DE69029799D1 - Modifizierte formen von fortpflanzungshormonen - Google Patents

Modifizierte formen von fortpflanzungshormonen

Info

Publication number
DE69029799D1
DE69029799D1 DE69029799T DE69029799T DE69029799D1 DE 69029799 D1 DE69029799 D1 DE 69029799D1 DE 69029799 T DE69029799 T DE 69029799T DE 69029799 T DE69029799 T DE 69029799T DE 69029799 D1 DE69029799 D1 DE 69029799D1
Authority
DE
Germany
Prior art keywords
hormones
reproduction
modified forms
muteins
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69029799T
Other languages
English (en)
Other versions
DE69029799T2 (de
Inventor
Irving Boime
Martin Matzuk
Jeffrey Keene
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Washington University in St Louis WUSTL
Original Assignee
University of Washington
Washington University in St Louis WUSTL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Washington University in St Louis WUSTL filed Critical University of Washington
Publication of DE69029799D1 publication Critical patent/DE69029799D1/de
Application granted granted Critical
Publication of DE69029799T2 publication Critical patent/DE69029799T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
    • C07K2319/91—Fusion polypeptide containing a motif for post-translational modification containing a motif for glycosylation
DE69029799T 1989-02-21 1990-02-20 Modifizierte formen von fortpflanzungshormonen Expired - Lifetime DE69029799T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31364689A 1989-02-21 1989-02-21
PCT/US1990/001037 WO1990009800A1 (en) 1989-02-21 1990-02-20 Modified forms of reproductive hormones

Publications (2)

Publication Number Publication Date
DE69029799D1 true DE69029799D1 (de) 1997-03-06
DE69029799T2 DE69029799T2 (de) 1997-05-28

Family

ID=23216537

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69029799T Expired - Lifetime DE69029799T2 (de) 1989-02-21 1990-02-20 Modifizierte formen von fortpflanzungshormonen
DE201012000006 Active DE122010000006I2 (de) 1989-02-21 1990-02-20 Modifizierte formen von fortpflanzungshormonen.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE201012000006 Active DE122010000006I2 (de) 1989-02-21 1990-02-20 Modifizierte formen von fortpflanzungshormonen.

Country Status (12)

Country Link
US (5) US5177193A (de)
EP (1) EP0461200B1 (de)
JP (1) JP3045539B2 (de)
AT (1) ATE148171T1 (de)
AU (2) AU648020B2 (de)
CA (1) CA2053864C (de)
DE (2) DE69029799T2 (de)
DK (1) DK0461200T3 (de)
ES (1) ES2098261T3 (de)
LU (1) LU91648I2 (de)
NL (1) NL300434I1 (de)
WO (1) WO1990009800A1 (de)

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US5177193A (en) 1993-01-05
AU6747494A (en) 1994-09-29
NL300434I1 (nl) 2010-04-01
DE69029799T2 (de) 1997-05-28
AU6581996A (en) 1997-01-16
LU91648I2 (fr) 2010-04-06
EP0461200A1 (de) 1991-12-18
US5585345A (en) 1996-12-17
DE122010000006I2 (de) 2012-06-21
AU648020B2 (en) 1994-04-14
ES2098261T3 (es) 1997-05-01
WO1990009800A1 (en) 1990-09-07
EP0461200A4 (en) 1992-11-19
CA2053864A1 (en) 1990-08-22
US6306654B1 (en) 2001-10-23
AU5332790A (en) 1990-09-26
ATE148171T1 (de) 1997-02-15
US5405945A (en) 1995-04-11
JPH04503606A (ja) 1992-07-02
DE122010000006I1 (de) 2010-05-06
US5712122A (en) 1998-01-27
CA2053864C (en) 2001-11-20
DK0461200T3 (da) 1997-03-10
JP3045539B2 (ja) 2000-05-29
EP0461200B1 (de) 1997-01-22
AU670510B2 (en) 1996-07-18
AU697899B2 (en) 1998-10-22

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