12-22
PT1200386E (pt) 2004-02-27
ATE297372T1 (de) 2005-06-15
US20050119339A1 (en) 2005-06-02
PL353092A1 (en) 2003-10-06
ZA200200478B (en) 2003-10-29
NO20020515L (no) 2002-02-01
TR200200290T2 (tr) 2002-05-21
AU778694B2 (en) 2004-12-16
US6700011B1 (en) 2004-03-02
AU6438500A (en) 2001-03-05

Similar Documents

Publication Publication Date Title
PT1384707E (pt) Ester 4-nitroxibutilico de naproxeno
ATE249418T1 (de) Neuartige ester abgeleitet von substituierten phenyl-cyclohexyl-verbindungen
PT1627880E (pt) Compostos de ácido e éster borónico, sínteses e utilizações
DE69813540D1 (de) Kosmetische zusammensetzung enthaltend ferulasäureester
ID22095A (id) Asam aril-akrilat ester
DK1138325T3 (da) Anvendelse af syntetiske triglycerider på basis af konjugeret linolsyre til fremstilling af midler til støtte for tumorbehandlingen
DE50113582D1 (de) Verwendung einer Pulver-Zusammensetzung zur Hydrophobierung von Baustoffmassen
ATE240299T1 (de) Diester prodrugs von decahydroischinoline-3- carbonsäure
ATE183394T1 (de) Verwendung von phosphorsäurediester-verbindungen zur unterdrückung von krebsmetastasen in der leber
DE69920568D1 (de) Verfahren zur Herstellung von optisch aktivem 4-Halo-3-hydroxybuttersäureester
DE59913680D1 (de) Fettsäurepartialester von Polyolen
DE59810578D1 (de) Mischungen von langkettigen Phosphorsäurealkylestern
DE59712000D1 (de) Herstellung von Carbonsäurefluoriden
NO993796L (no) Fremgangsmåte for omforestring av <alfa>- ketokarboksylsyreestre
ITRM950193A0 (it) Procedimento per la produzione di miscugli di diesteri polietilenglicolici dell'acido 2-(4-cloro-2-metilfenossi)-propionico.
EP0673914A3 (en) Preparation of alpha-keto acid esters.
EP1449823A4 (en) DIESTER DIBASIC ACIDS
EP0997534A3 (de) Verfahren zur Racematspaltung von Arylalkylcarbonsäureestern
FR2757165B1 (fr) Ester de l'acide maleimidobenzoique
DE69932269D1 (de) Herstellung optisch aktiver Cyclohexylphenylglykolsäureester
EP0770611A3 (en) Fungicidal 2- (4-pyrazolyloxypyrimidin-5-yl) acetic acid derivatives
ATE280755T1 (de) 3-oxo-1-propansulfonsäure und -sulfonate
DE50012694D1 (de) Verwendung von fettsäurealkanolaminestern
DE69809692D1 (de) Herstellung von Carbonsäureestern
ES2159665T3 (es) Preparacion y utilizacion de enantiomeros puros de los acidos 8-halogeno-6-hidroxioctanoicos, sus esteres alquilicos y sus sales con los enantiomeros puros de alfa-metilbencilamina.