ATE313554T1 - Derivatisierung von proteinen in wässrigem lösungsmittel - Google Patents
Derivatisierung von proteinen in wässrigem lösungsmittelInfo
- Publication number
- ATE313554T1 ATE313554T1 AT01931843T AT01931843T ATE313554T1 AT E313554 T1 ATE313554 T1 AT E313554T1 AT 01931843 T AT01931843 T AT 01931843T AT 01931843 T AT01931843 T AT 01931843T AT E313554 T1 ATE313554 T1 AT E313554T1
- Authority
- AT
- Austria
- Prior art keywords
- derivatization
- groups
- denaturant
- vivo
- proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
- C12Y111/01—Peroxidases (1.11.1)
- C12Y111/01006—Catalase (1.11.1.6)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00304108 | 2000-05-16 | ||
PCT/GB2001/002115 WO2001087922A2 (en) | 2000-05-16 | 2001-05-14 | Derivatisation of proteins in aqueous solution |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE313554T1 true ATE313554T1 (de) | 2006-01-15 |
Family
ID=8172993
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01931843T ATE313554T1 (de) | 2000-05-16 | 2001-05-14 | Derivatisierung von proteinen in wässrigem lösungsmittel |
Country Status (8)
Country | Link |
---|---|
US (1) | US6962972B2 (de) |
EP (1) | EP1335931B1 (de) |
JP (1) | JP2003533537A (de) |
AT (1) | ATE313554T1 (de) |
AU (1) | AU2001258536A1 (de) |
DE (1) | DE60116137T2 (de) |
ES (1) | ES2256234T3 (de) |
WO (1) | WO2001087922A2 (de) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005016974A1 (en) | 2003-08-12 | 2005-02-24 | Lipoxen Technologies Limited | Sialic acid derivatives for protein derivatisation and conjugation |
US7691826B2 (en) | 2003-08-12 | 2010-04-06 | Lipoxen Technologies Limited | Polysialic acid derivatives |
WO2006016168A2 (en) | 2004-08-12 | 2006-02-16 | Lipoxen Technologies Limited | Sialic acid derivatives |
ES2640767T3 (es) | 2004-08-12 | 2017-11-06 | Lipoxen Technologies Limited | Fraccionamientodepolisacáridos cargados |
TWI376234B (en) | 2005-02-01 | 2012-11-11 | Msd Oss Bv | Conjugates of a polypeptide and an oligosaccharide |
CN101160326B (zh) | 2005-02-23 | 2013-04-10 | 利普生技术有限公司 | 用于蛋白质衍生和缀合的活化的唾液酸衍生物 |
JP5096466B2 (ja) | 2006-07-25 | 2012-12-12 | リポクセン テクノロジーズ リミテッド | N末端ポリシアリル化 |
ES2375314T3 (es) | 2007-02-28 | 2012-02-28 | Lipoxen Technologies Limited | Reducción de endotoxina en ácidos polisiálicos. |
RU2744370C2 (ru) * | 2009-07-27 | 2021-03-05 | Баксалта Инкорпорейтед | Конъюгаты белков свертывания крови |
NZ597600A (en) | 2009-07-27 | 2014-05-30 | Lipoxen Technologies Ltd | Glycopolysialylation of non-blood coagulation proteins |
US20120263701A1 (en) | 2009-08-24 | 2012-10-18 | Volker Schellenberger | Coagulation factor vii compositions and methods of making and using same |
CA2806684C (en) | 2010-07-30 | 2020-11-17 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
CA3012117A1 (en) | 2011-05-27 | 2012-12-06 | Baxalta Incorporated | Fusions of psa with serpins and other therapeutic proteins |
EP2717898B1 (de) | 2011-06-10 | 2018-12-19 | Bioverativ Therapeutics Inc. | Gerinnungsfördernde verbindungen und anwendungsverfahren dafür |
WO2013106787A1 (en) | 2012-01-12 | 2013-07-18 | Biogen Idec Ma Inc. | Chimeric factor viii polypeptides and uses thereof |
PL3564260T3 (pl) | 2012-02-15 | 2023-03-06 | Bioverativ Therapeutics Inc. | Kompozycje czynnika viii oraz sposoby ich wytwarzania i stosowania |
AU2013204636B2 (en) | 2012-02-15 | 2016-04-14 | Bioverativ Therapeutics Inc. | Recombinant Factor VIII proteins |
AU2013204754C1 (en) | 2012-05-16 | 2018-10-11 | Takeda Pharmaceutical Company Limited | Nucleophilic Catalysts for Oxime Linkage |
JP2015525222A (ja) | 2012-06-08 | 2015-09-03 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | キメラ性凝固因子 |
CA2875246A1 (en) | 2012-06-08 | 2013-12-12 | Biogen Idec Ma Inc. | Procoagulant compounds |
PL2882450T3 (pl) | 2012-07-11 | 2020-06-29 | Bioverativ Therapeutics Inc. | Kompleks czynnika viii z xten i białkiem czynnika von willebranda oraz jego zastosowania |
CN113817069A (zh) | 2013-06-28 | 2021-12-21 | 比奥贝拉蒂治疗公司 | 具有xten的凝血酶可裂解连接子和其用途 |
TW202003554A (zh) | 2013-08-14 | 2020-01-16 | 美商百歐維拉提夫治療公司 | 因子viii-xten融合物及其用途 |
WO2015048330A2 (en) | 2013-09-25 | 2015-04-02 | Biogen Idec Ma Inc. | On-column viral inactivation methods |
US10584147B2 (en) | 2013-11-08 | 2020-03-10 | Biovertiv Therapeutics Inc. | Procoagulant fusion compound |
IL282168B2 (en) | 2014-01-10 | 2023-03-01 | Bioverativ Therapeutics Inc | Factor viii chimeric proteins and their uses |
US10188739B2 (en) | 2014-02-27 | 2019-01-29 | Xenetic Biosciences, Inc. | Compositions and methods for administering insulin or insulin-like protein to the brain |
EP3197481A1 (de) | 2014-09-26 | 2017-08-02 | Bayer Pharma Aktiengesellschaft | Stabilisierte adrenomedullinderivate und verwendung davon |
KR102122463B1 (ko) | 2014-10-14 | 2020-06-15 | 할로자임, 아이엔씨 | 아데노신 디아미네이즈-2(ada2)의 조성물, 이의 변이체 및 이를 사용하는 방법 |
MA40835A (fr) | 2014-10-23 | 2017-08-29 | Biogen Ma Inc | Anticorps anti-gpiib/iiia et leurs utilisations |
MA40861A (fr) | 2014-10-31 | 2017-09-05 | Biogen Ma Inc | Anticorps anti-glycoprotéines iib/iiia |
CN108472337B (zh) | 2015-08-03 | 2022-11-25 | 比奥贝拉蒂治疗公司 | 因子ix融合蛋白以及其制备和使用方法 |
TW201731869A (zh) | 2015-12-03 | 2017-09-16 | 百克莎塔股份有限公司 | 具有延長之半衰期及降低之配位體結合性質的因子viii |
MA45473A (fr) | 2016-04-04 | 2019-02-13 | Shire Human Genetic Therapies | Inhibiteur de c1 estérase conjugué et ses utilisations |
TW202003551A (zh) | 2018-03-28 | 2020-01-16 | 美商必治妥美雅史谷比公司 | 介白素-2/介白素-2受體阿法融合蛋白及其使用方法 |
EP3817720A2 (de) | 2018-07-03 | 2021-05-12 | Bristol-Myers Squibb Company | Fgf21-formulierungen |
JP2022537369A (ja) | 2019-06-18 | 2022-08-25 | バイエル アクチェンゲゼルシャフト | 長期安定化のためのアドレノメデュリン-類似体およびその使用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4356170A (en) * | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
US4727136A (en) * | 1985-10-01 | 1988-02-23 | Canadian Patents And Development Ltd. | Modified meningococcal group B polysaccharide for conjugate vaccine |
GB9112212D0 (en) | 1991-06-06 | 1991-07-24 | Gregoriadis Gregory | Pharmaceutical compositions |
US5846951A (en) * | 1991-06-06 | 1998-12-08 | The School Of Pharmacy, University Of London | Pharmaceutical compositions |
US5951974A (en) * | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
US5738846A (en) * | 1994-11-10 | 1998-04-14 | Enzon, Inc. | Interferon polymer conjugates and process for preparing the same |
US5705364A (en) * | 1995-06-06 | 1998-01-06 | Genentech, Inc. | Mammalian cell culture process |
-
2001
- 2001-05-14 US US10/276,552 patent/US6962972B2/en not_active Expired - Lifetime
- 2001-05-14 ES ES01931843T patent/ES2256234T3/es not_active Expired - Lifetime
- 2001-05-14 DE DE60116137T patent/DE60116137T2/de not_active Expired - Lifetime
- 2001-05-14 WO PCT/GB2001/002115 patent/WO2001087922A2/en active IP Right Grant
- 2001-05-14 JP JP2001585141A patent/JP2003533537A/ja active Pending
- 2001-05-14 EP EP01931843A patent/EP1335931B1/de not_active Expired - Lifetime
- 2001-05-14 AU AU2001258536A patent/AU2001258536A1/en not_active Abandoned
- 2001-05-14 AT AT01931843T patent/ATE313554T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE60116137D1 (de) | 2006-01-26 |
AU2001258536A1 (en) | 2001-11-26 |
EP1335931A2 (de) | 2003-08-20 |
ES2256234T3 (es) | 2006-07-16 |
US6962972B2 (en) | 2005-11-08 |
WO2001087922A2 (en) | 2001-11-22 |
EP1335931B1 (de) | 2005-12-21 |
JP2003533537A (ja) | 2003-11-11 |
US20030129159A1 (en) | 2003-07-10 |
WO2001087922A3 (en) | 2003-05-30 |
DE60116137T2 (de) | 2006-08-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |