CY1122729T1 - Συμπλοκο παραγοντα viii με χτεν και πρωτεϊνη παραγοντα von willebrand, και χρησεις αυτου - Google Patents

Συμπλοκο παραγοντα viii με χτεν και πρωτεϊνη παραγοντα von willebrand, και χρησεις αυτου

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Publication number
CY1122729T1
CY1122729T1 CY20201100105T CY201100105T CY1122729T1 CY 1122729 T1 CY1122729 T1 CY 1122729T1 CY 20201100105 T CY20201100105 T CY 20201100105T CY 201100105 T CY201100105 T CY 201100105T CY 1122729 T1 CY1122729 T1 CY 1122729T1
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Cyprus
Prior art keywords
vwf
protein
fragment
fviii
region
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CY20201100105T
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English (en)
Inventor
Ekta Seth CHHABRA
Tongyao Liu
Pei-Yun Chang
Robert T. Peters
John KULMAN
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Bioverativ Therapeutics Inc.
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Publication date
Application filed by Bioverativ Therapeutics Inc. filed Critical Bioverativ Therapeutics Inc.
Publication of CY1122729T1 publication Critical patent/CY1122729T1/el

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
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    • A61K38/00—Medicinal preparations containing peptides
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    • C07K2319/00—Fusion polypeptide
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
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  • Diabetes (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Η παρούσα εφεύρεση περιλαμβάνει μια χιμαιρική πρωτεΐνη που αποτελείται από μια πρωτεΐνη VWF με D' περιοχή και D3 περιοχή του VWF, μια ή περισσότερες αλληλουχίες ΧΤΕΝ, και μια πρωτεΐνη FVIII, όπου το θραύσμα VWF, η αλληλουχία ΧΤΕΝ, ή η πρωτεΐνη FVIII συνδέονται σε ή σχετίζονται μεταξύ τους. Η χιμαιρική πρωτεΐνη μπορεί περαιτέρω να αποτελείται από μια ή περισσότερες σταθερές περιοχές Ιg ή ένα τμήμα αυτών (π.χ., μια Fc περιοχή). Μια πολυπεπτιδική αλυσίδα ενός θραύσματος VWF σχετίζεται με μια πολυπεπτιδική αλυσίδα FVIΙΙ συνδεδεμένη σε μια αλληλουχία ΧΤΕΝ. Το θραύσμα πολυπεπτιδικής αλυσίδας VWF μπορεί να αποτρέψει ή να αναστείλει την πρόσδεση ενδογενούς VWF σε πρωτεΐνη FVIΙΙ συνδεδεμένη στην αλληλουχία ΧΤΕΝ. Μέσω της αποτροπής ή αναστολής της πρόσδεσης ενδογενούς VWF σε πρωτεΐνη FVIII, το θραύσμα VWF μπορεί να επιμηκύνει την ημίσεια ζωή της χιμαιρικής πρωτεΐνης που αποτελείται από πρωτεΐνη FVIIΙ. Η εφεύρεση περιλαμβάνει νουκλεοτίδια, φορείς, κύτταρα ξενιστές, χρήση θραύσματος VWF, ή χιμαιρικές πρωτεΐνες.
CY20201100105T 2012-07-11 2020-02-05 Συμπλοκο παραγοντα viii με χτεν και πρωτεϊνη παραγοντα von willebrand, και χρησεις αυτου CY1122729T1 (el)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261670401P 2012-07-11 2012-07-11
US201361759819P 2013-02-01 2013-02-01
US201361801504P 2013-03-15 2013-03-15
US201361801544P 2013-03-15 2013-03-15
US201361827158P 2013-05-24 2013-05-24
US201361840811P 2013-06-28 2013-06-28
PCT/US2013/049989 WO2014011819A2 (en) 2012-07-11 2013-07-10 Factor viii complex with xten and von willebrand factor protein, and uses thereof

Publications (1)

Publication Number Publication Date
CY1122729T1 true CY1122729T1 (el) 2021-03-12

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Country Status (31)

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US (3) US10138291B2 (el)
EP (3) EP2882450B1 (el)
JP (5) JP6603128B2 (el)
KR (2) KR102329315B1 (el)
CN (2) CN104661674A (el)
AR (1) AR091735A1 (el)
AU (4) AU2013290173B2 (el)
BR (1) BR112015000267B1 (el)
CA (1) CA2878679A1 (el)
CL (1) CL2015000060A1 (el)
CO (1) CO7170123A2 (el)
CY (1) CY1122729T1 (el)
DK (1) DK2882450T3 (el)
EA (2) EA201792485A3 (el)
ES (1) ES2770501T3 (el)
HK (1) HK1211228A1 (el)
HR (1) HRP20200007T1 (el)
HU (1) HUE047088T2 (el)
IL (1) IL236412B (el)
LT (1) LT2882450T (el)
MX (1) MX2015000397A (el)
NZ (1) NZ703366A (el)
PH (1) PH12015500039A1 (el)
PL (1) PL2882450T3 (el)
PT (1) PT2882450T (el)
RS (1) RS59876B1 (el)
SG (3) SG11201500045RA (el)
SI (1) SI2882450T1 (el)
TW (1) TWI667258B (el)
UA (1) UA116632C2 (el)
WO (1) WO2014011819A2 (el)

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