HRP20200007T1 - Kompleks proteina faktora viii s xten i von willebrandovim faktorom, te njegova uporaba - Google Patents

Kompleks proteina faktora viii s xten i von willebrandovim faktorom, te njegova uporaba Download PDF

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HRP20200007T1
HRP20200007T1 HRP20200007TT HRP20200007T HRP20200007T1 HR P20200007 T1 HRP20200007 T1 HR P20200007T1 HR P20200007T T HRP20200007T T HR P20200007TT HR P20200007 T HRP20200007 T HR P20200007T HR P20200007 T1 HRP20200007 T1 HR P20200007T1
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fviii
constant region
protein
chimeric protein
xten
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HRP20200007TT
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Ekta Seth Chhabra
Tongyao Liu
Pei-Yun Chang
Robert T. Peters
John KULMAN
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Bioverativ Therapeutics Inc.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Diabetes (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Claims (15)

1. Kimerni protein koji sadrži (i) ulomak von Willebrandovog faktora (VWF) koji sadrži D' domenu i D3 domenu VWF, (ii) sekvencu polipeptida produljene dužine (XTEN), (iii) protein faktora VIII (FVIII), (iv) prvu Ig konstantnu regiju ili njezin dio, te (v) drugu Ig konstantnu regiju ili njezin dio, pri čemu su VWF ulomak i sekvenca XTEN vezani s proizvoljnom poveznicom, pri čemu sekvenca XTEN ili VWF ulomak su vezani na prvu Ig konstantnu regiju ili njezin dio, pri čemu je protein FVIII vezan na drugu Ig konstantnu regiju ili njezin dio, i pri čemu je prva Ig konstantna regija ili njezin dio povezana sa ili vezana na drugu Ig konstantnu regiju ili njezin dio putem kovalentne veze.
2. Kimerni protein prema patentnom zahtjevu 1, naznačen time što sadrži (i) pojedinačni polipeptidni lanac koji sadrži VWF ulomak, sekvencu XTEN, prvu Ig konstantnu regiju ili njezin dio, drugu Ig konstantnu regiju ili njezin dio i protein FVIII, ili (ii) prvi polipeptidni lanac ili drugi polipeptidni lanac, pri čemu prvi polipeptidni lanac sadrži VWF ulomak, sekvencu XTEN i prvu Ig konstantnu regiju ili njezin dio i drugi polipeptidni lanac sadrži protein FVIII i drugu Ig konstantnu regiju ili njezin dio.
3. Kimerni protein prema patentnom zahtjevu 1, naznačen time što ima formulu: (a) V-L2-X-L1-F1:FVIII-L3-F2; (b) V-L2-X-L1-F1:F2-L3-FVIII; (c) F1-L1-X-L2-V: FVIII-L3-F2; (d) F1-L1-X-L2-V:F2-L3-FVIII; (e) V-L2-X-LI-FI-L4-FVIII-L3-F2; (f) F2-L3-FVIII-L4-F1-L1-X-L2-V; (g) FVIII-L3-F2-L4-V-L2-X-L1-F1; ili (h) F1-L1-X-L2-V-L4-F2-L3-FVIII; pri čemu V je VWF ulomak; svaki od L1, L2, i L3 je proizvoljna poveznica; L4 je proizvoljna poveznica; FVIII je protein FVIII; X je sekvenca XTEN; F1 je prva konstantna regija imunoglobulina (Ig) ili njezin dio; F2 je druga Ig konstantna regija ili njezin dio; (-) je peptidna veza; i (:) je kovalentna veza.
4. Kimerni protein prema patentnom zahtjevu 1, naznačen time što ima formulu: (a) FVIII(X1)-L1-F1:V-L2-X2-L3-F2; (b) FVIII(X1)-L1-F1:F2-L3-X2-L2-V; (c) F1-L1-FVIII(X1):V-L2-X2-L3-F2; (d) F1-L1-FVIII(X1):F2-L3-X2-L2-V; (e) FVIII(X1)-L1-F1-L4-V-L2-X2-L3-F2; (f) FVIII(X1)-L1-F1-L4-F2-L3-X2-L2-V; (g) F1-L1-FVIII(X1)-L4-V-L2-X2-L3-F2; ili (h) F1-L1-FVIII(X1)-L4-F2-L3-X2-L2-V; pri čemu FVIII(X1) sadrži protein FVIII i XTEN sekvencu, pri čemu je sekvenca XTEN vezana na N-terminalni kraj ili C-terminalni kraj proteina FVIII ili se ubacuje neposredno nizvodno od jedne ili više aminokiselina ("jedno ili više mjesta umetanja") u proteinu FVIII; svaki od L1, L2, ili L3 je proizvoljna poveznica; L4 je poveznica; X2 je druga sekvenca XTEN; F1 je prva Ig konstantna regija ili njezin dio; F2 je druga Ig konstantna regija ili njezin dio; V je VWF ulomak; (-) je peptidna veza; i (:) je kovalentna veza.
5. Kimerni protein prema bilo kojem od patentnih zahtjeva 1-4, naznačen time što (a) prva Ig konstantna regija ili njezin dio je prva Fc regija; (b) druga Ig konstantna regija ili njezin dio je druga Fc regija; ili (c) oboje (a) i (b).
6. Kimerni protein prema patentnom zahtjevu 4 ili 5, naznačen time što su jedno ili više mjesta umetanja u protein FVIII odabrana iz skupine koja se sastoji od aminokiselinskih ostataka u Tablici 7, Tablici 8, Tablici 9 i Tablici 10.
7. Kimerni protein prema bilo kojem od patentnih zahtjeva 1 do 6, naznačen time što protein FVIII sadrži B domenu ili njezin dio ili ne sadrži B domenu.
8. Kimerni protein prema bilo kojem od patentnih zahtjeva 1 do 7, naznačen time što kimerni protein sadrži najmanje dva XTEN-a, najmanje tri XTEN-a, najmanje četiri XTEN-a, najmanje pet XTEN-ova, ili najmanje šest XTEN-ova.
9. Kimerni protein prema bilo kojem od patentnih zahtjeva 1 do 8, naznačen time što je protein FVIII jednolančani FVIII.
10. Polinukleotid ili skup polinukleotida naznačen time što kodiraju kimerni protein prema bilo kojem od patentnih zahtjeva 1 do 9.
11. Vektor naznačen time što sadrži polinukleotid ili skup polinukleotida prema zahtjevu 10 i jedan ili više promotora operativno vezan za polinukleotid ili skup polinukleotida.
12. Stanica domaćina naznačena time što sadrži polinukleotid ili skup polinukleotida prema zahtjevu 10 ili vektor prema zahtjevu 11.
13. Farmaceutski pripravak naznačen time što sadrži kimerni protein prema bilo kojem od patentnih zahtjeva 1 do 9, polinukleotid ili skup polinukleotida iz patentnog zahtjeva 10, vektor prema zahtjevu 11, ili stanicu domaćina prema zahtjevu 12, te farmaceutski prihvatljiv nosač.
14. Kimerni protein prema bilo kojem od patentnih zahtjeva 1 do 9, polinukleotid prema zahtjevu 10, vektor prema zahtjevu 11, stanicu domaćina prema zahtjevu 12, ili pripravak prema zahtjevu 13 naznačen time što je za upotrebu u liječenju bolesti krvarenja ili poremećaja krvarenja kod subjekta kojem je potrebno.
15. Postupak za proizvodnju kimernog proteina, naznačen time što obuhvaća transfekciju jedne ili više stanica domaćina s polinukleotidom ili skupom polinukleotida prema zahtjevu 10 ili vektorom prema zahtjevu 11 i eksprimiranje kimernog proteina u stanici domaćinu.
HRP20200007TT 2012-07-11 2020-01-03 Kompleks proteina faktora viii s xten i von willebrandovim faktorom, te njegova uporaba HRP20200007T1 (hr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201261670401P 2012-07-11 2012-07-11
US201361759819P 2013-02-01 2013-02-01
US201361801544P 2013-03-15 2013-03-15
US201361801504P 2013-03-15 2013-03-15
US201361827158P 2013-05-24 2013-05-24
US201361840811P 2013-06-28 2013-06-28
PCT/US2013/049989 WO2014011819A2 (en) 2012-07-11 2013-07-10 Factor viii complex with xten and von willebrand factor protein, and uses thereof
EP13816031.2A EP2882450B1 (en) 2012-07-11 2013-07-10 Factor viii complex with xten and von willebrand factor protein, and uses thereof

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HRP20200007T1 true HRP20200007T1 (hr) 2020-03-20

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US (3) US10138291B2 (hr)
EP (3) EP3674410A1 (hr)
JP (5) JP6603128B2 (hr)
KR (2) KR102403545B1 (hr)
CN (2) CN104661674A (hr)
AR (1) AR091735A1 (hr)
AU (4) AU2013290173B2 (hr)
BR (1) BR112015000267B1 (hr)
CA (1) CA2878679A1 (hr)
CL (1) CL2015000060A1 (hr)
CO (1) CO7170123A2 (hr)
CY (1) CY1122729T1 (hr)
DK (1) DK2882450T3 (hr)
EA (2) EA029685B1 (hr)
ES (1) ES2770501T3 (hr)
HK (1) HK1211228A1 (hr)
HR (1) HRP20200007T1 (hr)
HU (1) HUE047088T2 (hr)
IL (1) IL236412B (hr)
LT (1) LT2882450T (hr)
MX (1) MX2015000397A (hr)
NZ (1) NZ703366A (hr)
PH (1) PH12015500039A1 (hr)
PL (1) PL2882450T3 (hr)
PT (1) PT2882450T (hr)
RS (1) RS59876B1 (hr)
SG (3) SG10201913893XA (hr)
SI (1) SI2882450T1 (hr)
TW (1) TWI667258B (hr)
UA (1) UA116632C2 (hr)
WO (1) WO2014011819A2 (hr)

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EP2882450A4 (en) 2016-06-22
LT2882450T (lt) 2020-03-25
MX2015000397A (es) 2015-11-23
EP3674410A1 (en) 2020-07-01
SG10201913893XA (en) 2020-03-30
RS59876B1 (sr) 2020-03-31
EA201590198A1 (ru) 2015-06-30
AU2013290173B2 (en) 2018-02-15
JP2015527882A (ja) 2015-09-24
CN110054699A (zh) 2019-07-26
US20150266943A1 (en) 2015-09-24
JP2023166024A (ja) 2023-11-17
EA201792485A3 (ru) 2019-03-29
HK1211228A1 (en) 2016-05-20

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