JP2017531687A5 - - Google Patents
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- JP2017531687A5 JP2017531687A5 JP2017522502A JP2017522502A JP2017531687A5 JP 2017531687 A5 JP2017531687 A5 JP 2017531687A5 JP 2017522502 A JP2017522502 A JP 2017522502A JP 2017522502 A JP2017522502 A JP 2017522502A JP 2017531687 A5 JP2017531687 A5 JP 2017531687A5
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- modified human
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- immune system
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462069168P | 2014-10-27 | 2014-10-27 | |
| US62/069,168 | 2014-10-27 | ||
| PCT/US2015/057652 WO2016069647A1 (en) | 2014-10-27 | 2015-10-27 | Compositions and methods for boosting the efficacy of adoptive cellular immunotherapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017531687A JP2017531687A (ja) | 2017-10-26 |
| JP2017531687A5 true JP2017531687A5 (enExample) | 2018-12-06 |
| JP7005346B2 JP7005346B2 (ja) | 2022-02-04 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017522502A Active JP7005346B2 (ja) | 2014-10-27 | 2015-10-27 | 養子細胞免疫療法の有効性を増強させるための組成物および方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10828352B2 (enExample) |
| EP (1) | EP3212223B1 (enExample) |
| JP (1) | JP7005346B2 (enExample) |
| KR (1) | KR102357004B1 (enExample) |
| CN (1) | CN107106611B (enExample) |
| AU (1) | AU2015339402B2 (enExample) |
| BR (2) | BR122021000068A8 (enExample) |
| CA (1) | CA2965347C (enExample) |
| ES (1) | ES2897731T3 (enExample) |
| HK (1) | HK1243631A1 (enExample) |
| MX (1) | MX389823B (enExample) |
| NZ (1) | NZ731279A (enExample) |
| RU (1) | RU2716716C2 (enExample) |
| WO (1) | WO2016069647A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013035099A1 (en) | 2011-09-08 | 2013-03-14 | Yeda Research And Development Co. Ltd. | Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment |
| JP6375289B2 (ja) | 2012-04-05 | 2018-08-15 | マサチューセッツ インスティテュート オブ テクノロジー | 免疫刺激組成物およびその使用方法 |
| US10611837B2 (en) | 2014-04-10 | 2020-04-07 | Seattle Children's Hospital | Transgene genetic tags and methods of use |
| ES2818103T3 (es) | 2015-01-16 | 2021-04-09 | Juno Therapeutics Inc | Anticuerpos y receptores de antígenos quiméricos específicos para ROR1 |
| EP3322424B1 (en) | 2015-07-16 | 2023-10-11 | Yeda Research and Development Co., Ltd. | Use of anti third party central memory t cells |
| US20180214487A1 (en) | 2015-07-21 | 2018-08-02 | The Children's Medical Center Corporation | Pd-l1 expressing hematopoietic stem cells and uses |
| AU2016306209B2 (en) | 2015-08-07 | 2023-07-06 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Bispecific CAR T-cells for solid tumor targeting |
| SG11201803098VA (en) | 2015-10-30 | 2018-05-30 | Nbe Therapeutics Ag | Anti-ror1 antibodies |
| UA125718C2 (uk) | 2016-01-20 | 2022-05-25 | Зе Скріппс Ресеарч Інстітьют | Композиції антитіл до ror1 і пов'язані з ними способи |
| EP4006056A1 (en) | 2016-02-02 | 2022-06-01 | Fred Hutchinson Cancer Research Center | Anti-ror1 antibodies and uses thereof |
| EP3452082A1 (en) | 2016-05-04 | 2019-03-13 | Fred Hutchinson Cancer Research Center | Cell-based neoantigen vaccines and uses thereof |
| JP7194022B2 (ja) * | 2016-05-20 | 2022-12-21 | イーライ リリー アンド カンパニー | Ｎｏｔｃｈ阻害剤とＰＤ－１またはＰＤ－Ｌ１阻害剤との併用療法 |
| CN106199005B (zh) * | 2016-07-26 | 2019-02-01 | 浙江大学 | 采用cd137表达量检测淋巴细胞抗大肠癌活性的方法 |
| BR112019011065A2 (pt) | 2016-12-03 | 2019-10-01 | Juno Therapeutics Inc | métodos para determinação da dosagem de células t car |
| KR20190098747A (ko) | 2016-12-05 | 2019-08-22 | 주노 쎄러퓨티크스 인코퍼레이티드 | 입양 세포 치료법을 위한 조작된 세포의 제조방법 |
| ES3064681T3 (en) * | 2017-01-18 | 2026-04-28 | Yeda Res And Development Co Ltd | Genetically modified veto cells and use of same in immunotherapy |
| CN107267555B (zh) * | 2017-05-27 | 2020-03-20 | 上海优卡迪生物医药科技有限公司 | 一种基于octs技术的恶性胶质瘤car-t治疗载体及其构建方法和应用 |
| KR20230008269A (ko) | 2017-08-07 | 2023-01-13 | 엔비이-테라퓨틱스 아게 | 생체 내 내성이 높은 항체 약물 결합체 |
| US12398191B2 (en) | 2017-08-11 | 2025-08-26 | Fred Hutchinson Cancer Center | BRAF-specific TCRs and uses thereof |
| KR20260026092A (ko) * | 2017-09-19 | 2026-02-25 | 메사추세츠 인스티튜트 오브 테크놀로지 | 키메라 항원 수용체 t 세포 요법을 위한 조성물 및 그의 용도 |
| US11879137B2 (en) | 2017-09-22 | 2024-01-23 | The Children's Medical Center Corporation | Treatment of type 1 diabetes and autoimmune diseases or disorders |
| MX2020007357A (es) * | 2017-09-26 | 2021-08-11 | Longwood Univ | Reporte de antígeno quimérico específico de pd1 como una inmunoterapia. |
| TWI687227B (zh) * | 2017-10-03 | 2020-03-11 | 生倍科技股份有限公司 | 用於t細胞免疫療法之組合及其用途 |
| JP7517983B2 (ja) * | 2017-11-20 | 2024-07-17 | ユリウス－マクシミリアン－ウニヴェルシテート・ヴュルツブルク | 非常に低レベルのｃｄ１９を発現する骨髄腫細胞を除去するｃｄ１９ｃａｒｔ細胞 |
| MA51210A (fr) | 2017-12-01 | 2020-10-07 | Juno Therapeutics Inc | Procédés de dosage et de modulation de cellules génétiquement modifiées |
| CN109810995B (zh) * | 2017-12-06 | 2020-10-02 | 阿思科力(苏州)生物科技有限公司 | 编码car的核苷酸序列、表达该car的robo1 car-nk细胞及其制备和应用 |
| CN108148137B (zh) * | 2017-12-29 | 2021-03-23 | 中国人民解放军第四军医大学 | 一种b7h4/1e10单克隆抗体及其应用 |
| CA3110089A1 (en) * | 2018-08-28 | 2020-03-05 | Fred Hutchinson Cancer Research Center | Methods and compositions for adoptive t cell therapy incorporating induced notch signaling |
| CN111544585B (zh) * | 2019-02-11 | 2024-12-27 | 北京卡替医疗技术有限公司 | 一种可助推免疫细胞在体内扩增的佐剂 |
| WO2020191305A2 (en) | 2019-03-20 | 2020-09-24 | Massachusetts Institute Of Technology | Uses of amphiphiles in immune cell therapy and compositions therefor |
| JP2022537154A (ja) * | 2019-06-14 | 2022-08-24 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | 細胞治療のための環状ｒｎａ |
| WO2021129927A1 (en) * | 2019-12-23 | 2021-07-01 | Biontech Cell & Gene Therapies Gmbh | Treatment with immune effector cells engineered to express an antigen receptor |
| CA3188143A1 (en) * | 2020-06-25 | 2021-12-30 | The Methodist Hospital | Antigen-specific t cell receptors and chimeric antigen receptors, and methods of use in immune signaling modulation for cancer immunotherapy |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| GB9518220D0 (en) | 1995-09-06 | 1995-11-08 | Medical Res Council | Checkpoint gene |
| US5853719A (en) * | 1996-04-30 | 1998-12-29 | Duke University | Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA |
| GB0224442D0 (en) | 2002-10-21 | 2002-11-27 | Molmed Spa | A delivery system |
| US20050129671A1 (en) * | 2003-03-11 | 2005-06-16 | City Of Hope | Mammalian antigen-presenting T cells and bi-specific T cells |
| JP2008527001A (ja) | 2005-01-13 | 2008-07-24 | ザ ジョンズ ホプキンス ユニバーシティー | 前立腺幹細胞抗原ワクチンおよびその使用 |
| US20090324630A1 (en) * | 2008-04-21 | 2009-12-31 | Jensen Michael C | Fusion multiviral chimeric antigen |
| EP2258719A1 (en) | 2009-05-19 | 2010-12-08 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Multiple target T cell receptor |
| US9987308B2 (en) * | 2011-03-23 | 2018-06-05 | Fred Hutchinson Cancer Research Center | Method and compositions for cellular immunotherapy |
| CN103502439B (zh) * | 2011-04-13 | 2016-10-12 | 因缪尼卡姆股份公司 | 用于抗原特异性t细胞增殖的方法 |
| JP6117515B2 (ja) | 2011-11-01 | 2017-04-19 | 国立大学法人名古屋大学 | 髄膜腫治療用医薬組成物 |
| CN113684185A (zh) * | 2013-02-26 | 2021-11-23 | 纪念斯隆-凯特琳癌症中心 | 用于免疫疗法的组合物和方法 |
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| WO2014165707A2 (en) * | 2013-04-03 | 2014-10-09 | Memorial Sloan-Kettering Cancer Center | Effective generation of tumor-targeted t-cells derived from pluripotent stem cells |
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