DK0461200T3 - Modificerede former af reproduktionshormoner - Google Patents

Modificerede former af reproduktionshormoner

Info

Publication number
DK0461200T3
DK0461200T3 DK90905115.3T DK90905115T DK0461200T3 DK 0461200 T3 DK0461200 T3 DK 0461200T3 DK 90905115 T DK90905115 T DK 90905115T DK 0461200 T3 DK0461200 T3 DK 0461200T3
Authority
DK
Denmark
Prior art keywords
modified forms
reproductive hormones
hormones
reproductive
muteins
Prior art date
Application number
DK90905115.3T
Other languages
English (en)
Inventor
Irving Boime
Jeffrey L Keene
Martin M Matzuk
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Application granted granted Critical
Publication of DK0461200T3 publication Critical patent/DK0461200T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
    • C07K2319/91—Fusion polypeptide containing a motif for post-translational modification containing a motif for glycosylation
DK90905115.3T 1989-02-21 1990-02-20 Modificerede former af reproduktionshormoner DK0461200T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31364689A 1989-02-21 1989-02-21

Publications (1)

Publication Number Publication Date
DK0461200T3 true DK0461200T3 (da) 1997-03-10

Family

ID=23216537

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90905115.3T DK0461200T3 (da) 1989-02-21 1990-02-20 Modificerede former af reproduktionshormoner

Country Status (12)

Country Link
US (5) US5177193A (da)
EP (1) EP0461200B1 (da)
JP (1) JP3045539B2 (da)
AT (1) ATE148171T1 (da)
AU (2) AU648020B2 (da)
CA (1) CA2053864C (da)
DE (2) DE122010000006I2 (da)
DK (1) DK0461200T3 (da)
ES (1) ES2098261T3 (da)
LU (1) LU91648I2 (da)
NL (1) NL300434I1 (da)
WO (1) WO1990009800A1 (da)

Families Citing this family (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260421A (en) * 1987-12-21 1993-11-09 Applied Research Systems Ars Holding N.V. Site-directed mutagenesis modified glycoprotein hormones
US5792460A (en) * 1989-02-21 1998-08-11 Washington University Modified glycoprotein hormones having a CTP at the amino terminus
US6225449B1 (en) * 1991-10-04 2001-05-01 Washington University Hormone analogs with multiple CTP extensions
US5705478A (en) * 1989-02-21 1998-01-06 Washington University Covalently linked β subunits of the glycoprotein hormones as antagonists
US5240832A (en) * 1989-06-20 1993-08-31 Genzyme Corporation Heteropolymeric protein production methods
EP0673383B1 (en) * 1991-06-18 2000-05-31 University Of Medicine & Dentistry Of New Jersey Analogs of glycoprotein hormones having altered receptor binding specificity and activity and methods for preparing and using same
US6028177A (en) * 1991-10-04 2000-02-22 Washington University Methods of detecting single-chain forms of the glycoprotein hormone quartet
US5985611A (en) * 1992-04-30 1999-11-16 Washington University Recombinant production of gonadotropins in secretory cells
WO1994024148A1 (en) * 1993-04-20 1994-10-27 Washington University Modified protein and peptide pharmaceuticals
US5643745A (en) * 1994-02-03 1997-07-01 University Of Hawaii Heterologous dimeric proteins produced in heterokaryons
US5683899A (en) * 1994-02-03 1997-11-04 University Of Hawaii Methods and compositions for combinatorial-based discovery of new multimeric molecules
US6238890B1 (en) 1994-02-18 2001-05-29 Washington University Single chain forms of the glycoprotein hormone quartet
GB9403600D0 (en) * 1994-02-24 1994-04-13 Univ Glasgow Three dimensional hormone structure
AU2603995A (en) * 1994-05-25 1995-12-18 University Of Nebraska Board Of Regents Biologically active glycoprotein hormones produced in procaryotic cells
AU703718B2 (en) * 1994-08-12 1999-04-01 Washington University Single-chain forms of the glycoprotein hormone quartet
BR9506313A (pt) * 1994-08-12 1997-08-05 Univ Washington Formas de cadeia simples do quarteto de hormônio de glicoproteína
US5733735A (en) * 1996-06-11 1998-03-31 Washington University Assay system to determine receptor antagonist target site
TW518235B (en) * 1997-01-15 2003-01-21 Akzo Nobel Nv A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage
US5883073A (en) * 1997-04-03 1999-03-16 Washington University Single-chain double-alpha peptide
EP1816199A1 (en) * 1997-09-22 2007-08-08 University of Maryland at Baltimore Mutants of thyroid stimulating hormone and methods based thereon
US6635256B1 (en) 1998-10-19 2003-10-21 Washington University Glycoprotein hormone compositions comprising two β subunits and methods of use thereof
US6103501A (en) * 1997-11-17 2000-08-15 Washington University Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof
JP2002524514A (ja) 1998-09-17 2002-08-06 イーライ・リリー・アンド・カンパニー タンパク質製剤
TWI277425B (en) 1999-04-13 2007-04-01 Lilly Co Eli Pulmonary administration of dry powder formulations for treating infertility
CN100480258C (zh) * 2000-02-22 2009-04-22 雪兰诺实验室有限公司 纯化的黄体生成激素
EA006605B1 (ru) 2000-02-22 2006-02-24 Апплайд Резеч Системз Арс Холдинг Н.В. СПОСОБ ОЧИСТКИ РЕКОМБИНАНТНОГО чХГ
US7514239B2 (en) * 2000-03-28 2009-04-07 Amgen Inc. Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof
JP2001333772A (ja) 2000-04-25 2001-12-04 Washington Univ 可変性の活性を有する単鎖稔性ホルモン
US20040005554A1 (en) * 2000-05-08 2004-01-08 Tayar Nabil El Novel glycoproteins and methods of use thereof
US6493964B1 (en) 2000-05-25 2002-12-17 Tousimis Research Corp. Supercritical point drying apparatus for semiconductor device manufacturing and bio-medical sample processing
ATE320449T1 (de) * 2000-12-11 2006-04-15 Cheil Jedang Corp Fusionsprotein mit verbesserter in vivo erythropoietinwirkung
KR101229995B1 (ko) * 2000-12-11 2013-02-06 씨제이 주식회사 생체내 에리스로포이에틴 활성이 증진된 융합단백질
US6987172B2 (en) 2001-03-05 2006-01-17 Washington University In St. Louis Multifunctional single chain glycoprotein hormones comprising three or more β subunits
US6573237B2 (en) 2001-03-16 2003-06-03 Eli Lilly And Company Protein formulations
WO2003040695A2 (en) * 2001-11-08 2003-05-15 Moyle William R Protein knobs
KR100467750B1 (ko) * 2001-11-29 2005-01-24 씨제이 주식회사 생체내 에리스로포이에틴 활성이 증진된 융합단백질
KR100467751B1 (ko) * 2001-12-03 2005-01-24 씨제이 주식회사 생체내 에리스로포이에틴 활성이 증진된 융합단백질
US7081446B2 (en) * 2002-01-31 2006-07-25 The Trustees Of Columbia University In The City Of New York Long-acting follicle stimulating hormone analogues and uses thereof
US7173113B2 (en) * 2002-01-31 2007-02-06 The Trustees Of Columbia University In The City Of New York Long-acting hormone and growth factor compositions and uses thereof
CA2485365A1 (en) * 2002-05-13 2003-11-20 Modigenetech Ltd. Ctp-extended erythropoietin
US20060177894A1 (en) * 2002-11-08 2006-08-10 Moyle William R Protein knobs
EP1610803B8 (en) 2003-03-04 2011-09-14 AspenBio Pharma, Inc. LH for use in maintaining one or more pregnancies by inducing accessory corpus luteum formation.
JP4718459B2 (ja) * 2003-07-25 2011-07-06 メルク セローノ ソシエテ アノニム 雄性の精子染色体異常の減少のための卵胞刺激ホルモンの使用
UA88879C2 (en) * 2003-09-02 2009-12-10 Эплайд Рисерч Системз Эрс Холдинг Н.В. Fsh glycosylation mutant
AU2004287645A1 (en) * 2003-11-06 2005-05-19 Compugen Ltd. Variants of human glycoprotein hormone alpha chain: compositions and uses thereof
JP4412989B2 (ja) * 2003-12-15 2010-02-10 株式会社日立製作所 複数の記憶システムを有するデータ処理システム
US20050220640A1 (en) * 2004-04-02 2005-10-06 Finkenbinder David B Fan motor assembly with noise suppression
US20060052303A1 (en) * 2004-07-27 2006-03-09 Sampath Kuber T Use of thyrotropin for regeneration of bone
JP5735194B2 (ja) 2005-01-25 2015-06-17 セル セラピューティクス インコーポレーテッド 改善された生体内半減期を有する生物学的に活性なタンパク質
US20080039372A1 (en) * 2005-07-21 2008-02-14 The Trustees Of Columbia University In The City Of New York Human chorionic gonadotropin antagonists and methods to prevent ovarian hyperstimulation
DK1917276T3 (da) * 2005-08-26 2018-05-07 Ares Trading Sa Fremgangsmåde til fremstilling af glycosyleret Interferon Beta
AU2006323925B2 (en) * 2005-12-09 2012-08-02 Ares Trading S.A. Method for purifying FSH or a FSH mutant
US8450269B2 (en) 2006-02-03 2013-05-28 Prolor Biotech Ltd. Long-acting growth hormone and methods of producing same
US20140113860A1 (en) 2006-02-03 2014-04-24 Prolor Biotech Ltd. Long-acting polypeptides and methods of producing and administering same
US8476234B2 (en) * 2006-02-03 2013-07-02 Prolor Biotech Inc. Long-acting coagulation factors and methods of producing same
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US7553940B2 (en) 2006-02-03 2009-06-30 Modigene Inc Long-acting EPO polypeptides and derivatives thereof and methods thereof
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US8048848B2 (en) 2006-02-03 2011-11-01 Prolor Biotech Ltd. Long-acting interferons and derivatives thereof and methods thereof
US8048849B2 (en) 2006-02-03 2011-11-01 Modigene, Inc. Long-acting polypeptides and methods of producing same
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
US8304386B2 (en) * 2006-02-03 2012-11-06 Prolor Biotech, Inc. Long-acting growth hormone and methods of producing same
US8759292B2 (en) 2006-02-03 2014-06-24 Prolor Biotech, Llc Long-acting coagulation factors and methods of producing same
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US20070281883A1 (en) * 2006-06-05 2007-12-06 Hanna Rosenfeld Development of follicle stimulating hormone agonists and antagonists in fish
EP2203474A1 (en) * 2007-10-22 2010-07-07 Merck Serono S.A. Method for purifying fc-fusion proteins
US20100256337A1 (en) * 2007-10-22 2010-10-07 Merck Serono Sa Method for purifying an fc-containing protein
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
WO2011028228A1 (en) 2009-08-24 2011-03-10 Amunix Operating Inc. Coagulation factor vii compositions and methods of making and using same
AR081755A1 (es) 2010-04-02 2012-10-17 Hanmi Holdings Co Ltd Formulacion de accion prolongada de la hormona estimuladora de los foliculos donde se usa un fragmento de inmunoglobulina, metodo de preparacion y metodo para tratar a un sujeto que sufre un trastorno reproductivo
PL2717898T3 (pl) 2011-06-10 2019-06-28 Bioverativ Therapeutics Inc. Związki o działaniu prokoagulacyjnym i sposoby ich stosowania
EP3513804B1 (en) 2011-07-08 2022-03-23 Bioverativ Therapeutics Inc. Factor viii chimeric and hybrid polypeptides, and methods of use thereof
AU2012286048A1 (en) 2011-07-18 2014-02-20 Arts Biologics A/S Long acting luteinizing hormone (LH) compound
DK2822576T3 (da) 2012-02-14 2018-04-16 Opko Biologics Ltd Langtidsvirkende koagulationsfaktorer og fremgangsmåder til fremstilling heraf
NZ628014A (en) 2012-02-15 2016-09-30 Biogen Ma Inc Recombinant factor viii proteins
CN104487452A (zh) 2012-02-15 2015-04-01 阿穆尼克斯运营公司 因子viii组合物及其制备和使用方法
MY167814A (en) 2012-04-19 2018-09-26 Opko Biologics Ltd Long-acting oxyntomodulin variants and methods of producing same
JP2015525222A (ja) 2012-06-08 2015-09-03 バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． キメラ性凝固因子
US10287564B2 (en) 2012-06-08 2019-05-14 Bioverativ Therapeutics Inc. Procoagulant compounds
WO2014008480A2 (en) 2012-07-06 2014-01-09 Biogen Idec Ma Inc. Cell line expressing single chain factor viii polypeptides and uses thereof
EP2908847B1 (en) 2012-10-18 2022-03-30 Bioverativ Therapeutics Inc. Methods of using a fixed dose of a clotting factor
WO2014070953A1 (en) 2012-10-30 2014-05-08 Biogen Idec Ma Inc. Methods of Using FVIII Polypeptide
KR102341581B1 (ko) 2012-11-20 2021-12-21 옵코 바이오로직스 리미티드 생식샘자극 호르몬 카복시 말단 펩타이드들과 부착하여 폴리펩타이드들의 유체역학적 부피를 증가시키는 방법
CN103509121B (zh) 2012-11-22 2015-01-28 苏州康宁杰瑞生物科技有限公司 一种fsh融合蛋白及其制备方法和用途
CA2890048C (en) 2012-12-03 2022-05-03 Merck Sharp & Dohme Corp. O-glycosylated carboxy terminal portion (ctp) peptide-based insulin and insulin analogues
HUE063051T2 (hu) 2013-02-15 2023-12-28 Bioverativ Therapeutics Inc Optimalizált VIII. faktor gén
US20160024181A1 (en) 2013-03-13 2016-01-28 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
AU2014228938B2 (en) 2013-03-15 2019-05-02 Bioverativ Therapeutics Inc. Factor IX polypeptide formulations
US9623088B2 (en) 2013-03-15 2017-04-18 Bioverativ Therapeutics Inc. Factor VIII polypeptide formulations
US20160311885A1 (en) 2013-08-14 2016-10-27 Biogen Ma Inc. Recombinant factor viii proteins
EP3033097B1 (en) 2013-08-14 2021-03-10 Bioverativ Therapeutics Inc. Factor viii-xten fusions and uses thereof
US20150158926A1 (en) 2013-10-21 2015-06-11 Opko Biologics, Ltd. Long-acting polypeptides and methods of producing and administering same
KR20160068969A (ko) 2013-10-21 2016-06-15 옵코 바이오로직스 리미티드 장시간-작용하는 폴리펩티드, 그의 생산 방법, 및 그의 투여 방법
CN103539860B (zh) * 2013-11-01 2014-12-03 广州优联康医药科技有限公司 一种长效重组人促卵泡激素融合蛋白
EP3065769A4 (en) 2013-11-08 2017-05-31 Biogen MA Inc. Procoagulant fusion compound
US10325687B2 (en) 2013-12-06 2019-06-18 Bioverativ Therapeutics Inc. Population pharmacokinetics tools and uses thereof
MA39779A (fr) 2014-03-24 2017-02-01 Biogen Ma Inc Formulations de facteur ix lyophilisées
EP3160478A4 (en) 2014-06-30 2018-05-16 Bioverativ Therapeutics Inc. Optimized factor ix gene
EA201700181A1 (ru) 2014-10-14 2017-09-29 Галозим, Инк. Композиции аденозиндеаминазы-2 (ада-2), их варианты и способы использования
MA40835A (fr) 2014-10-23 2017-08-29 Biogen Ma Inc Anticorps anti-gpiib/iiia et leurs utilisations
MA40861A (fr) 2014-10-31 2017-09-05 Biogen Ma Inc Anticorps anti-glycoprotéines iib/iiia
EP3230309B1 (en) 2014-12-10 2023-03-29 OPKO Biologics Ltd. Methods of producing long acting ctp-modified growth hormone polypeptides
WO2016203482A2 (en) 2015-06-19 2016-12-22 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
EA201890423A1 (ru) 2015-08-03 2018-07-31 Биовератив Терапьютикс Инк. Слитые белки фактора ix, способы их получения и применения
SG10201913278PA (en) 2016-02-01 2020-02-27 Bioverativ Therapeutics Inc Optimized factor viii genes
EP4303228A3 (en) 2016-07-11 2024-03-13 OPKO Biologics Ltd. Long-acting coagulation factor vii and methods of producing same
CN110520150A (zh) 2016-12-02 2019-11-29 比奥维拉迪维治疗股份有限公司 使用嵌合凝血因子治疗血友病性关节病的方法
US20200085915A1 (en) 2016-12-02 2020-03-19 Bioverativ Therapeutics Inc. Methods of inducing immune tolerance to clotting factors
WO2018112362A1 (en) 2016-12-16 2018-06-21 Biogen Ma Inc. Stabilized proteolytically activated growth differentiation factor 11
EA201991768A1 (ru) 2017-01-31 2020-01-22 Байоверетив Терапьютикс Инк. Слитые белки на основе фактора ix и способы их получения и пути применения
SG11202000764RA (en) 2017-08-09 2020-02-27 Bioverativ Therapeutics Inc Nucleic acid molecules and uses thereof
EP3746136A1 (en) 2018-02-01 2020-12-09 Bioverativ Therapeutics Inc. Use of lentiviral vectors expressing factor viii
WO2019211842A1 (en) 2018-04-30 2019-11-07 Opko Biologics Ltd. Long-acting human growth hormone-antagonists and methods of producing the same
KR20210020030A (ko) 2018-05-18 2021-02-23 바이오버라티브 테라퓨틱스 인크. A형 혈우병의 치료 방법
CN108676096B (zh) * 2018-05-22 2022-03-29 北京伟杰信生物科技有限公司 重组猪fsh-ctp融合蛋白及其制备方法与应用
AU2019319984A1 (en) 2018-08-09 2021-03-04 Bioverativ Therapeutics Inc. Nucleic acid molecules and uses thereof for non-viral gene therapy
KR20210100661A (ko) 2018-12-06 2021-08-17 바이오버라티브 테라퓨틱스 인크. 인자 ix를 발현하는 렌티바이러스 벡터의 용도
US11254530B2 (en) * 2019-03-26 2022-02-22 Toshiba Tec Kabushiki Kaisha Sheet aligning mechanism
BR112021022860A2 (pt) 2019-05-16 2022-01-18 Ceva Sante Animale Composições e métodos para aumentar o desempenho da reprodução em mamíferos não humanos com uso de hormônio luteinizante recombinante
WO2021005604A1 (en) 2019-07-11 2021-01-14 Opko Biologics Ltd. Long-acting igf-1 or igf-1 variants and methods of producing same
US20210113634A1 (en) 2019-09-30 2021-04-22 Bioverativ Therapeutics Inc. Lentiviral vector formulations
JP2023538533A (ja) 2020-08-07 2023-09-08 ブリストル－マイヤーズ スクイブ カンパニー 線維症の処置のための、ｃｃｒ２／５拮抗剤と組み合わせたｆｇｆ２１
WO2022115597A1 (en) 2020-11-25 2022-06-02 Bristol-Myers Squibb Company Methods of treating liver diseases

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4302386A (en) * 1978-08-25 1981-11-24 The Ohio State University Antigenic modification of polypeptides
JPS5781447A (en) * 1980-11-11 1982-05-21 Toyo Jozo Co Ltd Human chorionic gonadotropic hormone c-terminal fragment
US4746508A (en) * 1983-06-06 1988-05-24 Beth Israel Hospital Assn. Drug administration
US4840896A (en) * 1983-11-02 1989-06-20 Integrated Genetics, Inc. Heteropolymeric protein
EP0578328B1 (en) * 1983-11-02 1999-12-29 Applied Research Systems ARS Holding N.V. Material and methods for the production of a heterodimeric human LH with a Met42 Val55 alpha subunit
US4923805A (en) * 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
US4668476A (en) * 1984-03-23 1987-05-26 Applied Biosystems, Inc. Automated polypeptide synthesis apparatus
US4879226A (en) * 1984-04-06 1989-11-07 Asahi Kasei Kogyo Kabushiki Kaisha Novel human physiologically active polypeptide
US4717670A (en) * 1984-06-08 1988-01-05 Integrated Genetics, Inc. Porcine beta FSH
NZ213759A (en) * 1984-10-19 1989-01-27 Genentech Inc Lhrh-ctp protein conjugates influencing prolactin fsh and lh release
CA1239346A (en) * 1985-06-04 1988-07-19 Gursaran P. Talwar Birth control vaccine
US4855285A (en) * 1985-12-04 1989-08-08 The Ohio State University Research Foundation Antigenic modification of polypeptides
US4959455A (en) * 1986-07-14 1990-09-25 Genetics Institute, Inc. Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
US4804626A (en) * 1986-10-22 1989-02-14 The General Hospital Corporation Immunometric assay for the detection of human chorionic gonadotropin
US4780451B1 (en) * 1987-01-23 1995-04-04 Asua International Inc Composition and method for producing superovulation in cattle
US6225449B1 (en) 1991-10-04 2001-05-01 Washington University Hormone analogs with multiple CTP extensions
US5043270A (en) * 1989-03-31 1991-08-27 The Board Of Trustees Of The Leland Stanford Junior University Intronic overexpression vectors

Also Published As

Publication number Publication date
US5405945A (en) 1995-04-11
NL300434I1 (nl) 2010-04-01
AU648020B2 (en) 1994-04-14
CA2053864A1 (en) 1990-08-22
DE122010000006I2 (de) 2012-06-21
US6306654B1 (en) 2001-10-23
US5585345A (en) 1996-12-17
EP0461200A1 (en) 1991-12-18
ATE148171T1 (de) 1997-02-15
JPH04503606A (ja) 1992-07-02
AU670510B2 (en) 1996-07-18
EP0461200A4 (en) 1992-11-19
US5712122A (en) 1998-01-27
AU5332790A (en) 1990-09-26
JP3045539B2 (ja) 2000-05-29
AU697899B2 (en) 1998-10-22
AU6747494A (en) 1994-09-29
US5177193A (en) 1993-01-05
LU91648I2 (fr) 2010-04-06
WO1990009800A1 (en) 1990-09-07
ES2098261T3 (es) 1997-05-01
CA2053864C (en) 2001-11-20
DE69029799D1 (de) 1997-03-06
DE122010000006I1 (de) 2010-05-06
EP0461200B1 (en) 1997-01-22
AU6581996A (en) 1997-01-16
DE69029799T2 (de) 1997-05-28

Similar Documents

Publication Publication Date Title
DK0461200T3 (da) Modificerede former af reproduktionshormoner
LU90806I2 (fr) Ovidrelle-choriogonadotropine alfa et ses d-riv-s pharmaceutiquement acceptables
ATE254095T1 (de) Selektive analoge der thyroidhormone
ES2052829T3 (es) Aminoetiltetralinas substituidas asi como sus analogos heterociclicos.
DE3888385D1 (de) Projektionsschirm mit hoher Auflösung und guter mechanischer Stabilität.
IT8050466A0 (it) Composizione ad attivita' ormonica a base di complessi con destrine eprocedimento per prepararne l'ingre diente attivo
DK0620728T3 (da) Fremstilling af tabletter med forøget styrke
ES2020890A6 (es) Procedimiento de preparacion de una composicion farmaceutica en forma de microparticulas.
NO911116D0 (no) Ildfastmateriale med lavt sementinnhold.
DE69033603T2 (de) Antagonisten von wachstumshormonen
FR2300573A1 (fr) Composition pharmaceutique a base de gonadotrophine chorionique humaine partiellement desialylee
DE69529674T2 (de) Biologisch aktive ligande der eph familie
DE69528531T2 (de) D-2-alkyltryptophan enthaltende polypeptide mit wachstumhormon freisetzender aktivitaet
IT8441570A0 (it) Derivati dell'urochinasi ad azione farmacologica.
DK13087D0 (da) Gensekvens til fremstilling af human serumalbumin i bacillus
DK420589D0 (da) Syntetiske peptider, der er immunokemisk reaktionsdygtige med hiv-antistoffer
DK527287D0 (da) Polypeptid med interleukin-2-aktiviteter
NO912072D0 (no) Rekombinante proteiner med adipsin- og komplement-d-aktiviteter.
DK346387A (da) Fremgangsmaade til at reducere alkaliindholdet i cementklinker
Bosnoyan Role of interleukin-2 and interleukin-2 receptor in B cell proliferation
DK438889A (da) Syntetiske polypeptider, der er immunokemisk reaktionsdygtige med hiv-antistoffer
Seisser WUNSIEDEL DISTRICT SETS OFF TO A NEW AGE
BR6802090U (pt) Mesa de snooker com os pes retrateis
ES247125U (es) Lampara orientable de mesa
MX9203427A (es) Nuevos derivados 2-((2,6-diclorofenil)amina) fenilacetoxiacetilo, procesos para prepararlos y su uso en terapeutica.