JP2018521628A5 - - Google Patents
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- JP2018521628A5 JP2018521628A5 JP2017556597A JP2017556597A JP2018521628A5 JP 2018521628 A5 JP2018521628 A5 JP 2018521628A5 JP 2017556597 A JP2017556597 A JP 2017556597A JP 2017556597 A JP2017556597 A JP 2017556597A JP 2018521628 A5 JP2018521628 A5 JP 2018521628A5
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- JP
- Japan
- Prior art keywords
- seq
- domain
- tag cassette
- amino acid
- natural killer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021109884A JP2021168667A (ja) | 2015-04-29 | 2021-07-01 | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
| JP2022199333A JP2023036712A (ja) | 2015-04-29 | 2022-12-14 | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562154565P | 2015-04-29 | 2015-04-29 | |
| US62/154,565 | 2015-04-29 | ||
| PCT/US2016/030281 WO2016176651A2 (en) | 2015-04-29 | 2016-04-29 | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021109884A Division JP2021168667A (ja) | 2015-04-29 | 2021-07-01 | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018521628A JP2018521628A (ja) | 2018-08-09 |
| JP2018521628A5 true JP2018521628A5 (enExample) | 2019-11-07 |
| JP6985934B2 JP6985934B2 (ja) | 2021-12-22 |
Family
ID=57198772
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017556597A Expired - Fee Related JP6985934B2 (ja) | 2015-04-29 | 2016-04-29 | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
| JP2021109884A Pending JP2021168667A (ja) | 2015-04-29 | 2021-07-01 | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
| JP2022199333A Pending JP2023036712A (ja) | 2015-04-29 | 2022-12-14 | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021109884A Pending JP2021168667A (ja) | 2015-04-29 | 2021-07-01 | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
| JP2022199333A Pending JP2023036712A (ja) | 2015-04-29 | 2022-12-14 | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20180355318A1 (enExample) |
| EP (2) | EP3288569A4 (enExample) |
| JP (3) | JP6985934B2 (enExample) |
| WO (1) | WO2016176651A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150131208A (ko) | 2013-03-13 | 2015-11-24 | 이미지냅 인코포레이티드 | Cd8에의 항원 결합 구조체들 |
| NZ759969A (en) | 2013-12-20 | 2022-12-23 | Fred Hutchinson Cancer Center | Tagged chimeric effector molecules and receptors thereof |
| EP3288570A4 (en) | 2015-04-29 | 2018-11-21 | Fred Hutchinson Cancer Research Center | Modified stem cells and uses thereof |
| JP7032304B2 (ja) | 2015-07-28 | 2022-03-08 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | キメラ抗原受容体を発現する改変された単球/マクロファージおよびその使用 |
| CN108136012B (zh) | 2015-08-07 | 2022-10-04 | 伊麦吉纳博公司 | 靶向分子的抗原结合构建体 |
| IL258491B2 (en) | 2015-10-16 | 2023-09-01 | Univ Columbia | Preparations and methods for inhibiting antigens of a particular lineage |
| EP3571221A2 (en) * | 2017-01-20 | 2019-11-27 | Juno Therapeutics GmbH | Cell surface conjugates and related cell compositions and methods |
| CN108395482B (zh) | 2017-02-08 | 2021-02-05 | 西比曼生物科技(香港)有限公司 | 一种靶向cd20抗原嵌合抗原受体的构建及其工程化t细胞的活性鉴定 |
| KR102709603B1 (ko) | 2017-02-28 | 2024-09-27 | 보르 바이오파마 인크. | 계통 특이적 단백질의 억제를 위한 조성물 및 방법 |
| CN111051349A (zh) * | 2017-09-06 | 2020-04-21 | 弗雷德哈钦森癌症研究中心 | Strep-tag特异性嵌合受体及其用途 |
| CA3082334A1 (en) * | 2017-11-20 | 2019-05-23 | Julius-Maximilians-Universitat Wurzburg | Cd19cart cells eliminate myeloma cells that express very low levels of cd19 |
| JPWO2020004337A1 (ja) * | 2018-06-27 | 2021-08-02 | 国立大学法人東海国立大学機構 | Cd37特異的キメラ抗原レセプター |
| CA3110837A1 (en) | 2018-08-28 | 2020-03-05 | Vor Biopharma Inc. | Genetically engineered hematopoietic stem cells and uses thereof |
| EP3844191A4 (en) * | 2018-08-31 | 2022-06-15 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | METHODS AND COMPOSITIONS USING CHIMERIC B7H3 ANTIGEN RECEPTORS |
| CA3128871A1 (en) * | 2019-02-09 | 2020-08-13 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Genetically modified hematopoietic stem and progenitor cells (hspcs) and mesenchymal cells as a platform to reduce or prevent metastasis, treat autoimmune and inflammatory disorders, and rebalance the immune milieu_and dysregulated niches |
| CN113402612A (zh) | 2020-03-17 | 2021-09-17 | 西比曼生物科技(香港)有限公司 | 靶向cd19和cd20的联合嵌合抗原受体及其应用 |
| EP4161536A4 (en) | 2020-06-04 | 2024-08-14 | Carisma Therapeutics Inc. | Novel constructs for chimeric antigen receptors |
| KR102594083B1 (ko) | 2020-07-07 | 2023-10-25 | 칸큐어 엘엘씨 | Mic 항체 및 결합제 및 이의 사용 방법 |
| AU2022227686A1 (en) | 2021-02-25 | 2023-07-27 | Lyell Immunopharma, Inc. | Ror1 targeting chimeric antigen receptor |
| CN114733455B (zh) * | 2022-04-15 | 2023-02-14 | 北京田园奥瑞生物科技有限公司 | 一种利用生物改性β-环糊精纳米磁颗粒进行快速哺乳动物精子分型的方法 |
| PE20260290A1 (es) | 2023-03-31 | 2026-02-10 | Abelzeta Inc | Receptores de antigeno quimericos biespecificos dirigidos a cd20 y bcma |
| CN118853562B (zh) * | 2024-07-11 | 2025-08-29 | 中国科学院广州生物医药与健康研究院 | 一种靶向cd19的car-nk细胞及其制备方法和应用 |
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| US3753357A (en) | 1970-12-14 | 1973-08-21 | Ovitron Res Corp | Method and apparatus for the preservation of cells and tissues |
| US4199022A (en) | 1978-12-08 | 1980-04-22 | The United States Of America As Represented By The Department Of Energy | Method of freezing living cells and tissues with improved subsequent survival |
| US4559298A (en) | 1982-11-23 | 1985-12-17 | American National Red Cross | Cryopreservation of biological materials in a non-frozen or vitreous state |
| US5004681B1 (en) | 1987-11-12 | 2000-04-11 | Biocyte Corp | Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood |
| US6291161B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertiore |
| US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
| US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| ATE159548T1 (de) | 1990-11-13 | 1997-11-15 | Immunex Corp | Bifunktionelle wählbare fusionsgene |
| IL101728A (en) | 1991-05-03 | 2007-08-19 | Univ Yale | Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them |
| US5856441A (en) | 1991-05-03 | 1999-01-05 | Yale University | Serrate fragments and derivatives |
| IE20030749A1 (en) | 1991-05-03 | 2003-11-12 | Indiana University Foundation | Human notch and delta binding domains in torporythmic proteins, and methods based thereon |
| US5869282A (en) | 1991-12-11 | 1999-02-09 | Imperial Cancer Research Technology, Ltd. | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| WO1993012141A1 (en) | 1991-12-11 | 1993-06-24 | Yale University | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| AU6953394A (en) | 1993-05-21 | 1994-12-20 | Targeted Genetics Corporation | Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene |
| EP0737207B1 (en) | 1994-01-11 | 2004-09-22 | Dyax Corporation | Inhibitors of human plasmin derived from the kunitz domains |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| US5877299A (en) | 1995-06-16 | 1999-03-02 | Stemcell Technologies Inc. | Methods for preparing enriched human hematopoietic cell preparations |
| DK0861261T3 (da) | 1995-06-28 | 2009-12-14 | Imp Cancer Res Tech | Nukleotid- og proteinsekvenser af hvirveldyrs-Delta-gener og fremgangsmåder baseret derpå |
| US5780300A (en) | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
| AUPP221098A0 (en) | 1998-03-06 | 1998-04-02 | Diatech Pty Ltd | V-like domain binding molecules |
| CA2347973C (en) * | 1999-07-20 | 2010-06-22 | Morphosys Ag | Novel methods for displaying (poly)peptides/proteins on bacteriophage particles via disulfide bonds |
| WO2002059285A1 (en) | 2000-10-27 | 2002-08-01 | Fred Hutchinson Cancer Research Center | Methods for immortalizing cells |
| DE10113776B4 (de) | 2001-03-21 | 2012-08-09 | "Iba Gmbh" | Isoliertes streptavidinbindendes, kompetitiv eluierbares Peptid, dieses umfassendes Fusionspeptid, dafür codierende Nukleinsäure, Expressionsvektor, Verfahren zur Herstellung eines rekombinanten Fusionsproteins und Verfahren zum Nachweis und/oder zur Gewinnung des Fusionsproteins |
| ES2559763T3 (es) * | 2002-09-10 | 2016-02-15 | Affimed Gmbh | Anticuerpo humano específico de CD3 con propiedades inmunosupresoras |
| EP1791865B1 (en) | 2004-06-29 | 2010-07-28 | Immunocore Ltd. | Cells expressing a modified t cell receptor |
| US7147626B2 (en) | 2004-09-23 | 2006-12-12 | Celgene Corporation | Cord blood and placenta collection kit |
| US8252587B2 (en) | 2004-10-25 | 2012-08-28 | Celerant Therapeutics, Inc. | Methods of expanding myeloid cell populations and uses thereof |
| ATE423140T1 (de) | 2005-01-05 | 2009-03-15 | F Star Biotech Forsch & Entw | Synthetische immunoglobulindomänen mit in regionen des moleküls, die sich von den die komplementarität bestimmenden bereichen unterscheiden, modifizierten bindeeigenschaften |
| GB0504767D0 (en) | 2005-03-08 | 2005-04-13 | Ares Trading Sa | Lipocalin protein |
| US20090220501A1 (en) * | 2006-01-30 | 2009-09-03 | Fey Georg H | Anti-CD19 Antibody, Immunotoxin and Treatment Method |
| WO2007095594A2 (en) | 2006-02-14 | 2007-08-23 | Cellerant Therapeutics, Inc. | Methods and compositions for enhancing engraftment of hematopoietic stem cells |
| EP1829895A1 (en) | 2006-03-03 | 2007-09-05 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies |
| KR20090021217A (ko) | 2006-06-14 | 2009-02-27 | 추가이 세이야쿠 가부시키가이샤 | 조혈 줄기세포 증가 촉진제 |
| WO2008042814A2 (en) | 2006-09-29 | 2008-04-10 | California Institute Of Technology | Mart-1 t cell receptors |
| CA2700391A1 (en) | 2007-09-24 | 2009-04-02 | University Of Zuerich | Designed armadillo repeat proteins |
| PE20100362A1 (es) | 2008-10-30 | 2010-05-27 | Irm Llc | Derivados de purina que expanden las celulas madre hematopoyeticas |
| ES2621181T3 (es) * | 2008-11-21 | 2017-07-03 | Lallemand Hungary Liquidity Management Llc | Levaduras que expresan celulasas para la sacarificación y fermentación simultáneas utilizando celulosa |
| CA2753158A1 (en) * | 2009-02-23 | 2010-08-26 | Glenmark Pharmaceuticals S.A. | Humanized antibodies that bind to cd19 and their uses |
| EP3097916B1 (en) | 2010-04-09 | 2021-07-07 | Fred Hutchinson Cancer Research Center | Compositions and methods for providing hematopoietic function |
| EP3590520B1 (en) | 2010-04-09 | 2021-12-29 | Fred Hutchinson Cancer Research Center | Compositions for providing hematopoietic function without hla matching |
| WO2012136231A1 (en) * | 2010-09-08 | 2012-10-11 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Interleukin 15 as selectable marker for gene transfer in lymphocytes |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| WO2013086436A1 (en) | 2011-12-08 | 2013-06-13 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
| US20160145348A1 (en) * | 2013-03-14 | 2016-05-26 | Fred Hutchinson Cancer Research Center | Compositions and methods to modify cells for therapeutic objectives |
| US20160250258A1 (en) * | 2013-10-31 | 2016-09-01 | Fred Hutchinson Cancer Research Center | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
| NZ759969A (en) * | 2013-12-20 | 2022-12-23 | Fred Hutchinson Cancer Center | Tagged chimeric effector molecules and receptors thereof |
-
2016
- 2016-04-29 EP EP16787279.5A patent/EP3288569A4/en not_active Withdrawn
- 2016-04-29 EP EP21199232.6A patent/EP3995142A3/en not_active Withdrawn
- 2016-04-29 JP JP2017556597A patent/JP6985934B2/ja not_active Expired - Fee Related
- 2016-04-29 US US15/570,191 patent/US20180355318A1/en not_active Abandoned
- 2016-04-29 WO PCT/US2016/030281 patent/WO2016176651A2/en not_active Ceased
-
2021
- 2021-07-01 JP JP2021109884A patent/JP2021168667A/ja active Pending
- 2021-11-11 US US17/524,592 patent/US20220204935A1/en not_active Abandoned
-
2022
- 2022-12-14 JP JP2022199333A patent/JP2023036712A/ja active Pending
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