CY1123197T1 - Μεθοδοι παρασκευης πολυνουκλεοτιδιου με χρηση χημικων συνθεσεων πολυσθενους αλατος κατιοντων - Google Patents
Μεθοδοι παρασκευης πολυνουκλεοτιδιου με χρηση χημικων συνθεσεων πολυσθενους αλατος κατιοντωνInfo
- Publication number
- CY1123197T1 CY1123197T1 CY20201100632T CY201100632T CY1123197T1 CY 1123197 T1 CY1123197 T1 CY 1123197T1 CY 20201100632 T CY20201100632 T CY 20201100632T CY 201100632 T CY201100632 T CY 201100632T CY 1123197 T1 CY1123197 T1 CY 1123197T1
- Authority
- CY
- Cyprus
- Prior art keywords
- polynucleotide
- salt
- chemical composition
- chemical compositions
- polystene
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
- C12N15/101—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by chromatography, e.g. electrophoresis, ion-exchange, reverse phase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/314—Phosphoramidates
- C12N2310/3145—Phosphoramidates with the nitrogen in 3' or 5'-position
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07049—RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Πτυχές της γνωστοποίησης περιλαμβάνουν μεθόδους για την παρασκευή ενός πολυνουκλεοτιδίου. Σε μερικές υλοποιήσεις, η μέθοδος περιλαμβάνει την επαφή μιας πρώτης χημικής σύνθεσης πολυνουκλεοτιδίου, η οποία περιλαμβάνει: ένα πολυνουκλεοτίδιο το οποίο έχει μια αλληλουχία 7 ή περισσοτέρων υπομονάδων νουκλεοζίτη και τουλάχιστον δύο εκ των υπομονάδων νουκλεοζίτη είναι ενωμένες με μια θειοφωσφοραμιδική συνένωση Ν3'→ Ρ5' μεταξύ των υπομονάδων• και συνθετικά προϊόντα και αντιδραστήρια μη στόχοι• με ένα πολυσθενές άλας κατιόντων ώστε να καθιζάνει ένα άλας πολυνουκλεοτιδίου συμπεριλαμβανομένου τουλάχιστον ενός ιόντος αντίθετου φορτίου πολυσθενούς κατιόντος• και το διαχωρισμό του άλατος πολυνουκλεοτιδίου από την πρώτη χημική σύνθεση πολυνουκλεοτιδίου με την οποία έρχεται σε επαφή, για την παραγωγή μιας δεύτερης χημικής σύνθεσης πολυνουκλεοτιδίου, συμπεριλαμβανομένου του άλατος πολυνουκλεοτιδίου. Σε ορισμένες υλοποιήσεις, η μέθοδος περιλαμβάνει περαιτέρω την επαφή του άλατος πολυνουκλεοτιδίου με ένα υπόθεμα χρωματογραφίας αντίστροφης φάσης• και την έκλουση από το υπόθεμα χρωματογραφίας μιας τρίτης χημικής σύνθεσης πολυνουκλεοτιδίου συμπεριλαμβανομένου του πολυνουκλεοτιδίου. Παρέχονται επίσης χημικές συνθέσεις οι οποίες περιλαμβάνουν ένα άλας του πολυνουκλεοτιδίου συμπεριλαμβανομένου τουλάχιστον ενός ιόντος αντίθετου φορτίου πολυσθενούς κατιόντος.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562151891P | 2015-04-23 | 2015-04-23 | |
PCT/US2016/028657 WO2016172346A1 (en) | 2015-04-23 | 2016-04-21 | Methods of polynucleotide preparation using multivalent cation salt compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1123197T1 true CY1123197T1 (el) | 2021-10-29 |
Family
ID=55911083
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20201100632T CY1123197T1 (el) | 2015-04-23 | 2020-07-09 | Μεθοδοι παρασκευης πολυνουκλεοτιδιου με χρηση χημικων συνθεσεων πολυσθενους αλατος κατιοντων |
Country Status (36)
Country | Link |
---|---|
US (2) | US10745687B2 (el) |
EP (1) | EP3286203B1 (el) |
JP (3) | JP2018513127A (el) |
KR (1) | KR102401252B1 (el) |
CN (2) | CN113564168A (el) |
AU (2) | AU2016250576C1 (el) |
BR (1) | BR112017019627B1 (el) |
CA (1) | CA2978191C (el) |
CL (1) | CL2017002314A1 (el) |
CO (1) | CO2017009217A2 (el) |
CY (1) | CY1123197T1 (el) |
DK (1) | DK3286203T3 (el) |
EA (1) | EA035885B1 (el) |
ES (1) | ES2798270T3 (el) |
HK (1) | HK1251234A1 (el) |
HR (1) | HRP20201218T1 (el) |
HU (1) | HUE051148T2 (el) |
IL (1) | IL254222A0 (el) |
LT (1) | LT3286203T (el) |
MA (2) | MA42157A (el) |
MD (1) | MD3286203T2 (el) |
ME (1) | ME03811B (el) |
MX (1) | MX2017011642A (el) |
MY (1) | MY187804A (el) |
PE (2) | PE20221275A1 (el) |
PH (1) | PH12017501927A1 (el) |
PT (1) | PT3286203T (el) |
RS (1) | RS60645B1 (el) |
SA (1) | SA517390103B1 (el) |
SG (2) | SG11201707893RA (el) |
SI (1) | SI3286203T1 (el) |
TN (1) | TN2017000411A1 (el) |
TW (1) | TWI736532B (el) |
UA (1) | UA124521C2 (el) |
WO (1) | WO2016172346A1 (el) |
ZA (1) | ZA201706041B (el) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI3286203T1 (sl) | 2015-04-23 | 2020-10-30 | Geron Corporation | Metode priprave polinukleotida, z uporabo sestavkov multivalentne kationske soli |
WO2018111967A1 (en) | 2016-12-13 | 2018-06-21 | Modernatx, Inc. | Rna affinity purification |
EP3554556B1 (en) | 2016-12-19 | 2022-03-09 | Ventana Medical Systems, Inc. | Peptide nucleic acid conjugates |
WO2019036683A1 (en) * | 2017-08-18 | 2019-02-21 | Modernatx, Inc. | ANALYTICAL METHODS BY HPLC |
EP3684933A4 (en) * | 2017-09-22 | 2021-06-23 | The Regents of the University of Colorado, A Body Corporate | OLIGONUCLEOTIDES THIOMORPHOLINO FOR THE TREATMENT OF MUSCLE DYSTROPHY |
WO2019120635A1 (en) * | 2017-12-18 | 2019-06-27 | Ventana Medical Systems, Inc. | Peptide nucleic acid conjugates |
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SI3286203T1 (sl) | 2015-04-23 | 2020-10-30 | Geron Corporation | Metode priprave polinukleotida, z uporabo sestavkov multivalentne kationske soli |
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2016
- 2016-04-21 SI SI201630771T patent/SI3286203T1/sl unknown
- 2016-04-21 TW TW105112455A patent/TWI736532B/zh active
- 2016-04-21 SG SG11201707893RA patent/SG11201707893RA/en unknown
- 2016-04-21 MA MA042157A patent/MA42157A/fr unknown
- 2016-04-21 BR BR112017019627-1A patent/BR112017019627B1/pt active IP Right Grant
- 2016-04-21 WO PCT/US2016/028657 patent/WO2016172346A1/en active Application Filing
- 2016-04-21 MD MDE20180204T patent/MD3286203T2/ro unknown
- 2016-04-21 PT PT167206366T patent/PT3286203T/pt unknown
- 2016-04-21 CA CA2978191A patent/CA2978191C/en active Active
- 2016-04-21 CN CN202110878917.1A patent/CN113564168A/zh active Pending
- 2016-04-21 TN TNP/2017/000411A patent/TN2017000411A1/en unknown
- 2016-04-21 PE PE2022001164A patent/PE20221275A1/es unknown
- 2016-04-21 HU HUE16720636A patent/HUE051148T2/hu unknown
- 2016-04-21 EA EA201791753A patent/EA035885B1/ru unknown
- 2016-04-21 AU AU2016250576A patent/AU2016250576C1/en active Active
- 2016-04-21 SG SG10201909816P patent/SG10201909816PA/en unknown
- 2016-04-21 PE PE2017001516A patent/PE20171785A1/es unknown
- 2016-04-21 LT LTEP16720636.6T patent/LT3286203T/lt unknown
- 2016-04-21 UA UAA201708890A patent/UA124521C2/uk unknown
- 2016-04-21 CN CN201680014382.0A patent/CN107429247B/zh active Active
- 2016-04-21 US US15/134,740 patent/US10745687B2/en active Active
- 2016-04-21 MA MA42569A patent/MA42569B1/fr unknown
- 2016-04-21 ES ES16720636T patent/ES2798270T3/es active Active
- 2016-04-21 RS RS20200935A patent/RS60645B1/sr unknown
- 2016-04-21 DK DK16720636.6T patent/DK3286203T3/da active
- 2016-04-21 MY MYPI2017703910A patent/MY187804A/en unknown
- 2016-04-21 KR KR1020177025835A patent/KR102401252B1/ko active IP Right Grant
- 2016-04-21 MX MX2017011642A patent/MX2017011642A/es unknown
- 2016-04-21 ME MEP-2020-161A patent/ME03811B/me unknown
- 2016-04-21 JP JP2017548279A patent/JP2018513127A/ja not_active Withdrawn
- 2016-04-21 EP EP16720636.6A patent/EP3286203B1/en active Active
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2017
- 2017-08-30 IL IL254222A patent/IL254222A0/en active IP Right Grant
- 2017-09-05 ZA ZA201706041A patent/ZA201706041B/en unknown
- 2017-09-12 CO CONC2017/0009217A patent/CO2017009217A2/es unknown
- 2017-09-13 CL CL2017002314A patent/CL2017002314A1/es unknown
- 2017-10-04 SA SA517390103A patent/SA517390103B1/ar unknown
- 2017-10-20 PH PH12017501927A patent/PH12017501927A1/en unknown
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2018
- 2018-08-18 HK HK18110626.1A patent/HK1251234A1/zh unknown
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2020
- 2020-07-09 CY CY20201100632T patent/CY1123197T1/el unknown
- 2020-07-10 US US16/926,340 patent/US11441144B2/en active Active
- 2020-08-03 HR HRP20201218TT patent/HRP20201218T1/hr unknown
-
2021
- 2021-05-04 AU AU2021202803A patent/AU2021202803A1/en not_active Abandoned
- 2021-07-01 JP JP2021110090A patent/JP2021152079A/ja active Pending
-
2022
- 2022-09-02 JP JP2022140111A patent/JP2022168017A/ja active Pending
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