JP2018521628A5 - - Google Patents

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JP2018521628A5
JP2018521628A5 JP2017556597A JP2017556597A JP2018521628A5 JP 2018521628 A5 JP2018521628 A5 JP 2018521628A5 JP 2017556597 A JP2017556597 A JP 2017556597A JP 2017556597 A JP2017556597 A JP 2017556597A JP 2018521628 A5 JP2018521628 A5 JP 2018521628A5
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seq
domain
tag cassette
amino acid
natural killer
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JP2017556597A
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JP6985934B2 (ja
JP2018521628A (ja
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Priority claimed from PCT/US2016/030281 external-priority patent/WO2016176651A2/en
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Priority to JP2021109884A priority Critical patent/JP2021168667A/ja
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Publication of JP6985934B2 publication Critical patent/JP6985934B2/ja
Priority to JP2022199333A priority patent/JP2023036712A/ja
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JP2017556597A 2015-04-29 2016-04-29 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 Active JP6985934B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021109884A JP2021168667A (ja) 2015-04-29 2021-07-01 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用
JP2022199333A JP2023036712A (ja) 2015-04-29 2022-12-14 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562154565P 2015-04-29 2015-04-29
US62/154,565 2015-04-29
PCT/US2016/030281 WO2016176651A2 (en) 2015-04-29 2016-04-29 Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof

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JP2021109884A Division JP2021168667A (ja) 2015-04-29 2021-07-01 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用

Publications (3)

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JP2018521628A JP2018521628A (ja) 2018-08-09
JP2018521628A5 true JP2018521628A5 (enExample) 2019-11-07
JP6985934B2 JP6985934B2 (ja) 2021-12-22

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JP2017556597A Active JP6985934B2 (ja) 2015-04-29 2016-04-29 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用
JP2021109884A Pending JP2021168667A (ja) 2015-04-29 2021-07-01 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用
JP2022199333A Pending JP2023036712A (ja) 2015-04-29 2022-12-14 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用

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JP2021109884A Pending JP2021168667A (ja) 2015-04-29 2021-07-01 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用
JP2022199333A Pending JP2023036712A (ja) 2015-04-29 2022-12-14 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用

Country Status (4)

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US (2) US20180355318A1 (enExample)
EP (2) EP3995142A3 (enExample)
JP (3) JP6985934B2 (enExample)
WO (1) WO2016176651A2 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6815196B2 (ja) 2013-03-13 2021-01-20 イマジナブ、 インコーポレイテッド Cd8に対する抗原結合性構築物
AU2014368892B2 (en) 2013-12-20 2019-06-13 Fred Hutchinson Cancer Center Tagged chimeric effector molecules and receptors thereof
WO2016176652A2 (en) 2015-04-29 2016-11-03 Fred Hutchinson Cancer Research Center Modified stem cells and uses thereof
CN108025024B (zh) 2015-07-28 2022-11-29 宾夕法尼亚大学董事会 表达嵌合抗原受体的修饰单核细胞/巨噬细胞及其用途
KR20250008141A (ko) 2015-08-07 2025-01-14 이미지냅 인코포레이티드 분자를 표적화하기 위한 항원 결합 구조체
AU2016337525B2 (en) 2015-10-16 2022-01-20 The Trustees Of Columbia University In The City Of New York Compositions and methods for inhibition of lineage specific antigens
CA3050085A1 (en) 2017-01-20 2018-07-26 Juno Therapeutics Gmbh Cell surface conjugates and related cell compositions and methods
CN108395482B (zh) 2017-02-08 2021-02-05 西比曼生物科技(香港)有限公司 一种靶向cd20抗原嵌合抗原受体的构建及其工程化t细胞的活性鉴定
IL268895B2 (en) * 2017-02-28 2025-05-01 Vor Biopharma Inc Compositions and methods for inhibition of lineage specific proteins
CA3071661A1 (en) * 2017-09-06 2019-03-14 Fred Hutchinson Cancer Research Center Strep-tag specific chimeric receptors and uses thereof
CN111373261B (zh) * 2017-11-20 2024-06-14 尤利乌斯·马克西米利安维尔茨堡大学 Cd19 cart细胞可清除表达极低水平cd19的骨髓瘤细胞
WO2020004337A1 (ja) * 2018-06-27 2020-01-02 国立大学法人名古屋大学 Cd37特異的キメラ抗原レセプター
WO2020047164A1 (en) 2018-08-28 2020-03-05 Vor Biopharma, Inc Genetically engineered hematopoietic stem cells and uses thereof
CA3110858A1 (en) * 2018-08-31 2020-03-05 Seattle Children's Hospital (dba Seattle Children's Research Institute) Methods and compositions comprising b7h3 chimeric antigen receptors
CN118240767A (zh) * 2019-02-09 2024-06-25 美国卫生和人力服务部 作为减少或预防转移、治疗自身免疫和炎性病症以及重新平衡免疫环境和失调的小生境的平台的基因修饰的hspc及间充质细胞
CN113402612A (zh) 2020-03-17 2021-09-17 西比曼生物科技(香港)有限公司 靶向cd19和cd20的联合嵌合抗原受体及其应用
KR20230042691A (ko) 2020-06-04 2023-03-29 카리스마 테라퓨틱스 인코포레이티드 키메라 항원 수용체에 대한 신규한 작제물
KR20230152783A (ko) 2020-07-07 2023-11-03 칸큐어 엘엘씨 Mic 항체 및 결합제 및 이의 사용 방법
CA3172530A1 (en) 2021-02-25 2022-09-01 Spencer PARK Ror1 targeting chimeric antigen receptor
CN114733455B (zh) * 2022-04-15 2023-02-14 北京田园奥瑞生物科技有限公司 一种利用生物改性β-环糊精纳米磁颗粒进行快速哺乳动物精子分型的方法
AU2024244733B2 (en) 2023-03-31 2025-12-11 AbelZeta Inc. Bispecific chimeric antigen receptors targeting cd20 and bcma
CN118853562B (zh) * 2024-07-11 2025-08-29 中国科学院广州生物医药与健康研究院 一种靶向cd19的car-nk细胞及其制备方法和应用

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3753357A (en) 1970-12-14 1973-08-21 Ovitron Res Corp Method and apparatus for the preservation of cells and tissues
US4199022A (en) 1978-12-08 1980-04-22 The United States Of America As Represented By The Department Of Energy Method of freezing living cells and tissues with improved subsequent survival
US4559298A (en) 1982-11-23 1985-12-17 American National Red Cross Cryopreservation of biological materials in a non-frozen or vitreous state
US5004681B1 (en) 1987-11-12 2000-04-11 Biocyte Corp Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood
US6291158B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertoire
US6291161B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertiore
US5283173A (en) 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
WO1992008796A1 (en) 1990-11-13 1992-05-29 Immunex Corporation Bifunctional selectable fusion genes
IL101728A (en) 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
US5856441A (en) 1991-05-03 1999-01-05 Yale University Serrate fragments and derivatives
IE20030749A1 (en) 1991-05-03 2003-11-12 Indiana University Foundation Human notch and delta binding domains in torporythmic proteins, and methods based thereon
WO1993012141A1 (en) 1991-12-11 1993-06-24 Yale University Nucleotide and protein sequences of the serrate gene and methods based thereon
US5869282A (en) 1991-12-11 1999-02-09 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of the serrate gene and methods based thereon
AU6953394A (en) 1993-05-21 1994-12-20 Targeted Genetics Corporation Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene
ATE529444T1 (de) 1994-01-11 2011-11-15 Dyax Corp Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
US5877299A (en) 1995-06-16 1999-03-02 Stemcell Technologies Inc. Methods for preparing enriched human hematopoietic cell preparations
AU723939B2 (en) 1995-06-28 2000-09-07 Imperial Cancer Research Technology Ltd Nucleotide and protein sequences of vertebrate delta genes and methods based thereon
US5780300A (en) 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
AUPP221098A0 (en) 1998-03-06 1998-04-02 Diatech Pty Ltd V-like domain binding molecules
EP1990409A3 (en) * 1999-07-20 2011-05-18 MorphoSys AG Bacteriophage
WO2002059285A1 (en) 2000-10-27 2002-08-01 Fred Hutchinson Cancer Research Center Methods for immortalizing cells
DE10113776B4 (de) 2001-03-21 2012-08-09 "Iba Gmbh" Isoliertes streptavidinbindendes, kompetitiv eluierbares Peptid, dieses umfassendes Fusionspeptid, dafür codierende Nukleinsäure, Expressionsvektor, Verfahren zur Herstellung eines rekombinanten Fusionsproteins und Verfahren zum Nachweis und/oder zur Gewinnung des Fusionsproteins
ES2559763T3 (es) * 2002-09-10 2016-02-15 Affimed Gmbh Anticuerpo humano específico de CD3 con propiedades inmunosupresoras
JP5563194B2 (ja) 2004-06-29 2014-07-30 イムノコア リミテッド 改変t細胞レセプターを発現する細胞
US7147626B2 (en) 2004-09-23 2006-12-12 Celgene Corporation Cord blood and placenta collection kit
ES2538305T3 (es) 2004-10-25 2015-06-18 Cellerant Therapeutics, Inc. Métodos para expandir poblaciones de células mieloides y usos de las mismas
US20090298195A1 (en) 2005-01-05 2009-12-03 F-Star Biotechnologische Forschungs-Und Entwicklun Gseges M.B.H. Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions
GB0504767D0 (en) 2005-03-08 2005-04-13 Ares Trading Sa Lipocalin protein
US20090220501A1 (en) * 2006-01-30 2009-09-03 Fey Georg H Anti-CD19 Antibody, Immunotoxin and Treatment Method
JP5341525B2 (ja) 2006-02-14 2013-11-13 セルラント セラピューティクス,インコーポレイティド 造血幹細胞の生着を増強するための方法および組成物
EP1829895A1 (en) 2006-03-03 2007-09-05 f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies
KR20090021217A (ko) 2006-06-14 2009-02-27 추가이 세이야쿠 가부시키가이샤 조혈 줄기세포 증가 촉진제
US8119772B2 (en) 2006-09-29 2012-02-21 California Institute Of Technology MART-1 T cell receptors
CA2700391A1 (en) 2007-09-24 2009-04-02 University Of Zuerich Designed armadillo repeat proteins
PE20100362A1 (es) 2008-10-30 2010-05-27 Irm Llc Derivados de purina que expanden las celulas madre hematopoyeticas
NZ593469A (en) * 2008-11-21 2012-12-21 Mascoma Corp Yeast expressing cellulases for simultaneous saccharification and fermentation using cellulose
JP2012518404A (ja) * 2009-02-23 2012-08-16 グレンマーク・ファーマシューティカルズ・エスエー Cd19に結合するヒト化抗体及びその使用
US20130095079A1 (en) 2010-04-09 2013-04-18 Fred Hutchinson Cancer Research Center Compositions and methods for providing hematopoietic function without hla matching
US20130095080A1 (en) 2010-04-09 2013-04-18 Fred Hutchinson Cancer Reserach Center Compositions and methods for providing hematopoietic function
WO2012136231A1 (en) * 2010-09-08 2012-10-11 Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus Interleukin 15 as selectable marker for gene transfer in lymphocytes
PH12013501201A1 (en) * 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
EP2788476B1 (en) 2011-12-08 2019-05-22 Fred Hutchinson Cancer Research Center Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
US20160145348A1 (en) * 2013-03-14 2016-05-26 Fred Hutchinson Cancer Research Center Compositions and methods to modify cells for therapeutic objectives
AU2014342020C1 (en) * 2013-10-31 2019-09-05 Fred Hutchinson Cancer Research Center Modified hematopoietic stem/progenitor and non-T effector cells, and uses thereof
AU2014368892B2 (en) * 2013-12-20 2019-06-13 Fred Hutchinson Cancer Center Tagged chimeric effector molecules and receptors thereof

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