DE69621953D1 - Vehikel zum einbringen von nukleinsäuren in zellen - Google Patents

Vehikel zum einbringen von nukleinsäuren in zellen

Info

Publication number
DE69621953D1
DE69621953D1 DE69621953T DE69621953T DE69621953D1 DE 69621953 D1 DE69621953 D1 DE 69621953D1 DE 69621953 T DE69621953 T DE 69621953T DE 69621953 T DE69621953 T DE 69621953T DE 69621953 D1 DE69621953 D1 DE 69621953D1
Authority
DE
Germany
Prior art keywords
cells
nucleic acids
vehicle
inserting nucleic
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69621953T
Other languages
English (en)
Other versions
DE69621953T2 (de
Inventor
Moshe Baru
Israel Nur
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Opperbas Holding BV
Original Assignee
Opperbas Holding BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Opperbas Holding BV filed Critical Opperbas Holding BV
Publication of DE69621953D1 publication Critical patent/DE69621953D1/de
Application granted granted Critical
Publication of DE69621953T2 publication Critical patent/DE69621953T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69621953T 1995-09-07 1996-09-05 Vehikel zum einbringen von nukleinsäuren in zellen Expired - Lifetime DE69621953T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL11519995A IL115199A (en) 1995-09-07 1995-09-07 Composition comprising a polynucleic acid molecule in a liposome and method using said composition
PCT/IL1996/000101 WO1997010851A2 (en) 1995-09-07 1996-09-05 Nucleic acid delivery vehicle

Publications (2)

Publication Number Publication Date
DE69621953D1 true DE69621953D1 (de) 2002-07-25
DE69621953T2 DE69621953T2 (de) 2003-01-30

Family

ID=11067956

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69621953T Expired - Lifetime DE69621953T2 (de) 1995-09-07 1996-09-05 Vehikel zum einbringen von nukleinsäuren in zellen

Country Status (8)

Country Link
US (1) US6207456B1 (de)
EP (1) EP0879062B1 (de)
JP (1) JPH11514349A (de)
AT (1) ATE219380T1 (de)
CA (1) CA2231172A1 (de)
DE (1) DE69621953T2 (de)
IL (1) IL115199A (de)
WO (1) WO1997010851A2 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6890555B1 (en) * 1992-02-05 2005-05-10 Qlt, Inc. Liposome compositions of porphyrin photosensitizers
DE19605548A1 (de) * 1996-02-15 1997-09-04 Boehringer Ingelheim Int Zusammensetzung für die Transfektion höherer eukaryotischer Zellen
FR2751222B1 (fr) * 1996-07-16 1998-10-09 Capsulis Compositions contenant au moins un acide nucleique et leurs applications dans le domaine biomedical, en particulier en therapie genique
DE19740092A1 (de) * 1997-09-12 1999-03-18 Ulrich Dr Med Hengge Liposomen und Verfahren zur Transfektion von Zellen
WO1999042091A2 (en) * 1998-02-19 1999-08-26 Massachusetts Institute Of Technology Use of polycations as endosomolytic agents
US7276359B1 (en) * 1998-03-13 2007-10-02 Wyeth Polynucleotide composition, method of preparation, and use thereof
IL126681A0 (en) * 1998-10-21 1999-08-17 Opperbas Holding Bv Treatment of trauma-related conditions
US20040086558A1 (en) * 2001-02-22 2004-05-06 Moshe Baru Liposome mediated dna administration
PL208666B1 (pl) 2001-07-13 2011-05-31 Cms Peptides Patent Holding Company Ltd Środek farmaceutyczny zawierający peptyd, sposób wytwarzania środka farmaceutycznego i zastosowanie peptydu
CN1216069C (zh) * 2001-07-13 2005-08-24 一泰医药研究（深圳）有限公司 序列号25的生物活性肽
MXPA05003771A (es) * 2002-10-09 2005-06-08 Pfizer Prod Inc Composiciones estabilizadas de adn desnudo.
WO2004083244A2 (en) * 2003-03-19 2004-09-30 Isogenis, Inc. Specific inhibition of allograft rejection
TWI353252B (en) 2004-04-28 2011-12-01 Cms Peptides Patent Holding Company Ltd Biologically active peptide vapeehptllteaplnpk der
EP1778296B1 (de) * 2004-07-20 2012-06-06 Isogenis, Inc. Spezifische inhibition von autoimmunität und krankheiten im zusammenhang mit autoantigenen
US8586525B2 (en) 2005-07-26 2013-11-19 Cms Peptides Patent Holding Company Limited Biologically active peptides and their new uses
US20080184618A1 (en) * 2005-08-03 2008-08-07 Amcol International Virus-Interacting Layered Phyllosilicates and Methods of Use
US20100272769A1 (en) * 2005-08-03 2010-10-28 Amcol International Virus-, Bacteria-, and Fungi-Interacting Layered Phyllosilicates and Methods of Use
US20070031512A1 (en) * 2005-08-03 2007-02-08 Amcol International Corporation Virus-interacting layered phyllosilicates and methods of inactivating viruses
AU2006308765B2 (en) 2005-11-02 2013-09-05 Arbutus Biopharma Corporation Modified siRNA molecules and uses thereof
US8158152B2 (en) * 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
EP2058009A4 (de) * 2006-08-31 2009-10-28 Astellas Pharma Inc Reverse-targeting-lipidvesikel
KR101333279B1 (ko) * 2006-10-06 2013-11-27 에스씨아이엘 테크놀로지 게엠베하 약학적 응용을 위한 건조된 재구성 소포 형성
US8481084B2 (en) * 2007-05-23 2013-07-09 Amcol International Corporation Cholesterol-interacting layered phyllosilicates and methods of reducing hypercholesteremia in a mammal
JP5697988B2 (ja) 2007-12-27 2015-04-08 プロチバ バイオセラピューティクス インコーポレイティッド 干渉ｒｎａを使用したポロ様キナーゼ発現のサイレンシング方法
WO2009129319A2 (en) 2008-04-15 2009-10-22 Protiva Biotherapeutics, Inc. Silencing of csn5 gene expression using interfering rna
WO2010033722A2 (en) 2008-09-17 2010-03-25 Isogenis, Inc. Construction of fully-deleted adenovirus-based gene delivery vectors and uses thereof
WO2011160062A2 (en) 2010-06-17 2011-12-22 The Usa As Represented By The Secretary, National Institutes Of Health Compositions and methods for treating inflammatory conditions
EP2670843B1 (de) 2011-02-03 2014-10-29 The Government Of The U.S.A, As Represented By The Secretary, Dept. Of Health And Human Services Multivalente impfstoffe für tollwutvirus und filoviren
EP2780456A1 (de) 2011-11-17 2014-09-24 The U.S.A. as represented by the Secretary, Department of Health and Human Services Therapeutische rna schalter-zusammensetzungen und anwendungsverfahren dafür
US9035039B2 (en) 2011-12-22 2015-05-19 Protiva Biotherapeutics, Inc. Compositions and methods for silencing SMAD4
BR112015006176B1 (pt) 2012-09-21 2023-04-18 Intensity Therapeutics, Inc Uso de um agente terapêutico e de um agente de intensificação de permeação intracelular
WO2016054421A1 (en) 2014-10-02 2016-04-07 Protiva Biotherapeutics, Inc Compositions and methods for silencing hepatitis b virus gene expression
US10627340B2 (en) 2015-04-09 2020-04-21 Bikanta Corporation Imaging systems and methods using fluorescent nanodiamonds
WO2016197132A1 (en) 2015-06-04 2016-12-08 Protiva Biotherapeutics Inc. Treating hepatitis b virus infection using crispr
EP3329003A2 (de) 2015-07-29 2018-06-06 Arbutus Biopharma Corporation Zusammensetzungen und verfahren zur ausschaltung einer hepatitis-b-virus-genexpression
US20170360815A1 (en) 2016-02-25 2017-12-21 Applied Biological Laboratories, Inc. Compositions and methods for protecting against airborne pathogens and irritants
US20170246262A1 (en) 2016-02-25 2017-08-31 Applied Biological Laboratories, Inc. Compositions and methods for protecting against airborne pathogens and irritants
EP3439695B1 (de) 2016-04-04 2022-05-04 The U.S.A. as represented by the Secretary, Department of Health and Human Services Multivalente impfstoffe gegen tollwut- und coronaviren

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4789633A (en) * 1984-04-19 1988-12-06 University Of Tennessee Research Corporation Fused liposome and acid induced method for liposome fusion
US5283122A (en) 1984-04-19 1994-02-01 University Of Tennessee Research Corporation Fused liposome and acid induced method for liposome fusion
EP0800830A3 (de) 1989-11-03 1999-03-17 Vanderbilt University Verfahren zur in Vivo-Verabreichung von funktionellen fremden Genen
NZ244306A (en) * 1991-09-30 1995-07-26 Boehringer Ingelheim Int Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation
US5928944A (en) * 1994-02-04 1999-07-27 The United States Of America As Represented By The Department Of Health And Human Services Method of adenoviral-medicated cell transfection

Also Published As

Publication number Publication date
AU703271B2 (en) 1999-03-25
CA2231172A1 (en) 1997-03-27
US6207456B1 (en) 2001-03-27
EP0879062B1 (de) 2002-06-19
WO1997010851A2 (en) 1997-03-27
AU6888496A (en) 1997-04-09
DE69621953T2 (de) 2003-01-30
EP0879062A2 (de) 1998-11-25
ATE219380T1 (de) 2002-07-15
JPH11514349A (ja) 1999-12-07
IL115199A0 (en) 1995-12-31
WO1997010851A3 (en) 1997-06-05
IL115199A (en) 2005-05-17

Similar Documents

Publication Publication Date Title
DE69621953D1 (de) Vehikel zum einbringen von nukleinsäuren in zellen
ID18631A (id) Proses pembuatan asam l-amino melalui fermentasi
ID21045A (id) Asam amino termodifikasi, obat-obatan yang mengandung senyawa ini dan proses pembuatannya
ID27724A (id) Penstabil sediaan parmasi dari turunan-turunan asam gamma-aminobutira dan proses pembuatannya
EP1674571A3 (de) Verwendung von paramagnetischen Partikeln zur Reinigung und Manipulation von Nukleinsäuren
AU4567499A (en) Novel mtbx protein and nucleic acid molecules and uses therefor
ATE237312T1 (de) In liposomen verkapselte nukleinsäurekomplexe
ID21753A (id) Proses pembuatan asam asetat
HUP0001937A2 (hu) Új vegyületek, eljárás előállításukra és alkalmazásuk nukleinsavak sejtekbe való bevitelére
TR199802394A3 (tr) Proteinleri stabilize etmek için gelistirilmis proses.
AR244544A1 (es) Composicion desodorante.
WO1999025878A3 (en) Methods for modulating and identifying cellular senescence
WO1997009420A3 (en) Dna sequences coding for a human metalloproteinase and variants thereof
AU3107699A (en) Novel forms of t cell costimulatory proteins, nucleic acid molecules, and uses thereof
ID28021A (id) Proses pemisahan dan pemurnian asam adipat
AU8505898A (en) Nucleic acid compositions and methods of introducing nucleic acids into cells
IL138216A0 (en) Novel fdrg protein and nucleic acid molecules and uses therefor
ID16035A (id) PROSES PEMBUATAN ε-KAPROLAKTAM DARI ASAM 6-AMINOKAPROAT
ID17326A (id) Turunan-turunan asam 4-arilbutirat tersubstitusi sebagai inhibitor-inhibitor matriks metalloprotease
PL320084A1 (en) Nucleic acids of amino acid type
EP1071749A4 (de) Neues lrsg-protein und nukleinsäuremoleküle sowie deren verwendung
ES2189014T3 (es) Procedimiento para insomerizacion de alcoholes alilicos.
ID24609A (id) Proses pembuatan turunan asam pentenoat
AU5178698A (en) Novel serine protease inhibitor nucleic acid molecules, proteins and uses hereof
ID23337A (id) Proses pembuatan asam hidroksamat

Legal Events

Date Code Title Description
8364 No opposition during term of opposition