HRP20201906T1 - Označene kimerne efektorske molekule i njihovi receptori - Google Patents

Označene kimerne efektorske molekule i njihovi receptori Download PDF

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Publication number
HRP20201906T1
HRP20201906T1 HRP20201906TT HRP20201906T HRP20201906T1 HR P20201906 T1 HRP20201906 T1 HR P20201906T1 HR P20201906T T HRP20201906T T HR P20201906TT HR P20201906 T HRP20201906 T HR P20201906T HR P20201906 T1 HRP20201906 T1 HR P20201906T1
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Croatia
Prior art keywords
signal
fusion protein
binding
domain
cassette
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HRP20201906TT
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English (en)
Croatian (hr)
Inventor
Stanley R. Riddell
Lingfeng LIU
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Fred Hutchinson Cancer Research Center
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Publication of HRP20201906T1 publication Critical patent/HRP20201906T1/hr

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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K—PEPTIDES
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    • C07K14/70521—CD28, CD152
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)
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HRP20201906TT 2013-12-20 2014-12-22 Označene kimerne efektorske molekule i njihovi receptori HRP20201906T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361919201P 2013-12-20 2013-12-20
PCT/US2014/072007 WO2015095895A1 (en) 2013-12-20 2014-12-22 Tagged chimeric effector molecules and receptors thereof
EP14830770.5A EP3083671B1 (en) 2013-12-20 2014-12-22 Tagged chimeric effector molecules and receptors thereof

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HRP20201906T1 true HRP20201906T1 (hr) 2021-04-02

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HRP20201906TT HRP20201906T1 (hr) 2013-12-20 2014-12-22 Označene kimerne efektorske molekule i njihovi receptori

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US (3) US10494434B2 (enExample)
EP (1) EP3083671B1 (enExample)
JP (4) JP6942467B2 (enExample)
KR (2) KR20230007559A (enExample)
CN (2) CN105980402B (enExample)
AU (3) AU2014368892B2 (enExample)
BR (1) BR112016014156A8 (enExample)
CA (1) CA2933707A1 (enExample)
CY (1) CY1123747T1 (enExample)
DK (1) DK3083671T3 (enExample)
ES (1) ES2837856T3 (enExample)
HR (1) HRP20201906T1 (enExample)
HU (1) HUE052573T2 (enExample)
IL (1) IL245845B (enExample)
LT (1) LT3083671T (enExample)
MX (1) MX386422B (enExample)
MY (1) MY178233A (enExample)
NZ (2) NZ759969A (enExample)
PL (1) PL3083671T3 (enExample)
PT (1) PT3083671T (enExample)
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