JP2018521628A5 - - Google Patents
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- JP2018521628A5 JP2018521628A5 JP2017556597A JP2017556597A JP2018521628A5 JP 2018521628 A5 JP2018521628 A5 JP 2018521628A5 JP 2017556597 A JP2017556597 A JP 2017556597A JP 2017556597 A JP2017556597 A JP 2017556597A JP 2018521628 A5 JP2018521628 A5 JP 2018521628A5
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- Prior art keywords
- seq
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- tag cassette
- amino acid
- natural killer
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- 210000000822 natural killer cell Anatomy 0.000 claims 22
- 125000003275 alpha amino acid group Chemical group 0.000 claims 21
- -1 MAGE-A Proteins 0.000 claims 12
- 238000009472 formulation Methods 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 11
- 239000012636 effector Substances 0.000 claims 10
- 230000003834 intracellular effect Effects 0.000 claims 10
- 230000002209 hydrophobic effect Effects 0.000 claims 9
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 8
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 230000011664 signaling Effects 0.000 claims 8
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 6
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 6
- 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 claims 6
- 101000634846 Homo sapiens T-cell receptor-associated transmembrane adapter 1 Proteins 0.000 claims 6
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 6
- 102100029453 T-cell receptor-associated transmembrane adapter 1 Human genes 0.000 claims 6
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 6
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 6
- 102100022748 Wilms tumor protein Human genes 0.000 claims 6
- 125000006850 spacer group Chemical group 0.000 claims 6
- 210000004899 c-terminal region Anatomy 0.000 claims 5
- 239000002771 cell marker Substances 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- 102100023635 Alpha-fetoprotein Human genes 0.000 claims 4
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 4
- 102100038078 CD276 antigen Human genes 0.000 claims 4
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 4
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims 4
- 101150013553 CD40 gene Proteins 0.000 claims 4
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 4
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 4
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 4
- 101001103039 Homo sapiens Inactive tyrosine-protein kinase transmembrane receptor ROR1 Proteins 0.000 claims 4
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 4
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 4
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 4
- 101000621309 Homo sapiens Wilms tumor protein Chemical group 0.000 claims 4
- 102100039615 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Human genes 0.000 claims 4
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 4
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 4
- 102000003735 Mesothelin Human genes 0.000 claims 4
- 108090000015 Mesothelin Proteins 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims 4
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 4
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 4
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 4
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims 4
- 230000000779 depleting effect Effects 0.000 claims 3
- 108020003175 receptors Proteins 0.000 claims 3
- 102000005962 receptors Human genes 0.000 claims 3
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
- 102100026882 Alpha-synuclein Human genes 0.000 claims 2
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims 2
- 102100027205 B-cell antigen receptor complex-associated protein alpha chain Human genes 0.000 claims 2
- 102100027203 B-cell antigen receptor complex-associated protein beta chain Human genes 0.000 claims 2
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 2
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 2
- 102100024217 CAMPATH-1 antigen Human genes 0.000 claims 2
- 102100035893 CD151 antigen Human genes 0.000 claims 2
- 102100027207 CD27 antigen Human genes 0.000 claims 2
- 102100032912 CD44 antigen Human genes 0.000 claims 2
- 108010065524 CD52 Antigen Proteins 0.000 claims 2
- 102100027221 CD81 antigen Human genes 0.000 claims 2
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 2
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 2
- 101100364669 Caenorhabditis elegans lin-18 gene Proteins 0.000 claims 2
- 102100025473 Carcinoembryonic antigen-related cell adhesion molecule 6 Human genes 0.000 claims 2
- 102100024965 Caspase recruitment domain-containing protein 11 Human genes 0.000 claims 2
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 2
- 101150029707 ERBB2 gene Proteins 0.000 claims 2
- 108010055196 EphA2 Receptor Proteins 0.000 claims 2
- 102100030340 Ephrin type-A receptor 2 Human genes 0.000 claims 2
- 102100020948 Growth hormone receptor Human genes 0.000 claims 2
- 102100033365 Growth hormone-releasing hormone receptor Human genes 0.000 claims 2
- 102100029360 Hematopoietic cell signal transducer Human genes 0.000 claims 2
- 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 claims 2
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims 2
- 101000914489 Homo sapiens B-cell antigen receptor complex-associated protein alpha chain Proteins 0.000 claims 2
- 101000914491 Homo sapiens B-cell antigen receptor complex-associated protein beta chain Proteins 0.000 claims 2
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 2
- 101000946874 Homo sapiens CD151 antigen Proteins 0.000 claims 2
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 2
- 101000884279 Homo sapiens CD276 antigen Proteins 0.000 claims 2
- 101100166600 Homo sapiens CD28 gene Proteins 0.000 claims 2
- 101100005713 Homo sapiens CD4 gene Proteins 0.000 claims 2
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 2
- 101000914479 Homo sapiens CD81 antigen Proteins 0.000 claims 2
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 claims 2
- 101000914326 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 6 Proteins 0.000 claims 2
- 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 claims 2
- 101000761179 Homo sapiens Caspase recruitment domain-containing protein 11 Proteins 0.000 claims 2
- 101001075287 Homo sapiens Growth hormone receptor Proteins 0.000 claims 2
- 101000997535 Homo sapiens Growth hormone-releasing hormone receptor Proteins 0.000 claims 2
- 101000990188 Homo sapiens Hematopoietic cell signal transducer Proteins 0.000 claims 2
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 claims 2
- 101000998120 Homo sapiens Interleukin-3 receptor subunit alpha Proteins 0.000 claims 2
- 101000599048 Homo sapiens Interleukin-6 receptor subunit alpha Proteins 0.000 claims 2
- 101001047640 Homo sapiens Linker for activation of T-cells family member 1 Proteins 0.000 claims 2
- 101001043594 Homo sapiens Low-density lipoprotein receptor-related protein 5 Proteins 0.000 claims 2
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 2
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims 2
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 claims 2
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 2
- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 claims 2
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims 2
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 2
- 101001051490 Homo sapiens Neural cell adhesion molecule L1 Proteins 0.000 claims 2
- 101001024605 Homo sapiens Next to BRCA1 gene 1 protein Proteins 0.000 claims 2
- 101000586302 Homo sapiens Oncostatin-M-specific receptor subunit beta Proteins 0.000 claims 2
- 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 claims 2
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims 2
- 101001136592 Homo sapiens Prostate stem cell antigen Proteins 0.000 claims 2
- 101000702132 Homo sapiens Protein spinster homolog 1 Proteins 0.000 claims 2
- 101000652359 Homo sapiens Spermatogenesis-associated protein 2 Proteins 0.000 claims 2
- 101000914496 Homo sapiens T-cell antigen CD7 Proteins 0.000 claims 2
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims 2
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims 2
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 2
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 claims 2
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 2
- 101000679851 Homo sapiens Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 2
- 101001103033 Homo sapiens Tyrosine-protein kinase transmembrane receptor ROR2 Proteins 0.000 claims 2
- 101000955999 Homo sapiens V-set domain-containing T-cell activation inhibitor 1 Proteins 0.000 claims 2
- 101000851018 Homo sapiens Vascular endothelial growth factor receptor 1 Proteins 0.000 claims 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 2
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims 2
- 102100025390 Integrin beta-2 Human genes 0.000 claims 2
- 102100033493 Interleukin-3 receptor subunit alpha Human genes 0.000 claims 2
- 102100037792 Interleukin-6 receptor subunit alpha Human genes 0.000 claims 2
- 102100037795 Interleukin-6 receptor subunit beta Human genes 0.000 claims 2
- 101710152369 Interleukin-6 receptor subunit beta Proteins 0.000 claims 2
- 102000017578 LAG3 Human genes 0.000 claims 2
- 101150028321 Lck gene Proteins 0.000 claims 2
- 102100021926 Low-density lipoprotein receptor-related protein 5 Human genes 0.000 claims 2
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims 2
- 102100034256 Mucin-1 Human genes 0.000 claims 2
- 102100023123 Mucin-16 Human genes 0.000 claims 2
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims 2
- 101100364671 Mus musculus Ryk gene Proteins 0.000 claims 2
- 101100268066 Mus musculus Zap70 gene Proteins 0.000 claims 2
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 2
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 claims 2
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims 2
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 2
- 102100024964 Neural cell adhesion molecule L1 Human genes 0.000 claims 2
- 102100030098 Oncostatin-M-specific receptor subunit beta Human genes 0.000 claims 2
- 108010065129 Patched-1 Receptor Proteins 0.000 claims 2
- 108010071083 Patched-2 Receptor Proteins 0.000 claims 2
- 102100022019 Pregnancy-specific beta-1-glycoprotein 2 Human genes 0.000 claims 2
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims 2
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 2
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims 2
- 102100036735 Prostate stem cell antigen Human genes 0.000 claims 2
- 102100028680 Protein patched homolog 1 Human genes 0.000 claims 2
- 102100036894 Protein patched homolog 2 Human genes 0.000 claims 2
- 101150097792 Robo1 gene Proteins 0.000 claims 2
- 108010074687 Signaling Lymphocytic Activation Molecule Family Member 1 Proteins 0.000 claims 2
- 102100029215 Signaling lymphocytic activation molecule Human genes 0.000 claims 2
- 102100027208 T-cell antigen CD7 Human genes 0.000 claims 2
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims 2
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims 2
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 2
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 2
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 2
- 102100033456 TGF-beta receptor type-1 Human genes 0.000 claims 2
- 102100033455 TGF-beta receptor type-2 Human genes 0.000 claims 2
- 108010060818 Toll-Like Receptor 9 Proteins 0.000 claims 2
- 102100039390 Toll-like receptor 7 Human genes 0.000 claims 2
- 102100033117 Toll-like receptor 9 Human genes 0.000 claims 2
- 108010011702 Transforming Growth Factor-beta Type I Receptor Proteins 0.000 claims 2
- 108010082684 Transforming Growth Factor-beta Type II Receptor Proteins 0.000 claims 2
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 2
- 102100033732 Tumor necrosis factor receptor superfamily member 1A Human genes 0.000 claims 2
- 101710187743 Tumor necrosis factor receptor superfamily member 1A Proteins 0.000 claims 2
- 102100033733 Tumor necrosis factor receptor superfamily member 1B Human genes 0.000 claims 2
- 101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 claims 2
- 102000003425 Tyrosinase Human genes 0.000 claims 2
- 108060008724 Tyrosinase Proteins 0.000 claims 2
- 102100039616 Tyrosine-protein kinase transmembrane receptor ROR2 Human genes 0.000 claims 2
- 102100038929 V-set domain-containing T-cell activation inhibitor 1 Human genes 0.000 claims 2
- 108010053100 Vascular Endothelial Growth Factor Receptor-3 Proteins 0.000 claims 2
- 102100033178 Vascular endothelial growth factor receptor 1 Human genes 0.000 claims 2
- 102100033179 Vascular endothelial growth factor receptor 3 Human genes 0.000 claims 2
- 108700020467 WT1 Proteins 0.000 claims 2
- 101150084041 WT1 gene Proteins 0.000 claims 2
- 101001038499 Yarrowia lipolytica (strain CLIB 122 / E 150) Lysine acetyltransferase Proteins 0.000 claims 2
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 230000000139 costimulatory effect Effects 0.000 claims 2
- 230000001086 cytosolic effect Effects 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 239000002254 cytotoxic agent Substances 0.000 claims 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims 2
- 108010087914 epidermal growth factor receptor VIII Proteins 0.000 claims 2
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 2
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 2
- 230000004068 intracellular signaling Effects 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 2
- 244000052769 pathogen Species 0.000 claims 2
- 230000001717 pathogenic effect Effects 0.000 claims 2
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021109884A JP2021168667A (ja) | 2015-04-29 | 2021-07-01 | 操作された造血幹細胞／前駆細胞及び非ｔエフェクター細胞、ならびにその使用 |
| JP2022199333A JP2023036712A (ja) | 2015-04-29 | 2022-12-14 | 操作された造血幹細胞／前駆細胞及び非ｔエフェクター細胞、ならびにその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562154565P | 2015-04-29 | 2015-04-29 | |
| US62/154,565 | 2015-04-29 | ||
| PCT/US2016/030281 WO2016176651A2 (en) | 2015-04-29 | 2016-04-29 | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021109884A Division JP2021168667A (ja) | 2015-04-29 | 2021-07-01 | 操作された造血幹細胞／前駆細胞及び非ｔエフェクター細胞、ならびにその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018521628A JP2018521628A (ja) | 2018-08-09 |
| JP2018521628A5 true JP2018521628A5 (enExample) | 2019-11-07 |
| JP6985934B2 JP6985934B2 (ja) | 2021-12-22 |
Family
ID=57198772
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017556597A Active JP6985934B2 (ja) | 2015-04-29 | 2016-04-29 | 操作された造血幹細胞／前駆細胞及び非ｔエフェクター細胞、ならびにその使用 |
| JP2021109884A Pending JP2021168667A (ja) | 2015-04-29 | 2021-07-01 | 操作された造血幹細胞／前駆細胞及び非ｔエフェクター細胞、ならびにその使用 |
| JP2022199333A Pending JP2023036712A (ja) | 2015-04-29 | 2022-12-14 | 操作された造血幹細胞／前駆細胞及び非ｔエフェクター細胞、ならびにその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021109884A Pending JP2021168667A (ja) | 2015-04-29 | 2021-07-01 | 操作された造血幹細胞／前駆細胞及び非ｔエフェクター細胞、ならびにその使用 |
| JP2022199333A Pending JP2023036712A (ja) | 2015-04-29 | 2022-12-14 | 操作された造血幹細胞／前駆細胞及び非ｔエフェクター細胞、ならびにその使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20180355318A1 (enExample) |
| EP (2) | EP3995142A3 (enExample) |
| JP (3) | JP6985934B2 (enExample) |
| WO (1) | WO2016176651A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113045660B (zh) | 2013-03-13 | 2023-09-01 | 伊麦吉纳博公司 | 与cd8的抗原结合构建体 |
| HRP20201906T1 (hr) | 2013-12-20 | 2021-04-02 | Fred Hutchinson Cancer Research Center | Označene kimerne efektorske molekule i njihovi receptori |
| WO2016176652A2 (en) | 2015-04-29 | 2016-11-03 | Fred Hutchinson Cancer Research Center | Modified stem cells and uses thereof |
| KR102697827B1 (ko) | 2015-07-28 | 2024-08-23 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | 키메릭 항원 수용체를 발현하는 변형된 단핵세포/대식세포 및 그의 용도 |
| ES3020458T3 (en) | 2015-08-07 | 2025-05-22 | Imaginab Inc | Antigen binding constructs to target molecules |
| EP4265633A3 (en) | 2015-10-16 | 2024-01-24 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for inhibition of lineage specific antigens |
| US11517627B2 (en) * | 2017-01-20 | 2022-12-06 | Juno Therapeutics Gmbh | Cell surface conjugates and related cell compositions and methods |
| BR112019017751A2 (pt) * | 2017-02-28 | 2020-04-07 | Vor Biopharma, Inc. | composições e métodos de inibição de proteínas de linhagem específica |
| WO2019051128A1 (en) * | 2017-09-06 | 2019-03-14 | Fred Hutchinson Cancer Research Center | SPECIFIC STREP LABEL CHIMERIC RECEPTORS AND USES THEREOF |
| JP7517983B2 (ja) * | 2017-11-20 | 2024-07-17 | ユリウス－マクシミリアン－ウニヴェルシテート・ヴュルツブルク | 非常に低レベルのｃｄ１９を発現する骨髄腫細胞を除去するｃｄ１９ｃａｒｔ細胞 |
| JPWO2020004337A1 (ja) * | 2018-06-27 | 2021-08-02 | 国立大学法人東海国立大学機構 | Ｃｄ３７特異的キメラ抗原レセプター |
| SG11202101994XA (en) | 2018-08-28 | 2021-03-30 | Vor Biopharma Inc | Genetically engineered hematopoietic stem cells and uses thereof |
| CA3110858A1 (en) * | 2018-08-31 | 2020-03-05 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Methods and compositions comprising b7h3 chimeric antigen receptors |
| CN113402612A (zh) * | 2020-03-17 | 2021-09-17 | 西比曼生物科技（香港）有限公司 | 靶向cd19和cd20的联合嵌合抗原受体及其应用 |
| EP4161536A4 (en) | 2020-06-04 | 2024-08-14 | Carisma Therapeutics Inc. | Novel constructs for chimeric antigen receptors |
| TW202216776A (zh) | 2020-07-07 | 2022-05-01 | 美商康愈有限責任公司 | Mic抗體及結合劑以及其使用方法 |
| AU2022227686A1 (en) | 2021-02-25 | 2023-07-27 | Lyell Immunopharma, Inc. | Ror1 targeting chimeric antigen receptor |
| CN114733455B (zh) * | 2022-04-15 | 2023-02-14 | 北京田园奥瑞生物科技有限公司 | 一种利用生物改性β-环糊精纳米磁颗粒进行快速哺乳动物精子分型的方法 |
| KR20250131823A (ko) | 2023-03-31 | 2025-09-03 | 아벨제타 인크. | Cd20 및 bcma를 표적화하는 이중특이적 키메라 항원 수용체 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3753357A (en) | 1970-12-14 | 1973-08-21 | Ovitron Res Corp | Method and apparatus for the preservation of cells and tissues |
| US4199022A (en) | 1978-12-08 | 1980-04-22 | The United States Of America As Represented By The Department Of Energy | Method of freezing living cells and tissues with improved subsequent survival |
| US4559298A (en) | 1982-11-23 | 1985-12-17 | American National Red Cross | Cryopreservation of biological materials in a non-frozen or vitreous state |
| US5004681B1 (en) | 1987-11-12 | 2000-04-11 | Biocyte Corp | Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood |
| US6291161B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertiore |
| US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
| US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| EP0557459B1 (en) | 1990-11-13 | 1997-10-22 | Immunex Corporation | Bifunctional selectable fusion genes |
| IL101728A (en) | 1991-05-03 | 2007-08-19 | Univ Yale | Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them |
| IE20030749A1 (en) | 1991-05-03 | 2003-11-12 | Indiana University Foundation | Human notch and delta binding domains in torporythmic proteins, and methods based thereon |
| US5856441A (en) | 1991-05-03 | 1999-01-05 | Yale University | Serrate fragments and derivatives |
| US5869282A (en) | 1991-12-11 | 1999-02-09 | Imperial Cancer Research Technology, Ltd. | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| WO1993012141A1 (en) | 1991-12-11 | 1993-06-24 | Yale University | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| WO1994028143A1 (en) | 1993-05-21 | 1994-12-08 | Targeted Genetics Corporation | Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene |
| ES2229236T3 (es) | 1994-01-11 | 2005-04-16 | Dyax Corporation | Inhibidores de la plasmina humana derivados de los dominios de kunitz. |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| US5877299A (en) | 1995-06-16 | 1999-03-02 | Stemcell Technologies Inc. | Methods for preparing enriched human hematopoietic cell preparations |
| EP0861261B9 (en) | 1995-06-28 | 2010-02-24 | Imperial Cancer Research Technology Limited | Nucleotide and protein sequences of vertebrate delta genes and methods based thereon |
| US5780300A (en) | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
| AUPP221098A0 (en) | 1998-03-06 | 1998-04-02 | Diatech Pty Ltd | V-like domain binding molecules |
| EP1990409A3 (en) * | 1999-07-20 | 2011-05-18 | MorphoSys AG | Bacteriophage |
| US7399633B2 (en) | 2000-10-27 | 2008-07-15 | Fred Hutchinson Cancer Research Center | Methods for immortalizing cells |
| DE10113776B4 (de) | 2001-03-21 | 2012-08-09 | "Iba Gmbh" | Isoliertes streptavidinbindendes, kompetitiv eluierbares Peptid, dieses umfassendes Fusionspeptid, dafür codierende Nukleinsäure, Expressionsvektor, Verfahren zur Herstellung eines rekombinanten Fusionsproteins und Verfahren zum Nachweis und/oder zur Gewinnung des Fusionsproteins |
| ES2559763T3 (es) * | 2002-09-10 | 2016-02-15 | Affimed Gmbh | Anticuerpo humano específico de CD3 con propiedades inmunosupresoras |
| JP5563194B2 (ja) | 2004-06-29 | 2014-07-30 | イムノコア リミテッド | 改変ｔ細胞レセプターを発現する細胞 |
| US7147626B2 (en) | 2004-09-23 | 2006-12-12 | Celgene Corporation | Cord blood and placenta collection kit |
| CN105168250B (zh) | 2004-10-25 | 2019-02-05 | 塞勒兰特治疗公司 | 增殖骨髓细胞群体的方法及其应用 |
| AU2006204459B2 (en) | 2005-01-05 | 2012-11-01 | F-Star Therapeutics Limited | Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions |
| GB0504767D0 (en) | 2005-03-08 | 2005-04-13 | Ares Trading Sa | Lipocalin protein |
| US20090220501A1 (en) * | 2006-01-30 | 2009-09-03 | Fey Georg H | Anti-CD19 Antibody, Immunotoxin and Treatment Method |
| CN101421393B (zh) | 2006-02-14 | 2013-08-14 | 塞勒兰特治疗公司 | 提高造血干细胞植入的方法和组合物 |
| EP1829895A1 (en) | 2006-03-03 | 2007-09-05 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies |
| RU2009100930A (ru) | 2006-06-14 | 2010-07-20 | Чугаи Сейяку Кабусики Кайся (Jp) | Лекарственные средства для стимуляции роста гемопоэтических стволовых клеток |
| US8119772B2 (en) | 2006-09-29 | 2012-02-21 | California Institute Of Technology | MART-1 T cell receptors |
| JP2010539915A (ja) | 2007-09-24 | 2010-12-24 | ユニバーシティ・オブ・チューリッヒ | 設計されたアルマジロリピートタンパク質 |
| PE20100362A1 (es) | 2008-10-30 | 2010-05-27 | Irm Llc | Derivados de purina que expanden las celulas madre hematopoyeticas |
| BRPI0921966B1 (pt) * | 2008-11-21 | 2019-05-07 | Lallemand Hungary Liquidity Management Llc. | Célula hospedeira de levedura termotolerante, método de fermentar celulose e cultura |
| WO2010095031A2 (en) * | 2009-02-23 | 2010-08-26 | Glenmark Pharmaceuticals S.A. | Humanized antibodies that bind to cd19 and their uses |
| EP2555781A1 (en) | 2010-04-09 | 2013-02-13 | Fred Hutchinson Cancer Research Center | Compositions and methods for providing hematopoietic function |
| US20130095079A1 (en) | 2010-04-09 | 2013-04-18 | Fred Hutchinson Cancer Research Center | Compositions and methods for providing hematopoietic function without hla matching |
| WO2012136231A1 (en) * | 2010-09-08 | 2012-10-11 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Interleukin 15 as selectable marker for gene transfer in lymphocytes |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| US9834755B2 (en) | 2011-12-08 | 2017-12-05 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
| EP2970985A1 (en) * | 2013-03-14 | 2016-01-20 | Fred Hutchinson Cancer Research Center | Compositions and methods to modify cells for therapeutic objectives |
| AU2014342020C1 (en) * | 2013-10-31 | 2019-09-05 | Fred Hutchinson Cancer Research Center | Modified hematopoietic stem/progenitor and non-T effector cells, and uses thereof |
| HRP20201906T1 (hr) * | 2013-12-20 | 2021-04-02 | Fred Hutchinson Cancer Research Center | Označene kimerne efektorske molekule i njihovi receptori |
-
2016
- 2016-04-29 JP JP2017556597A patent/JP6985934B2/ja active Active
- 2016-04-29 WO PCT/US2016/030281 patent/WO2016176651A2/en not_active Ceased
- 2016-04-29 EP EP21199232.6A patent/EP3995142A3/en not_active Withdrawn
- 2016-04-29 EP EP16787279.5A patent/EP3288569A4/en not_active Withdrawn
- 2016-04-29 US US15/570,191 patent/US20180355318A1/en not_active Abandoned
-
2021
- 2021-07-01 JP JP2021109884A patent/JP2021168667A/ja active Pending
- 2021-11-11 US US17/524,592 patent/US20220204935A1/en not_active Abandoned
-
2022
- 2022-12-14 JP JP2022199333A patent/JP2023036712A/ja active Pending
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