CY1122509T1 - Πολυπεπτιδια χιμαιρικου παραγοντα viii και χρησεις αυτων - Google Patents

Πολυπεπτιδια χιμαιρικου παραγοντα viii και χρησεις αυτων

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Publication number
CY1122509T1
CY1122509T1 CY20191101171T CY191101171T CY1122509T1 CY 1122509 T1 CY1122509 T1 CY 1122509T1 CY 20191101171 T CY20191101171 T CY 20191101171T CY 191101171 T CY191101171 T CY 191101171T CY 1122509 T1 CY1122509 T1 CY 1122509T1
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Cyprus
Prior art keywords
vwf
fviii
protein
moiety
polypeptide chain
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CY20191101171T
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English (en)
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Ekta Seth CHHABRA
Tongyao Liu
Robert Peters
Haiyan Jiang
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Bioverativ Therapeutics Inc.
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Publication of CY1122509T1 publication Critical patent/CY1122509T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει κλάσμα VWF το οποίο περιέχει την επικράτεια D' και επικράτεια D3 του VWF, χιμαιρική πρωτεΐνη η οποία περιέχει το κλάσμα VWF και ένα ετερόλογο τμήμα ή χιμαιρική πρωτεΐνη η οποία περιέχει το κλάσμα VWF και πρωτεΐνη FVIII και μεθόδους χρήσης αυτών. Μία πολυπεπτιδική άλυσος η οποία περιέχει ένα κλάσμα VWF της εφεύρεσης δεσμεύεται ή σχετίζεται με πολυπεπτιδική άλυσο η οποία περιέχει μία πρωτεΐνη FVIII και η πολυπεπτιδική άλυσος που περιέχει το κλάσμα YWF μπορεί να αποτρέψει ή να αναστείλει τη δέσμευση ενδογενούς VWF στην πρωτεΐνη FVIII. Αποτρέποντας ή αναστέλλοντας τη δέσμευση του ενδογενούς VWF στον FVIII, ο οποίος είναι παράγοντας περιορισμού του χρόνου ημιζωής για τον FVIII, το κλάσμα VWF μπορεί να επιφέρει επέκταση του χρόνου ημιζωής στην πρωτεΐνη FVIII. Η εφεύρεση επίσης περιλαμβάνει νουκλεοτίδια, διαβιβαστές, κύτταρα ξενιστές, μεθόδους χρήσης του κλάσματος VWF ή των χιμαιρικών πρωτεϊνών.
CY20191101171T 2012-01-12 2019-11-07 Πολυπεπτιδια χιμαιρικου παραγοντα viii και χρησεις αυτων CY1122509T1 (el)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261586099P 2012-01-12 2012-01-12
US201261586654P 2012-01-13 2012-01-13
US201261667901P 2012-07-03 2012-07-03
US201261734954P 2012-12-07 2012-12-07
PCT/US2013/021330 WO2013106787A1 (en) 2012-01-12 2013-01-12 Chimeric factor viii polypeptides and uses thereof

Publications (1)

Publication Number Publication Date
CY1122509T1 true CY1122509T1 (el) 2021-01-27

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Country Status (29)

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US (2) US11370827B2 (el)
EP (2) EP3505179A1 (el)
JP (4) JP6255630B2 (el)
KR (1) KR102212098B1 (el)
CN (4) CN104271150A (el)
AU (2) AU2016202875B2 (el)
BR (1) BR112014017165B1 (el)
CA (1) CA2863328A1 (el)
CO (1) CO7010788A2 (el)
CY (1) CY1122509T1 (el)
DK (1) DK2804623T3 (el)
EA (2) EA035323B1 (el)
ES (1) ES2753124T3 (el)
HK (1) HK1202799A1 (el)
HR (1) HRP20191920T1 (el)
HU (1) HUE046396T2 (el)
IL (2) IL233463B (el)
LT (1) LT2804623T (el)
MX (1) MX357403B (el)
MY (1) MY201293A (el)
NZ (1) NZ626945A (el)
PH (2) PH12014501602A1 (el)
PL (1) PL2804623T3 (el)
PT (1) PT2804623T (el)
RS (1) RS59670B1 (el)
SG (2) SG11201403764XA (el)
SI (1) SI2804623T1 (el)
TW (3) TWI826778B (el)
WO (1) WO2013106787A1 (el)

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