JP2017500009A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017500009A5 JP2017500009A5 JP2016527261A JP2016527261A JP2017500009A5 JP 2017500009 A5 JP2017500009 A5 JP 2017500009A5 JP 2016527261 A JP2016527261 A JP 2016527261A JP 2016527261 A JP2016527261 A JP 2016527261A JP 2017500009 A5 JP2017500009 A5 JP 2017500009A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- domain
- sequence
- kit
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361898387P | 2013-10-31 | 2013-10-31 | |
| US61/898,387 | 2013-10-31 | ||
| PCT/US2014/063576 WO2015066551A2 (en) | 2013-10-31 | 2014-10-31 | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020062173A Division JP7046112B2 (ja) | 2013-10-31 | 2020-03-31 | 改変された造血幹／前駆細胞及び非エフェクターｔ細胞、そしてそれらの用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017500009A JP2017500009A (ja) | 2017-01-05 |
| JP2017500009A5 true JP2017500009A5 (enExample) | 2017-12-14 |
| JP6685900B2 JP6685900B2 (ja) | 2020-04-22 |
Family
ID=53005396
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016527261A Active JP6685900B2 (ja) | 2013-10-31 | 2014-10-31 | 改変された造血幹／前駆細胞及び非エフェクターｔ細胞、そしてそれらの用途 |
| JP2020062173A Active JP7046112B2 (ja) | 2013-10-31 | 2020-03-31 | 改変された造血幹／前駆細胞及び非エフェクターｔ細胞、そしてそれらの用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020062173A Active JP7046112B2 (ja) | 2013-10-31 | 2020-03-31 | 改変された造血幹／前駆細胞及び非エフェクターｔ細胞、そしてそれらの用途 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20160250258A1 (enExample) |
| EP (2) | EP3063175A4 (enExample) |
| JP (2) | JP6685900B2 (enExample) |
| KR (1) | KR20160079854A (enExample) |
| CN (1) | CN105873952A (enExample) |
| AU (2) | AU2014342020C1 (enExample) |
| BR (1) | BR112016009898A2 (enExample) |
| CA (1) | CA2929087A1 (enExample) |
| IL (2) | IL245360B (enExample) |
| MX (1) | MX389160B (enExample) |
| NZ (2) | NZ719840A (enExample) |
| RU (1) | RU2733652C2 (enExample) |
| SG (2) | SG11201603228TA (enExample) |
| WO (1) | WO2015066551A2 (enExample) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2934532B1 (en) | 2012-12-20 | 2019-10-23 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| SG11201505858VA (en) | 2013-01-28 | 2015-09-29 | St Jude Childrens Res Hospital | A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease |
| NZ759969A (en) | 2013-12-20 | 2022-12-23 | Fred Hutchinson Cancer Center | Tagged chimeric effector molecules and receptors thereof |
| SG10201808811QA (en) | 2014-04-10 | 2018-11-29 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Method and compositions for cellular immunotherapy |
| US20170158749A1 (en) * | 2014-04-23 | 2017-06-08 | Board Of Regents, The University Of Texas System | Chimeric antigen receptors (car) and methods for making and using the same |
| EP3805371A1 (en) | 2014-05-15 | 2021-04-14 | National University of Singapore | Modified natural killer cells and uses thereof |
| TWI751102B (zh) | 2014-08-28 | 2022-01-01 | 美商奇諾治療有限公司 | 對ｃｄ１９具專一性之抗體及嵌合抗原受體 |
| JP6740234B2 (ja) | 2014-11-05 | 2020-08-12 | ジュノー セラピューティクス インコーポレイテッド | 形質導入および細胞プロセシングのための方法 |
| US20160208018A1 (en) | 2015-01-16 | 2016-07-21 | Juno Therapeutics, Inc. | Antibodies and chimeric antigen receptors specific for ror1 |
| US20170151281A1 (en) | 2015-02-19 | 2017-06-01 | Batu Biologics, Inc. | Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer |
| EP3262166A4 (en) | 2015-02-24 | 2018-08-15 | The Regents of The University of California | Binding-triggered transcriptional switches and methods of use thereof |
| EP3288570A4 (en) | 2015-04-29 | 2018-11-21 | Fred Hutchinson Cancer Research Center | Modified stem cells and uses thereof |
| EP3288569A4 (en) * | 2015-04-29 | 2018-12-19 | Fred Hutchinson Cancer Research Center | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
| MX2017015239A (es) * | 2015-05-29 | 2018-02-19 | Juno Therapeutics Inc | Composicion y metodos para regular interacciones inhibitorias en celulas geneticamente modificadas. |
| TWI833684B (zh) | 2015-06-25 | 2024-03-01 | 美商生物細胞基因治療有限公司 | 嵌合抗原受體（ｃａｒ）、組合物及其使用方法 |
| US11173179B2 (en) | 2015-06-25 | 2021-11-16 | Icell Gene Therapeutics Llc | Chimeric antigen receptor (CAR) targeting multiple antigens, compositions and methods of use thereof |
| GB201513540D0 (en) | 2015-07-31 | 2015-09-16 | King S College London | Therapeutic agents |
| MX2018001568A (es) * | 2015-08-07 | 2019-04-25 | Seattle Children´S Hospital Dba Seattle Children´S Res Institute | Celulas t biespecificas de receptor quimerico de antigeno (car) para focalizacion a tumores solidos. |
| EP3747462A1 (en) * | 2015-10-06 | 2020-12-09 | City of Hope | Chimeric antigen receptors targeted to psca |
| ES2778651T3 (es) * | 2015-10-09 | 2020-08-11 | Miltenyi Biotec Technology Inc | Receptores de antígeno quimérico y métodos de uso |
| JP6976960B2 (ja) * | 2015-11-27 | 2021-12-08 | カーサリクス プロプライエタリー リミテッド | 遺伝子改変された細胞およびその使用 |
| US20200297760A1 (en) * | 2015-12-03 | 2020-09-24 | Juno Therapeutics, Inc. | Compositions and methods for reducing immune responses against chimeric antigen receptors |
| CA3019835A1 (en) | 2016-04-08 | 2017-10-12 | Purdue Research Foundation | Methods and compositions for car t cell therapy |
| EP4166161B1 (en) | 2016-04-14 | 2026-03-04 | Fred Hutchinson Cancer Center | Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers |
| WO2017193059A1 (en) | 2016-05-06 | 2017-11-09 | The Regents Of The University Of California | Systems and methods for targeting cancer cells |
| CN109562126A (zh) * | 2016-06-24 | 2019-04-02 | 美商生物细胞基因治疗有限公司 | 嵌合抗原受体(car)、组合物及其使用方法 |
| CN106222145A (zh) * | 2016-08-22 | 2016-12-14 | 侯昌禾 | 一种用于治疗肿瘤的基因重组造血干细胞及其制备方法 |
| CA3034093A1 (en) | 2016-08-23 | 2018-03-01 | The Regents Of The University Of California | Proteolytically cleavable chimeric polypeptides and methods of use thereof |
| KR20190062505A (ko) | 2016-10-03 | 2019-06-05 | 주노 쎄러퓨티크스 인코퍼레이티드 | Hpv-특이적 결합 분자 |
| EP3564356A4 (en) * | 2016-11-04 | 2020-05-06 | The University Of Tokyo | SOLUTION FOR THE CRYCON PRESERVATION OF ANIMAL CELLS OR ANIMAL TISSUE, CRYCON PRESERVED PRODUCT AND METHOD FOR THE CRYCON PRESERVATION |
| CN106755107B (zh) * | 2016-11-22 | 2019-10-01 | 上海健信生物医药科技有限公司 | 一种car新分子及其在肿瘤治疗中的应用 |
| US11286306B2 (en) | 2016-12-09 | 2022-03-29 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | TLR9-binding chimeric antigen receptors |
| CN106755397A (zh) * | 2016-12-20 | 2017-05-31 | 江苏省肿瘤医院 | 基因多态性位点的用途和试剂盒 |
| WO2018118494A2 (en) * | 2016-12-22 | 2018-06-28 | Xiaotong Song | Use of car-modified human natural killer cells to treat cancer |
| WO2018129270A1 (en) * | 2017-01-05 | 2018-07-12 | Fred Hutchinson Cancer Research Center | Systems and methods to improve vaccine efficacy |
| CN110582288B (zh) | 2017-02-28 | 2024-09-20 | 恩多塞特公司 | 用于car t细胞疗法的组合物和方法 |
| US12129487B2 (en) * | 2017-03-27 | 2024-10-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method to obtain lymphoid progenitors |
| MX2019011570A (es) | 2017-03-27 | 2019-11-18 | Nat Univ Singapore | Lineas celulares estimuladoras para expansion y activacion ex vivo de celulas asesinas naturales. |
| CN117363636A (zh) | 2017-03-27 | 2024-01-09 | 新加坡国立大学 | 一种编码嵌合受体的多核苷酸 |
| US11149073B2 (en) | 2017-04-28 | 2021-10-19 | Julius-Maximilians-Universität Würzburg | ROR1-specific chimeric antigen receptors (CAR) with humanized targeting domains |
| CN118853581A (zh) | 2017-06-21 | 2024-10-29 | 美商生物细胞基因治疗有限公司 | 嵌合抗原受体(CARs)、组合物及其使用方法 |
| CN107541499B (zh) * | 2017-07-27 | 2020-04-14 | 山东兴瑞生物科技有限公司 | 一种靶向免疫检测点tnfr2的cik的制备及其应用 |
| US11952408B2 (en) | 2017-10-03 | 2024-04-09 | Juno Therapeutics, Inc. | HPV-specific binding molecules |
| US10561686B2 (en) | 2018-01-12 | 2020-02-18 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expansion and uses thereof |
| WO2019143948A1 (en) | 2018-01-18 | 2019-07-25 | Fred Hutchinson Cancer Research Center | Altering inflammatory states of immune cells in vivo by modulating cellular activation states |
| WO2019144095A1 (en) | 2018-01-22 | 2019-07-25 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Methods of use for car t cells |
| ES3012854T3 (en) | 2018-02-08 | 2025-04-10 | Univ Leland Stanford Junior | Allogenic hematopoietic stem cell transplantation |
| JP7360174B2 (ja) | 2018-02-09 | 2023-10-12 | ナショナル ユニヴァーシティー オブ シンガポール | ナチュラルキラー細胞免疫療法における活性化キメラ受容体及びその使用 |
| JP7568224B2 (ja) | 2018-02-23 | 2024-10-16 | エンドサイト・インコーポレイテッド | Ｃａｒ ｔ細胞療法のための配列決定法 |
| US12441787B2 (en) | 2018-04-02 | 2025-10-14 | National University Of Singapore | Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells |
| CN112566698A (zh) | 2018-04-05 | 2021-03-26 | 朱诺治疗学股份有限公司 | T细胞受体和表达该t细胞受体的工程化细胞 |
| US10869888B2 (en) | 2018-04-17 | 2020-12-22 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expansion and uses thereof |
| US12304962B2 (en) | 2018-05-30 | 2025-05-20 | Glycostem Therapeutics B.V. | CAR NK cells |
| WO2020044239A1 (en) | 2018-08-29 | 2020-03-05 | National University Of Singapore | A method to specifically stimulate survival and expansion of genetically-modified immune cells |
| US12240915B2 (en) | 2018-08-30 | 2025-03-04 | Innovative Cellular Therapeutics Holdings, Ltd. | Chimeric antigen receptor cells for treating solid tumor |
| EP3844191A4 (en) * | 2018-08-31 | 2022-06-15 | Seattle Children's Hospital (DBA Seattle Children's Research Institute) | METHODS AND COMPOSITIONS USING CHIMERIC B7H3 ANTIGEN RECEPTORS |
| PL3620510T5 (pl) | 2018-09-06 | 2026-07-20 | Chr. Hansen HMO GmbH | Fermentacyjne wytwarzanie oligosacharydów przez całkowitą fermentację z wykorzystaniem mieszanego surowca |
| EP3876977A1 (en) | 2018-11-06 | 2021-09-15 | The Regents Of The University Of California | Chimeric antigen receptors for phagocytosis |
| US10918667B2 (en) | 2018-11-20 | 2021-02-16 | Innovative Cellular Therapeutics CO., LTD. | Modified cell expressing therapeutic agent and uses thereof |
| CN113226340A (zh) | 2018-11-26 | 2021-08-06 | 恩卡尔塔公司 | 同时扩增多种免疫细胞类型的方法、相关组合物及其在癌症免疫疗法中的用途 |
| KR20210137085A (ko) | 2019-03-05 | 2021-11-17 | 엔카르타, 인크. | Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도 |
| JP7352307B2 (ja) * | 2019-03-15 | 2023-09-28 | 阿思科力（蘇州）生物科技有限公司 | 自殺遺伝子を持つｒｏｂｏ１ ｃａｒ－ｎｋ細胞、その製造方法及び使用 |
| EP3941490A4 (en) * | 2019-03-20 | 2023-01-04 | 2seventy bio, Inc. | ADOPTIVE CELLULAR THERAPY |
| US11026973B2 (en) | 2019-04-30 | 2021-06-08 | Myeloid Therapeutics, Inc. | Engineered phagocytic receptor compositions and methods of use thereof |
| WO2020227446A1 (en) * | 2019-05-07 | 2020-11-12 | The Board Of Trustees Of The Leland Stanford Junior University | Enhancement of polypeptides and chimeric antigen receptors via hinge domains |
| JP2022533191A (ja) * | 2019-05-17 | 2022-07-21 | デヴェラ セラピューティクス インコーポレイテッド | 拡大した幹細胞生成物を使用して、血液悪性腫瘍を有する患者の処置転帰を改善するための組成物および方法 |
| AU2020295715A1 (en) * | 2019-06-19 | 2022-02-17 | Julius-Maximilians-Universität Würzburg | Ultramodular IgG3-based spacer domain and multi-function site for implementation in chimeric antigen receptor design |
| US12702708B2 (en) | 2019-08-21 | 2026-08-11 | Innovative Cellular Therapeutics Holdings, Ltd. | Presenting cell and use thereof in cell therapy |
| WO2021046243A2 (en) | 2019-09-03 | 2021-03-11 | Myeloid Therapeutics, Inc. | Methods and compositions for genomic integration |
| US10980836B1 (en) | 2019-12-11 | 2021-04-20 | Myeloid Therapeutics, Inc. | Therapeutic cell compositions and methods of manufacturing and use thereof |
| US12076343B2 (en) | 2020-02-19 | 2024-09-03 | Innovative Cellular Therapeutics Holdings, Ltd. | Engineered safety in cell therapy |
| US12043654B2 (en) | 2020-06-02 | 2024-07-23 | Innovative Cellular Therapeutics Holdings, Ltd. | Anti-GCC antibody and CAR thereof for treating digestive system cancer |
| CN112094817B (zh) * | 2020-09-23 | 2021-06-04 | 绿城农科检测技术有限公司 | 分泌丙硫氧嘧啶单克隆抗体的杂交瘤细胞株、单克隆抗体及应用 |
| EP4240367A4 (en) | 2020-11-04 | 2024-10-16 | Myeloid Therapeutics, Inc. | MODIFIED CHIMERIC FUSION PROTEIN COMPOSITIONS AND METHODS OF USE THEREOF |
| TW202241935A (zh) | 2020-12-18 | 2022-11-01 | 美商世紀治療股份有限公司 | 具有可調適受體專一性之嵌合抗原受體系統 |
| KR20240013094A (ko) | 2021-03-17 | 2024-01-30 | 마이얼로이드 테라퓨틱스, 인크. | 조작된 키메라 융합 단백질 조성물 및 그의 사용 방법 |
| WO2022241029A1 (en) | 2021-05-11 | 2022-11-17 | Myeloid Therapeutics, Inc. | Methods and compositions for genomic integration |
| JP2024540099A (ja) * | 2021-10-28 | 2024-10-31 | ライエル・イミュノファーマ・インコーポレイテッド | Ｒｏｒ１結合タンパク質を発現する細胞を培養する方法 |
| EP4476267A4 (en) * | 2022-02-11 | 2026-01-07 | Fred Hutchinson Cancer Center | CHIMERIC ANTIGENIC RECEPTORS BINDING TO STEAP1 |
| CN115433774A (zh) * | 2022-08-18 | 2022-12-06 | 浙江丰能医药科技有限公司 | 一种用于原发免疫性血小板减少症检测的生物标志物及其试剂盒 |
| WO2025059062A1 (en) * | 2023-09-11 | 2025-03-20 | The Trustees Of The University Of Pennsylvania | Genetic engineering of human hematopoietic stem/progenitor cells (hspcs) for locus-specific expression of therapeutic proteins |
| EP4780945A1 (en) * | 2023-09-20 | 2026-07-29 | Kure.AI, Inc. | Methods and reagents to improve cell therapy with the creation of novel car-targeting mr1 protein |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3753357A (en) | 1970-12-14 | 1973-08-21 | Ovitron Res Corp | Method and apparatus for the preservation of cells and tissues |
| US4199022A (en) | 1978-12-08 | 1980-04-22 | The United States Of America As Represented By The Department Of Energy | Method of freezing living cells and tissues with improved subsequent survival |
| US4559298A (en) | 1982-11-23 | 1985-12-17 | American National Red Cross | Cryopreservation of biological materials in a non-frozen or vitreous state |
| US5004681B1 (en) | 1987-11-12 | 2000-04-11 | Biocyte Corp | Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood |
| US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
| US6291161B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertiore |
| ATE159548T1 (de) | 1990-11-13 | 1997-11-15 | Immunex Corp | Bifunktionelle wählbare fusionsgene |
| IL101728A (en) | 1991-05-03 | 2007-08-19 | Univ Yale | Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them |
| US5856441A (en) | 1991-05-03 | 1999-01-05 | Yale University | Serrate fragments and derivatives |
| IE20030749A1 (en) | 1991-05-03 | 2003-11-12 | Indiana University Foundation | Human notch and delta binding domains in torporythmic proteins, and methods based thereon |
| US5869282A (en) | 1991-12-11 | 1999-02-09 | Imperial Cancer Research Technology, Ltd. | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| WO1993012141A1 (en) | 1991-12-11 | 1993-06-24 | Yale University | Nucleotide and protein sequences of the serrate gene and methods based thereon |
| AU6953394A (en) | 1993-05-21 | 1994-12-20 | Targeted Genetics Corporation | Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene |
| EP0737207B1 (en) | 1994-01-11 | 2004-09-22 | Dyax Corporation | Inhibitors of human plasmin derived from the kunitz domains |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| US5877299A (en) | 1995-06-16 | 1999-03-02 | Stemcell Technologies Inc. | Methods for preparing enriched human hematopoietic cell preparations |
| DK0861261T3 (da) | 1995-06-28 | 2009-12-14 | Imp Cancer Res Tech | Nukleotid- og proteinsekvenser af hvirveldyrs-Delta-gener og fremgangsmåder baseret derpå |
| US5780300A (en) | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
| AUPP221098A0 (en) | 1998-03-06 | 1998-04-02 | Diatech Pty Ltd | V-like domain binding molecules |
| JP2002522063A (ja) * | 1998-08-17 | 2002-07-23 | アブジェニックス インコーポレイテッド | 増加した血清半減期を有する改変された分子の生成 |
| WO2002059285A1 (en) | 2000-10-27 | 2002-08-01 | Fred Hutchinson Cancer Research Center | Methods for immortalizing cells |
| US20130266551A1 (en) * | 2003-11-05 | 2013-10-10 | St. Jude Children's Research Hospital, Inc. | Chimeric receptors with 4-1bb stimulatory signaling domain |
| EP1791865B1 (en) | 2004-06-29 | 2010-07-28 | Immunocore Ltd. | Cells expressing a modified t cell receptor |
| US7147626B2 (en) | 2004-09-23 | 2006-12-12 | Celgene Corporation | Cord blood and placenta collection kit |
| US8252587B2 (en) | 2004-10-25 | 2012-08-28 | Celerant Therapeutics, Inc. | Methods of expanding myeloid cell populations and uses thereof |
| ATE423140T1 (de) | 2005-01-05 | 2009-03-15 | F Star Biotech Forsch & Entw | Synthetische immunoglobulindomänen mit in regionen des moleküls, die sich von den die komplementarität bestimmenden bereichen unterscheiden, modifizierten bindeeigenschaften |
| GB0504767D0 (en) | 2005-03-08 | 2005-04-13 | Ares Trading Sa | Lipocalin protein |
| WO2007095594A2 (en) | 2006-02-14 | 2007-08-23 | Cellerant Therapeutics, Inc. | Methods and compositions for enhancing engraftment of hematopoietic stem cells |
| EP1829895A1 (en) | 2006-03-03 | 2007-09-05 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies |
| KR20090021217A (ko) | 2006-06-14 | 2009-02-27 | 추가이 세이야쿠 가부시키가이샤 | 조혈 줄기세포 증가 촉진제 |
| US8003761B2 (en) * | 2007-01-23 | 2011-08-23 | Hoffmann-La Roche Inc. | Cancerous disease modifying antibodies |
| CA2700391A1 (en) | 2007-09-24 | 2009-04-02 | University Of Zuerich | Designed armadillo repeat proteins |
| WO2009091826A2 (en) * | 2008-01-14 | 2009-07-23 | The Board Of Regents Of The University Of Texas System | Compositions and methods related to a human cd19-specific chimeric antigen receptor (h-car) |
| US10059923B2 (en) * | 2008-01-30 | 2018-08-28 | Memorial Sloan Kettering Cancer Center | Methods for off-the-shelf tumor immunotherapy using allogeneic T-cell precursors |
| PE20100362A1 (es) | 2008-10-30 | 2010-05-27 | Irm Llc | Derivados de purina que expanden las celulas madre hematopoyeticas |
| CA2753158A1 (en) * | 2009-02-23 | 2010-08-26 | Glenmark Pharmaceuticals S.A. | Humanized antibodies that bind to cd19 and their uses |
| US9150647B2 (en) * | 2009-12-18 | 2015-10-06 | Kancera Ab | Biological inhibitors of ROR1 capable of inducing cell death |
| EP3097916B1 (en) | 2010-04-09 | 2021-07-07 | Fred Hutchinson Cancer Research Center | Compositions and methods for providing hematopoietic function |
| EP3590520B1 (en) * | 2010-04-09 | 2021-12-29 | Fred Hutchinson Cancer Research Center | Compositions for providing hematopoietic function without hla matching |
| EP2646469B1 (en) * | 2010-12-01 | 2017-11-01 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Chimeric rabbit/human ror1 antibodies |
| WO2013086436A1 (en) | 2011-12-08 | 2013-06-13 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
| EP2814846B1 (en) * | 2012-02-13 | 2020-01-08 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
-
2014
- 2014-10-31 US US15/033,518 patent/US20160250258A1/en not_active Abandoned
- 2014-10-31 CN CN201480071639.7A patent/CN105873952A/zh active Pending
- 2014-10-31 RU RU2016121174A patent/RU2733652C2/ru active
- 2014-10-31 WO PCT/US2014/063576 patent/WO2015066551A2/en not_active Ceased
- 2014-10-31 KR KR1020167014445A patent/KR20160079854A/ko not_active Ceased
- 2014-10-31 EP EP14859129.0A patent/EP3063175A4/en not_active Withdrawn
- 2014-10-31 NZ NZ719840A patent/NZ719840A/en not_active IP Right Cessation
- 2014-10-31 AU AU2014342020A patent/AU2014342020C1/en active Active
- 2014-10-31 JP JP2016527261A patent/JP6685900B2/ja active Active
- 2014-10-31 BR BR112016009898A patent/BR112016009898A2/pt not_active Application Discontinuation
- 2014-10-31 EP EP22166188.7A patent/EP4083062A1/en not_active Withdrawn
- 2014-10-31 NZ NZ758715A patent/NZ758715A/en not_active IP Right Cessation
- 2014-10-31 MX MX2016005689A patent/MX389160B/es unknown
- 2014-10-31 SG SG11201603228TA patent/SG11201603228TA/en unknown
- 2014-10-31 SG SG10201803533YA patent/SG10201803533YA/en unknown
- 2014-10-31 CA CA2929087A patent/CA2929087A1/en active Pending
-
2016
- 2016-05-01 IL IL245360A patent/IL245360B/en active IP Right Grant
-
2019
- 2019-06-18 US US16/445,053 patent/US20190381104A1/en not_active Abandoned
- 2019-06-24 AU AU2019204429A patent/AU2019204429B2/en active Active
-
2020
- 2020-01-28 IL IL272325A patent/IL272325B/en unknown
- 2020-03-31 JP JP2020062173A patent/JP7046112B2/ja active Active
-
2022
- 2022-11-28 US US18/059,369 patent/US20240041933A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2016121174A (ru) | МОДИФИЦИРОВАННЫЕ ГЕМОПОЭТИЧЕСКИЕ СТВОЛОВЫЕ КЛЕТКИ/КЛЕТКИ-ПРЕДШЕСТВЕННИКИ И Не-Т ЭФФЕКТОРНЫЕ КЛЕТКИ, И ИХ ПРИМЕНЕНИЕ | |
| JP2018521628A5 (enExample) | ||
| JP2020114264A5 (enExample) | ||
| JP2015527070A5 (enExample) | ||
| US12161668B2 (en) | T cells expressing a chimeric antigen receptor | |
| TW202039563A (zh) | 嵌合抗原及t細胞受體以及使用方法 | |
| IL284744B1 (en) | Chimeric antigen receptors gprc5d and cells expressing them | |
| JP2016520074A5 (enExample) | ||
| RU2019126655A (ru) | Нуклеиновые кислоты, кодирующие химерные рецепторы, полипептидные химерные рецепторы, кодируемые ими, векторы экспрессии, содержащие их, выделенные клетки-хозяева, содержащие их, композиции, содержащие выделенные клетки-хозяева, а также способы получения выделенных клеток-хозяев in vitro, способы выбора нуклеиновых кислот, кодирующих химерные рецепторы, in vitro и способы проведения клеточной иммунотерапии у субъекта, имеющего опухоль | |
| JP2018518939A5 (enExample) | ||
| AU2025203414A1 (en) | T cells expressing a chimeric antigen receptor | |
| KR20210089179A (ko) | Cll1을 표적으로 하는 항체 및 이의 응용 | |
| WO2018191748A1 (en) | Chimeric antigen receptor t cells targeting the tumor microenvironment | |
| JP2019503200A (ja) | 癌の治療のための組成物及び方法 | |
| JP2019513009A (ja) | 免疫療法用改変細胞 | |
| JP2019532017A5 (enExample) | ||
| JP7319250B2 (ja) | Ｓｔｒｅｐ－タグ特異的結合タンパク質およびその使用 | |
| RU2018111462A (ru) | Химерные антигенные рецепторы, нацеленные на антиген созревания b-клеток | |
| HRP20211978T1 (hr) | Kimerični antigenski receptori koji ciljaju receptor spojen na g-protein i njihove uporabe | |
| JP2021503006A5 (enExample) | ||
| JP2018532407A5 (enExample) | ||
| TW201023863A (en) | Antitumor combinations containing antibodies recognizing specifically CD38 and cytarabine | |
| JP2018508219A5 (enExample) | ||
| JP2017531687A5 (enExample) | ||
| JP2020535796A5 (enExample) |