CY1123747T1 - Χιμαιρικα μορια τελεστες με σημανση και υποδοχεις αυτων - Google Patents

Χιμαιρικα μορια τελεστες με σημανση και υποδοχεις αυτων

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Publication number
CY1123747T1
CY1123747T1 CY20201101218T CY201101218T CY1123747T1 CY 1123747 T1 CY1123747 T1 CY 1123747T1 CY 20201101218 T CY20201101218 T CY 20201101218T CY 201101218 T CY201101218 T CY 201101218T CY 1123747 T1 CY1123747 T1 CY 1123747T1
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CY
Cyprus
Prior art keywords
molecules
domain
host cell
chimeral
acceptors
Prior art date
Application number
CY20201101218T
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English (en)
Inventor
Stanley R. Riddell
Lingfeng LIU
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Fred Hutchinson Cancer Research Center
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Publication date
Application filed by Fred Hutchinson Cancer Research Center filed Critical Fred Hutchinson Cancer Research Center
Publication of CY1123747T1 publication Critical patent/CY1123747T1/el

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
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Abstract

Η αίτηση αναφέρεται σε χιμαιρικά μόρια τελεστές με σήμανση και μόρια υποδοχείς αυτών για τη γενετική τροποποίηση ενός κυττάρου ξενιστή, όπου το ανασυνδυασμένο κύτταρο ξενιστής μπορεί να ταυτοποιηθεί, απομονωθεί, διαχωρισθεί, επαχθεί να πολλαπλασιασθεί, ιχνηλατηθεί ή εξαλειφθεί δια της χρήσεως της σήμανσης. Συγκεκριμένα, η αίτηση αναφέρεται σε χιμαιρικούς αντιγονικούς υποδοχείς (CAR) που έχουν ένα εξωκυτταρικό πεδίο που περιλαμβάνει ένα πεδίο δέσμευσης για έναν στόχο, μία περιοχή άρθρωσης και μία κασέτα σήμανσης, ένα υδρόφοβο μέρος ως διαμεμβρανικό πεδίο και ένα ενδοκυτταρικό μέρος με ένα πεδίο τελεστή. Ο προτιμώμενος στόχος είναι το CD19 και η προτιμώμενη σήμανση είναι μία σήμανση Step. Τ κύτταρα που έχουν τροποποιηθεί ανασυνδυασμένα για την έκφραση αυτών των μορίων μπορεί να χρησιμοποιηθούν σε θετή ανοσοθεραπεία.
CY20201101218T 2013-12-20 2020-12-23 Χιμαιρικα μορια τελεστες με σημανση και υποδοχεις αυτων CY1123747T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361919201P 2013-12-20 2013-12-20
PCT/US2014/072007 WO2015095895A1 (en) 2013-12-20 2014-12-22 Tagged chimeric effector molecules and receptors thereof

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