DE69621953D1 - Vehikel zum einbringen von nukleinsäuren in zellen - Google Patents

Vehikel zum einbringen von nukleinsäuren in zellen

Info

Publication number
DE69621953D1
DE69621953D1 DE69621953T DE69621953T DE69621953D1 DE 69621953 D1 DE69621953 D1 DE 69621953D1 DE 69621953 T DE69621953 T DE 69621953T DE 69621953 T DE69621953 T DE 69621953T DE 69621953 D1 DE69621953 D1 DE 69621953D1
Authority
DE
Germany
Prior art keywords
cells
nucleic acids
vehicle
inserting nucleic
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69621953T
Other languages
English (en)
Other versions
DE69621953T2 (de
Inventor
Moshe Baru
Israel Nur
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Opperbas Holding BV
Original Assignee
Opperbas Holding BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Opperbas Holding BV filed Critical Opperbas Holding BV
Application granted granted Critical
Publication of DE69621953D1 publication Critical patent/DE69621953D1/de
Publication of DE69621953T2 publication Critical patent/DE69621953T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69621953T 1995-09-07 1996-09-05 Vehikel zum einbringen von nukleinsäuren in zellen Expired - Lifetime DE69621953T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL11519995A IL115199A (en) 1995-09-07 1995-09-07 Composition comprising a polynucleic acid molecule in a liposome and method using said composition
PCT/IL1996/000101 WO1997010851A2 (en) 1995-09-07 1996-09-05 Nucleic acid delivery vehicle

Publications (2)

Publication Number Publication Date
DE69621953D1 true DE69621953D1 (de) 2002-07-25
DE69621953T2 DE69621953T2 (de) 2003-01-30

Family

ID=11067956

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69621953T Expired - Lifetime DE69621953T2 (de) 1995-09-07 1996-09-05 Vehikel zum einbringen von nukleinsäuren in zellen

Country Status (8)

Country Link
US (1) US6207456B1 (de)
EP (1) EP0879062B1 (de)
JP (1) JPH11514349A (de)
AT (1) ATE219380T1 (de)
CA (1) CA2231172A1 (de)
DE (1) DE69621953T2 (de)
IL (1) IL115199A (de)
WO (1) WO1997010851A2 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6890555B1 (en) * 1992-02-05 2005-05-10 Qlt, Inc. Liposome compositions of porphyrin photosensitizers
DE19605548A1 (de) * 1996-02-15 1997-09-04 Boehringer Ingelheim Int Zusammensetzung für die Transfektion höherer eukaryotischer Zellen
FR2751222B1 (fr) * 1996-07-16 1998-10-09 Capsulis Compositions contenant au moins un acide nucleique et leurs applications dans le domaine biomedical, en particulier en therapie genique
DE19740092A1 (de) * 1997-09-12 1999-03-18 Ulrich Dr Med Hengge Liposomen und Verfahren zur Transfektion von Zellen
WO1999042091A2 (en) 1998-02-19 1999-08-26 Massachusetts Institute Of Technology Use of polycations as endosomolytic agents
US7276359B1 (en) * 1998-03-13 2007-10-02 Wyeth Polynucleotide composition, method of preparation, and use thereof
IL126681A0 (en) * 1998-10-21 1999-08-17 Opperbas Holding Bv Treatment of trauma-related conditions
WO2002066013A2 (en) * 2001-02-22 2002-08-29 Opperbas Holding B.V. Liposome-mediated dna administration
CN1210295C (zh) * 2001-07-13 2005-07-13 一泰医药研究（深圳）有限公司 序列号24的生物活性肽
ES2345842T3 (es) 2001-07-13 2010-10-04 Cms Peptides Patent Holding Company Limited Peptidos biologicamente activos.
JP2006501838A (ja) * 2002-10-09 2006-01-19 ファイザー・プロダクツ・インク 安定化された裸ｄｎａ組成物
EP1616016B1 (de) * 2003-03-19 2012-11-14 Isogenis, Inc. Gentherapie-vektoren mit reduzierter immunität, die auf der verwendung von der cd8 alpha kette basieren
TWI353252B (en) 2004-04-28 2011-12-01 Cms Peptides Patent Holding Company Ltd Biologically active peptide vapeehptllteaplnpk der
WO2006012416A2 (en) * 2004-07-20 2006-02-02 Isogenis, Inc. Specific inhibition of autoimmunity and diseases associated with autoantigens
EP2417981A1 (de) 2005-07-26 2012-02-15 CMS Peptides Patent Holding Company Limited Peptid PTTKTYFPHF und seine Verwendungen
US20070031512A1 (en) * 2005-08-03 2007-02-08 Amcol International Corporation Virus-interacting layered phyllosilicates and methods of inactivating viruses
US20080184618A1 (en) * 2005-08-03 2008-08-07 Amcol International Virus-Interacting Layered Phyllosilicates and Methods of Use
US20100272769A1 (en) * 2005-08-03 2010-10-28 Amcol International Virus-, Bacteria-, and Fungi-Interacting Layered Phyllosilicates and Methods of Use
EP2395012B8 (de) 2005-11-02 2018-06-06 Arbutus Biopharma Corporation Modifizierte siRNA-Moleküle und Verwendungen davon
US8158152B2 (en) * 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
WO2008026781A1 (fr) * 2006-08-31 2008-03-06 Astellas Pharma Inc. Vésicule de lipide à ciblage inverse
JP5484059B2 (ja) * 2006-10-06 2014-05-07 エスシーアイエル テクノロジー ゲゼルシャフト ミット ベシュレンクテル ハフツング 脊髄核インプラント
EP2431043A1 (de) * 2007-05-23 2012-03-21 Amcol International Corporation Mit Cholesterin interagierende Phyllosilikate zur Unterdrückung der gastrointestinalen Cholesterinabsorption
JP5697988B2 (ja) 2007-12-27 2015-04-08 プロチバ バイオセラピューティクス インコーポレイティッド 干渉ｒｎａを使用したポロ様キナーゼ発現のサイレンシング方法
JP2011516094A (ja) 2008-04-15 2011-05-26 プロチバ バイオセラピューティクス インコーポレイティッド 干渉ｒｎａを用いたｃｓｎ５遺伝子発現のサイレンシング方法
US8871515B2 (en) * 2008-09-17 2014-10-28 Isogenis, Inc. Construction of fully-deleted adenovirus-based gene delivery vectors and uses thereof
AU2011268146A1 (en) 2010-06-17 2013-01-10 Actogenix Nv Compositions and methods for treating inflammatory conditions
CA2826594C (en) 2011-02-03 2019-09-17 The Government Of The U.S.A., As Represented By The Secretary, Department Of Health & Human Services Multivalent vaccines for rabies virus and filoviruses
AU2012340086A1 (en) 2011-11-17 2014-05-29 The Regents Of The University Of California Therapeutic RNA switches compositions and methods of use
US9035039B2 (en) 2011-12-22 2015-05-19 Protiva Biotherapeutics, Inc. Compositions and methods for silencing SMAD4
SG11201501850VA (en) 2012-09-21 2015-04-29 Intensity Therapeutics Inc Method of treating cancer
CR20170174A (es) 2014-10-02 2017-11-07 Protiva Biotherapeutics Inc Composiciones y métodos para el silenciamiento de la expresión cénica del virus de la hepatitis b
WO2016164827A1 (en) 2015-04-09 2016-10-13 Bikanta Corporation Imaging systems and methods using fluorescent nanodiamonds
WO2016197132A1 (en) 2015-06-04 2016-12-08 Protiva Biotherapeutics Inc. Treating hepatitis b virus infection using crispr
EP3329003A2 (de) 2015-07-29 2018-06-06 Arbutus Biopharma Corporation Zusammensetzungen und verfahren zur ausschaltung einer hepatitis-b-virus-genexpression
CN117942405A (zh) 2016-02-25 2024-04-30 应用生物实验室公司 保护空气传播的病原体和刺激物的组合物和方法
US20170360815A1 (en) 2016-02-25 2017-12-21 Applied Biological Laboratories, Inc. Compositions and methods for protecting against airborne pathogens and irritants
US11041170B2 (en) 2016-04-04 2021-06-22 Thomas Jefferson University Multivalent vaccines for rabies virus and coronaviruses

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4789633A (en) * 1984-04-19 1988-12-06 University Of Tennessee Research Corporation Fused liposome and acid induced method for liposome fusion
US5283122A (en) 1984-04-19 1994-02-01 University Of Tennessee Research Corporation Fused liposome and acid induced method for liposome fusion
ATE157012T1 (de) * 1989-11-03 1997-09-15 Univ Vanderbilt Verfahren zur in vivo-verabreichung von funktionsfähigen fremden genen
NZ244306A (en) 1991-09-30 1995-07-26 Boehringer Ingelheim Int Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation
US5928944A (en) * 1994-02-04 1999-07-27 The United States Of America As Represented By The Department Of Health And Human Services Method of adenoviral-medicated cell transfection

Also Published As

Publication number Publication date
CA2231172A1 (en) 1997-03-27
JPH11514349A (ja) 1999-12-07
AU6888496A (en) 1997-04-09
IL115199A0 (en) 1995-12-31
ATE219380T1 (de) 2002-07-15
US6207456B1 (en) 2001-03-27
DE69621953T2 (de) 2003-01-30
EP0879062A2 (de) 1998-11-25
IL115199A (en) 2005-05-17
AU703271B2 (en) 1999-03-25
WO1997010851A3 (en) 1997-06-05
WO1997010851A2 (en) 1997-03-27
EP0879062B1 (de) 2002-06-19

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Legal Events

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8364 No opposition during term of opposition