PT3564260T - Composições de fator viii e métodos de produção e utilização das mesmas - Google Patents

Composições de fator viii e métodos de produção e utilização das mesmas

Info

Publication number
PT3564260T
PT3564260T PT191655182T PT19165518T PT3564260T PT 3564260 T PT3564260 T PT 3564260T PT 191655182 T PT191655182 T PT 191655182T PT 19165518 T PT19165518 T PT 19165518T PT 3564260 T PT3564260 T PT 3564260T
Authority
PT
Portugal
Prior art keywords
making
methods
same
factor viii
viii compositions
Prior art date
Application number
PT191655182T
Other languages
English (en)
Original Assignee
Bioverativ Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioverativ Therapeutics Inc filed Critical Bioverativ Therapeutics Inc
Publication of PT3564260T publication Critical patent/PT3564260T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • C07K14/755Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/31Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
PT191655182T 2012-02-15 2012-07-11 Composições de fator viii e métodos de produção e utilização das mesmas PT3564260T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261599400P 2012-02-15 2012-02-15

Publications (1)

Publication Number Publication Date
PT3564260T true PT3564260T (pt) 2023-01-18

Family

ID=48984579

Family Applications (2)

Application Number Title Priority Date Filing Date
PT191655182T PT3564260T (pt) 2012-02-15 2012-07-11 Composições de fator viii e métodos de produção e utilização das mesmas
PT128684271T PT2814840T (pt) 2012-02-15 2012-07-11 Composições de fator viii e métodos de produção e utilização das mesmas

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT128684271T PT2814840T (pt) 2012-02-15 2012-07-11 Composições de fator viii e métodos de produção e utilização das mesmas

Country Status (29)

Country Link
US (3) US10421798B2 (pt)
EP (3) EP2814840B1 (pt)
JP (6) JP6256882B2 (pt)
KR (1) KR102097263B1 (pt)
CN (3) CN111548418A (pt)
AU (3) AU2012327217B2 (pt)
BR (1) BR112014020694A2 (pt)
CA (1) CA2864904C (pt)
CL (2) CL2014002166A1 (pt)
CO (1) CO7051009A2 (pt)
CY (1) CY1122800T1 (pt)
DK (2) DK3564260T3 (pt)
EA (1) EA201491470A1 (pt)
ES (2) ES2935489T3 (pt)
FI (1) FI3564260T3 (pt)
HK (1) HK1204330A1 (pt)
HR (2) HRP20221531T1 (pt)
HU (2) HUE046848T2 (pt)
IL (1) IL234108B (pt)
LT (2) LT2814840T (pt)
MX (2) MX369862B (pt)
MY (1) MY188897A (pt)
PH (2) PH12014501849A1 (pt)
PL (2) PL2814840T3 (pt)
PT (2) PT3564260T (pt)
RS (2) RS59833B1 (pt)
SG (2) SG10201606783RA (pt)
SI (2) SI3564260T1 (pt)
WO (1) WO2013122617A1 (pt)

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CN104271150A (zh) 2012-01-12 2015-01-07 比奥根艾迪克Ma公司 嵌合因子viii多肽及其用途
EP2822577B1 (en) 2012-02-15 2019-02-06 Bioverativ Therapeutics Inc. Recombinant factor viii proteins
LT2814840T (lt) 2012-02-15 2020-02-25 Bioverativ Therapeutics Inc. Faktoriaus viii kompozicijos ir jų gavimo ir naudojimo būdai
WO2013130683A2 (en) 2012-02-27 2013-09-06 Amunix Operating Inc. Xten conjugate compositions and methods of making same
PT2882450T (pt) 2012-07-11 2020-02-19 Bioverativ Therapeutics Inc Complexo de fator viii com xten e a proteína fator de von willebrand, e utilizações do mesmo
DK3889173T3 (da) 2013-02-15 2023-10-09 Bioverativ Therapeutics Inc Optimeret faktor viii-gen
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EP3013359A4 (en) * 2013-06-28 2017-01-25 Biogen MA Inc. Thrombin cleavable linker
MX2015016567A (es) * 2013-06-28 2016-03-31 Biogen Ma Inc Enlazador escindible por trombina con xten y usos del mismo.
EP3033098B1 (en) * 2013-08-14 2022-06-22 Bioverativ Therapeutics Inc. Recombinant factor viii proteins
EP3033097B1 (en) 2013-08-14 2021-03-10 Bioverativ Therapeutics Inc. Factor viii-xten fusions and uses thereof
DK4176894T3 (da) * 2014-01-10 2024-05-27 Bioverativ Therapeutics Inc Kimære faktor viii-proteiner og anvendelser deraf
WO2016004113A1 (en) 2014-06-30 2016-01-07 Biogen Ma Inc. Optimized factor ix gene
WO2016198521A1 (en) * 2015-06-10 2016-12-15 Novo Nordisk A/S Fviii fusion proteins
AU2016301303B2 (en) 2015-08-03 2021-10-07 Bioverativ Therapeutics Inc. Factor IX fusion proteins and methods of making and using same
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CA3005565A1 (en) * 2015-11-13 2017-05-18 Baxalta Incorporated Viral vectors encoding recombinant fviii variants with increased expression for gene therapy of hemophilia a
AU2016353353B2 (en) * 2015-11-13 2020-07-09 Takeda Pharmaceutical Company Limited Viral vectors encoding recombinant FVIII variants with increased expression for gene therapy of hemophilia A
PT3411478T (pt) 2016-02-01 2022-09-13 Bioverativ Therapeutics Inc Genes do fator viii otimizados
WO2017197048A1 (en) * 2016-05-11 2017-11-16 Amunix Operating Inc. Albumin binding conjugate compositions and methods of making and using same
EP3548066A1 (en) 2016-12-02 2019-10-09 Bioverativ Therapeutics Inc. Methods of treating hemophilic arthropathy using chimeric clotting factors
BR112019011198A2 (pt) 2016-12-02 2019-12-17 Bioverativ Therapeutics Inc métodos de indução de tolerância imune a fatores de coagulação
CA3068121A1 (en) * 2017-06-23 2018-12-27 Baxalta Incorporated Purification of factor viii subspecies
CN107392315B (zh) * 2017-07-07 2021-04-09 中南大学 一种优化大脑情感学习模型的乳腺癌数据分类方法
FR3069540B1 (fr) * 2017-07-28 2019-09-13 Universite Claude Bernard Lyon 1 Proteine modifiee avec demi-vie amelioree
SG11202000764RA (en) 2017-08-09 2020-02-27 Bioverativ Therapeutics Inc Nucleic acid molecules and uses thereof
BR112020015228A2 (pt) 2018-02-01 2020-12-29 Bioverativ Therapeutics Inc. Uso de vetores lentivirais que expressam fator viii
AU2019270184A1 (en) 2018-05-18 2020-11-26 Bioverativ Therapeutics Inc. Methods of treating hemophilia A
MX2021001599A (es) 2018-08-09 2021-07-02 Bioverativ Therapeutics Inc Moleculas de acido nucleico y sus usos para la terapia genica no viral.
JP2022512787A (ja) * 2018-10-23 2022-02-07 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア 第viii因子機能を調節するための組成物および方法
TW202039546A (zh) 2019-01-16 2020-11-01 美商巴克斯歐塔公司 用於a型血友病基因治療之編碼表現增加之重組fviii變異體的病毒載體
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JP2022520998A (ja) * 2019-02-22 2022-04-04 アンウィタ バイオサイエンシス, インク. アルブミン結合抗体及びその使用
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EP3986444A1 (en) 2019-06-19 2022-04-27 Bioverativ Therapeutics Inc. Recombinant factor viii-fc for treating hemophilia and low bone mineral density
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BR112022026127A2 (pt) 2020-06-24 2023-01-17 Bioverativ Therapeutics Inc Métodos para remoção de fator viii livre de preparações de vetores lentivirais modificados para expressar referida proteína
CN115925994B (zh) 2020-09-30 2023-09-22 北京质肽生物医药科技有限公司 多肽缀合物和使用方法
WO2022226048A1 (en) * 2021-04-21 2022-10-27 The Children's Hospital Of Philadelphia Immune tolerance induction and eradication of anti-drug antibodies (ada) to therapeutic factor viii
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