JP2017500009A5 - - Google Patents
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- JP2017500009A5 JP2017500009A5 JP2016527261A JP2016527261A JP2017500009A5 JP 2017500009 A5 JP2017500009 A5 JP 2017500009A5 JP 2016527261 A JP2016527261 A JP 2016527261A JP 2016527261 A JP2016527261 A JP 2016527261A JP 2017500009 A5 JP2017500009 A5 JP 2017500009A5
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- 238000009472 formulation Methods 0.000 claims 26
- 239000000203 mixture Substances 0.000 claims 26
- 210000004027 cell Anatomy 0.000 claims 23
- 108020001756 ligand binding domains Proteins 0.000 claims 17
- 239000012636 effector Substances 0.000 claims 15
- 230000003834 intracellular effect Effects 0.000 claims 15
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 14
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 14
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 14
- 125000006850 spacer group Chemical group 0.000 claims 14
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 12
- 230000011664 signaling Effects 0.000 claims 11
- 210000000130 stem cell Anatomy 0.000 claims 11
- 230000004068 intracellular signaling Effects 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 7
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 6
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 6
- 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 claims 5
- 210000004698 lymphocyte Anatomy 0.000 claims 5
- 102100027207 CD27 antigen Human genes 0.000 claims 4
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 4
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 4
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 4
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 4
- 239000002771 cell marker Substances 0.000 claims 4
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 3
- 101150029707 ERBB2 gene Proteins 0.000 claims 3
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 3
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 3
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 3
- 101001103039 Homo sapiens Inactive tyrosine-protein kinase transmembrane receptor ROR1 Proteins 0.000 claims 3
- 101000998120 Homo sapiens Interleukin-3 receptor subunit alpha Proteins 0.000 claims 3
- 101001136592 Homo sapiens Prostate stem cell antigen Proteins 0.000 claims 3
- 102100039615 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Human genes 0.000 claims 3
- 102000003735 Mesothelin Human genes 0.000 claims 3
- 108090000015 Mesothelin Proteins 0.000 claims 3
- 102100036735 Prostate stem cell antigen Human genes 0.000 claims 3
- 102000040856 WT1 Human genes 0.000 claims 3
- 108700020467 WT1 Proteins 0.000 claims 3
- 101150084041 WT1 gene Proteins 0.000 claims 3
- 230000003394 haemopoietic effect Effects 0.000 claims 3
- 210000000987 immune system Anatomy 0.000 claims 3
- 210000003643 myeloid progenitor cell Anatomy 0.000 claims 3
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 101710145634 Antigen 1 Proteins 0.000 claims 2
- 102100027205 B-cell antigen receptor complex-associated protein alpha chain Human genes 0.000 claims 2
- 102100027203 B-cell antigen receptor complex-associated protein beta chain Human genes 0.000 claims 2
- -1 CD3ζ Proteins 0.000 claims 2
- 101150013553 CD40 gene Proteins 0.000 claims 2
- 101001039256 Caenorhabditis elegans Low-density lipoprotein receptor-related protein Proteins 0.000 claims 2
- 101100364669 Caenorhabditis elegans lin-18 gene Proteins 0.000 claims 2
- 102100024965 Caspase recruitment domain-containing protein 11 Human genes 0.000 claims 2
- 102100029360 Hematopoietic cell signal transducer Human genes 0.000 claims 2
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 2
- 101000694288 Homo sapiens 40S ribosomal protein SA Proteins 0.000 claims 2
- 101000914489 Homo sapiens B-cell antigen receptor complex-associated protein alpha chain Proteins 0.000 claims 2
- 101000914491 Homo sapiens B-cell antigen receptor complex-associated protein beta chain Proteins 0.000 claims 2
- 101100166600 Homo sapiens CD28 gene Proteins 0.000 claims 2
- 101100005713 Homo sapiens CD4 gene Proteins 0.000 claims 2
- 101000761179 Homo sapiens Caspase recruitment domain-containing protein 11 Proteins 0.000 claims 2
- 101000990188 Homo sapiens Hematopoietic cell signal transducer Proteins 0.000 claims 2
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 2
- 101001047640 Homo sapiens Linker for activation of T-cells family member 1 Proteins 0.000 claims 2
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 2
- 101001030069 Homo sapiens Major vault protein Proteins 0.000 claims 2
- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 claims 2
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims 2
- 101001043564 Homo sapiens Prolow-density lipoprotein receptor-related protein 1 Proteins 0.000 claims 2
- 101000702132 Homo sapiens Protein spinster homolog 1 Proteins 0.000 claims 2
- 101000738769 Homo sapiens Receptor-type tyrosine-protein phosphatase alpha Proteins 0.000 claims 2
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims 2
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 2
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 2
- 101001103033 Homo sapiens Tyrosine-protein kinase transmembrane receptor ROR2 Proteins 0.000 claims 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 2
- 102000017578 LAG3 Human genes 0.000 claims 2
- 101150028321 Lck gene Proteins 0.000 claims 2
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 2
- 101100364671 Mus musculus Ryk gene Proteins 0.000 claims 2
- 101100268066 Mus musculus Zap70 gene Proteins 0.000 claims 2
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 claims 2
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims 2
- 108010029755 Notch1 Receptor Proteins 0.000 claims 2
- 108010071083 Patched-2 Receptor Proteins 0.000 claims 2
- 102000007497 Patched-2 Receptor Human genes 0.000 claims 2
- 108010074687 Signaling Lymphocytic Activation Molecule Family Member 1 Proteins 0.000 claims 2
- 102100029215 Signaling lymphocytic activation molecule Human genes 0.000 claims 2
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims 2
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 2
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 2
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 2
- 102100039616 Tyrosine-protein kinase transmembrane receptor ROR2 Human genes 0.000 claims 2
- 101001038499 Yarrowia lipolytica (strain CLIB 122 / E 150) Lysine acetyltransferase Proteins 0.000 claims 2
- 210000001185 bone marrow Anatomy 0.000 claims 2
- 230000000139 costimulatory effect Effects 0.000 claims 2
- 230000001086 cytosolic effect Effects 0.000 claims 2
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 2
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical group FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 230000000638 stimulation Effects 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 206010065553 Bone marrow failure Diseases 0.000 claims 1
- 206010061598 Immunodeficiency Diseases 0.000 claims 1
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010033661 Pancytopenia Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 208000018805 childhood acute lymphoblastic leukemia Diseases 0.000 claims 1
- 201000011633 childhood acute lymphocytic leukemia Diseases 0.000 claims 1
- 230000007547 defect Effects 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 230000007813 immunodeficiency Effects 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 201000002364 leukopenia Diseases 0.000 claims 1
- 208000004235 neutropenia Diseases 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361898387P | 2013-10-31 | 2013-10-31 | |
| US61/898,387 | 2013-10-31 | ||
| PCT/US2014/063576 WO2015066551A2 (en) | 2013-10-31 | 2014-10-31 | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020062173A Division JP7046112B2 (ja) | 2013-10-31 | 2020-03-31 | 改変された造血幹／前駆細胞及び非エフェクターｔ細胞、そしてそれらの用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017500009A JP2017500009A (ja) | 2017-01-05 |
| JP2017500009A5 true JP2017500009A5 (enExample) | 2017-12-14 |
| JP6685900B2 JP6685900B2 (ja) | 2020-04-22 |
Family
ID=53005396
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016527261A Active JP6685900B2 (ja) | 2013-10-31 | 2014-10-31 | 改変された造血幹／前駆細胞及び非エフェクターｔ細胞、そしてそれらの用途 |
| JP2020062173A Active JP7046112B2 (ja) | 2013-10-31 | 2020-03-31 | 改変された造血幹／前駆細胞及び非エフェクターｔ細胞、そしてそれらの用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020062173A Active JP7046112B2 (ja) | 2013-10-31 | 2020-03-31 | 改変された造血幹／前駆細胞及び非エフェクターｔ細胞、そしてそれらの用途 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20160250258A1 (enExample) |
| EP (2) | EP3063175A4 (enExample) |
| JP (2) | JP6685900B2 (enExample) |
| KR (1) | KR20160079854A (enExample) |
| CN (1) | CN105873952A (enExample) |
| AU (2) | AU2014342020C1 (enExample) |
| BR (1) | BR112016009898A2 (enExample) |
| CA (1) | CA2929087A1 (enExample) |
| IL (2) | IL245360B (enExample) |
| MX (1) | MX389160B (enExample) |
| NZ (2) | NZ719840A (enExample) |
| RU (1) | RU2733652C2 (enExample) |
| SG (2) | SG11201603228TA (enExample) |
| WO (1) | WO2015066551A2 (enExample) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150320799A1 (en) | 2012-12-20 | 2015-11-12 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| SG11201505858VA (en) | 2013-01-28 | 2015-09-29 | St Jude Childrens Res Hospital | A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease |
| HRP20201906T1 (hr) | 2013-12-20 | 2021-04-02 | Fred Hutchinson Cancer Research Center | Označene kimerne efektorske molekule i njihovi receptori |
| SG11201608393TA (en) | 2014-04-10 | 2016-11-29 | Seattle Children S Hospital Dba Seattle Children S Res Inst | Transgene genetic tags and methods of use |
| KR20160145802A (ko) * | 2014-04-23 | 2016-12-20 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 요법에 사용하기 위한 키메라 항원 수용체 (car) 및 이의 제조 방법 |
| EP3143134B1 (en) | 2014-05-15 | 2020-10-28 | National University of Singapore | Modified natural killer cells and uses thereof |
| TWI805109B (zh) | 2014-08-28 | 2023-06-11 | 美商奇諾治療有限公司 | 對cd19具專一性之抗體及嵌合抗原受體 |
| MA40318A (fr) | 2014-11-05 | 2017-09-13 | Juno Therapeutics Inc | Procédés de transduction et de traitement de cellules |
| NZ733841A (en) | 2015-01-16 | 2024-01-26 | Juno Therapeutics Inc | Antibodies and chimeric antigen receptors specific for ror1 |
| US20170151281A1 (en) | 2015-02-19 | 2017-06-01 | Batu Biologics, Inc. | Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer |
| KR102624023B1 (ko) | 2015-02-24 | 2024-01-11 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 결합-촉발된 전사 스위치 및 이들의 이용 방법 |
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| CN106222145A (zh) * | 2016-08-22 | 2016-12-14 | 侯昌禾 | 一种用于治疗肿瘤的基因重组造血干细胞及其制备方法 |
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| CN106755107B (zh) * | 2016-11-22 | 2019-10-01 | 上海健信生物医药科技有限公司 | 一种car新分子及其在肿瘤治疗中的应用 |
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| WO2018118494A2 (en) * | 2016-12-22 | 2018-06-28 | Xiaotong Song | Use of car-modified human natural killer cells to treat cancer |
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- 2014-10-31 SG SG11201603228TA patent/SG11201603228TA/en unknown
- 2014-10-31 US US15/033,518 patent/US20160250258A1/en not_active Abandoned
- 2014-10-31 EP EP14859129.0A patent/EP3063175A4/en not_active Withdrawn
- 2014-10-31 JP JP2016527261A patent/JP6685900B2/ja active Active
- 2014-10-31 CN CN201480071639.7A patent/CN105873952A/zh active Pending
- 2014-10-31 KR KR1020167014445A patent/KR20160079854A/ko not_active Ceased
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- 2014-10-31 BR BR112016009898A patent/BR112016009898A2/pt not_active Application Discontinuation
- 2014-10-31 RU RU2016121174A patent/RU2733652C2/ru active
- 2014-10-31 CA CA2929087A patent/CA2929087A1/en active Pending
- 2014-10-31 WO PCT/US2014/063576 patent/WO2015066551A2/en not_active Ceased
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