CZ20031455A3 - Zařízení a způsob pro zkoumání vzorků v nevakuovém prostředí s použitím skenovacího elektronového mikroskopu - Google Patents
Zařízení a způsob pro zkoumání vzorků v nevakuovém prostředí s použitím skenovacího elektronového mikroskopu Download PDFInfo
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- CZ20031455A3 CZ20031455A3 CZ20031455A CZ20031455A CZ20031455A3 CZ 20031455 A3 CZ20031455 A3 CZ 20031455A3 CZ 20031455 A CZ20031455 A CZ 20031455A CZ 20031455 A CZ20031455 A CZ 20031455A CZ 20031455 A3 CZ20031455 A3 CZ 20031455A3
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Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J37/00—Discharge tubes with provision for introducing objects or material to be exposed to the discharge, e.g. for the purpose of examination or processing thereof
- H01J37/26—Electron or ion microscopes; Electron or ion diffraction tubes
- H01J37/28—Electron or ion microscopes; Electron or ion diffraction tubes with scanning beams
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J37/00—Discharge tubes with provision for introducing objects or material to be exposed to the discharge, e.g. for the purpose of examination or processing thereof
- H01J37/02—Details
- H01J37/20—Means for supporting or positioning the object or the material; Means for adjusting diaphragms or lenses associated with the support
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J2237/00—Discharge tubes exposing object to beam, e.g. for analysis treatment, etching, imaging
- H01J2237/006—Details of gas supplies, e.g. in an ion source, to a beam line, to a specimen or to a workpiece
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J2237/00—Discharge tubes exposing object to beam, e.g. for analysis treatment, etching, imaging
- H01J2237/20—Positioning, supporting, modifying or maintaining the physical state of objects being observed or treated
- H01J2237/2002—Controlling environment of sample
- H01J2237/2003—Environmental cells
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J2237/00—Discharge tubes exposing object to beam, e.g. for analysis treatment, etching, imaging
- H01J2237/26—Electron or ion microscopes
- H01J2237/28—Scanning microscopes
- H01J2237/2803—Scanning microscopes characterised by the imaging method
- H01J2237/2807—X-rays
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25087900P | 2000-12-01 | 2000-12-01 | |
| US30645801P | 2001-07-20 | 2001-07-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CZ20031455A3 true CZ20031455A3 (cs) | 2003-10-15 |
Family
ID=26941209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ20031455A CZ20031455A3 (cs) | 2000-12-01 | 2001-11-30 | Zařízení a způsob pro zkoumání vzorků v nevakuovém prostředí s použitím skenovacího elektronového mikroskopu |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US6992300B2 (enExample) |
| EP (1) | EP1340241B1 (enExample) |
| JP (2) | JP4153303B2 (enExample) |
| CN (1) | CN1511332A (enExample) |
| AT (1) | ATE510298T1 (enExample) |
| AU (2) | AU2101902A (enExample) |
| CA (1) | CA2436237A1 (enExample) |
| CZ (1) | CZ20031455A3 (enExample) |
| IL (1) | IL156027A0 (enExample) |
| WO (1) | WO2002045125A1 (enExample) |
Families Citing this family (162)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2367686B (en) * | 2000-08-10 | 2002-12-11 | Leo Electron Microscopy Ltd | Improvements in or relating to particle detectors |
| US7230242B2 (en) | 2002-06-05 | 2007-06-12 | Quantomix Ltd | Methods for SEM inspection of fluid containing samples |
| IL150056A0 (en) | 2002-06-05 | 2002-12-01 | Yeda Res & Dev | Low-pressure chamber for scanning electron microscopy in a wet environment |
| US11243494B2 (en) | 2002-07-31 | 2022-02-08 | Abs Global, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
| US20070125947A1 (en) * | 2003-02-20 | 2007-06-07 | David Sprinzak | Sample enclosure for a scanning electron microscope and methods of use thereof |
| US20050017173A1 (en) * | 2003-07-15 | 2005-01-27 | Nalin Kumar | Individually addressable nanoelectrode array |
| US7274447B2 (en) * | 2004-06-21 | 2007-09-25 | Swce | Material porosity pressure impulse testing system |
| WO2007008216A2 (en) * | 2004-07-29 | 2007-01-18 | California Institute Of Technology | Low stress, ultra-thin, uniform membrane, methods of fabricating same and incorporation into detection devices |
| US7586097B2 (en) | 2006-01-05 | 2009-09-08 | Virgin Islands Microsystems, Inc. | Switching micro-resonant structures using at least one director |
| US7791290B2 (en) | 2005-09-30 | 2010-09-07 | Virgin Islands Microsystems, Inc. | Ultra-small resonating charged particle beam modulator |
| US7626179B2 (en) | 2005-09-30 | 2009-12-01 | Virgin Island Microsystems, Inc. | Electron beam induced resonance |
| US20090045349A1 (en) * | 2004-08-26 | 2009-02-19 | David Sprinzak | Sample enclosure for inspection and methods of use thereof |
| NL1027025C2 (nl) * | 2004-09-13 | 2006-03-14 | Univ Delft Tech | Microreactor voor een transmissie elektronenmicroscoop en verwarmingselement en werkwijze voor vervaardiging daarvan. |
| US7381970B2 (en) * | 2005-01-31 | 2008-06-03 | Summer Schneider | Specimen stage for charged-particle scanning microscopy |
| US20060172315A1 (en) * | 2005-02-01 | 2006-08-03 | Anderson Amy L | Methods for staining cells for identification and sorting |
| CN100511568C (zh) * | 2005-05-09 | 2009-07-08 | 东捷科技股份有限公司 | 在真空或低压环境中操作高压腔室且供观测的方法及装置 |
| WO2007064358A2 (en) | 2005-09-30 | 2007-06-07 | Virgin Islands Microsystems, Inc. | Structures and methods for coupling energy from an electromagnetic wave |
| TWI277734B (en) * | 2005-10-26 | 2007-04-01 | Li Bing Huan | Method for observing living bodies using an electron microscopy |
| TWI275118B (en) * | 2005-12-09 | 2007-03-01 | Li Bing Huan | Sample box of electron microscope for observing a general sample/live cell |
| JP2007163447A (ja) * | 2005-12-09 | 2007-06-28 | Lee Bing Huan | 電子顕微鏡用の超薄液体制御板 |
| US7579609B2 (en) | 2005-12-14 | 2009-08-25 | Virgin Islands Microsystems, Inc. | Coupling light of light emitting resonator to waveguide |
| US7470920B2 (en) | 2006-01-05 | 2008-12-30 | Virgin Islands Microsystems, Inc. | Resonant structure-based display |
| US7619373B2 (en) | 2006-01-05 | 2009-11-17 | Virgin Islands Microsystems, Inc. | Selectable frequency light emitter |
| KR100994516B1 (ko) * | 2006-02-02 | 2010-11-15 | 전자빔기술센터 주식회사 | 전자 칼럼용 진공 차등 유지 기구 |
| US7443358B2 (en) | 2006-02-28 | 2008-10-28 | Virgin Island Microsystems, Inc. | Integrated filter in antenna-based detector |
| US7558490B2 (en) | 2006-04-10 | 2009-07-07 | Virgin Islands Microsystems, Inc. | Resonant detector for optical signals |
| US7646991B2 (en) | 2006-04-26 | 2010-01-12 | Virgin Island Microsystems, Inc. | Selectable frequency EMR emitter |
| US7876793B2 (en) | 2006-04-26 | 2011-01-25 | Virgin Islands Microsystems, Inc. | Micro free electron laser (FEL) |
| US7492868B2 (en) | 2006-04-26 | 2009-02-17 | Virgin Islands Microsystems, Inc. | Source of x-rays |
| JP2007294365A (ja) * | 2006-04-27 | 2007-11-08 | Jeol Ltd | 試料検査方法、試料保持体、及び試料検査装置並びに試料検査システム |
| JP2007292702A (ja) * | 2006-04-27 | 2007-11-08 | Jeol Ltd | 試料検査装置及び試料検査方法並びに試料検査システム |
| US7436177B2 (en) | 2006-05-05 | 2008-10-14 | Virgin Islands Microsystems, Inc. | SEM test apparatus |
| US7442940B2 (en) | 2006-05-05 | 2008-10-28 | Virgin Island Microsystems, Inc. | Focal plane array incorporating ultra-small resonant structures |
| US7557647B2 (en) | 2006-05-05 | 2009-07-07 | Virgin Islands Microsystems, Inc. | Heterodyne receiver using resonant structures |
| US7554083B2 (en) | 2006-05-05 | 2009-06-30 | Virgin Islands Microsystems, Inc. | Integration of electromagnetic detector on integrated chip |
| US7443577B2 (en) | 2006-05-05 | 2008-10-28 | Virgin Islands Microsystems, Inc. | Reflecting filtering cover |
| US7476907B2 (en) | 2006-05-05 | 2009-01-13 | Virgin Island Microsystems, Inc. | Plated multi-faceted reflector |
| US7718977B2 (en) | 2006-05-05 | 2010-05-18 | Virgin Island Microsystems, Inc. | Stray charged particle removal device |
| US7723698B2 (en) | 2006-05-05 | 2010-05-25 | Virgin Islands Microsystems, Inc. | Top metal layer shield for ultra-small resonant structures |
| US7342441B2 (en) | 2006-05-05 | 2008-03-11 | Virgin Islands Microsystems, Inc. | Heterodyne receiver array using resonant structures |
| US7728397B2 (en) | 2006-05-05 | 2010-06-01 | Virgin Islands Microsystems, Inc. | Coupled nano-resonating energy emitting structures |
| US7746532B2 (en) | 2006-05-05 | 2010-06-29 | Virgin Island Microsystems, Inc. | Electro-optical switching system and method |
| US7586167B2 (en) | 2006-05-05 | 2009-09-08 | Virgin Islands Microsystems, Inc. | Detecting plasmons using a metallurgical junction |
| US7710040B2 (en) | 2006-05-05 | 2010-05-04 | Virgin Islands Microsystems, Inc. | Single layer construction for ultra small devices |
| US7359589B2 (en) | 2006-05-05 | 2008-04-15 | Virgin Islands Microsystems, Inc. | Coupling electromagnetic wave through microcircuit |
| US7728702B2 (en) | 2006-05-05 | 2010-06-01 | Virgin Islands Microsystems, Inc. | Shielding of integrated circuit package with high-permeability magnetic material |
| US8188431B2 (en) | 2006-05-05 | 2012-05-29 | Jonathan Gorrell | Integration of vacuum microelectronic device with integrated circuit |
| US7569836B2 (en) | 2006-05-05 | 2009-08-04 | Virgin Islands Microsystems, Inc. | Transmission of data between microchips using a particle beam |
| US7741934B2 (en) | 2006-05-05 | 2010-06-22 | Virgin Islands Microsystems, Inc. | Coupling a signal through a window |
| US7732786B2 (en) | 2006-05-05 | 2010-06-08 | Virgin Islands Microsystems, Inc. | Coupling energy in a plasmon wave to an electron beam |
| US7986113B2 (en) | 2006-05-05 | 2011-07-26 | Virgin Islands Microsystems, Inc. | Selectable frequency light emitter |
| US7656094B2 (en) * | 2006-05-05 | 2010-02-02 | Virgin Islands Microsystems, Inc. | Electron accelerator for ultra-small resonant structures |
| US7583370B2 (en) | 2006-05-05 | 2009-09-01 | Virgin Islands Microsystems, Inc. | Resonant structures and methods for encoding signals into surface plasmons |
| US7573045B2 (en) | 2006-05-15 | 2009-08-11 | Virgin Islands Microsystems, Inc. | Plasmon wave propagation devices and methods |
| US7679067B2 (en) | 2006-05-26 | 2010-03-16 | Virgin Island Microsystems, Inc. | Receiver array using shared electron beam |
| US7655934B2 (en) | 2006-06-28 | 2010-02-02 | Virgin Island Microsystems, Inc. | Data on light bulb |
| JP5084188B2 (ja) * | 2006-07-04 | 2012-11-28 | 日本電子株式会社 | 試料保持体、試料検査方法及び試料検査装置並びに試料検査システム |
| US7450794B2 (en) | 2006-09-19 | 2008-11-11 | Virgin Islands Microsystems, Inc. | Microcircuit using electromagnetic wave routing |
| US7560716B2 (en) | 2006-09-22 | 2009-07-14 | Virgin Islands Microsystems, Inc. | Free electron oscillator |
| JP4850654B2 (ja) * | 2006-10-23 | 2012-01-11 | 株式会社日立ハイテクノロジーズ | 荷電粒子線装置および荷電粒子線装置用試料保持装置 |
| WO2008050321A2 (en) | 2006-10-24 | 2008-05-02 | B-Nano Ltd. | An interface, a methof for observing an object within a non-vacuum environment and a scanning electron microscope |
| JP5002251B2 (ja) | 2006-12-06 | 2012-08-15 | 日本電子株式会社 | 試料検査方法及び試料検査装置 |
| TWI330380B (en) * | 2006-12-07 | 2010-09-11 | Nat Univ Tsing Hua | A specimen kit for electron microscope and its fabrication process |
| JP2008153086A (ja) * | 2006-12-19 | 2008-07-03 | Jeol Ltd | 試料検査装置及び試料検査方法並びに試料検査システム |
| EP2365321B1 (en) | 2006-12-19 | 2013-10-02 | JEOL Ltd. | Sample inspection apparatus, sample inspection method, and sample inspection system |
| US7659513B2 (en) | 2006-12-20 | 2010-02-09 | Virgin Islands Microsystems, Inc. | Low terahertz source and detector |
| JP5318364B2 (ja) | 2007-01-31 | 2013-10-16 | 日本電子株式会社 | 試料保持体、試料検査装置及び試料検査方法、並びに試料保持体の製造方法 |
| EP1953793B1 (en) | 2007-01-31 | 2012-05-16 | JEOL Ltd. | Specimen holder, specimen inspection apparatus, specimen inspection method, and method of fabricating specimen holder |
| JP2008210715A (ja) * | 2007-02-27 | 2008-09-11 | Ebara Corp | 荷電粒子線装置及びこれを用いた試料表面観察方法 |
| EP2130086A4 (en) | 2007-03-02 | 2012-03-14 | Protochips Inc | MEMBRANE SUPPORTS WITH REINFORCING FUNCTIONS |
| US7990336B2 (en) | 2007-06-19 | 2011-08-02 | Virgin Islands Microsystems, Inc. | Microwave coupled excitation of solid state resonant arrays |
| US9134307B2 (en) * | 2007-07-11 | 2015-09-15 | X-Body, Inc. | Method for determining ion channel modulating properties of a test reagent |
| EP2171454B1 (en) | 2007-07-11 | 2013-03-20 | X-Body, Inc. | Methods of identifying modulators of ion channels |
| US7791053B2 (en) | 2007-10-10 | 2010-09-07 | Virgin Islands Microsystems, Inc. | Depressed anode with plasmon-enabled devices such as ultra-small resonant structures |
| EP2061067A3 (en) | 2007-11-13 | 2010-04-07 | Carl Zeiss SMT Limited | Beam device and system comprising a particle beam device and an optical microscope |
| JP5253800B2 (ja) * | 2007-12-26 | 2013-07-31 | 日本電子株式会社 | 試料保持体及び観察・検査方法並びに観察・検査装置 |
| JP5215701B2 (ja) | 2008-03-26 | 2013-06-19 | 日本電子株式会社 | 試料検査装置及び試料検査方法 |
| EP2105944A1 (en) | 2008-03-28 | 2009-09-30 | FEI Company | Environmental cell for a particle-optical apparatus |
| JP5314317B2 (ja) | 2008-04-08 | 2013-10-16 | 日本電子株式会社 | 検査方法及び試液 |
| JP2010002300A (ja) | 2008-06-20 | 2010-01-07 | Jeol Ltd | 試料保持体、試料検査装置及び試料検査方法 |
| US8334510B2 (en) * | 2008-07-03 | 2012-12-18 | B-Nano Ltd. | Scanning electron microscope, an interface and a method for observing an object within a non-vacuum environment |
| US8981294B2 (en) | 2008-07-03 | 2015-03-17 | B-Nano Ltd. | Scanning electron microscope, an interface and a method for observing an object within a non-vacuum environment |
| JP2010027488A (ja) | 2008-07-23 | 2010-02-04 | Jeol Ltd | 試料保持体、試料検査装置及び試料検査方法 |
| EP2329252A4 (en) * | 2008-09-28 | 2012-04-11 | Nano Ltd B | VACUUM DEVICE AND ELECTRONIC SCAN MICROSCOPE |
| JP5205234B2 (ja) * | 2008-12-02 | 2013-06-05 | 株式会社日立ハイテクノロジーズ | 微小試料採取装置,検査解析システム、および検査解析方法 |
| US8059271B2 (en) | 2009-02-04 | 2011-11-15 | The United States Of America As Represented By The Secretary Of The Army | Reusable sample holding device permitting ready loading of very small wet samples |
| JP5124507B2 (ja) * | 2009-02-16 | 2013-01-23 | 株式会社日立ハイテクノロジーズ | 電子線装置および電子線装置用試料保持装置 |
| JP2010230417A (ja) | 2009-03-26 | 2010-10-14 | Jeol Ltd | 試料の検査装置及び検査方法 |
| US8087309B2 (en) | 2009-05-22 | 2012-01-03 | Sion Power Corporation | Hermetic sample holder and method for performing microanalysis under controlled atmosphere environment |
| NL2004888A (en) * | 2009-06-29 | 2010-12-30 | Asml Netherlands Bv | Deposition method and apparatus. |
| WO2011009209A1 (en) * | 2009-07-23 | 2011-01-27 | Maher Harb | Nanofluidic cell |
| JP5576406B2 (ja) * | 2010-01-27 | 2014-08-20 | 株式会社日立ハイテクノロジーズ | 荷電粒子線装置 |
| JP2011243483A (ja) | 2010-05-20 | 2011-12-01 | Jeol Ltd | 試料保持体、検査装置、及び検査方法 |
| JP5065516B2 (ja) * | 2010-08-04 | 2012-11-07 | エフ イー アイ カンパニ | 薄い電子検出器における後方散乱の減少 |
| JP5218503B2 (ja) * | 2010-09-01 | 2013-06-26 | コニカミノルタビジネステクノロジーズ株式会社 | 光走査装置および画像形成装置 |
| CN103261879B (zh) | 2010-10-01 | 2015-04-22 | 安托莱特公司 | 时间选通阴极发光图像的去卷积 |
| US10908066B2 (en) | 2010-11-16 | 2021-02-02 | 1087 Systems, Inc. | Use of vibrational spectroscopy for microfluidic liquid measurement |
| US20120190137A1 (en) * | 2011-01-24 | 2012-07-26 | Sumitomo Electric Industries, Ltd. | Cross section observation method |
| US10505234B2 (en) | 2011-03-14 | 2019-12-10 | Battelle Memorial Institute | Battery cell and n situ battery electrode analysis method |
| US9274059B2 (en) | 2011-03-14 | 2016-03-01 | Battelle Memorial Institute | Microfluidic electrochemical device and process for chemical imaging and electrochemical analysis at the electrode-liquid interface in-situ |
| US10598609B2 (en) * | 2011-03-14 | 2020-03-24 | Battelle Memorial Institute | Universal liquid sample device and process for high resolution transmission electron microscope imaging and multimodal analyses of liquid sample materials |
| US8555710B2 (en) * | 2011-03-14 | 2013-10-15 | Battelle Memorial Institute | Systems and methods for analyzing liquids under vacuum |
| JP5699023B2 (ja) | 2011-04-11 | 2015-04-08 | 株式会社日立ハイテクノロジーズ | 荷電粒子線装置 |
| CN103493171B (zh) * | 2011-04-28 | 2016-02-17 | 株式会社日立高新技术 | 电子显微镜用试样保持装置以及电子显微镜装置 |
| EP3528276A3 (en) | 2011-05-13 | 2019-09-04 | Fibics Incorporated | Microscopy imaging method |
| EP2732299A4 (en) | 2011-07-15 | 2015-03-25 | Orbotech Ltd | ELECTRICAL TESTING OF ELECTRONIC DEVICES BY MEANS OF ELECTRON BEAM-INDUCED PLASMA STONES |
| EP2734836A4 (en) | 2011-07-21 | 2015-07-22 | Univ Columbia | METHOD OF COLLECTING AND PROCESSING ELECTRON DIFFACTION DATA |
| JP5896708B2 (ja) | 2011-12-06 | 2016-03-30 | 株式会社日立ハイテクノロジーズ | 走査イオン顕微鏡および二次粒子制御方法 |
| JP5115997B1 (ja) * | 2011-12-27 | 2013-01-09 | 独立行政法人産業技術総合研究所 | 走査型電子顕微鏡像観察用の試料支持部材及び走査型電子顕微鏡像の観察方法 |
| JP2013187096A (ja) * | 2012-03-09 | 2013-09-19 | Hitachi Ltd | 電子顕微鏡の液体試料ホルダ及びその製造方法 |
| US8809783B2 (en) * | 2012-06-19 | 2014-08-19 | Rensselaer Polytechnic Institute | High spatial resolution non-contact temperature measurement |
| JP6002946B2 (ja) * | 2012-07-23 | 2016-10-05 | 国立研究開発法人産業技術総合研究所 | 試料ホルダおよび電子顕微鏡像の観察方法 |
| JP5936484B2 (ja) | 2012-08-20 | 2016-06-22 | 株式会社日立ハイテクノロジーズ | 荷電粒子線装置及び試料観察方法 |
| JP5923412B2 (ja) | 2012-08-24 | 2016-05-24 | 株式会社日立ハイテクノロジーズ | 観察装置および光軸調整方法 |
| JP5930922B2 (ja) | 2012-09-14 | 2016-06-08 | 株式会社日立ハイテクノロジーズ | 荷電粒子線装置及び試料観察方法 |
| JP6207824B2 (ja) | 2012-10-01 | 2017-10-04 | 株式会社日立ハイテクノロジーズ | 荷電粒子線装置、隔膜の位置調整方法および隔膜位置調整ジグ |
| JP6051014B2 (ja) | 2012-10-29 | 2016-12-21 | 株式会社日立ハイテクノロジーズ | 試料格納用容器、荷電粒子線装置、及び画像取得方法 |
| JP6035602B2 (ja) * | 2012-11-21 | 2016-11-30 | 株式会社日立ハイテクノロジーズ | 荷電粒子線装置、試料台ユニット、及び試料観察方法 |
| US8872105B2 (en) * | 2013-02-19 | 2014-10-28 | Fei Company | In situ reactivation of fluorescence marker |
| JP2016513349A (ja) | 2013-02-20 | 2016-05-12 | ビー−ナノ リミテッド | 走査型電子顕微鏡 |
| KR102026936B1 (ko) * | 2013-03-26 | 2019-10-01 | 삼성디스플레이 주식회사 | 주사 전자 현미경을 이용한 검사 시스템 |
| JP6112553B2 (ja) * | 2013-04-08 | 2017-04-12 | 国立研究開発法人産業技術総合研究所 | 観察システム及び観察方法 |
| CN105103262B (zh) * | 2013-04-12 | 2017-10-10 | 株式会社日立高新技术 | 带电粒子束装置以及过滤部件 |
| US8961904B2 (en) | 2013-07-16 | 2015-02-24 | Premium Genetics (Uk) Ltd. | Microfluidic chip |
| DE102013012609B4 (de) * | 2013-07-26 | 2024-06-27 | Carl Zeiss Microscopy Gmbh | Optoelektronischer Detektor, insbesondere für hochauflösende Lichtrastermikroskope und Lichtrastermikroskop |
| US9633817B2 (en) * | 2013-08-23 | 2017-04-25 | Hitachi High-Technologies Corporation | Diaphragm mounting member and charged particle beam device |
| KR101752164B1 (ko) | 2013-09-06 | 2017-06-29 | 가부시키가이샤 히다치 하이테크놀로지즈 | 하전 입자선 장치 및 시료 화상 취득 방법 |
| JP6364167B2 (ja) * | 2013-09-30 | 2018-07-25 | 株式会社日立ハイテクノロジーズ | 環境制御型荷電粒子観察システム |
| USD794816S1 (en) * | 2013-10-24 | 2017-08-15 | Hitachi High-Technologies Corporation | Sample holder for an electron microscope |
| US11796449B2 (en) | 2013-10-30 | 2023-10-24 | Abs Global, Inc. | Microfluidic system and method with focused energy apparatus |
| US10410338B2 (en) | 2013-11-04 | 2019-09-10 | Kla-Tencor Corporation | Method and system for correlating optical images with scanning electron microscopy images |
| JP6047508B2 (ja) | 2014-01-27 | 2016-12-21 | 株式会社日立ハイテクノロジーズ | 荷電粒子線装置、試料画像取得方法、およびプログラム記録媒体 |
| US9564291B1 (en) * | 2014-01-27 | 2017-02-07 | Mochii, Inc. | Hybrid charged-particle beam and light beam microscopy |
| US9997331B1 (en) | 2014-01-27 | 2018-06-12 | Mochii, Inc. | Charged-particle beam microscopy |
| US20160032281A1 (en) * | 2014-07-31 | 2016-02-04 | Fei Company | Functionalized grids for locating and imaging biological specimens and methods of using the same |
| GB2537579A (en) * | 2014-11-07 | 2016-10-26 | Linkam Scient Instr Ltd | Microscopic sample preparation |
| TWI546841B (zh) | 2014-12-10 | 2016-08-21 | 財團法人工業技術研究院 | 具有載台的電子顯微鏡 |
| US10180388B2 (en) | 2015-02-19 | 2019-01-15 | 1087 Systems, Inc. | Scanning infrared measurement system |
| JP6522133B2 (ja) | 2015-08-21 | 2019-05-29 | 株式会社日立ハイテクノロジーズ | 観察支援ユニットおよびこれを用いた試料観察方法、荷電粒子線装置 |
| TWI597481B (zh) * | 2015-12-22 | 2017-09-01 | 閤康生物科技股份有限公司 | 樣本收集元件及其製作方法 |
| TWI594288B (zh) * | 2016-03-14 | 2017-08-01 | 台灣電鏡儀器股份有限公司 | 電子顯微鏡 |
| CN106525845B (zh) * | 2016-10-11 | 2023-11-03 | 聚束科技(北京)有限公司 | 一种带电粒子束系统、光电联合探测系统及方法 |
| CN106783493B (zh) * | 2016-12-01 | 2018-07-10 | 聚束科技(北京)有限公司 | 一种真空气氛处理装置、样品观测系统及方法 |
| US11051390B2 (en) * | 2017-03-22 | 2021-06-29 | Japan Atomic Energy Agency | Functional membrane for ion beam transmission, beam line device and filter device each having the same, and method of adjusting filter device |
| EP3796998A1 (en) | 2018-05-23 | 2021-03-31 | ABS Global, Inc. | Systems and methods for particle focusing in microchannels |
| CN109187595B (zh) * | 2018-09-27 | 2021-05-11 | 南京宁智高新材料研究院有限公司 | 一种测量透射电镜中微气体束引起的局部等效压强的装置 |
| JP7189529B2 (ja) * | 2018-10-15 | 2022-12-14 | 国立大学法人 筑波大学 | 環境セルとその製造方法 |
| WO2020084729A1 (ja) * | 2018-10-25 | 2020-04-30 | 株式会社日立ハイテクノロジーズ | 荷電粒子線装置、荷電粒子線装置のオートフォーカス処理方法、及び検出器 |
| US10777379B1 (en) * | 2019-03-19 | 2020-09-15 | Hitachi High-Tech Corporation | Holder and charged particle beam apparatus |
| KR102198707B1 (ko) * | 2019-03-25 | 2021-01-05 | (주)코셈 | 착탈 가능한 컬럼을 구비하는 주사 전자 현미경 및, 이를 이용한 영상 획득 방법 |
| CN113784618B (zh) | 2019-04-18 | 2023-12-22 | 艾步思国际有限责任公司 | 用于连续添加冷冻保护剂的系统和工艺 |
| US11738312B2 (en) * | 2019-08-01 | 2023-08-29 | Government Of The United States Of America, As Represented By The Secretary Of Commerce | Multidimensional printer |
| US11628439B2 (en) | 2020-01-13 | 2023-04-18 | Abs Global, Inc. | Single-sheath microfluidic chip |
| NL2024861B1 (en) * | 2020-02-07 | 2021-09-13 | Univ Delft Tech | Method for recording and correlating light and charged particle microscopy images |
| US11410838B2 (en) | 2020-09-03 | 2022-08-09 | Thermo Finnigan Llc | Long life electron multiplier |
| AU2021365488A1 (en) | 2020-10-21 | 2023-06-01 | Abs Global, Inc. | Methods and systems for processing genetic samples to determine identity or detect contamination |
| WO2022108840A1 (en) | 2020-11-23 | 2022-05-27 | Abs Global, Inc. | Modular flow cytometry systems and methods of processing samples |
| CN112461807B (zh) * | 2020-11-26 | 2021-11-19 | 山西大学 | 碳量子点在靶向细胞核仁免洗成像中的应用 |
| WO2022136064A1 (en) * | 2020-12-23 | 2022-06-30 | Asml Netherlands B.V. | Charged particle optical device |
| DE102021101982A1 (de) | 2021-01-28 | 2022-07-28 | ebm-papst neo GmbH & Co. KG | Vorrichtung und Verfahren zur Erfassung einer Konzentration von vorbestimmten Partikeln anhand ihrer morphologischen Eigenschaften in Luft |
| CN114113182A (zh) * | 2021-10-22 | 2022-03-01 | 合肥国轩高科动力能源有限公司 | 一种用于扫描电镜拍摄硅基负极材料的定位处理方法 |
| CN118348039B (zh) * | 2024-05-06 | 2025-11-07 | 中国科学院上海高等研究院 | 一种扫描电镜原位厚液层的液体环境样品的显微分析方法 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1345670A (fr) * | 1962-10-25 | 1963-12-13 | Radiologie Cie Gle | Perfectionnements aux porte-échantillons liquides pour spectromètres à rayons chious vide |
| US3657596A (en) * | 1965-05-20 | 1972-04-18 | Westinghouse Electric Corp | Electron image device having target comprising porous region adjacent conductive layer and outer, denser region |
| US3378684A (en) * | 1965-06-16 | 1968-04-16 | Gen Electric | Fluid sample cell with means to keep constant pressure on the sample fluid |
| US4071766A (en) * | 1974-03-28 | 1978-01-31 | Mta Kozponti Kemiai Kutato Intezet | Micro-chamber for electron optical examinations particularly for the electron microscopic examination of biological objects |
| JPS5168585U (enExample) * | 1974-11-26 | 1976-05-31 | ||
| US4115689A (en) * | 1977-07-06 | 1978-09-19 | Won Vann Y | Leveling device for forming X-ray specimen |
| US4308547A (en) * | 1978-04-13 | 1981-12-29 | Recognition Equipment Incorporated | Liquid drop emitter |
| DE2921151C2 (de) * | 1979-05-25 | 1982-12-02 | Ernst Leitz Wetzlar Gmbh, 6330 Wetzlar | Vorrichtung zum Nachweis von in einem Abtast-Elektronenstrahlmikroskop von einer Probe ausgehenden Rückstreuelektronen |
| AU534811B2 (en) * | 1979-07-03 | 1984-02-16 | Unisearch Limited | Atmospheric scanning electron microscope |
| US4448311A (en) * | 1983-01-24 | 1984-05-15 | Tech Ref, Inc. | Sample cell |
| JPS59168652A (ja) * | 1983-03-16 | 1984-09-22 | Hitachi Ltd | 素子修正方法及びその装置 |
| US4618938A (en) * | 1984-02-22 | 1986-10-21 | Kla Instruments Corporation | Method and apparatus for automatic wafer inspection |
| US4587666A (en) * | 1984-05-03 | 1986-05-06 | Angelo M. Torrisi | System and a method for mounting film to a sample holder for X-ray spectroscopic fluorescence analysis |
| US4720622A (en) * | 1985-03-11 | 1988-01-19 | Sanyo Electric Co., Ltd | Wall-mounted type cooking apparatus |
| US4705949A (en) * | 1985-11-25 | 1987-11-10 | The United States Of America As Represented By The Secretary Of Commerce | Method and apparatus relating to specimen cells for scanning electron microscopes |
| US4720633A (en) * | 1986-01-17 | 1988-01-19 | Electro-Scan Corporation | Scanning electron microscope for visualization of wet samples |
| JPH0687410B2 (ja) * | 1986-08-01 | 1994-11-02 | エレクトロ‐スキャン コーポレーション | 走査電子顕微鏡及び試料の表面を電子顕微鏡的に像形成する方法 |
| US4880976A (en) * | 1987-05-21 | 1989-11-14 | Electroscan Corporation | Secondary electron detector for use in a gaseous atmosphere |
| US5250808A (en) * | 1987-05-21 | 1993-10-05 | Electroscan Corporation | Integrated electron optical/differential pumping/imaging signal system for an environmental scanning electron microscope |
| JPH0614461B2 (ja) | 1987-05-22 | 1994-02-23 | 日本電子株式会社 | 電子顕微鏡におけるガス雰囲気試料ホルダ |
| US4929831A (en) * | 1988-12-08 | 1990-05-29 | The United States Of America As Represented By The Secretary Of The Navy | Electron beam apparatus for testing infrared detectors in a cryogenically shielded environment |
| US4912330A (en) * | 1988-12-27 | 1990-03-27 | United States Of America As Represented By The Secretary Of The Navy | Apparatus for X-ray testing long wave infrared radiation detectors |
| US4929041A (en) * | 1989-01-09 | 1990-05-29 | Johnston Pump/General Valve, Inc. | Cathodoluminescence system for use in a scanning electron microscope including means for controlling optical fiber aperture |
| US5103102A (en) * | 1989-02-24 | 1992-04-07 | Micrion Corporation | Localized vacuum apparatus and method |
| JP2794471B2 (ja) * | 1989-11-24 | 1998-09-03 | 日本電子テクニクス株式会社 | 電子顕微鏡 |
| US5866904A (en) * | 1990-10-12 | 1999-02-02 | Hitachi, Ltd. | Scanning electron microscope and method for dimension measuring by using the same |
| JP3148353B2 (ja) * | 1991-05-30 | 2001-03-19 | ケーエルエー・インストルメンツ・コーポレーション | 電子ビーム検査方法とそのシステム |
| US5470757A (en) * | 1991-06-25 | 1995-11-28 | Minnesota Mining And Manufacturing Company | Spectroscopic sample holder and method for using same |
| US5122663A (en) * | 1991-07-24 | 1992-06-16 | International Business Machine Corporation | Compact, integrated electron beam imaging system |
| US5323441A (en) * | 1992-12-15 | 1994-06-21 | Angelo M. Torrisi | Sample holder for spectroscopic analysis and method for mounting film to sample holder |
| JP2781320B2 (ja) | 1993-01-18 | 1998-07-30 | 株式会社蛋白工学研究所 | 電子顕微鏡等の試料ホルダ |
| US5326971A (en) * | 1993-05-17 | 1994-07-05 | Motorola, Inc. | Transmission electron microscope environmental specimen holder |
| US5362964A (en) * | 1993-07-30 | 1994-11-08 | Electroscan Corporation | Environmental scanning electron microscope |
| US5412211A (en) * | 1993-07-30 | 1995-05-02 | Electroscan Corporation | Environmental scanning electron microscope |
| US5466940A (en) * | 1994-06-20 | 1995-11-14 | Opal Technologies Ltd. | Electron detector with high backscattered electron acceptance for particle beam apparatus |
| US5644132A (en) * | 1994-06-20 | 1997-07-01 | Opan Technologies Ltd. | System for high resolution imaging and measurement of topographic and material features on a specimen |
| US6025592A (en) * | 1995-08-11 | 2000-02-15 | Philips Electronics North America | High temperature specimen stage and detector for an environmental scanning electron microscope |
| US5898261A (en) * | 1996-01-31 | 1999-04-27 | The United States Of America As Represented By The Secretary Of The Air Force | Fluid-cooled particle-beam transmission window |
| AU2335097A (en) * | 1996-03-20 | 1997-10-10 | Hoechst Celanese Corporation | Addition of amine to improve paraformaldehyde |
| US5667791A (en) * | 1996-05-31 | 1997-09-16 | Thione International, Inc. | X-ray induced skin damage protective composition |
| JPH1064467A (ja) * | 1996-08-23 | 1998-03-06 | Toshiba Corp | 電子顕微鏡 |
| JP3500264B2 (ja) * | 1997-01-29 | 2004-02-23 | 株式会社日立製作所 | 試料分析装置 |
| US5859699A (en) * | 1997-02-07 | 1999-01-12 | Arcturus Engineering, Inc. | Laser capture microdissection analysis vessel |
| US5789748A (en) * | 1997-05-29 | 1998-08-04 | Stanford University | Low voltage electron beam system |
| US5945672A (en) * | 1998-01-29 | 1999-08-31 | Fei Company | Gaseous backscattered electron detector for an environmental scanning electron microscope |
| AU755545B2 (en) * | 1998-05-22 | 2002-12-12 | Euro-Celtique S.A. | Dissolution stage for an environmental scanning electron microscope |
| US6452177B1 (en) * | 1998-09-04 | 2002-09-17 | California Institute Of Technology | Atmospheric electron x-ray spectrometer |
| JP3610245B2 (ja) | 1998-10-27 | 2005-01-12 | 日本電子株式会社 | ガス雰囲気試料ホルダ |
| US20050244821A1 (en) | 2000-08-17 | 2005-11-03 | Ory Zik | Method of identification and quantification of biological molecules and apparatus therefore |
| JP2002273446A (ja) | 2001-03-19 | 2002-09-24 | Sanyo Electric Co Ltd | 汚水処理装置用電解槽 |
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2001
- 2001-11-30 AU AU2101902A patent/AU2101902A/xx active Pending
- 2001-11-30 CZ CZ20031455A patent/CZ20031455A3/cs unknown
- 2001-11-30 IL IL15602701A patent/IL156027A0/xx active IP Right Grant
- 2001-11-30 AT AT01998987T patent/ATE510298T1/de not_active IP Right Cessation
- 2001-11-30 CN CNA018199062A patent/CN1511332A/zh active Pending
- 2001-11-30 CA CA002436237A patent/CA2436237A1/en not_active Abandoned
- 2001-11-30 WO PCT/IL2001/001108 patent/WO2002045125A1/en not_active Ceased
- 2001-11-30 JP JP2002547196A patent/JP4153303B2/ja not_active Expired - Fee Related
- 2001-11-30 EP EP01998987A patent/EP1340241B1/en not_active Expired - Lifetime
- 2001-11-30 AU AU2002221019A patent/AU2002221019B2/en not_active Ceased
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2003
- 2003-05-27 US US10/448,313 patent/US6992300B2/en not_active Expired - Lifetime
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2004
- 2004-05-06 US US10/841,769 patent/US6989542B2/en not_active Expired - Lifetime
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2005
- 2005-08-19 US US11/207,611 patent/US7253418B2/en not_active Expired - Fee Related
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2008
- 2008-04-03 JP JP2008097275A patent/JP2008171830A/ja active Pending
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| AU2002221019B2 (en) | 2007-02-08 |
| US6992300B2 (en) | 2006-01-31 |
| US6989542B2 (en) | 2006-01-24 |
| US20040217297A1 (en) | 2004-11-04 |
| JP2004515049A (ja) | 2004-05-20 |
| EP1340241A4 (en) | 2009-01-14 |
| AU2101902A (en) | 2002-06-11 |
| IL156027A0 (en) | 2003-12-23 |
| US20060033038A1 (en) | 2006-02-16 |
| JP2008171830A (ja) | 2008-07-24 |
| US20040046120A1 (en) | 2004-03-11 |
| JP4153303B2 (ja) | 2008-09-24 |
| EP1340241B1 (en) | 2011-05-18 |
| EP1340241A1 (en) | 2003-09-03 |
| US7253418B2 (en) | 2007-08-07 |
| ATE510298T1 (de) | 2011-06-15 |
| CN1511332A (zh) | 2004-07-07 |
| CA2436237A1 (en) | 2002-06-06 |
| WO2002045125A1 (en) | 2002-06-06 |
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