JP4153303B2 - 走査型電子顕微鏡を用いた非真空環境内のサンプルの検査のための装置および方法 - Google Patents
走査型電子顕微鏡を用いた非真空環境内のサンプルの検査のための装置および方法 Download PDFInfo
- Publication number
- JP4153303B2 JP4153303B2 JP2002547196A JP2002547196A JP4153303B2 JP 4153303 B2 JP4153303 B2 JP 4153303B2 JP 2002547196 A JP2002547196 A JP 2002547196A JP 2002547196 A JP2002547196 A JP 2002547196A JP 4153303 B2 JP4153303 B2 JP 4153303B2
- Authority
- JP
- Japan
- Prior art keywords
- sample
- membrane
- cells
- chamber
- electrons
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title description 49
- 238000007689 inspection Methods 0.000 title description 13
- 239000000463 material Substances 0.000 claims description 67
- 238000010894 electron beam technology Methods 0.000 claims description 29
- 229920001721 polyimide Polymers 0.000 claims description 15
- 239000012530 fluid Substances 0.000 claims description 14
- 239000004642 Polyimide Substances 0.000 claims description 13
- 230000003993 interaction Effects 0.000 claims description 12
- 239000012298 atmosphere Substances 0.000 claims description 7
- 239000010410 layer Substances 0.000 claims description 7
- -1 polyethylene Polymers 0.000 claims description 5
- 239000004952 Polyamide Substances 0.000 claims description 4
- 239000004962 Polyamide-imide Substances 0.000 claims description 4
- 229920002647 polyamide Polymers 0.000 claims description 4
- 229920002312 polyamide-imide Polymers 0.000 claims description 4
- 239000004698 Polyethylene Substances 0.000 claims description 3
- 238000009434 installation Methods 0.000 claims description 3
- 229920003223 poly(pyromellitimide-1,4-diphenyl ether) Polymers 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- 229920000128 polypyrrole Polymers 0.000 claims description 3
- 229920002037 poly(vinyl butyral) polymer Polymers 0.000 claims 1
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical group OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 claims 1
- 239000012528 membrane Substances 0.000 abstract description 149
- 239000000523 sample Substances 0.000 description 147
- 210000004027 cell Anatomy 0.000 description 132
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 51
- 229910001868 water Inorganic materials 0.000 description 43
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 38
- 229910052737 gold Inorganic materials 0.000 description 32
- 239000010931 gold Substances 0.000 description 32
- 238000002372 labelling Methods 0.000 description 27
- 239000002245 particle Substances 0.000 description 21
- 238000005192 partition Methods 0.000 description 20
- 229910052799 carbon Inorganic materials 0.000 description 19
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 17
- 238000003384 imaging method Methods 0.000 description 15
- 238000010586 diagram Methods 0.000 description 13
- 239000000243 solution Substances 0.000 description 13
- 230000004888 barrier function Effects 0.000 description 12
- 239000011324 bead Substances 0.000 description 12
- 230000001464 adherent effect Effects 0.000 description 11
- 239000002609 medium Substances 0.000 description 11
- 238000002360 preparation method Methods 0.000 description 11
- 239000008055 phosphate buffer solution Substances 0.000 description 10
- 239000011248 coating agent Substances 0.000 description 9
- 238000000576 coating method Methods 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 238000001514 detection method Methods 0.000 description 8
- 238000001493 electron microscopy Methods 0.000 description 8
- 238000005259 measurement Methods 0.000 description 8
- 239000012472 biological sample Substances 0.000 description 7
- 238000004364 calculation method Methods 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- 230000003287 optical effect Effects 0.000 description 7
- 230000005855 radiation Effects 0.000 description 7
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 6
- 239000000839 emulsion Substances 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 239000003921 oil Substances 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 108010090804 Streptavidin Proteins 0.000 description 4
- 238000009825 accumulation Methods 0.000 description 4
- 239000012736 aqueous medium Substances 0.000 description 4
- 125000004429 atom Chemical group 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 238000004422 calculation algorithm Methods 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 239000003562 lightweight material Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- PQXKHYXIUOZZFA-UHFFFAOYSA-M lithium fluoride Chemical compound [Li+].[F-] PQXKHYXIUOZZFA-UHFFFAOYSA-M 0.000 description 4
- 239000003550 marker Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000013307 optical fiber Substances 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 238000005070 sampling Methods 0.000 description 4
- LIVNPJMFVYWSIS-UHFFFAOYSA-N silicon monoxide Chemical compound [Si-]#[O+] LIVNPJMFVYWSIS-UHFFFAOYSA-N 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 102000016359 Fibronectins Human genes 0.000 description 3
- 108010067306 Fibronectins Proteins 0.000 description 3
- 108010052285 Membrane Proteins Proteins 0.000 description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 229960002685 biotin Drugs 0.000 description 3
- 235000020958 biotin Nutrition 0.000 description 3
- 239000011616 biotin Substances 0.000 description 3
- 210000000170 cell membrane Anatomy 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 239000000084 colloidal system Substances 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 238000000635 electron micrograph Methods 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 239000006260 foam Substances 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 235000003642 hunger Nutrition 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 230000003834 intracellular effect Effects 0.000 description 3
- 210000003098 myoblast Anatomy 0.000 description 3
- 230000008823 permeabilization Effects 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 238000004626 scanning electron microscopy Methods 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 229910052709 silver Inorganic materials 0.000 description 3
- 239000004332 silver Substances 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- WWJZWCUNLNYYAU-UHFFFAOYSA-N temephos Chemical compound C1=CC(OP(=S)(OC)OC)=CC=C1SC1=CC=C(OP(=S)(OC)OC)C=C1 WWJZWCUNLNYYAU-UHFFFAOYSA-N 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 108091008794 FGF receptors Proteins 0.000 description 2
- 102000044168 Fibroblast Growth Factor Receptor Human genes 0.000 description 2
- 102000010789 Interleukin-2 Receptors Human genes 0.000 description 2
- 108010038453 Interleukin-2 Receptors Proteins 0.000 description 2
- 102000018697 Membrane Proteins Human genes 0.000 description 2
- 238000000342 Monte Carlo simulation Methods 0.000 description 2
- 229930040373 Paraformaldehyde Natural products 0.000 description 2
- 206010057249 Phagocytosis Diseases 0.000 description 2
- 108010039918 Polylysine Proteins 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 238000004125 X-ray microanalysis Methods 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 230000003833 cell viability Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 2
- 229920001940 conductive polymer Polymers 0.000 description 2
- 239000004020 conductor Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000001506 fluorescence spectroscopy Methods 0.000 description 2
- 239000012737 fresh medium Substances 0.000 description 2
- 238000010191 image analysis Methods 0.000 description 2
- 230000004941 influx Effects 0.000 description 2
- 239000012212 insulator Substances 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000005374 membrane filtration Methods 0.000 description 2
- 238000004377 microelectronic Methods 0.000 description 2
- 239000003068 molecular probe Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 238000012634 optical imaging Methods 0.000 description 2
- 238000000399 optical microscopy Methods 0.000 description 2
- 210000003463 organelle Anatomy 0.000 description 2
- 239000011368 organic material Substances 0.000 description 2
- 229920002866 paraformaldehyde Polymers 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- 230000008782 phagocytosis Effects 0.000 description 2
- 229920000656 polylysine Polymers 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 239000002096 quantum dot Substances 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 239000004065 semiconductor Substances 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- JJGWLCLUQNFDIS-GTSONSFRSA-M sodium;1-[6-[5-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoyloxy]-2,5-dioxopyrrolidine-3-sulfonate Chemical compound [Na+].O=C1C(S(=O)(=O)[O-])CC(=O)N1OC(=O)CCCCCNC(=O)CCCC[C@H]1[C@H]2NC(=O)N[C@H]2CS1 JJGWLCLUQNFDIS-GTSONSFRSA-M 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 2
- 229910052721 tungsten Inorganic materials 0.000 description 2
- 239000010937 tungsten Substances 0.000 description 2
- 238000009736 wetting Methods 0.000 description 2
- 241000212384 Bifora Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 108060006698 EGF receptor Proteins 0.000 description 1
- 102000001301 EGF receptor Human genes 0.000 description 1
- 102000009465 Growth Factor Receptors Human genes 0.000 description 1
- 108010009202 Growth Factor Receptors Proteins 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 230000002292 Radical scavenging effect Effects 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 201000009310 astigmatism Diseases 0.000 description 1
- 239000000227 bioadhesive Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 150000001722 carbon compounds Chemical class 0.000 description 1
- 238000005136 cathodoluminescence Methods 0.000 description 1
- 239000006143 cell culture medium Substances 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 210000004292 cytoskeleton Anatomy 0.000 description 1
- 210000000172 cytosol Anatomy 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000023077 detection of light stimulus Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000007876 drug discovery Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000008151 electrolyte solution Substances 0.000 description 1
- 238000001803 electron scattering Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 238000001215 fluorescent labelling Methods 0.000 description 1
- 102000034287 fluorescent proteins Human genes 0.000 description 1
- 108091006047 fluorescent proteins Proteins 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 230000007274 generation of a signal involved in cell-cell signaling Effects 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000004452 microanalysis Methods 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 210000004940 nucleus Anatomy 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 239000001194 polyoxyethylene (40) stearate Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000001878 scanning electron micrograph Methods 0.000 description 1
- 239000012679 serum free medium Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 238000004557 single molecule detection Methods 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000010421 standard material Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 125000000185 sucrose group Chemical group 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 239000012209 synthetic fiber Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- 238000004846 x-ray emission Methods 0.000 description 1
Images
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J37/00—Discharge tubes with provision for introducing objects or material to be exposed to the discharge, e.g. for the purpose of examination or processing thereof
- H01J37/26—Electron or ion microscopes; Electron or ion diffraction tubes
- H01J37/28—Electron or ion microscopes; Electron or ion diffraction tubes with scanning beams
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J37/00—Discharge tubes with provision for introducing objects or material to be exposed to the discharge, e.g. for the purpose of examination or processing thereof
- H01J37/02—Details
- H01J37/20—Means for supporting or positioning the object or the material; Means for adjusting diaphragms or lenses associated with the support
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J2237/00—Discharge tubes exposing object to beam, e.g. for analysis treatment, etching, imaging
- H01J2237/006—Details of gas supplies, e.g. in an ion source, to a beam line, to a specimen or to a workpiece
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J2237/00—Discharge tubes exposing object to beam, e.g. for analysis treatment, etching, imaging
- H01J2237/20—Positioning, supporting, modifying or maintaining the physical state of objects being observed or treated
- H01J2237/2002—Controlling environment of sample
- H01J2237/2003—Environmental cells
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J2237/00—Discharge tubes exposing object to beam, e.g. for analysis treatment, etching, imaging
- H01J2237/26—Electron or ion microscopes
- H01J2237/28—Scanning microscopes
- H01J2237/2803—Scanning microscopes characterised by the imaging method
- H01J2237/2807—X-rays
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25087900P | 2000-12-01 | 2000-12-01 | |
| US30645801P | 2001-07-20 | 2001-07-20 | |
| PCT/IL2001/001108 WO2002045125A1 (en) | 2000-12-01 | 2001-11-30 | Device and method for the examination of samples in a non-vacuum environment using a scanning electron microscope |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008097275A Division JP2008171830A (ja) | 2000-12-01 | 2008-04-03 | 走査型電子顕微鏡を用いた非真空環境内のサンプルの検査のための装置および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004515049A JP2004515049A (ja) | 2004-05-20 |
| JP2004515049A5 JP2004515049A5 (enExample) | 2005-12-22 |
| JP4153303B2 true JP4153303B2 (ja) | 2008-09-24 |
Family
ID=26941209
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002547196A Expired - Fee Related JP4153303B2 (ja) | 2000-12-01 | 2001-11-30 | 走査型電子顕微鏡を用いた非真空環境内のサンプルの検査のための装置および方法 |
| JP2008097275A Pending JP2008171830A (ja) | 2000-12-01 | 2008-04-03 | 走査型電子顕微鏡を用いた非真空環境内のサンプルの検査のための装置および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008097275A Pending JP2008171830A (ja) | 2000-12-01 | 2008-04-03 | 走査型電子顕微鏡を用いた非真空環境内のサンプルの検査のための装置および方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US6992300B2 (enExample) |
| EP (1) | EP1340241B1 (enExample) |
| JP (2) | JP4153303B2 (enExample) |
| CN (1) | CN1511332A (enExample) |
| AT (1) | ATE510298T1 (enExample) |
| AU (2) | AU2101902A (enExample) |
| CA (1) | CA2436237A1 (enExample) |
| CZ (1) | CZ20031455A3 (enExample) |
| IL (1) | IL156027A0 (enExample) |
| WO (1) | WO2002045125A1 (enExample) |
Families Citing this family (162)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2367686B (en) * | 2000-08-10 | 2002-12-11 | Leo Electron Microscopy Ltd | Improvements in or relating to particle detectors |
| US7230242B2 (en) | 2002-06-05 | 2007-06-12 | Quantomix Ltd | Methods for SEM inspection of fluid containing samples |
| IL150056A0 (en) | 2002-06-05 | 2002-12-01 | Yeda Res & Dev | Low-pressure chamber for scanning electron microscopy in a wet environment |
| US11243494B2 (en) | 2002-07-31 | 2022-02-08 | Abs Global, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
| US20070125947A1 (en) * | 2003-02-20 | 2007-06-07 | David Sprinzak | Sample enclosure for a scanning electron microscope and methods of use thereof |
| US20050017173A1 (en) * | 2003-07-15 | 2005-01-27 | Nalin Kumar | Individually addressable nanoelectrode array |
| US7274447B2 (en) * | 2004-06-21 | 2007-09-25 | Swce | Material porosity pressure impulse testing system |
| WO2007008216A2 (en) * | 2004-07-29 | 2007-01-18 | California Institute Of Technology | Low stress, ultra-thin, uniform membrane, methods of fabricating same and incorporation into detection devices |
| US7586097B2 (en) | 2006-01-05 | 2009-09-08 | Virgin Islands Microsystems, Inc. | Switching micro-resonant structures using at least one director |
| US7791290B2 (en) | 2005-09-30 | 2010-09-07 | Virgin Islands Microsystems, Inc. | Ultra-small resonating charged particle beam modulator |
| US7626179B2 (en) | 2005-09-30 | 2009-12-01 | Virgin Island Microsystems, Inc. | Electron beam induced resonance |
| US20090045349A1 (en) * | 2004-08-26 | 2009-02-19 | David Sprinzak | Sample enclosure for inspection and methods of use thereof |
| NL1027025C2 (nl) * | 2004-09-13 | 2006-03-14 | Univ Delft Tech | Microreactor voor een transmissie elektronenmicroscoop en verwarmingselement en werkwijze voor vervaardiging daarvan. |
| US7381970B2 (en) * | 2005-01-31 | 2008-06-03 | Summer Schneider | Specimen stage for charged-particle scanning microscopy |
| US20060172315A1 (en) * | 2005-02-01 | 2006-08-03 | Anderson Amy L | Methods for staining cells for identification and sorting |
| CN100511568C (zh) * | 2005-05-09 | 2009-07-08 | 东捷科技股份有限公司 | 在真空或低压环境中操作高压腔室且供观测的方法及装置 |
| WO2007064358A2 (en) | 2005-09-30 | 2007-06-07 | Virgin Islands Microsystems, Inc. | Structures and methods for coupling energy from an electromagnetic wave |
| TWI277734B (en) * | 2005-10-26 | 2007-04-01 | Li Bing Huan | Method for observing living bodies using an electron microscopy |
| TWI275118B (en) * | 2005-12-09 | 2007-03-01 | Li Bing Huan | Sample box of electron microscope for observing a general sample/live cell |
| JP2007163447A (ja) * | 2005-12-09 | 2007-06-28 | Lee Bing Huan | 電子顕微鏡用の超薄液体制御板 |
| US7579609B2 (en) | 2005-12-14 | 2009-08-25 | Virgin Islands Microsystems, Inc. | Coupling light of light emitting resonator to waveguide |
| US7470920B2 (en) | 2006-01-05 | 2008-12-30 | Virgin Islands Microsystems, Inc. | Resonant structure-based display |
| US7619373B2 (en) | 2006-01-05 | 2009-11-17 | Virgin Islands Microsystems, Inc. | Selectable frequency light emitter |
| KR100994516B1 (ko) * | 2006-02-02 | 2010-11-15 | 전자빔기술센터 주식회사 | 전자 칼럼용 진공 차등 유지 기구 |
| US7443358B2 (en) | 2006-02-28 | 2008-10-28 | Virgin Island Microsystems, Inc. | Integrated filter in antenna-based detector |
| US7558490B2 (en) | 2006-04-10 | 2009-07-07 | Virgin Islands Microsystems, Inc. | Resonant detector for optical signals |
| US7646991B2 (en) | 2006-04-26 | 2010-01-12 | Virgin Island Microsystems, Inc. | Selectable frequency EMR emitter |
| US7876793B2 (en) | 2006-04-26 | 2011-01-25 | Virgin Islands Microsystems, Inc. | Micro free electron laser (FEL) |
| US7492868B2 (en) | 2006-04-26 | 2009-02-17 | Virgin Islands Microsystems, Inc. | Source of x-rays |
| JP2007294365A (ja) * | 2006-04-27 | 2007-11-08 | Jeol Ltd | 試料検査方法、試料保持体、及び試料検査装置並びに試料検査システム |
| JP2007292702A (ja) * | 2006-04-27 | 2007-11-08 | Jeol Ltd | 試料検査装置及び試料検査方法並びに試料検査システム |
| US7436177B2 (en) | 2006-05-05 | 2008-10-14 | Virgin Islands Microsystems, Inc. | SEM test apparatus |
| US7442940B2 (en) | 2006-05-05 | 2008-10-28 | Virgin Island Microsystems, Inc. | Focal plane array incorporating ultra-small resonant structures |
| US7557647B2 (en) | 2006-05-05 | 2009-07-07 | Virgin Islands Microsystems, Inc. | Heterodyne receiver using resonant structures |
| US7554083B2 (en) | 2006-05-05 | 2009-06-30 | Virgin Islands Microsystems, Inc. | Integration of electromagnetic detector on integrated chip |
| US7443577B2 (en) | 2006-05-05 | 2008-10-28 | Virgin Islands Microsystems, Inc. | Reflecting filtering cover |
| US7476907B2 (en) | 2006-05-05 | 2009-01-13 | Virgin Island Microsystems, Inc. | Plated multi-faceted reflector |
| US7718977B2 (en) | 2006-05-05 | 2010-05-18 | Virgin Island Microsystems, Inc. | Stray charged particle removal device |
| US7723698B2 (en) | 2006-05-05 | 2010-05-25 | Virgin Islands Microsystems, Inc. | Top metal layer shield for ultra-small resonant structures |
| US7342441B2 (en) | 2006-05-05 | 2008-03-11 | Virgin Islands Microsystems, Inc. | Heterodyne receiver array using resonant structures |
| US7728397B2 (en) | 2006-05-05 | 2010-06-01 | Virgin Islands Microsystems, Inc. | Coupled nano-resonating energy emitting structures |
| US7746532B2 (en) | 2006-05-05 | 2010-06-29 | Virgin Island Microsystems, Inc. | Electro-optical switching system and method |
| US7586167B2 (en) | 2006-05-05 | 2009-09-08 | Virgin Islands Microsystems, Inc. | Detecting plasmons using a metallurgical junction |
| US7710040B2 (en) | 2006-05-05 | 2010-05-04 | Virgin Islands Microsystems, Inc. | Single layer construction for ultra small devices |
| US7359589B2 (en) | 2006-05-05 | 2008-04-15 | Virgin Islands Microsystems, Inc. | Coupling electromagnetic wave through microcircuit |
| US7728702B2 (en) | 2006-05-05 | 2010-06-01 | Virgin Islands Microsystems, Inc. | Shielding of integrated circuit package with high-permeability magnetic material |
| US8188431B2 (en) | 2006-05-05 | 2012-05-29 | Jonathan Gorrell | Integration of vacuum microelectronic device with integrated circuit |
| US7569836B2 (en) | 2006-05-05 | 2009-08-04 | Virgin Islands Microsystems, Inc. | Transmission of data between microchips using a particle beam |
| US7741934B2 (en) | 2006-05-05 | 2010-06-22 | Virgin Islands Microsystems, Inc. | Coupling a signal through a window |
| US7732786B2 (en) | 2006-05-05 | 2010-06-08 | Virgin Islands Microsystems, Inc. | Coupling energy in a plasmon wave to an electron beam |
| US7986113B2 (en) | 2006-05-05 | 2011-07-26 | Virgin Islands Microsystems, Inc. | Selectable frequency light emitter |
| US7656094B2 (en) * | 2006-05-05 | 2010-02-02 | Virgin Islands Microsystems, Inc. | Electron accelerator for ultra-small resonant structures |
| US7583370B2 (en) | 2006-05-05 | 2009-09-01 | Virgin Islands Microsystems, Inc. | Resonant structures and methods for encoding signals into surface plasmons |
| US7573045B2 (en) | 2006-05-15 | 2009-08-11 | Virgin Islands Microsystems, Inc. | Plasmon wave propagation devices and methods |
| US7679067B2 (en) | 2006-05-26 | 2010-03-16 | Virgin Island Microsystems, Inc. | Receiver array using shared electron beam |
| US7655934B2 (en) | 2006-06-28 | 2010-02-02 | Virgin Island Microsystems, Inc. | Data on light bulb |
| JP5084188B2 (ja) * | 2006-07-04 | 2012-11-28 | 日本電子株式会社 | 試料保持体、試料検査方法及び試料検査装置並びに試料検査システム |
| US7450794B2 (en) | 2006-09-19 | 2008-11-11 | Virgin Islands Microsystems, Inc. | Microcircuit using electromagnetic wave routing |
| US7560716B2 (en) | 2006-09-22 | 2009-07-14 | Virgin Islands Microsystems, Inc. | Free electron oscillator |
| JP4850654B2 (ja) * | 2006-10-23 | 2012-01-11 | 株式会社日立ハイテクノロジーズ | 荷電粒子線装置および荷電粒子線装置用試料保持装置 |
| WO2008050321A2 (en) | 2006-10-24 | 2008-05-02 | B-Nano Ltd. | An interface, a methof for observing an object within a non-vacuum environment and a scanning electron microscope |
| JP5002251B2 (ja) | 2006-12-06 | 2012-08-15 | 日本電子株式会社 | 試料検査方法及び試料検査装置 |
| TWI330380B (en) * | 2006-12-07 | 2010-09-11 | Nat Univ Tsing Hua | A specimen kit for electron microscope and its fabrication process |
| JP2008153086A (ja) * | 2006-12-19 | 2008-07-03 | Jeol Ltd | 試料検査装置及び試料検査方法並びに試料検査システム |
| EP2365321B1 (en) | 2006-12-19 | 2013-10-02 | JEOL Ltd. | Sample inspection apparatus, sample inspection method, and sample inspection system |
| US7659513B2 (en) | 2006-12-20 | 2010-02-09 | Virgin Islands Microsystems, Inc. | Low terahertz source and detector |
| JP5318364B2 (ja) | 2007-01-31 | 2013-10-16 | 日本電子株式会社 | 試料保持体、試料検査装置及び試料検査方法、並びに試料保持体の製造方法 |
| EP1953793B1 (en) | 2007-01-31 | 2012-05-16 | JEOL Ltd. | Specimen holder, specimen inspection apparatus, specimen inspection method, and method of fabricating specimen holder |
| JP2008210715A (ja) * | 2007-02-27 | 2008-09-11 | Ebara Corp | 荷電粒子線装置及びこれを用いた試料表面観察方法 |
| EP2130086A4 (en) | 2007-03-02 | 2012-03-14 | Protochips Inc | MEMBRANE SUPPORTS WITH REINFORCING FUNCTIONS |
| US7990336B2 (en) | 2007-06-19 | 2011-08-02 | Virgin Islands Microsystems, Inc. | Microwave coupled excitation of solid state resonant arrays |
| US9134307B2 (en) * | 2007-07-11 | 2015-09-15 | X-Body, Inc. | Method for determining ion channel modulating properties of a test reagent |
| EP2171454B1 (en) | 2007-07-11 | 2013-03-20 | X-Body, Inc. | Methods of identifying modulators of ion channels |
| US7791053B2 (en) | 2007-10-10 | 2010-09-07 | Virgin Islands Microsystems, Inc. | Depressed anode with plasmon-enabled devices such as ultra-small resonant structures |
| EP2061067A3 (en) | 2007-11-13 | 2010-04-07 | Carl Zeiss SMT Limited | Beam device and system comprising a particle beam device and an optical microscope |
| JP5253800B2 (ja) * | 2007-12-26 | 2013-07-31 | 日本電子株式会社 | 試料保持体及び観察・検査方法並びに観察・検査装置 |
| JP5215701B2 (ja) | 2008-03-26 | 2013-06-19 | 日本電子株式会社 | 試料検査装置及び試料検査方法 |
| EP2105944A1 (en) | 2008-03-28 | 2009-09-30 | FEI Company | Environmental cell for a particle-optical apparatus |
| JP5314317B2 (ja) | 2008-04-08 | 2013-10-16 | 日本電子株式会社 | 検査方法及び試液 |
| JP2010002300A (ja) | 2008-06-20 | 2010-01-07 | Jeol Ltd | 試料保持体、試料検査装置及び試料検査方法 |
| US8334510B2 (en) * | 2008-07-03 | 2012-12-18 | B-Nano Ltd. | Scanning electron microscope, an interface and a method for observing an object within a non-vacuum environment |
| US8981294B2 (en) | 2008-07-03 | 2015-03-17 | B-Nano Ltd. | Scanning electron microscope, an interface and a method for observing an object within a non-vacuum environment |
| JP2010027488A (ja) | 2008-07-23 | 2010-02-04 | Jeol Ltd | 試料保持体、試料検査装置及び試料検査方法 |
| EP2329252A4 (en) * | 2008-09-28 | 2012-04-11 | Nano Ltd B | VACUUM DEVICE AND ELECTRONIC SCAN MICROSCOPE |
| JP5205234B2 (ja) * | 2008-12-02 | 2013-06-05 | 株式会社日立ハイテクノロジーズ | 微小試料採取装置,検査解析システム、および検査解析方法 |
| US8059271B2 (en) | 2009-02-04 | 2011-11-15 | The United States Of America As Represented By The Secretary Of The Army | Reusable sample holding device permitting ready loading of very small wet samples |
| JP5124507B2 (ja) * | 2009-02-16 | 2013-01-23 | 株式会社日立ハイテクノロジーズ | 電子線装置および電子線装置用試料保持装置 |
| JP2010230417A (ja) | 2009-03-26 | 2010-10-14 | Jeol Ltd | 試料の検査装置及び検査方法 |
| US8087309B2 (en) | 2009-05-22 | 2012-01-03 | Sion Power Corporation | Hermetic sample holder and method for performing microanalysis under controlled atmosphere environment |
| NL2004888A (en) * | 2009-06-29 | 2010-12-30 | Asml Netherlands Bv | Deposition method and apparatus. |
| WO2011009209A1 (en) * | 2009-07-23 | 2011-01-27 | Maher Harb | Nanofluidic cell |
| JP5576406B2 (ja) * | 2010-01-27 | 2014-08-20 | 株式会社日立ハイテクノロジーズ | 荷電粒子線装置 |
| JP2011243483A (ja) | 2010-05-20 | 2011-12-01 | Jeol Ltd | 試料保持体、検査装置、及び検査方法 |
| JP5065516B2 (ja) * | 2010-08-04 | 2012-11-07 | エフ イー アイ カンパニ | 薄い電子検出器における後方散乱の減少 |
| JP5218503B2 (ja) * | 2010-09-01 | 2013-06-26 | コニカミノルタビジネステクノロジーズ株式会社 | 光走査装置および画像形成装置 |
| CN103261879B (zh) | 2010-10-01 | 2015-04-22 | 安托莱特公司 | 时间选通阴极发光图像的去卷积 |
| US10908066B2 (en) | 2010-11-16 | 2021-02-02 | 1087 Systems, Inc. | Use of vibrational spectroscopy for microfluidic liquid measurement |
| US20120190137A1 (en) * | 2011-01-24 | 2012-07-26 | Sumitomo Electric Industries, Ltd. | Cross section observation method |
| US10505234B2 (en) | 2011-03-14 | 2019-12-10 | Battelle Memorial Institute | Battery cell and n situ battery electrode analysis method |
| US9274059B2 (en) | 2011-03-14 | 2016-03-01 | Battelle Memorial Institute | Microfluidic electrochemical device and process for chemical imaging and electrochemical analysis at the electrode-liquid interface in-situ |
| US10598609B2 (en) * | 2011-03-14 | 2020-03-24 | Battelle Memorial Institute | Universal liquid sample device and process for high resolution transmission electron microscope imaging and multimodal analyses of liquid sample materials |
| US8555710B2 (en) * | 2011-03-14 | 2013-10-15 | Battelle Memorial Institute | Systems and methods for analyzing liquids under vacuum |
| JP5699023B2 (ja) | 2011-04-11 | 2015-04-08 | 株式会社日立ハイテクノロジーズ | 荷電粒子線装置 |
| CN103493171B (zh) * | 2011-04-28 | 2016-02-17 | 株式会社日立高新技术 | 电子显微镜用试样保持装置以及电子显微镜装置 |
| EP3528276A3 (en) | 2011-05-13 | 2019-09-04 | Fibics Incorporated | Microscopy imaging method |
| EP2732299A4 (en) | 2011-07-15 | 2015-03-25 | Orbotech Ltd | ELECTRICAL TESTING OF ELECTRONIC DEVICES BY MEANS OF ELECTRON BEAM-INDUCED PLASMA STONES |
| EP2734836A4 (en) | 2011-07-21 | 2015-07-22 | Univ Columbia | METHOD OF COLLECTING AND PROCESSING ELECTRON DIFFACTION DATA |
| JP5896708B2 (ja) | 2011-12-06 | 2016-03-30 | 株式会社日立ハイテクノロジーズ | 走査イオン顕微鏡および二次粒子制御方法 |
| JP5115997B1 (ja) * | 2011-12-27 | 2013-01-09 | 独立行政法人産業技術総合研究所 | 走査型電子顕微鏡像観察用の試料支持部材及び走査型電子顕微鏡像の観察方法 |
| JP2013187096A (ja) * | 2012-03-09 | 2013-09-19 | Hitachi Ltd | 電子顕微鏡の液体試料ホルダ及びその製造方法 |
| US8809783B2 (en) * | 2012-06-19 | 2014-08-19 | Rensselaer Polytechnic Institute | High spatial resolution non-contact temperature measurement |
| JP6002946B2 (ja) * | 2012-07-23 | 2016-10-05 | 国立研究開発法人産業技術総合研究所 | 試料ホルダおよび電子顕微鏡像の観察方法 |
| JP5936484B2 (ja) | 2012-08-20 | 2016-06-22 | 株式会社日立ハイテクノロジーズ | 荷電粒子線装置及び試料観察方法 |
| JP5923412B2 (ja) | 2012-08-24 | 2016-05-24 | 株式会社日立ハイテクノロジーズ | 観察装置および光軸調整方法 |
| JP5930922B2 (ja) | 2012-09-14 | 2016-06-08 | 株式会社日立ハイテクノロジーズ | 荷電粒子線装置及び試料観察方法 |
| JP6207824B2 (ja) | 2012-10-01 | 2017-10-04 | 株式会社日立ハイテクノロジーズ | 荷電粒子線装置、隔膜の位置調整方法および隔膜位置調整ジグ |
| JP6051014B2 (ja) | 2012-10-29 | 2016-12-21 | 株式会社日立ハイテクノロジーズ | 試料格納用容器、荷電粒子線装置、及び画像取得方法 |
| JP6035602B2 (ja) * | 2012-11-21 | 2016-11-30 | 株式会社日立ハイテクノロジーズ | 荷電粒子線装置、試料台ユニット、及び試料観察方法 |
| US8872105B2 (en) * | 2013-02-19 | 2014-10-28 | Fei Company | In situ reactivation of fluorescence marker |
| JP2016513349A (ja) | 2013-02-20 | 2016-05-12 | ビー−ナノ リミテッド | 走査型電子顕微鏡 |
| KR102026936B1 (ko) * | 2013-03-26 | 2019-10-01 | 삼성디스플레이 주식회사 | 주사 전자 현미경을 이용한 검사 시스템 |
| JP6112553B2 (ja) * | 2013-04-08 | 2017-04-12 | 国立研究開発法人産業技術総合研究所 | 観察システム及び観察方法 |
| CN105103262B (zh) * | 2013-04-12 | 2017-10-10 | 株式会社日立高新技术 | 带电粒子束装置以及过滤部件 |
| US8961904B2 (en) | 2013-07-16 | 2015-02-24 | Premium Genetics (Uk) Ltd. | Microfluidic chip |
| DE102013012609B4 (de) * | 2013-07-26 | 2024-06-27 | Carl Zeiss Microscopy Gmbh | Optoelektronischer Detektor, insbesondere für hochauflösende Lichtrastermikroskope und Lichtrastermikroskop |
| US9633817B2 (en) * | 2013-08-23 | 2017-04-25 | Hitachi High-Technologies Corporation | Diaphragm mounting member and charged particle beam device |
| KR101752164B1 (ko) | 2013-09-06 | 2017-06-29 | 가부시키가이샤 히다치 하이테크놀로지즈 | 하전 입자선 장치 및 시료 화상 취득 방법 |
| JP6364167B2 (ja) * | 2013-09-30 | 2018-07-25 | 株式会社日立ハイテクノロジーズ | 環境制御型荷電粒子観察システム |
| USD794816S1 (en) * | 2013-10-24 | 2017-08-15 | Hitachi High-Technologies Corporation | Sample holder for an electron microscope |
| US11796449B2 (en) | 2013-10-30 | 2023-10-24 | Abs Global, Inc. | Microfluidic system and method with focused energy apparatus |
| US10410338B2 (en) | 2013-11-04 | 2019-09-10 | Kla-Tencor Corporation | Method and system for correlating optical images with scanning electron microscopy images |
| JP6047508B2 (ja) | 2014-01-27 | 2016-12-21 | 株式会社日立ハイテクノロジーズ | 荷電粒子線装置、試料画像取得方法、およびプログラム記録媒体 |
| US9564291B1 (en) * | 2014-01-27 | 2017-02-07 | Mochii, Inc. | Hybrid charged-particle beam and light beam microscopy |
| US9997331B1 (en) | 2014-01-27 | 2018-06-12 | Mochii, Inc. | Charged-particle beam microscopy |
| US20160032281A1 (en) * | 2014-07-31 | 2016-02-04 | Fei Company | Functionalized grids for locating and imaging biological specimens and methods of using the same |
| GB2537579A (en) * | 2014-11-07 | 2016-10-26 | Linkam Scient Instr Ltd | Microscopic sample preparation |
| TWI546841B (zh) | 2014-12-10 | 2016-08-21 | 財團法人工業技術研究院 | 具有載台的電子顯微鏡 |
| US10180388B2 (en) | 2015-02-19 | 2019-01-15 | 1087 Systems, Inc. | Scanning infrared measurement system |
| JP6522133B2 (ja) | 2015-08-21 | 2019-05-29 | 株式会社日立ハイテクノロジーズ | 観察支援ユニットおよびこれを用いた試料観察方法、荷電粒子線装置 |
| TWI597481B (zh) * | 2015-12-22 | 2017-09-01 | 閤康生物科技股份有限公司 | 樣本收集元件及其製作方法 |
| TWI594288B (zh) * | 2016-03-14 | 2017-08-01 | 台灣電鏡儀器股份有限公司 | 電子顯微鏡 |
| CN106525845B (zh) * | 2016-10-11 | 2023-11-03 | 聚束科技(北京)有限公司 | 一种带电粒子束系统、光电联合探测系统及方法 |
| CN106783493B (zh) * | 2016-12-01 | 2018-07-10 | 聚束科技(北京)有限公司 | 一种真空气氛处理装置、样品观测系统及方法 |
| US11051390B2 (en) * | 2017-03-22 | 2021-06-29 | Japan Atomic Energy Agency | Functional membrane for ion beam transmission, beam line device and filter device each having the same, and method of adjusting filter device |
| EP3796998A1 (en) | 2018-05-23 | 2021-03-31 | ABS Global, Inc. | Systems and methods for particle focusing in microchannels |
| CN109187595B (zh) * | 2018-09-27 | 2021-05-11 | 南京宁智高新材料研究院有限公司 | 一种测量透射电镜中微气体束引起的局部等效压强的装置 |
| JP7189529B2 (ja) * | 2018-10-15 | 2022-12-14 | 国立大学法人 筑波大学 | 環境セルとその製造方法 |
| WO2020084729A1 (ja) * | 2018-10-25 | 2020-04-30 | 株式会社日立ハイテクノロジーズ | 荷電粒子線装置、荷電粒子線装置のオートフォーカス処理方法、及び検出器 |
| US10777379B1 (en) * | 2019-03-19 | 2020-09-15 | Hitachi High-Tech Corporation | Holder and charged particle beam apparatus |
| KR102198707B1 (ko) * | 2019-03-25 | 2021-01-05 | (주)코셈 | 착탈 가능한 컬럼을 구비하는 주사 전자 현미경 및, 이를 이용한 영상 획득 방법 |
| CN113784618B (zh) | 2019-04-18 | 2023-12-22 | 艾步思国际有限责任公司 | 用于连续添加冷冻保护剂的系统和工艺 |
| US11738312B2 (en) * | 2019-08-01 | 2023-08-29 | Government Of The United States Of America, As Represented By The Secretary Of Commerce | Multidimensional printer |
| US11628439B2 (en) | 2020-01-13 | 2023-04-18 | Abs Global, Inc. | Single-sheath microfluidic chip |
| NL2024861B1 (en) * | 2020-02-07 | 2021-09-13 | Univ Delft Tech | Method for recording and correlating light and charged particle microscopy images |
| US11410838B2 (en) | 2020-09-03 | 2022-08-09 | Thermo Finnigan Llc | Long life electron multiplier |
| AU2021365488A1 (en) | 2020-10-21 | 2023-06-01 | Abs Global, Inc. | Methods and systems for processing genetic samples to determine identity or detect contamination |
| WO2022108840A1 (en) | 2020-11-23 | 2022-05-27 | Abs Global, Inc. | Modular flow cytometry systems and methods of processing samples |
| CN112461807B (zh) * | 2020-11-26 | 2021-11-19 | 山西大学 | 碳量子点在靶向细胞核仁免洗成像中的应用 |
| WO2022136064A1 (en) * | 2020-12-23 | 2022-06-30 | Asml Netherlands B.V. | Charged particle optical device |
| DE102021101982A1 (de) | 2021-01-28 | 2022-07-28 | ebm-papst neo GmbH & Co. KG | Vorrichtung und Verfahren zur Erfassung einer Konzentration von vorbestimmten Partikeln anhand ihrer morphologischen Eigenschaften in Luft |
| CN114113182A (zh) * | 2021-10-22 | 2022-03-01 | 合肥国轩高科动力能源有限公司 | 一种用于扫描电镜拍摄硅基负极材料的定位处理方法 |
| CN118348039B (zh) * | 2024-05-06 | 2025-11-07 | 中国科学院上海高等研究院 | 一种扫描电镜原位厚液层的液体环境样品的显微分析方法 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1345670A (fr) * | 1962-10-25 | 1963-12-13 | Radiologie Cie Gle | Perfectionnements aux porte-échantillons liquides pour spectromètres à rayons chious vide |
| US3657596A (en) * | 1965-05-20 | 1972-04-18 | Westinghouse Electric Corp | Electron image device having target comprising porous region adjacent conductive layer and outer, denser region |
| US3378684A (en) * | 1965-06-16 | 1968-04-16 | Gen Electric | Fluid sample cell with means to keep constant pressure on the sample fluid |
| US4071766A (en) * | 1974-03-28 | 1978-01-31 | Mta Kozponti Kemiai Kutato Intezet | Micro-chamber for electron optical examinations particularly for the electron microscopic examination of biological objects |
| JPS5168585U (enExample) * | 1974-11-26 | 1976-05-31 | ||
| US4115689A (en) * | 1977-07-06 | 1978-09-19 | Won Vann Y | Leveling device for forming X-ray specimen |
| US4308547A (en) * | 1978-04-13 | 1981-12-29 | Recognition Equipment Incorporated | Liquid drop emitter |
| DE2921151C2 (de) * | 1979-05-25 | 1982-12-02 | Ernst Leitz Wetzlar Gmbh, 6330 Wetzlar | Vorrichtung zum Nachweis von in einem Abtast-Elektronenstrahlmikroskop von einer Probe ausgehenden Rückstreuelektronen |
| AU534811B2 (en) * | 1979-07-03 | 1984-02-16 | Unisearch Limited | Atmospheric scanning electron microscope |
| US4448311A (en) * | 1983-01-24 | 1984-05-15 | Tech Ref, Inc. | Sample cell |
| JPS59168652A (ja) * | 1983-03-16 | 1984-09-22 | Hitachi Ltd | 素子修正方法及びその装置 |
| US4618938A (en) * | 1984-02-22 | 1986-10-21 | Kla Instruments Corporation | Method and apparatus for automatic wafer inspection |
| US4587666A (en) * | 1984-05-03 | 1986-05-06 | Angelo M. Torrisi | System and a method for mounting film to a sample holder for X-ray spectroscopic fluorescence analysis |
| US4720622A (en) * | 1985-03-11 | 1988-01-19 | Sanyo Electric Co., Ltd | Wall-mounted type cooking apparatus |
| US4705949A (en) * | 1985-11-25 | 1987-11-10 | The United States Of America As Represented By The Secretary Of Commerce | Method and apparatus relating to specimen cells for scanning electron microscopes |
| US4720633A (en) * | 1986-01-17 | 1988-01-19 | Electro-Scan Corporation | Scanning electron microscope for visualization of wet samples |
| JPH0687410B2 (ja) * | 1986-08-01 | 1994-11-02 | エレクトロ‐スキャン コーポレーション | 走査電子顕微鏡及び試料の表面を電子顕微鏡的に像形成する方法 |
| US4880976A (en) * | 1987-05-21 | 1989-11-14 | Electroscan Corporation | Secondary electron detector for use in a gaseous atmosphere |
| US5250808A (en) * | 1987-05-21 | 1993-10-05 | Electroscan Corporation | Integrated electron optical/differential pumping/imaging signal system for an environmental scanning electron microscope |
| JPH0614461B2 (ja) | 1987-05-22 | 1994-02-23 | 日本電子株式会社 | 電子顕微鏡におけるガス雰囲気試料ホルダ |
| US4929831A (en) * | 1988-12-08 | 1990-05-29 | The United States Of America As Represented By The Secretary Of The Navy | Electron beam apparatus for testing infrared detectors in a cryogenically shielded environment |
| US4912330A (en) * | 1988-12-27 | 1990-03-27 | United States Of America As Represented By The Secretary Of The Navy | Apparatus for X-ray testing long wave infrared radiation detectors |
| US4929041A (en) * | 1989-01-09 | 1990-05-29 | Johnston Pump/General Valve, Inc. | Cathodoluminescence system for use in a scanning electron microscope including means for controlling optical fiber aperture |
| US5103102A (en) * | 1989-02-24 | 1992-04-07 | Micrion Corporation | Localized vacuum apparatus and method |
| JP2794471B2 (ja) * | 1989-11-24 | 1998-09-03 | 日本電子テクニクス株式会社 | 電子顕微鏡 |
| US5866904A (en) * | 1990-10-12 | 1999-02-02 | Hitachi, Ltd. | Scanning electron microscope and method for dimension measuring by using the same |
| JP3148353B2 (ja) * | 1991-05-30 | 2001-03-19 | ケーエルエー・インストルメンツ・コーポレーション | 電子ビーム検査方法とそのシステム |
| US5470757A (en) * | 1991-06-25 | 1995-11-28 | Minnesota Mining And Manufacturing Company | Spectroscopic sample holder and method for using same |
| US5122663A (en) * | 1991-07-24 | 1992-06-16 | International Business Machine Corporation | Compact, integrated electron beam imaging system |
| US5323441A (en) * | 1992-12-15 | 1994-06-21 | Angelo M. Torrisi | Sample holder for spectroscopic analysis and method for mounting film to sample holder |
| JP2781320B2 (ja) | 1993-01-18 | 1998-07-30 | 株式会社蛋白工学研究所 | 電子顕微鏡等の試料ホルダ |
| US5326971A (en) * | 1993-05-17 | 1994-07-05 | Motorola, Inc. | Transmission electron microscope environmental specimen holder |
| US5362964A (en) * | 1993-07-30 | 1994-11-08 | Electroscan Corporation | Environmental scanning electron microscope |
| US5412211A (en) * | 1993-07-30 | 1995-05-02 | Electroscan Corporation | Environmental scanning electron microscope |
| US5466940A (en) * | 1994-06-20 | 1995-11-14 | Opal Technologies Ltd. | Electron detector with high backscattered electron acceptance for particle beam apparatus |
| US5644132A (en) * | 1994-06-20 | 1997-07-01 | Opan Technologies Ltd. | System for high resolution imaging and measurement of topographic and material features on a specimen |
| US6025592A (en) * | 1995-08-11 | 2000-02-15 | Philips Electronics North America | High temperature specimen stage and detector for an environmental scanning electron microscope |
| US5898261A (en) * | 1996-01-31 | 1999-04-27 | The United States Of America As Represented By The Secretary Of The Air Force | Fluid-cooled particle-beam transmission window |
| AU2335097A (en) * | 1996-03-20 | 1997-10-10 | Hoechst Celanese Corporation | Addition of amine to improve paraformaldehyde |
| US5667791A (en) * | 1996-05-31 | 1997-09-16 | Thione International, Inc. | X-ray induced skin damage protective composition |
| JPH1064467A (ja) * | 1996-08-23 | 1998-03-06 | Toshiba Corp | 電子顕微鏡 |
| JP3500264B2 (ja) * | 1997-01-29 | 2004-02-23 | 株式会社日立製作所 | 試料分析装置 |
| US5859699A (en) * | 1997-02-07 | 1999-01-12 | Arcturus Engineering, Inc. | Laser capture microdissection analysis vessel |
| US5789748A (en) * | 1997-05-29 | 1998-08-04 | Stanford University | Low voltage electron beam system |
| US5945672A (en) * | 1998-01-29 | 1999-08-31 | Fei Company | Gaseous backscattered electron detector for an environmental scanning electron microscope |
| AU755545B2 (en) * | 1998-05-22 | 2002-12-12 | Euro-Celtique S.A. | Dissolution stage for an environmental scanning electron microscope |
| US6452177B1 (en) * | 1998-09-04 | 2002-09-17 | California Institute Of Technology | Atmospheric electron x-ray spectrometer |
| JP3610245B2 (ja) | 1998-10-27 | 2005-01-12 | 日本電子株式会社 | ガス雰囲気試料ホルダ |
| US20050244821A1 (en) | 2000-08-17 | 2005-11-03 | Ory Zik | Method of identification and quantification of biological molecules and apparatus therefore |
| JP2002273446A (ja) | 2001-03-19 | 2002-09-24 | Sanyo Electric Co Ltd | 汚水処理装置用電解槽 |
-
2001
- 2001-11-30 AU AU2101902A patent/AU2101902A/xx active Pending
- 2001-11-30 CZ CZ20031455A patent/CZ20031455A3/cs unknown
- 2001-11-30 IL IL15602701A patent/IL156027A0/xx active IP Right Grant
- 2001-11-30 AT AT01998987T patent/ATE510298T1/de not_active IP Right Cessation
- 2001-11-30 CN CNA018199062A patent/CN1511332A/zh active Pending
- 2001-11-30 CA CA002436237A patent/CA2436237A1/en not_active Abandoned
- 2001-11-30 WO PCT/IL2001/001108 patent/WO2002045125A1/en not_active Ceased
- 2001-11-30 JP JP2002547196A patent/JP4153303B2/ja not_active Expired - Fee Related
- 2001-11-30 EP EP01998987A patent/EP1340241B1/en not_active Expired - Lifetime
- 2001-11-30 AU AU2002221019A patent/AU2002221019B2/en not_active Ceased
-
2003
- 2003-05-27 US US10/448,313 patent/US6992300B2/en not_active Expired - Lifetime
-
2004
- 2004-05-06 US US10/841,769 patent/US6989542B2/en not_active Expired - Lifetime
-
2005
- 2005-08-19 US US11/207,611 patent/US7253418B2/en not_active Expired - Fee Related
-
2008
- 2008-04-03 JP JP2008097275A patent/JP2008171830A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002221019B2 (en) | 2007-02-08 |
| US6992300B2 (en) | 2006-01-31 |
| US6989542B2 (en) | 2006-01-24 |
| US20040217297A1 (en) | 2004-11-04 |
| JP2004515049A (ja) | 2004-05-20 |
| EP1340241A4 (en) | 2009-01-14 |
| AU2101902A (en) | 2002-06-11 |
| IL156027A0 (en) | 2003-12-23 |
| US20060033038A1 (en) | 2006-02-16 |
| JP2008171830A (ja) | 2008-07-24 |
| US20040046120A1 (en) | 2004-03-11 |
| EP1340241B1 (en) | 2011-05-18 |
| CZ20031455A3 (cs) | 2003-10-15 |
| EP1340241A1 (en) | 2003-09-03 |
| US7253418B2 (en) | 2007-08-07 |
| ATE510298T1 (de) | 2011-06-15 |
| CN1511332A (zh) | 2004-07-07 |
| CA2436237A1 (en) | 2002-06-06 |
| WO2002045125A1 (en) | 2002-06-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4153303B2 (ja) | 走査型電子顕微鏡を用いた非真空環境内のサンプルの検査のための装置および方法 | |
| AU2002221019A1 (en) | Device and method for the examination of samples in a non-vacuum environment using a scanning electron microscope | |
| US9207196B2 (en) | Transmission electron microscopy for imaging live cells | |
| Peckys et al. | Nanoscale imaging of whole cells using a liquid enclosure and a scanning transmission electron microscope | |
| US7745802B2 (en) | Specimen holder, specimen inspection apparatus, specimen inspection method, and method of fabricating specimen holder | |
| EP2312302A1 (en) | Apparatus and method for inspecting samples | |
| US8530856B2 (en) | Beam device system comprising a particle beam device and an optical microscope | |
| US4992662A (en) | Multipurpose gaseous detector device for electron microscope | |
| EP2388575A1 (en) | Sample holder, inspection apparatus and inspection method | |
| US8030622B2 (en) | Specimen holder, specimen inspection apparatus, and specimen inspection method | |
| US8119994B2 (en) | Apparatus and method for inspecting sample | |
| US7906760B2 (en) | Inspection method and reagent solution | |
| US7968843B2 (en) | Method and apparatus for simultaneous SEM and optical examination | |
| Białas et al. | Signal detection and imaging methods for MEMS electron microscope | |
| Griffith et al. | Photoelectron imaging in cell biology | |
| Pawley | LVSEM for biology | |
| IL156027A (en) | Device and method for the examination of samples in a non-vacuum environment using a scanning electron microscope | |
| Setou et al. | Mammalian cell nano structures visualized by cryo Hilbert differential contrast transmission electron microscopy | |
| EP1953793B1 (en) | Specimen holder, specimen inspection apparatus, specimen inspection method, and method of fabricating specimen holder | |
| Postek et al. | Nanomanufacturing concerns about measurements made in the SEM part IV: Charging and its mitigation | |
| Tousimis | Electron probe microanalysis of biological structures | |
| JP2024081144A (ja) | 荷電粒子顕微鏡法を使用して試料を評価する方法 | |
| Stegmann et al. | 13 Electron Microscopic Image Acquisition | |
| JPH0665014B2 (ja) | 自然状態試料観察可能走査型電子顕微鏡 | |
| Griffith et al. | AHIGH VACUUM PHOTOELECTRON MICROSCOPE FOR THE STUVV OP BIOLOGICAL SPECIMENS |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20041122 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20041122 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20060213 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20060228 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20060530 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20060607 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060831 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20070522 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20070820 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20071217 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20080311 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20080403 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20080603 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20080703 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 4153303 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110711 Year of fee payment: 3 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110711 Year of fee payment: 3 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120711 Year of fee payment: 4 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130711 Year of fee payment: 5 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |