JP2017501702A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017501702A5 JP2017501702A5 JP2016540620A JP2016540620A JP2017501702A5 JP 2017501702 A5 JP2017501702 A5 JP 2017501702A5 JP 2016540620 A JP2016540620 A JP 2016540620A JP 2016540620 A JP2016540620 A JP 2016540620A JP 2017501702 A5 JP2017501702 A5 JP 2017501702A5
- Authority
- JP
- Japan
- Prior art keywords
- tag
- gly
- fusion protein
- item
- binding domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000027455 binding Effects 0.000 claims description 146
- 108020001507 fusion proteins Proteins 0.000 claims description 141
- 102000037865 fusion proteins Human genes 0.000 claims description 141
- 210000004027 cell Anatomy 0.000 claims description 82
- 239000012636 effector Substances 0.000 claims description 70
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 38
- 230000003834 intracellular effect Effects 0.000 claims description 34
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 30
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 30
- 230000002209 hydrophobic effect Effects 0.000 claims description 28
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 27
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims description 27
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 22
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims description 21
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims description 21
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 20
- 102100027207 CD27 antigen Human genes 0.000 claims description 19
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 19
- 108010011170 Ala-Trp-Arg-His-Pro-Gln-Phe-Gly-Gly Proteins 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 18
- 108020004707 nucleic acids Proteins 0.000 claims description 18
- 102000039446 nucleic acids Human genes 0.000 claims description 18
- 150000007523 nucleic acids Chemical class 0.000 claims description 18
- -1 c-Met Proteins 0.000 claims description 17
- 102000005962 receptors Human genes 0.000 claims description 17
- 108020003175 receptors Proteins 0.000 claims description 17
- 210000004899 c-terminal region Anatomy 0.000 claims description 16
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 15
- 238000001727 in vivo Methods 0.000 claims description 15
- 239000013598 vector Substances 0.000 claims description 13
- 102100023635 Alpha-fetoprotein Human genes 0.000 claims description 10
- 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 claims description 10
- 101000621309 Homo sapiens Wilms tumor protein Chemical group 0.000 claims description 10
- 102100022748 Wilms tumor protein Human genes 0.000 claims description 10
- HKZAAJSTFUZYTO-LURJTMIESA-N (2s)-2-[[2-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]acetyl]amino]-3-hydroxypropanoic acid Chemical compound NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(O)=O HKZAAJSTFUZYTO-LURJTMIESA-N 0.000 claims description 9
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 9
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims description 9
- 108010028230 Trp-Ser- His-Pro-Gln-Phe-Glu-Lys Proteins 0.000 claims description 9
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims description 9
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims description 8
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims description 8
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims description 8
- 239000003446 ligand Substances 0.000 claims description 8
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 108010074708 B7-H1 Antigen Proteins 0.000 claims description 6
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims description 6
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims description 6
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims description 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 6
- 102100026882 Alpha-synuclein Human genes 0.000 claims description 5
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims description 5
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims description 5
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 5
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims description 5
- 102100024217 CAMPATH-1 antigen Human genes 0.000 claims description 5
- 102100035893 CD151 antigen Human genes 0.000 claims description 5
- 102100038078 CD276 antigen Human genes 0.000 claims description 5
- 101150013553 CD40 gene Proteins 0.000 claims description 5
- 108010065524 CD52 Antigen Proteins 0.000 claims description 5
- 102100027221 CD81 antigen Human genes 0.000 claims description 5
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims description 5
- 229940045513 CTLA4 antagonist Drugs 0.000 claims description 5
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 claims description 5
- 102100025473 Carcinoembryonic antigen-related cell adhesion molecule 6 Human genes 0.000 claims description 5
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims description 5
- 108010055196 EphA2 Receptor Proteins 0.000 claims description 5
- 102100030340 Ephrin type-A receptor 2 Human genes 0.000 claims description 5
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims description 5
- 102100020948 Growth hormone receptor Human genes 0.000 claims description 5
- 102100033365 Growth hormone-releasing hormone receptor Human genes 0.000 claims description 5
- 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 claims description 5
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims description 5
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims description 5
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 5
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims description 5
- 101000946874 Homo sapiens CD151 antigen Proteins 0.000 claims description 5
- 101000884279 Homo sapiens CD276 antigen Proteins 0.000 claims description 5
- 101000914479 Homo sapiens CD81 antigen Proteins 0.000 claims description 5
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 claims description 5
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 claims description 5
- 101000914326 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 6 Proteins 0.000 claims description 5
- 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 claims description 5
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims description 5
- 101001075287 Homo sapiens Growth hormone receptor Proteins 0.000 claims description 5
- 101000997535 Homo sapiens Growth hormone-releasing hormone receptor Proteins 0.000 claims description 5
- 101001103039 Homo sapiens Inactive tyrosine-protein kinase transmembrane receptor ROR1 Proteins 0.000 claims description 5
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 claims description 5
- 101000998120 Homo sapiens Interleukin-3 receptor subunit alpha Proteins 0.000 claims description 5
- 101000599048 Homo sapiens Interleukin-6 receptor subunit alpha Proteins 0.000 claims description 5
- 101001043594 Homo sapiens Low-density lipoprotein receptor-related protein 5 Proteins 0.000 claims description 5
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims description 5
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 claims description 5
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims description 5
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims description 5
- 101001051490 Homo sapiens Neural cell adhesion molecule L1 Proteins 0.000 claims description 5
- 101001024605 Homo sapiens Next to BRCA1 gene 1 protein Proteins 0.000 claims description 5
- 101000586302 Homo sapiens Oncostatin-M-specific receptor subunit beta Proteins 0.000 claims description 5
- 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 claims description 5
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims description 5
- 101000652359 Homo sapiens Spermatogenesis-associated protein 2 Proteins 0.000 claims description 5
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims description 5
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims description 5
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 claims description 5
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims description 5
- 101000679851 Homo sapiens Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims description 5
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims description 5
- 101001103033 Homo sapiens Tyrosine-protein kinase transmembrane receptor ROR2 Proteins 0.000 claims description 5
- 101000955999 Homo sapiens V-set domain-containing T-cell activation inhibitor 1 Proteins 0.000 claims description 5
- 101000851018 Homo sapiens Vascular endothelial growth factor receptor 1 Proteins 0.000 claims description 5
- 102100039615 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Human genes 0.000 claims description 5
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims description 5
- 102100033493 Interleukin-3 receptor subunit alpha Human genes 0.000 claims description 5
- 102100037792 Interleukin-6 receptor subunit alpha Human genes 0.000 claims description 5
- 102100037795 Interleukin-6 receptor subunit beta Human genes 0.000 claims description 5
- 101710152369 Interleukin-6 receptor subunit beta Proteins 0.000 claims description 5
- 102100021926 Low-density lipoprotein receptor-related protein 5 Human genes 0.000 claims description 5
- 102000003735 Mesothelin Human genes 0.000 claims description 5
- 108090000015 Mesothelin Proteins 0.000 claims description 5
- 102100034256 Mucin-1 Human genes 0.000 claims description 5
- 102100023123 Mucin-16 Human genes 0.000 claims description 5
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims description 5
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims description 5
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims description 5
- 102100024964 Neural cell adhesion molecule L1 Human genes 0.000 claims description 5
- 102100030098 Oncostatin-M-specific receptor subunit beta Human genes 0.000 claims description 5
- 108010065129 Patched-1 Receptor Proteins 0.000 claims description 5
- 102100022019 Pregnancy-specific beta-1-glycoprotein 2 Human genes 0.000 claims description 5
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims description 5
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims description 5
- 102100028680 Protein patched homolog 1 Human genes 0.000 claims description 5
- 101150097792 Robo1 gene Proteins 0.000 claims description 5
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims description 5
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims description 5
- 102100033456 TGF-beta receptor type-1 Human genes 0.000 claims description 5
- 102100033455 TGF-beta receptor type-2 Human genes 0.000 claims description 5
- 108010060818 Toll-Like Receptor 9 Proteins 0.000 claims description 5
- 102100039390 Toll-like receptor 7 Human genes 0.000 claims description 5
- 102100033117 Toll-like receptor 9 Human genes 0.000 claims description 5
- 108010011702 Transforming Growth Factor-beta Type I Receptor Proteins 0.000 claims description 5
- 108010082684 Transforming Growth Factor-beta Type II Receptor Proteins 0.000 claims description 5
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims description 5
- 102100033732 Tumor necrosis factor receptor superfamily member 1A Human genes 0.000 claims description 5
- 101710187743 Tumor necrosis factor receptor superfamily member 1A Proteins 0.000 claims description 5
- 102100033733 Tumor necrosis factor receptor superfamily member 1B Human genes 0.000 claims description 5
- 101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 claims description 5
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims description 5
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims description 5
- 108060008724 Tyrosinase Proteins 0.000 claims description 5
- 102100039616 Tyrosine-protein kinase transmembrane receptor ROR2 Human genes 0.000 claims description 5
- 102100038929 V-set domain-containing T-cell activation inhibitor 1 Human genes 0.000 claims description 5
- 108010053100 Vascular Endothelial Growth Factor Receptor-3 Proteins 0.000 claims description 5
- 102100033178 Vascular endothelial growth factor receptor 1 Human genes 0.000 claims description 5
- 102100033179 Vascular endothelial growth factor receptor 3 Human genes 0.000 claims description 5
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims description 5
- 201000010099 disease Diseases 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 108010087914 epidermal growth factor receptor VIII Proteins 0.000 claims description 5
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims description 5
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims description 5
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims description 5
- 244000052769 pathogen Species 0.000 claims description 5
- 230000001717 pathogenic effect Effects 0.000 claims description 5
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims description 5
- 102100027205 B-cell antigen receptor complex-associated protein alpha chain Human genes 0.000 claims description 4
- 102100027203 B-cell antigen receptor complex-associated protein beta chain Human genes 0.000 claims description 4
- 102000000584 Calmodulin Human genes 0.000 claims description 4
- 108010041952 Calmodulin Proteins 0.000 claims description 4
- 102100024965 Caspase recruitment domain-containing protein 11 Human genes 0.000 claims description 4
- 108090000695 Cytokines Proteins 0.000 claims description 4
- 102000004127 Cytokines Human genes 0.000 claims description 4
- HVLSXIKZNLPZJJ-TXZCQADKSA-N HA peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 HVLSXIKZNLPZJJ-TXZCQADKSA-N 0.000 claims description 4
- 102100029360 Hematopoietic cell signal transducer Human genes 0.000 claims description 4
- 101000914489 Homo sapiens B-cell antigen receptor complex-associated protein alpha chain Proteins 0.000 claims description 4
- 101000914491 Homo sapiens B-cell antigen receptor complex-associated protein beta chain Proteins 0.000 claims description 4
- 101000761179 Homo sapiens Caspase recruitment domain-containing protein 11 Proteins 0.000 claims description 4
- 101000990188 Homo sapiens Hematopoietic cell signal transducer Proteins 0.000 claims description 4
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims description 4
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims description 4
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims description 4
- 102000017578 LAG3 Human genes 0.000 claims description 4
- 101100268066 Mus musculus Zap70 gene Proteins 0.000 claims description 4
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims description 4
- 108010071083 Patched-2 Receptor Proteins 0.000 claims description 4
- 108010020346 Polyglutamic Acid Proteins 0.000 claims description 4
- 102100036894 Protein patched homolog 2 Human genes 0.000 claims description 4
- 108010074687 Signaling Lymphocytic Activation Molecule Family Member 1 Proteins 0.000 claims description 4
- 102100029215 Signaling lymphocytic activation molecule Human genes 0.000 claims description 4
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims description 4
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims description 4
- 108010023649 Tripartite Motif Proteins Proteins 0.000 claims description 4
- 239000000427 antigen Substances 0.000 claims description 4
- 108091007433 antigens Proteins 0.000 claims description 4
- 102000036639 antigens Human genes 0.000 claims description 4
- 229920000370 gamma-poly(glutamate) polymer Polymers 0.000 claims description 4
- 239000003102 growth factor Substances 0.000 claims description 4
- 108060008226 thioredoxin Proteins 0.000 claims description 4
- 229940094937 thioredoxin Drugs 0.000 claims description 4
- 102100032912 CD44 antigen Human genes 0.000 claims description 3
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims description 3
- 230000003213 activating effect Effects 0.000 claims description 3
- 230000004663 cell proliferation Effects 0.000 claims description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 3
- 230000009870 specific binding Effects 0.000 claims description 3
- 239000013603 viral vector Substances 0.000 claims description 3
- 101100364669 Caenorhabditis elegans lin-18 gene Proteins 0.000 claims description 2
- 101001047640 Homo sapiens Linker for activation of T-cells family member 1 Proteins 0.000 claims description 2
- 101000702132 Homo sapiens Protein spinster homolog 1 Proteins 0.000 claims description 2
- 101100364671 Mus musculus Ryk gene Proteins 0.000 claims description 2
- 101001038499 Yarrowia lipolytica (strain CLIB 122 / E 150) Lysine acetyltransferase Proteins 0.000 claims description 2
- 230000030833 cell death Effects 0.000 claims description 2
- 230000000779 depleting effect Effects 0.000 claims description 2
- 238000002955 isolation Methods 0.000 claims description 2
- 230000001737 promoting effect Effects 0.000 claims description 2
- 108010090804 Streptavidin Proteins 0.000 claims 2
- 101001039256 Caenorhabditis elegans Low-density lipoprotein receptor-related protein Proteins 0.000 claims 1
- 101000694288 Homo sapiens 40S ribosomal protein SA Proteins 0.000 claims 1
- 101001030069 Homo sapiens Major vault protein Proteins 0.000 claims 1
- 101001043564 Homo sapiens Prolow-density lipoprotein receptor-related protein 1 Proteins 0.000 claims 1
- 101000738769 Homo sapiens Receptor-type tyrosine-protein phosphatase alpha Proteins 0.000 claims 1
- 108010029755 Notch1 Receptor Proteins 0.000 claims 1
- 108010029751 Notch2 Receptor Proteins 0.000 claims 1
- 108010029756 Notch3 Receptor Proteins 0.000 claims 1
- 108010029741 Notch4 Receptor Proteins 0.000 claims 1
- 102100036407 Thioredoxin Human genes 0.000 claims 1
- 102100039094 Tyrosinase Human genes 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 108010070409 phenylalanyl-glycyl-glycine Proteins 0.000 claims 1
- 230000001177 retroviral effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 103
- 239000011159 matrix material Substances 0.000 description 14
- 230000004913 activation Effects 0.000 description 8
- 239000011324 bead Substances 0.000 description 8
- 229920000936 Agarose Polymers 0.000 description 6
- 239000004744 fabric Substances 0.000 description 6
- 210000002865 immune cell Anatomy 0.000 description 6
- 239000011347 resin Substances 0.000 description 6
- 229920005989 resin Polymers 0.000 description 6
- 210000000130 stem cell Anatomy 0.000 description 6
- 102000043871 biotin binding protein Human genes 0.000 description 5
- 108700021042 biotin binding protein Proteins 0.000 description 5
- 102000003425 Tyrosinase Human genes 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 230000000139 costimulatory effect Effects 0.000 description 4
- WTFXARWRTYJXII-UHFFFAOYSA-N iron(2+);iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+2].[Fe+3].[Fe+3] WTFXARWRTYJXII-UHFFFAOYSA-N 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 description 3
- 102000002933 Thioredoxin Human genes 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 229940127089 cytotoxic agent Drugs 0.000 description 3
- 239000002254 cytotoxic agent Substances 0.000 description 3
- 231100000599 cytotoxic agent Toxicity 0.000 description 3
- 239000011325 microbead Substances 0.000 description 3
- 239000002102 nanobead Substances 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- AOYNUTHNTBLRMT-SLPGGIOYSA-N 2-deoxy-2-fluoro-aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](F)C=O AOYNUTHNTBLRMT-SLPGGIOYSA-N 0.000 description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 2
- 108010058905 CD44v6 antigen Proteins 0.000 description 2
- YWAQATDNEKZFFK-BYPYZUCNSA-N Gly-Gly-Ser Chemical compound NCC(=O)NCC(=O)N[C@@H](CO)C(O)=O YWAQATDNEKZFFK-BYPYZUCNSA-N 0.000 description 2
- 238000012879 PET imaging Methods 0.000 description 2
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 description 2
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 229940072056 alginate Drugs 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 210000002469 basement membrane Anatomy 0.000 description 2
- 229920001222 biopolymer Polymers 0.000 description 2
- 230000010261 cell growth Effects 0.000 description 2
- 108700010039 chimeric receptor Proteins 0.000 description 2
- 238000000684 flow cytometry Methods 0.000 description 2
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 2
- 239000007850 fluorescent dye Substances 0.000 description 2
- 239000006249 magnetic particle Substances 0.000 description 2
- 238000002595 magnetic resonance imaging Methods 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 238000003333 near-infrared imaging Methods 0.000 description 2
- 210000003289 regulatory T cell Anatomy 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 102000003812 Interleukin-15 Human genes 0.000 description 1
- 108090000172 Interleukin-15 Proteins 0.000 description 1
- 101150028321 Lck gene Proteins 0.000 description 1
- 241000713666 Lentivirus Species 0.000 description 1
- 102100024032 Linker for activation of T-cells family member 1 Human genes 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 210000003071 memory t lymphocyte Anatomy 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- VYNDHICBIRRPFP-UHFFFAOYSA-N pacific blue Chemical compound FC1=C(O)C(F)=C2OC(=O)C(C(=O)O)=CC2=C1 VYNDHICBIRRPFP-UHFFFAOYSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021116355A JP2021164482A (ja) | 2013-12-20 | 2021-07-14 | タグ化キメラエフェクター分子およびそのレセプター |
| JP2022161138A JP2022176327A (ja) | 2013-12-20 | 2022-10-05 | タグ化キメラエフェクター分子およびそのレセプター |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361919201P | 2013-12-20 | 2013-12-20 | |
| US61/919,201 | 2013-12-20 | ||
| PCT/US2014/072007 WO2015095895A1 (en) | 2013-12-20 | 2014-12-22 | Tagged chimeric effector molecules and receptors thereof |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019038969A Division JP2019083821A (ja) | 2013-12-20 | 2019-03-04 | タグ化キメラエフェクター分子およびそのレセプター |
| JP2021116355A Division JP2021164482A (ja) | 2013-12-20 | 2021-07-14 | タグ化キメラエフェクター分子およびそのレセプター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017501702A JP2017501702A (ja) | 2017-01-19 |
| JP2017501702A5 true JP2017501702A5 (enExample) | 2018-02-08 |
| JP6942467B2 JP6942467B2 (ja) | 2021-10-06 |
Family
ID=52396818
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016540620A Active JP6942467B2 (ja) | 2013-12-20 | 2014-12-22 | タグ化キメラエフェクター分子およびそのレセプター |
| JP2019038969A Pending JP2019083821A (ja) | 2013-12-20 | 2019-03-04 | タグ化キメラエフェクター分子およびそのレセプター |
| JP2021116355A Pending JP2021164482A (ja) | 2013-12-20 | 2021-07-14 | タグ化キメラエフェクター分子およびそのレセプター |
| JP2022161138A Withdrawn JP2022176327A (ja) | 2013-12-20 | 2022-10-05 | タグ化キメラエフェクター分子およびそのレセプター |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019038969A Pending JP2019083821A (ja) | 2013-12-20 | 2019-03-04 | タグ化キメラエフェクター分子およびそのレセプター |
| JP2021116355A Pending JP2021164482A (ja) | 2013-12-20 | 2021-07-14 | タグ化キメラエフェクター分子およびそのレセプター |
| JP2022161138A Withdrawn JP2022176327A (ja) | 2013-12-20 | 2022-10-05 | タグ化キメラエフェクター分子およびそのレセプター |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US10494434B2 (enExample) |
| EP (1) | EP3083671B1 (enExample) |
| JP (4) | JP6942467B2 (enExample) |
| KR (2) | KR20230007559A (enExample) |
| CN (2) | CN113354744A (enExample) |
| AU (3) | AU2014368892B2 (enExample) |
| BR (1) | BR112016014156A8 (enExample) |
| CA (1) | CA2933707A1 (enExample) |
| CY (1) | CY1123747T1 (enExample) |
| DK (1) | DK3083671T3 (enExample) |
| ES (1) | ES2837856T3 (enExample) |
| HR (1) | HRP20201906T1 (enExample) |
| HU (1) | HUE052573T2 (enExample) |
| IL (1) | IL245845B (enExample) |
| LT (1) | LT3083671T (enExample) |
| MX (1) | MX386422B (enExample) |
| MY (1) | MY178233A (enExample) |
| NZ (2) | NZ759969A (enExample) |
| PL (1) | PL3083671T3 (enExample) |
| PT (1) | PT3083671T (enExample) |
| RS (1) | RS61223B1 (enExample) |
| RU (1) | RU2729463C2 (enExample) |
| SG (2) | SG11201605046YA (enExample) |
| SI (1) | SI3083671T1 (enExample) |
| SM (1) | SMT202000699T1 (enExample) |
| WO (1) | WO2015095895A1 (enExample) |
Families Citing this family (161)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201404991YA (en) | 2012-02-23 | 2014-09-26 | Stage Cell Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
| SG11201505858VA (en) | 2013-01-28 | 2015-09-29 | St Jude Childrens Res Hospital | A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease |
| NZ759969A (en) * | 2013-12-20 | 2022-12-23 | Fred Hutchinson Cancer Center | Tagged chimeric effector molecules and receptors thereof |
| EP3105333B1 (en) * | 2014-02-10 | 2020-04-08 | Emory University | Expression of chimeric polypeptide with variable lymphocyte receptors on immune cells and uses for treating cancer |
| KR20200029627A (ko) | 2014-03-12 | 2020-03-18 | 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 | Cns의 질환 및 손상을 치료하기 위한 전신적 조절 t 세포 수준 또는 활성의 감소 |
| US10618963B2 (en) | 2014-03-12 | 2020-04-14 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
| US9394365B1 (en) | 2014-03-12 | 2016-07-19 | Yeda Research And Development Co., Ltd | Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease |
| RS62471B1 (sr) | 2014-04-16 | 2021-11-30 | Juno Therapeutics Gmbh | Metode, kompleti i uređaji za proširenje populacije ćelija |
| IL292038B2 (en) | 2014-04-23 | 2024-12-01 | Juno Therapeutics Inc | Methods for enriching or producing immune cell populations for adoptive therapy |
| EP3805371A1 (en) | 2014-05-15 | 2021-04-14 | National University of Singapore | Modified natural killer cells and uses thereof |
| CA2956385A1 (en) * | 2014-07-25 | 2016-01-28 | Theravectys | Lentiviral vectors for regulated expression of a chimeric antigen receptor molecule |
| TWI751102B (zh) | 2014-08-28 | 2022-01-01 | 美商奇諾治療有限公司 | 對cd19具專一性之抗體及嵌合抗原受體 |
| GB201415344D0 (en) * | 2014-08-29 | 2014-10-15 | Ucl Business Plc | Protein |
| AU2015357535B2 (en) | 2014-12-05 | 2020-05-14 | Eureka Therapeutics, Inc. | Antibodies targeting G-protein coupled receptor and methods of use |
| MA41346A (fr) | 2015-01-12 | 2017-11-21 | Juno Therapeutics Inc | Eléments régulateurs post-transcriptionnels d'hépatite modifiée |
| US20160208018A1 (en) | 2015-01-16 | 2016-07-21 | Juno Therapeutics, Inc. | Antibodies and chimeric antigen receptors specific for ror1 |
| EP3250602A1 (en) * | 2015-01-26 | 2017-12-06 | Cellectis | T cell receptor knock out engineered immune cells, endowed with chimeric antigen receptors binding to cd123 for the treatment of relapsed/refractory acute myeloid lymphoma or blastic plasmacytoid dendritic cell neoplasm |
| MA42971A (fr) | 2015-03-13 | 2018-08-15 | Cytomx Therapeutics Inc | Anticorps anti-pdl1, anticorps anti-pld1 activables, et leurs procédés d'utilisation |
| GB201504840D0 (en) * | 2015-03-23 | 2015-05-06 | Ucl Business Plc | Chimeric antigen receptor |
| EP3288569A4 (en) * | 2015-04-29 | 2018-12-19 | Fred Hutchinson Cancer Research Center | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
| EP3288570A4 (en) * | 2015-04-29 | 2018-11-21 | Fred Hutchinson Cancer Research Center | Modified stem cells and uses thereof |
| EP3770168A1 (en) | 2015-05-18 | 2021-01-27 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| MX383464B (es) | 2015-07-13 | 2025-03-14 | Cytomx Therapeutics Inc | Anticuerpos anti-pd-1, anticuerpos anti-pd-1 activables, y métodos de uso de los mismos. |
| KR102011789B1 (ko) * | 2015-08-05 | 2019-08-19 | 주식회사 셀랩메드 | 키메라 항원 수용체 및 키메라 항원 수용체가 발현된 t 세포 |
| CA2994969A1 (en) | 2015-08-06 | 2017-02-09 | Dana-Farber Cancer Institute, Inc. | Targeted protein degradation to attenuate adoptive t-cell therapy associated adverse inflammatory responses |
| EP3858388B1 (en) | 2015-09-28 | 2024-07-03 | Regents of the University of Minnesota | Chimeric antigen receptor (car) t cells as therapeutic interventions for gvhd |
| KR102908806B1 (ko) | 2015-10-22 | 2026-01-07 | 주노 테라퓨틱스 게엠베하 | 세포의 배양 방법 및 이를 위한 키트와 장치 |
| MA45489A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés de culture de cellules, kits et appareil associés |
| RU2761555C2 (ru) | 2015-10-22 | 2021-12-09 | Джуно Терапьютикс Гмбх | Способы, наборы, средства и устройства для трансдукции |
| JP7092662B2 (ja) * | 2015-10-30 | 2022-06-28 | チルドレンズ ナショナル メディカル センター | ナイーブt細胞集団からのhpv抗原特異的t細胞の生成 |
| WO2017075537A1 (en) | 2015-10-30 | 2017-05-04 | Aleta Biotherapeutics Inc. | Compositions and methods for treatment of cancer |
| MA43134A (fr) | 2015-10-30 | 2018-09-05 | Aleta Biotherapeutics Inc | Compositions et méthodes de transduction tumorale |
| US11034933B2 (en) | 2016-01-28 | 2021-06-15 | The Regents Of The University Of California | Methods for selectively expanding and enriching cells transduced with chimeric antigen receptors and treating HIV infection |
| AU2017235657B2 (en) | 2016-03-18 | 2022-07-21 | Fred Hutchinson Cancer Center | Compositions and methods for CD20 immunotherapy |
| WO2017172952A1 (en) * | 2016-04-01 | 2017-10-05 | Promab Biotechnologies, Inc. | Flag tagged cd19-car-t cells |
| CN106399255B (zh) * | 2016-04-13 | 2019-10-18 | 阿思科力(苏州)生物科技有限公司 | Pd-1 car-t细胞及其制备方法和应用 |
| WO2017177337A1 (en) * | 2016-04-15 | 2017-10-19 | Zymeworks Inc. | Multi-specific antigen-binding constructs targeting immunotherapeutics |
| CN105907719B (zh) * | 2016-04-18 | 2019-10-18 | 阿思科力(苏州)生物科技有限公司 | Anti ROBO1 CAR-T细胞及其制备和应用 |
| CN107365387B (zh) * | 2016-05-12 | 2022-03-15 | 阿思科力(苏州)生物科技有限公司 | 一种双特异性抗原结合构建体及其制备方法和应用 |
| US11339225B2 (en) | 2016-05-12 | 2022-05-24 | Asclepius (Suzhou) Technology Company Group, Co., Ltd. | Bispecific antigen-binding construct and preparation method and use thereof |
| EP3458481A4 (en) * | 2016-05-18 | 2020-07-29 | Mayo Foundation for Medical Education and Research | TARGETING PD-L1 ON TUMOR CELLS |
| CN107522786A (zh) * | 2016-06-20 | 2017-12-29 | 深圳市体内生物医药科技有限公司 | 一种分子、表达其的细胞及其制备方法和用途 |
| WO2018014039A1 (en) * | 2016-07-15 | 2018-01-18 | Poseida Therapeutics, Inc. | Chimeric antigen receptors (cars) specific for muc1 and methods for their use |
| WO2018014122A1 (en) * | 2016-07-18 | 2018-01-25 | Helix Biopharma Corp. | Car immune cells directed to carcinoembryonic antigen related cell adhesion molecule 6 to treat cancer |
| WO2018026953A1 (en) | 2016-08-02 | 2018-02-08 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| EP3344263A4 (en) | 2016-08-04 | 2020-07-01 | Memorial Sloan-Kettering Cancer Center | CANCER ANTIGEN TARGETS AND USES THEREOF |
| BR112019007100A2 (pt) | 2016-10-07 | 2019-06-25 | Tcr2 Therapeutics Inc | composições e métodos para reprogramação de receptores de célula t com o uso de proteínas de fusão |
| CA3042049A1 (en) | 2016-11-03 | 2018-05-11 | Juno Therapeutics, Inc. | Combination therapy of a t cell therapy and a btk inhibitor |
| CN110177803A (zh) | 2016-11-22 | 2019-08-27 | T细胞受体治疗公司 | 用于使用融合蛋白进行tcr重新编程的组合物和方法 |
| JP2019536460A (ja) | 2016-12-03 | 2019-12-19 | ジュノー セラピューティクス インコーポレイテッド | Car−t細胞の調節方法 |
| CN106701827A (zh) * | 2016-12-05 | 2017-05-24 | 刘晓明 | 表达cd19和cd20抗体基因嵌合抗原受体t细胞的转化及扩增培养与保存方法 |
| CA3047313A1 (en) * | 2016-12-16 | 2018-06-21 | B-Mogen Biotechnologies, Inc. | Enhanced hat family transposon-mediated gene transfer and associated compositions, systems, and methods |
| WO2018124766A2 (ko) | 2016-12-28 | 2018-07-05 | 주식회사 녹십자랩셀 | 키메라 항원 수용체 및 이를 발현하는 자연 살해 세포 |
| WO2018128486A1 (ko) * | 2017-01-05 | 2018-07-12 | 한국생명공학연구원 | Ceacam6에 특이적으로 결합하는 항-ceacam6 키메릭 항원 수용체 |
| EP3571221A2 (en) | 2017-01-20 | 2019-11-27 | Juno Therapeutics GmbH | Cell surface conjugates and related cell compositions and methods |
| CN108395482B (zh) | 2017-02-08 | 2021-02-05 | 西比曼生物科技(香港)有限公司 | 一种靶向cd20抗原嵌合抗原受体的构建及其工程化t细胞的活性鉴定 |
| EP4119552A1 (en) | 2017-02-08 | 2023-01-18 | Dana-Farber Cancer Institute, Inc. | Regulating chimeric antigen receptors |
| CA3052474A1 (en) | 2017-02-09 | 2018-08-16 | Fred Hutchinson Cancer Research Center | Biomarkers and uses thereof for selecting immunotherapy intervention |
| IL268349B2 (en) | 2017-02-17 | 2024-08-01 | Hutchinson Fred Cancer Res | Combination therapies for treatment of bcma-related cancers and autoimmune disorders |
| CN117363636A (zh) | 2017-03-27 | 2024-01-09 | 新加坡国立大学 | 一种编码嵌合受体的多核苷酸 |
| MX2019011570A (es) | 2017-03-27 | 2019-11-18 | Nat Univ Singapore | Lineas celulares estimuladoras para expansion y activacion ex vivo de celulas asesinas naturales. |
| MX2019012017A (es) | 2017-04-07 | 2020-02-12 | Juno Therapeutics Inc | Celulas modificadas que expresan antigeno de membrana especifico de prostata (psma) o una forma modificada del mismo y metodos relacionados. |
| AU2018260380B2 (en) | 2017-04-27 | 2025-02-13 | Juno Therapeutics Gmbh | Oligomeric particle reagents and methods of use thereof |
| WO2018222880A1 (en) | 2017-05-31 | 2018-12-06 | Trustees Of Boston University | Mechano-activated control of gene expression |
| CN110914302A (zh) | 2017-06-01 | 2020-03-24 | 赛托姆克斯治疗学股份有限公司 | 可活化抗pdl1抗体及其使用方法 |
| IL327498A (en) | 2017-06-02 | 2026-05-01 | Juno Therapeutics Inc | Articles of manufacture and methods for treatment using adoptive cell therapy |
| CN107098969B (zh) * | 2017-06-28 | 2018-10-12 | 武汉波睿达生物科技有限公司 | 一种治疗hiv感染的嵌合抗原受体的重组基因构建及其应用 |
| CN107541499B (zh) * | 2017-07-27 | 2020-04-14 | 山东兴瑞生物科技有限公司 | 一种靶向免疫检测点tnfr2的cik的制备及其应用 |
| AU2018314242A1 (en) * | 2017-08-11 | 2020-02-13 | Fred Hutchinson Cancer Center | BRAF-specific TCRs and uses thereof |
| US20200299340A1 (en) * | 2017-08-25 | 2020-09-24 | Icahn School Of Medicine At Mount Sinai | Fusion proteins comprising detectable tags, nucleic acid molecules, and method of tracking a cell |
| KR20200041377A (ko) * | 2017-09-06 | 2020-04-21 | 프레드 헛친슨 켄서 리서치 센터 | Strep-tag 특이적 결합 단백질 및 그 용도 |
| CN111051349A (zh) * | 2017-09-06 | 2020-04-21 | 弗雷德哈钦森癌症研究中心 | Strep-tag特异性嵌合受体及其用途 |
| MA50079A (fr) | 2017-09-07 | 2020-07-15 | Juno Therapeutics Inc | Procédés d'identification de caractéristiques cellulaires relatives à des réponses associées à une thérapie cellulaire |
| KR102742741B1 (ko) | 2017-10-18 | 2024-12-16 | 프레시전 인코포레이티드 | 스페이서를 포함하는 폴리펩타이드 조성물 |
| CN109706120A (zh) * | 2017-10-26 | 2019-05-03 | 深圳宾德生物技术有限公司 | 一种双靶点特异性t淋巴细胞及其制备方法和应用 |
| US11066475B2 (en) | 2017-11-01 | 2021-07-20 | Juno Therapeutics, Inc. | Chimeric antigen receptors specific for B-cell maturation antigen and encoding polynucleotides |
| JP7357626B2 (ja) | 2017-11-01 | 2023-10-06 | ジュノー セラピューティクス インコーポレイテッド | 操作された細胞の治療用組成物を生成するためのプロセス |
| AU2018359907A1 (en) | 2017-11-06 | 2020-05-07 | Fred Hutchinson Cancer Center | Combination of a cell therapy and a gamma secretase inhibitor |
| KR102774451B1 (ko) | 2017-11-14 | 2025-02-28 | 앱클론(주) | 항-her2 항체 또는 그의 항원 결합 단편, 및 이를 포함하는 키메라 항원 수용체 |
| US11649294B2 (en) | 2017-11-14 | 2023-05-16 | GC Cell Corporation | Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same |
| CN109810995B (zh) | 2017-12-06 | 2020-10-02 | 阿思科力(苏州)生物科技有限公司 | 编码car的核苷酸序列、表达该car的robo1 car-nk细胞及其制备和应用 |
| BR112020011223A2 (pt) | 2017-12-08 | 2020-11-17 | Juno Therapeutics Inc | marcadores fenotípicos para terapia celular e mé-todos relacionados |
| CN119193493A (zh) | 2017-12-08 | 2024-12-27 | 朱诺治疗学股份有限公司 | 生产工程化t细胞组合物的过程 |
| AU2018379091A1 (en) | 2017-12-08 | 2020-06-25 | Juno Therapeutics, Inc. | Serum-free media formulation for culturing cells and methods of use thereof |
| CN111971059A (zh) | 2018-01-31 | 2020-11-20 | 细胞基因公司 | 使用过继细胞疗法和检查点抑制剂的组合疗法 |
| WO2019152957A1 (en) * | 2018-02-02 | 2019-08-08 | Arizona Board Of Regents On Behalf Of Arizona State University | Dna-chimeric antigen receptor t cells for immunotherapy |
| JP7360174B2 (ja) | 2018-02-09 | 2023-10-12 | ナショナル ユニヴァーシティー オブ シンガポール | ナチュラルキラー細胞免疫療法における活性化キメラ受容体及びその使用 |
| US20210023170A1 (en) * | 2018-02-12 | 2021-01-28 | University Of Florida Research Foundation, Incorporated | Fviii chimeric antigen receptor tregs for tolerance induction in hemophilia a |
| US20210079061A1 (en) * | 2018-02-26 | 2021-03-18 | Fred Hutchinson Cancer Research Center | Compositions and methods for cellular immunotherapy |
| WO2019178342A1 (en) * | 2018-03-15 | 2019-09-19 | Fundamental Solutions Corporation | Programmable immunocyte receptor complex system |
| US12441787B2 (en) | 2018-04-02 | 2025-10-14 | National University Of Singapore | Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells |
| BR112020022185A2 (pt) | 2018-05-03 | 2021-02-02 | Juno Therapeutics Inc | terapia de combinação de uma terapia de células t do receptor de antígeno quimérico (car) e um inibidor de quinase |
| CN112533942A (zh) | 2018-06-01 | 2021-03-19 | 华盛顿大学 | 嵌合抗原受体细胞疗法中细胞因子释放综合征的抑制 |
| US20210223248A1 (en) | 2018-06-01 | 2021-07-22 | Fred Hutchinson Cancer Research Center | Biomarkers, uses thereof for selecting immunotherapy intervention, and immunotherapy methods |
| EP3807317A4 (en) * | 2018-06-15 | 2022-03-30 | The Regents of University of California | CHIMERIC FUSION FRAGMENT ANTIGEN RECEPTORS AND USES THEREOF |
| BR112021002390A2 (pt) | 2018-08-09 | 2021-05-11 | Juno Therapeutics Inc | processos para gerar células modificadas e suas composições |
| MX2021001431A (es) | 2018-08-10 | 2021-05-12 | Chugai Pharmaceutical Co Ltd | Molecula de union al antigeno anti grupo de diferenciacion 137 (cd137) y su uso. |
| CN110856724B (zh) * | 2018-08-24 | 2022-05-27 | 杭州康万达医药科技有限公司 | 包含核酸及car修饰的免疫细胞的治疗剂及其应用 |
| WO2020044239A1 (en) | 2018-08-29 | 2020-03-05 | National University Of Singapore | A method to specifically stimulate survival and expansion of genetically-modified immune cells |
| CN109136244A (zh) * | 2018-08-31 | 2019-01-04 | 河北璋达生物科技有限公司 | 一种可诱导凋亡的携带检测标签的cd20嵌合抗原受体t淋巴细胞及其应用 |
| US20210246189A1 (en) * | 2018-09-03 | 2021-08-12 | Technische Universitaet Muenchen | A double peptide tag combining reversibility and flexible functionalization |
| WO2020089343A1 (en) | 2018-10-31 | 2020-05-07 | Juno Therapeutics Gmbh | Methods for selection and stimulation of cells and apparatus for same |
| US12473345B2 (en) | 2018-11-01 | 2025-11-18 | Juno Therapeutics, Inc. | Methods for treatment using chimeric antigen receptors specific for B-cell maturation antigen |
| BR112021009420A2 (pt) | 2018-11-16 | 2021-11-23 | Juno Therapeutics Inc | Métodos de dosagem de células t manipuladas para o tratamento de malignidades de células b |
| CN113226340A (zh) | 2018-11-26 | 2021-08-06 | 恩卡尔塔公司 | 同时扩增多种免疫细胞类型的方法、相关组合物及其在癌症免疫疗法中的用途 |
| CN109467598B (zh) * | 2018-11-28 | 2021-11-09 | 生命谷(海南)生物科技股份有限公司 | 肿瘤相关基因notch1突变短肽及其应用 |
| KR20210110811A (ko) | 2018-11-30 | 2021-09-09 | 주노 쎄러퓨티크스 인코퍼레이티드 | 입양 세포 요법에서 b 세포 악성 종양의 투약 및 치료 방법 |
| EP4427810A3 (en) | 2018-11-30 | 2024-12-04 | Juno Therapeutics, Inc. | Methods for treatment using adoptive cell therapy |
| CR20210326A (es) | 2018-12-21 | 2021-09-10 | Hoffmann La Roche | Moléculas agonistas de unión al antígeno cd28 que actúan sobre el tumor |
| EA202192103A1 (ru) | 2019-01-29 | 2021-12-15 | Джуно Терапьютикс, Инк. | Антитела и химерные антигенные рецепторы, специфичные к орфанному рецептору типа рецеторной тирозинкиназы 1 (ror1) |
| KR20210137085A (ko) | 2019-03-05 | 2021-11-17 | 엔카르타, 인크. | Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도 |
| CN119954959A (zh) | 2019-03-11 | 2025-05-09 | 詹森生物科技公司 | 抗Vβ17/抗CD123双特异性抗体 |
| EP3725370A1 (en) | 2019-04-19 | 2020-10-21 | ImmunoBrain Checkpoint, Inc. | Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease |
| SG11202113356XA (en) | 2019-06-12 | 2021-12-30 | Juno Therapeutics Inc | Combination therapy of a cell-mediated cytotoxic therapy and an inhibitor of a prosurvival bcl2 family protein |
| CN110358734B (zh) * | 2019-06-13 | 2020-08-25 | 首都医科大学宣武医院 | 以Tcm为主要效应成分的CAR-T制备方法及其应用 |
| AU2020299774A1 (en) | 2019-07-03 | 2022-01-20 | Peptidream Inc. | CD38-binding agents and uses thereof |
| US12516096B2 (en) * | 2019-08-08 | 2026-01-06 | Navrogen, Inc. | Composition and use of humoral immune suppressor antagonists for the treatment of humoral immune suppressed diseases |
| US20220401537A1 (en) * | 2019-09-16 | 2022-12-22 | Fred Hutchinson Cancer Research Center | Chimeric receptor proteins and uses thereof |
| WO2021061862A1 (en) * | 2019-09-24 | 2021-04-01 | The Regents Of The University Of California | Notch receptors with hinge domain |
| EP4054623A1 (en) | 2019-11-07 | 2022-09-14 | Juno Therapeutics, Inc. | Combination of a t cell therapy and (s)-3-[4-(4-morpholin-4 ylmethyl-benzyloxy)-l-oxo-l,3-dihydro-isoindol-2-yl]- piperidine-2,6-dione |
| CN110734931A (zh) * | 2019-11-18 | 2020-01-31 | 山东省齐鲁细胞治疗工程技术有限公司 | 一种靶向CD19的人源化scFv嵌合抗原受体T细胞及制备方法、应用 |
| WO2021101349A1 (ko) * | 2019-11-21 | 2021-05-27 | 에이비엘바이오 주식회사 | Ror1 및 b7-h3에 결합하는 항체, 이를 포함하는 항체-약물 접합체 및 그 용도 |
| CN113677704B (zh) * | 2019-11-22 | 2024-03-26 | 南通壹宸生物医药科技有限公司 | Psma抗体及其应用 |
| EP4070097A1 (en) | 2019-12-06 | 2022-10-12 | Juno Therapeutics, Inc. | Methods related to toxicity and response associated with cell therapy for treating b cell malignancies |
| US10980836B1 (en) | 2019-12-11 | 2021-04-20 | Myeloid Therapeutics, Inc. | Therapeutic cell compositions and methods of manufacturing and use thereof |
| CN115135672A (zh) | 2019-12-20 | 2022-09-30 | 波赛达治疗公司 | 抗muc1组合物和使用方法 |
| US20230071910A1 (en) | 2020-01-24 | 2023-03-09 | Juno Therapeutics, Inc. | Methods for dosing and treatment of follicular lymphoma and marginal zone lymphoma in adoptive cell therapy |
| CA3169672A1 (en) | 2020-02-12 | 2021-08-19 | Juno Therapeutics, Inc. | Cd19-directed chimeric antigen receptor t cell compositions and methods and uses thereof |
| JP2023517011A (ja) | 2020-03-05 | 2023-04-21 | ネオティーエックス セラピューティクス リミテッド | 免疫細胞を用いて癌を治療するための方法および組成物 |
| CN113402612A (zh) | 2020-03-17 | 2021-09-17 | 西比曼生物科技(香港)有限公司 | 靶向cd19和cd20的联合嵌合抗原受体及其应用 |
| WO2021190551A1 (zh) * | 2020-03-25 | 2021-09-30 | 上海先博生物科技有限公司 | 结合cd19的嵌合抗原受体及其用途 |
| KR20230024283A (ko) | 2020-05-13 | 2023-02-20 | 주노 쎄러퓨티크스 인코퍼레이티드 | 임상 반응과 관련된 특징을 식별하는 방법 및 이의 용도 |
| CN111848797B (zh) * | 2020-07-20 | 2021-02-09 | 北京鼎成肽源生物技术有限公司 | 一种靶向c-Met的单链抗体、嵌合抗原受体、重组载体、CAR-T细胞及应用 |
| WO2022036495A1 (en) * | 2020-08-17 | 2022-02-24 | Utc Therapeutics Inc. | Lymphocytes-antigen presenting cells co-stimulators and uses thereof |
| UY39415A (es) | 2020-09-11 | 2022-03-31 | Janssen Biotech Inc | Métodos y composiciones para modular la inmunidad mediada por cadenas beta |
| TW202607038A (zh) | 2020-10-19 | 2026-02-16 | 美商碩騰服務公司 | 犬及貓抑瘤素M受體β之抗體及其用途 |
| EP4240367A4 (en) * | 2020-11-04 | 2024-10-16 | Myeloid Therapeutics, Inc. | MODIFIED CHIMERIC FUSION PROTEIN COMPOSITIONS AND METHODS OF USE THEREOF |
| WO2022133030A1 (en) | 2020-12-16 | 2022-06-23 | Juno Therapeutics, Inc. | Combination therapy of a cell therapy and a bcl2 inhibitor |
| TW202241935A (zh) | 2020-12-18 | 2022-11-01 | 美商世紀治療股份有限公司 | 具有可調適受體專一性之嵌合抗原受體系統 |
| AU2022227686A1 (en) | 2021-02-25 | 2023-07-27 | Lyell Immunopharma, Inc. | Ror1 targeting chimeric antigen receptor |
| KR102671408B1 (ko) * | 2021-02-26 | 2024-06-04 | 진화섭 | HLA class II에 특이적으로 결합하는 키메릭 항원 수용체 및 이의 용도 |
| KR20230165771A (ko) | 2021-03-03 | 2023-12-05 | 주노 쎄러퓨티크스 인코퍼레이티드 | T 세포 요법 및 dgk 억제제의 조합 |
| KR20240013094A (ko) | 2021-03-17 | 2024-01-30 | 마이얼로이드 테라퓨틱스, 인크. | 조작된 키메라 융합 단백질 조성물 및 그의 사용 방법 |
| IL307257A (en) | 2021-03-29 | 2023-11-01 | Juno Therapeutics Inc | A combination of car cell therapy and an immunomodulatory compound for the treatment of lymphoma |
| CN117858719A (zh) | 2021-03-29 | 2024-04-09 | 朱诺治疗学股份有限公司 | 使用检查点抑制剂疗法和car t细胞疗法的组合进行给药和治疗的方法 |
| EP4319794A4 (en) * | 2021-04-08 | 2025-03-12 | Artiva Biotherapeutics, Inc. | CHIMERIC ANTIGEN RECEPTOR COMPRISING AN ANTI-CD19 ANTIBODY OR AN ANTIGEN-BINDING FRAGMENT THEREOF AND NATURAL KILLER CELLS COMPRISING SAME |
| CN113549158B (zh) * | 2021-07-19 | 2022-10-21 | 广州百暨基因科技有限公司 | 包含突变型il15以及嵌合抗原受体的融合蛋白 |
| WO2023058406A1 (ja) | 2021-10-06 | 2023-04-13 | 旭化成株式会社 | 印刷版の製造方法、及び印刷方法 |
| JP2024542027A (ja) * | 2021-11-02 | 2024-11-13 | フレッド ハッチンソン キャンサー センター | 細胞標的療法を利用したがんの治療及び関連する研究プロトコル |
| US20260083848A1 (en) | 2021-11-03 | 2026-03-26 | Viracta Therapeutics, Inc. | Combination of car t-cell therapy with btk inhibitors and methods of use thereof |
| WO2023215725A1 (en) | 2022-05-02 | 2023-11-09 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
| JP2025521543A (ja) | 2022-06-22 | 2025-07-10 | ジュノー セラピューティクス インコーポレイテッド | Cd19標的car t細胞のセカンドライン治療のための処置方法 |
| KR20250061756A (ko) | 2022-09-08 | 2025-05-08 | 주노 쎄러퓨티크스 인코퍼레이티드 | T 세포 요법과 연속적 또는 간헐적 dgk 억제제 투여의 조합 |
| CN116179495B (zh) * | 2022-11-28 | 2025-06-06 | 上海恩凯细胞技术有限公司 | 转基因免疫细胞及其应用 |
| WO2024182516A1 (en) | 2023-02-28 | 2024-09-06 | Juno Therapeutics, Inc. | Cell therapy for treating systemic autoimmune diseases |
| EP4680748A1 (en) | 2023-03-13 | 2026-01-21 | Arsenal Biosciences, Inc. | Synthetic pathway activators |
| PE20260290A1 (es) | 2023-03-31 | 2026-02-10 | Abelzeta Inc | Receptores de antigeno quimericos biespecificos dirigidos a cd20 y bcma |
| KR20250067749A (ko) * | 2023-11-07 | 2025-05-15 | 주식회사 박셀바이오 | EphA2를 타겟하는 개선된 특성을 갖는 친수성 모노바디 및 이를 포함하는 다중특이적 키메라 항원 수용체 및 조작된 면역세포 |
| WO2025101820A1 (en) | 2023-11-08 | 2025-05-15 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
| KR20250074841A (ko) * | 2023-11-20 | 2025-05-28 | (재) 스크립스코리아항체연구원 | 키메라 항원 수용체를 발현하는 면역 세포 및 트렙타비딘 스캐폴드 항체 유사 단백질을 포함하는 항암용 조성물, 및 이의 용도 |
Family Cites Families (99)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6291161B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertiore |
| US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
| US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| US5637481A (en) | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
| US5420032A (en) | 1991-12-23 | 1995-05-30 | Universitge Laval | Homing endonuclease which originates from chlamydomonas eugametos and recognizes and cleaves a 15, 17 or 19 degenerate double stranded nucleotide sequence |
| US5792632A (en) | 1992-05-05 | 1998-08-11 | Institut Pasteur | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof |
| EP0737207B1 (en) | 1994-01-11 | 2004-09-22 | Dyax Corporation | Inhibitors of human plasmin derived from the kunitz domains |
| AU708339B2 (en) * | 1995-02-24 | 1999-08-05 | General Hospital Corporation, The | Redirection of cellular immunity by receptor chimeras |
| DE19641876B4 (de) | 1996-10-10 | 2011-09-29 | Iba Gmbh | Streptavidinmuteine |
| US6759243B2 (en) | 1998-01-20 | 2004-07-06 | Board Of Trustees Of The University Of Illinois | High affinity TCR proteins and methods |
| KR100722578B1 (ko) | 1998-02-23 | 2007-05-28 | 아크 테라퓨틱스 리미티드 | 비오틴-결합 수용체 분자 |
| AUPP221098A0 (en) | 1998-03-06 | 1998-04-02 | Diatech Pty Ltd | V-like domain binding molecules |
| ATE382681T1 (de) | 1998-07-31 | 2008-01-15 | Genzyme Corp | Verbesserung der herzfunktion durch transplantation mesenchymaler stammzellen |
| AU2472400A (en) | 1998-10-20 | 2000-05-08 | City Of Hope | CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies |
| AU5477500A (en) * | 1999-06-09 | 2000-12-28 | General Hospital Corporation, The | Method of measuring plasma membrane targeting of glut4 |
| CA2347973C (en) | 1999-07-20 | 2010-06-22 | Morphosys Ag | Novel methods for displaying (poly)peptides/proteins on bacteriophage particles via disulfide bonds |
| AU2001264946A1 (en) | 2000-05-24 | 2001-12-03 | Imclone Systems Incorporated | Bispecific immunoglobulin-like antigen binding proteins and method of production |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| WO2002059285A1 (en) | 2000-10-27 | 2002-08-01 | Fred Hutchinson Cancer Research Center | Methods for immortalizing cells |
| EP1227321A1 (en) * | 2000-12-28 | 2002-07-31 | Institut für Bioanalytik GmbH | Reversible MHC multimer staining for functional purification of antigen-specific T cells |
| DE10113776B4 (de) | 2001-03-21 | 2012-08-09 | "Iba Gmbh" | Isoliertes streptavidinbindendes, kompetitiv eluierbares Peptid, dieses umfassendes Fusionspeptid, dafür codierende Nukleinsäure, Expressionsvektor, Verfahren zur Herstellung eines rekombinanten Fusionsproteins und Verfahren zum Nachweis und/oder zur Gewinnung des Fusionsproteins |
| US7070995B2 (en) | 2001-04-11 | 2006-07-04 | City Of Hope | CE7-specific redirected immune cells |
| US7514537B2 (en) | 2001-04-30 | 2009-04-07 | City Of Hope | Chimeric immunoreceptor useful in treating human gliomas |
| AU2002315337A1 (en) | 2001-06-18 | 2003-01-02 | Psychiatric Genomics, Inc. | Method for neural stem cell differentiation using valproate |
| DE10137792A1 (de) | 2001-08-06 | 2003-02-27 | Erdmann Volker | Verfahren zur Genexpression |
| EP1430114B1 (en) | 2001-09-14 | 2012-01-18 | Stem Cell Therapeutics Inc. | Prolactin induced increase in neural stem cell numbers and therapeutical use thereof |
| CA2461290C (en) | 2001-09-24 | 2014-11-25 | Sangamo Biosciences, Inc. | Modulation of stem cells using zinc finger proteins |
| US8206965B2 (en) | 2002-03-15 | 2012-06-26 | Cellectis S.A. | Hybrid and single chain meganucleases and use thereof |
| WO2004011497A1 (en) | 2002-07-31 | 2004-02-05 | Stem Cell Therapeutics Inc. | Method of enhancing neural stem cell proliferation, differentiation, and survival using pituitary adenylate cyclase activating polypeptide (pacap) |
| ES2559763T3 (es) | 2002-09-10 | 2016-02-15 | Affimed Gmbh | Anticuerpo humano específico de CD3 con propiedades inmunosupresoras |
| US7575925B2 (en) | 2002-12-10 | 2009-08-18 | Sunnybrook Health Sciences Centre | Cell preparations comprising cells of the T cell lineage and methods of making and using them |
| US20060206949A1 (en) | 2003-01-28 | 2006-09-14 | Sylvain Arnould | Custom-made meganuclease and use thereof |
| US7368428B2 (en) | 2003-06-23 | 2008-05-06 | A&G Pharmaceutical, Inc. | Compositions and methods for restoring sensitivity of tumor cells to antitumor therapy and inducing apoptosis |
| EP1791865B1 (en) | 2004-06-29 | 2010-07-28 | Immunocore Ltd. | Cells expressing a modified t cell receptor |
| ATE423140T1 (de) | 2005-01-05 | 2009-03-15 | F Star Biotech Forsch & Entw | Synthetische immunoglobulindomänen mit in regionen des moleküls, die sich von den die komplementarität bestimmenden bereichen unterscheiden, modifizierten bindeeigenschaften |
| WO2006076678A2 (en) | 2005-01-13 | 2006-07-20 | The Johns Hopkins University | Prostate stem cell antigen vaccines and uses thereof |
| GB0504767D0 (en) | 2005-03-08 | 2005-04-13 | Ares Trading Sa | Lipocalin protein |
| DK3246403T3 (da) | 2005-10-18 | 2020-10-26 | Prec Biosciences | Rationelt designede meganucleaser med ændret sekvens-specificitet og dna-bindende affinitet |
| US20090220501A1 (en) | 2006-01-30 | 2009-09-03 | Fey Georg H | Anti-CD19 Antibody, Immunotoxin and Treatment Method |
| EP1829895A1 (en) | 2006-03-03 | 2007-09-05 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies |
| EP1878744A1 (en) | 2006-07-13 | 2008-01-16 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Epitope-tag for surface-expressed T-cell receptor proteins, uses thereof and method of selecting host cells expressing them |
| WO2008042814A2 (en) | 2006-09-29 | 2008-04-10 | California Institute Of Technology | Mart-1 t cell receptors |
| US20100105136A1 (en) * | 2006-10-09 | 2010-04-29 | The General Hospital Corporation | Chimeric t-cell receptors and t-cells targeting egfrviii on tumors |
| CN101541954B (zh) | 2006-11-30 | 2012-12-26 | Medipost株式会社 | 含有人脐带血衍生的间充质干细胞的组合物诱导神经前体细胞或神经干细胞分化和增殖为神经细胞的用途 |
| AU2008204541B2 (en) | 2007-01-09 | 2014-07-10 | Lead Pharma Cel Models Ip B.V. | Provision of new cardiomyocyte progenitor cells and cardiomyocytes derived therefrom |
| US20090042795A1 (en) | 2007-06-05 | 2009-02-12 | Pasan Fernando | Cardiac stem cell proliferation proteins, fragments thereof and methods of modulating stem cell proliferation and differentiation |
| CA2700391A1 (en) | 2007-09-24 | 2009-04-02 | University Of Zuerich | Designed armadillo repeat proteins |
| KR101319499B1 (ko) | 2008-02-22 | 2013-10-17 | 엘지디스플레이 주식회사 | 화학적 자기조립 방법을 이용한 나노선 혹은탄소나노튜브의 적층 및 패턴형성 방법과, 이를 적용한액정표시장치의 제조방법 |
| CA2735456C (en) | 2008-08-26 | 2021-11-16 | City Of Hope | Method and compositions for enhanced anti-tumor effector functioning of t cells |
| WO2010040073A1 (en) | 2008-10-03 | 2010-04-08 | Xoma Technology Ltd. | Novel triple tag sequences and methods of use thereof |
| ES2621181T3 (es) | 2008-11-21 | 2017-07-03 | Lallemand Hungary Liquidity Management Llc | Levaduras que expresan celulasas para la sacarificación y fermentación simultáneas utilizando celulosa |
| EP2210903A1 (en) | 2009-01-21 | 2010-07-28 | Monoclonal Antibodies Therapeutics | Anti-CD160 monoclonal antibodies and uses thereof |
| EP2424882A2 (en) * | 2009-02-05 | 2012-03-07 | Intercell AG | Peptides protective against e. faecalis, methods and uses relating thereto |
| JP5812418B2 (ja) | 2009-04-17 | 2015-11-11 | イムナス・ファーマ株式会社 | Aβオリゴマーに特異的に結合する抗体およびその利用 |
| EP2258719A1 (en) | 2009-05-19 | 2010-12-08 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Multiple target T cell receptor |
| JP5934099B2 (ja) * | 2009-10-01 | 2016-06-15 | アメリカ合衆国 | 抗血管内皮増殖因子受容体−2キメラ抗原受容体及び癌の治療のためのその使用 |
| US20130096281A1 (en) * | 2010-01-21 | 2013-04-18 | Oxyrane Uk Limited | Methods and compositions for displaying a polypeptide on a yeast cell surface |
| AU2011256838B2 (en) | 2010-05-17 | 2014-10-09 | Sangamo Therapeutics, Inc. | Novel DNA-binding proteins and uses thereof |
| GB201008682D0 (en) * | 2010-05-25 | 2010-07-07 | Vib Vzw | Epitope tag for affinity based applications |
| US20130315962A1 (en) | 2010-07-06 | 2013-11-28 | Nanologica Ab | Method for stem cell differentiation in vivo by delivery of morphogenes with mesoporous silica and corresponding pharmceutical active ingredients |
| WO2012136231A1 (en) | 2010-09-08 | 2012-10-11 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Interleukin 15 as selectable marker for gene transfer in lymphocytes |
| US20120107282A1 (en) | 2010-10-01 | 2012-05-03 | S. Biomedics Co., Ltd. | Neural stem cell composition capable of treating cancer and method of treatment |
| WO2012068378A1 (en) | 2010-11-17 | 2012-05-24 | Wake Forest University Health Sciences | Stem cell differentiation using keratin biomaterials |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| JP5897035B2 (ja) * | 2010-12-14 | 2016-03-30 | ユニバーシティ オブ メリーランド,ボルチモア | 汎用の抗タグキメラ抗原受容体発現t細胞及びがんを治療する方法 |
| WO2012127464A2 (en) * | 2011-03-23 | 2012-09-27 | Gavish-Galilee Bio Applications Ltd | Constitutively activated t cells for use in adoptive cell therapy |
| EP3415528B1 (en) | 2011-04-13 | 2021-05-26 | Bristol-Myers Squibb Company | Fc fusion proteins comprising novel linkers or arrangements |
| US20120308530A1 (en) | 2011-06-03 | 2012-12-06 | Beijing Allgens Medical Science & Technology Co., Ltd. | Materials Composition and Methods to Control Neural Progenitor and Stem Cell Attachment, Proliferation and Guide Cell Differentiation |
| US9676854B2 (en) | 2011-08-15 | 2017-06-13 | Medimmune, Llc | Anti-B7-H4 antibodies and their uses |
| US9708384B2 (en) | 2011-09-22 | 2017-07-18 | The Trustees Of The University Of Pennsylvania | Universal immune receptor expressed by T cells for the targeting of diverse and multiple antigens |
| WO2013076726A1 (en) | 2011-11-21 | 2013-05-30 | Ramot At Tel-Aviv University Ltd. | Stem cell-derived neural cells for cell therapy in neurological disorders |
| WO2013090205A2 (en) | 2011-12-12 | 2013-06-20 | The Regents Of The University Of California | Methods for use of neural stem cell compositions for treatment of central nervous system lesions |
| JP6274510B2 (ja) | 2012-01-27 | 2018-02-07 | 国立大学法人京都大学 | 多能性幹細胞の心筋分化誘導法 |
| EP2814846B1 (en) | 2012-02-13 | 2020-01-08 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| SG11201404991YA (en) | 2012-02-23 | 2014-09-26 | Stage Cell Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
| ES2728782T3 (es) | 2012-05-25 | 2019-10-28 | Univ California | Métodos y composiciones para la modificación de ADN objetivo dirigida por ARN y para la modulación de la transcripción dirigida por ARN |
| LT2884999T (lt) | 2012-08-20 | 2021-04-12 | Fred Hutchinson Cancer Research Center | Ląstelinės imunoterapijos būdas ir kompozicijos |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| EP3064585B1 (en) | 2012-12-12 | 2020-02-05 | The Broad Institute, Inc. | Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation |
| AU2013361275B2 (en) | 2012-12-19 | 2016-11-24 | Amplimmune, Inc. | Anti-human B7-H4 antibodies and their uses |
| US20150329640A1 (en) | 2012-12-20 | 2015-11-19 | Bluebird Bio, Inc. | Chimeric antigen receptors and immune cells targeting b cell malignancies |
| CA2913052A1 (en) | 2013-05-24 | 2014-11-27 | Board Of Regents, The University Of Texas System | Chimeric antigen receptor-targeting monoclonal antibodies |
| WO2014201431A1 (en) | 2013-06-14 | 2014-12-18 | Massachusetts Institute Of Technology | Articles and methods for stem cell differentiation |
| US20160250258A1 (en) | 2013-10-31 | 2016-09-01 | Fred Hutchinson Cancer Research Center | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
| EP2871189A1 (en) | 2013-11-07 | 2015-05-13 | Institut Pasteur | High-affinity monoclonal anti-strep-tag antibody |
| EP3760719A1 (en) | 2013-11-18 | 2021-01-06 | CRISPR Therapeutics AG | Crispr-cas system materials and methods |
| EP3858379A1 (en) | 2013-11-21 | 2021-08-04 | Autolus Limited | Cell |
| NZ759969A (en) * | 2013-12-20 | 2022-12-23 | Fred Hutchinson Cancer Center | Tagged chimeric effector molecules and receptors thereof |
| CN107074957B (zh) | 2014-01-13 | 2021-05-07 | 希望之城公司 | 在Fc间隔物区中具有突变的嵌合抗原受体(CAR)及其使用方法 |
| GB201415347D0 (en) | 2014-08-29 | 2014-10-15 | Ucl Business Plc | Signalling system |
| TW201625689A (zh) | 2014-09-12 | 2016-07-16 | 建南德克公司 | 抗-b7-h4抗體及免疫結合物 |
| RU2017115315A (ru) | 2014-10-03 | 2018-11-08 | Дана-Фарбер Кэнсер Инститьют, Инк. | Антитела к рецептору глюкокортикоид-индуцированного фактора некроза опухоли (gitr) и способы их применения |
| IL254039B2 (en) | 2015-02-19 | 2023-12-01 | Compugen Ltd | Anti-pvrig antibodies and methods of use |
| EP3288570A4 (en) | 2015-04-29 | 2018-11-21 | Fred Hutchinson Cancer Research Center | Modified stem cells and uses thereof |
| EP3288569A4 (en) | 2015-04-29 | 2018-12-19 | Fred Hutchinson Cancer Research Center | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
| JO3620B1 (ar) | 2015-08-05 | 2020-08-27 | Amgen Res Munich Gmbh | مثبطات نقطة فحص مناعية للاستخدام في علاج سرطانات محمولة عبر الدم |
| EP3571221A2 (en) | 2017-01-20 | 2019-11-27 | Juno Therapeutics GmbH | Cell surface conjugates and related cell compositions and methods |
| KR20200041377A (ko) | 2017-09-06 | 2020-04-21 | 프레드 헛친슨 켄서 리서치 센터 | Strep-tag 특이적 결합 단백질 및 그 용도 |
| CN111051349A (zh) | 2017-09-06 | 2020-04-21 | 弗雷德哈钦森癌症研究中心 | Strep-tag特异性嵌合受体及其用途 |
-
2014
- 2014-12-22 NZ NZ759969A patent/NZ759969A/en unknown
- 2014-12-22 JP JP2016540620A patent/JP6942467B2/ja active Active
- 2014-12-22 AU AU2014368892A patent/AU2014368892B2/en not_active Ceased
- 2014-12-22 KR KR1020227046118A patent/KR20230007559A/ko not_active Abandoned
- 2014-12-22 KR KR1020167017510A patent/KR102483822B1/ko active Active
- 2014-12-22 HR HRP20201906TT patent/HRP20201906T1/hr unknown
- 2014-12-22 NZ NZ720520A patent/NZ720520A/en unknown
- 2014-12-22 SG SG11201605046YA patent/SG11201605046YA/en unknown
- 2014-12-22 PL PL14830770.5T patent/PL3083671T3/pl unknown
- 2014-12-22 US US15/106,657 patent/US10494434B2/en active Active
- 2014-12-22 MY MYPI2016001073A patent/MY178233A/en unknown
- 2014-12-22 CN CN202110592499.XA patent/CN113354744A/zh active Pending
- 2014-12-22 EP EP14830770.5A patent/EP3083671B1/en active Active
- 2014-12-22 MX MX2016007927A patent/MX386422B/es unknown
- 2014-12-22 ES ES14830770T patent/ES2837856T3/es active Active
- 2014-12-22 SM SM20200699T patent/SMT202000699T1/it unknown
- 2014-12-22 WO PCT/US2014/072007 patent/WO2015095895A1/en not_active Ceased
- 2014-12-22 SG SG10201804439PA patent/SG10201804439PA/en unknown
- 2014-12-22 HU HUE14830770A patent/HUE052573T2/hu unknown
- 2014-12-22 RU RU2016129045A patent/RU2729463C2/ru active
- 2014-12-22 CA CA2933707A patent/CA2933707A1/en active Pending
- 2014-12-22 LT LTEP14830770.5T patent/LT3083671T/lt unknown
- 2014-12-22 RS RS20201392A patent/RS61223B1/sr unknown
- 2014-12-22 SI SI201431722T patent/SI3083671T1/sl unknown
- 2014-12-22 DK DK14830770.5T patent/DK3083671T3/da active
- 2014-12-22 BR BR112016014156A patent/BR112016014156A8/pt not_active Application Discontinuation
- 2014-12-22 PT PT148307705T patent/PT3083671T/pt unknown
- 2014-12-22 CN CN201480075007.8A patent/CN105980402B/zh active Active
-
2016
- 2016-05-25 IL IL245845A patent/IL245845B/en active IP Right Grant
-
2019
- 2019-03-04 JP JP2019038969A patent/JP2019083821A/ja active Pending
- 2019-09-13 AU AU2019229438A patent/AU2019229438B2/en not_active Ceased
- 2019-10-25 US US16/664,706 patent/US11046766B2/en active Active
-
2020
- 2020-12-23 CY CY20201101218T patent/CY1123747T1/el unknown
-
2021
- 2021-05-24 US US17/329,115 patent/US11993652B2/en active Active
- 2021-06-29 AU AU2021204475A patent/AU2021204475B2/en not_active Ceased
- 2021-07-14 JP JP2021116355A patent/JP2021164482A/ja active Pending
-
2022
- 2022-10-05 JP JP2022161138A patent/JP2022176327A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2016129045A (ru) | Меченые химерные эффекторные молекулы и их рецепторы | |
| CN111263641B (zh) | 用于制备基因工程化细胞的方法和组合物 | |
| US11180553B2 (en) | Chimeric antigen receptor | |
| JP2023036657A (ja) | 修飾されたt細胞及びその使用方法 | |
| KR102488477B1 (ko) | 신속하고 포괄적인 t-세포 면역 모니터링을 위한 세포 플랫폼 | |
| CN116194130A (zh) | 新颖的抗原结合结构域和包含这些抗原结合结构域的合成抗原受体 | |
| CN110461335A (zh) | 用于治疗bcma相关癌症和自身免疫性失调的联合疗法 | |
| CN110730908A (zh) | 表达前列腺特异性膜抗原(psma)或其修饰形式的工程化细胞及相关方法 | |
| JP2018521628A5 (enExample) | ||
| JP2019513347A5 (enExample) | ||
| JP2019503200A (ja) | 癌の治療のための組成物及び方法 | |
| JP2018532432A5 (enExample) | ||
| de Bruin et al. | Highly specific and potently activating Vγ9Vδ2-T cell specific nanobodies for diagnostic and therapeutic applications | |
| JP2015524255A (ja) | 二重特異性抗体を共導入することによってcart細胞の活性を強化する方法 | |
| CN113286875B (zh) | 表达嵌合抗原受体的黏膜相关不变t(mait)细胞 | |
| JP2019535262A5 (enExample) | ||
| CN111819186A (zh) | 表达嵌合抗原受体的免疫细胞 | |
| JP2020535796A5 (enExample) | ||
| US20230167184A1 (en) | Bcma-specific antibody and chimeric antigen receptor | |
| KR20220083667A (ko) | 압타머 기반의 다중특이 치료제 | |
| CN119613563A (zh) | 编码car的核酸分子和含其的载体、car、含car的免疫细胞及其制造方法和含该细胞的医药组合物及提升细胞损伤活性的方法 | |
| CN109400697B (zh) | 一种识别prame抗原短肽的tcr及其相关组合物 | |
| CN108948184B (zh) | 一种识别衍生自prame抗原短肽的t细胞受体 | |
| CN121263439A (zh) | 用于激活car-t细胞的分子和方法 | |
| NZ736022B2 (en) | De novo binding domain containing polypeptides and uses thereof |