CL2017002314A1 - Métodos de preparación de polinucleótidos usando composiciones salinas de cationes multivalentes - Google Patents
Métodos de preparación de polinucleótidos usando composiciones salinas de cationes multivalentesInfo
- Publication number
- CL2017002314A1 CL2017002314A1 CL2017002314A CL2017002314A CL2017002314A1 CL 2017002314 A1 CL2017002314 A1 CL 2017002314A1 CL 2017002314 A CL2017002314 A CL 2017002314A CL 2017002314 A CL2017002314 A CL 2017002314A CL 2017002314 A1 CL2017002314 A1 CL 2017002314A1
- Authority
- CL
- Chile
- Prior art keywords
- polynucleotide
- salt
- composition
- methods
- multivalent cations
- Prior art date
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- C—CHEMISTRY; METALLURGY
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
- C12N15/101—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by chromatography, e.g. electrophoresis, ion-exchange, reverse phase
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/314—Phosphoramidates
- C12N2310/3145—Phosphoramidates with the nitrogen in 3' or 5'-position
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07049—RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
<p>Los aspectos de la descripción incluyen métodos para la preparación de un polinucleótido. En algunas modalidades, el método incluye poner en contacto una primera composición de polinucleótidos que incluye: un polinucleótido que tiene una secuencia de 7 o más subunidades nucleósido donde al menos dos de las subunidades nucleósido están unidas por un enlace entre subunidades de tiofosforamidato N3'→P5'; y reactivos y productos sintéticos no objetivo; con una sal de cationes multivalente para precipitar una primera sal de polinucleótidos que incluye al menos un contraión de cationes multivalente; y separar la sal de polinucleótidos de la primera composición de polinucleótidos en contacto para producir una segunda composición de polinucleótidos que incluye la primera sal de polinucleótidos. En determinadas modalidades, el método incluye además poner en contacto la primera sal de polinucleótidos con un soporte de cromatografía de fase inversa; y eluir a partir del soporte de cromatografía una tercera composición de polinucleótidos que incluye una segunda sal de polinucleótidos. También se proporcionan composiciones que incluyen una sal del polinucleótido que incluye al menos un contraión de cationes multivalentes.</p>
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562151891P | 2015-04-23 | 2015-04-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2017002314A1 true CL2017002314A1 (es) | 2018-05-04 |
Family
ID=55911083
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2017002314A CL2017002314A1 (es) | 2015-04-23 | 2017-09-13 | Métodos de preparación de polinucleótidos usando composiciones salinas de cationes multivalentes |
Country Status (36)
Country | Link |
---|---|
US (2) | US10745687B2 (es) |
EP (1) | EP3286203B1 (es) |
JP (3) | JP2018513127A (es) |
KR (1) | KR102401252B1 (es) |
CN (2) | CN113564168A (es) |
AU (2) | AU2016250576C1 (es) |
BR (1) | BR112017019627B1 (es) |
CA (1) | CA2978191C (es) |
CL (1) | CL2017002314A1 (es) |
CO (1) | CO2017009217A2 (es) |
CY (1) | CY1123197T1 (es) |
DK (1) | DK3286203T3 (es) |
EA (1) | EA035885B1 (es) |
ES (1) | ES2798270T3 (es) |
HK (1) | HK1251234A1 (es) |
HR (1) | HRP20201218T1 (es) |
HU (1) | HUE051148T2 (es) |
IL (1) | IL254222A0 (es) |
LT (1) | LT3286203T (es) |
MA (2) | MA42157A (es) |
MD (1) | MD3286203T2 (es) |
ME (1) | ME03811B (es) |
MX (1) | MX2017011642A (es) |
MY (1) | MY187804A (es) |
PE (2) | PE20221275A1 (es) |
PH (1) | PH12017501927A1 (es) |
PT (1) | PT3286203T (es) |
RS (1) | RS60645B1 (es) |
SA (1) | SA517390103B1 (es) |
SG (2) | SG11201707893RA (es) |
SI (1) | SI3286203T1 (es) |
TN (1) | TN2017000411A1 (es) |
TW (1) | TWI736532B (es) |
UA (1) | UA124521C2 (es) |
WO (1) | WO2016172346A1 (es) |
ZA (1) | ZA201706041B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI3286203T1 (sl) | 2015-04-23 | 2020-10-30 | Geron Corporation | Metode priprave polinukleotida, z uporabo sestavkov multivalentne kationske soli |
WO2018111967A1 (en) | 2016-12-13 | 2018-06-21 | Modernatx, Inc. | Rna affinity purification |
EP3554556B1 (en) | 2016-12-19 | 2022-03-09 | Ventana Medical Systems, Inc. | Peptide nucleic acid conjugates |
WO2019036683A1 (en) * | 2017-08-18 | 2019-02-21 | Modernatx, Inc. | ANALYTICAL METHODS BY HPLC |
EP3684933A4 (en) * | 2017-09-22 | 2021-06-23 | The Regents of the University of Colorado, A Body Corporate | OLIGONUCLEOTIDES THIOMORPHOLINO FOR THE TREATMENT OF MUSCLE DYSTROPHY |
WO2019120635A1 (en) * | 2017-12-18 | 2019-06-27 | Ventana Medical Systems, Inc. | Peptide nucleic acid conjugates |
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DE69120821T2 (de) | 1990-08-31 | 1997-01-23 | Univ Minnesota | Polyethylenglykol-Derivate für Festphasenanwendungen |
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JP2002060341A (ja) * | 2000-08-21 | 2002-02-26 | Terumo Corp | 止血剤 |
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JOP20200257A1 (ar) | 2014-05-01 | 2017-06-16 | Geron Corp | تركيبات أوليجو نوكليوتيد وطرق لتحضيرها |
SI3286203T1 (sl) | 2015-04-23 | 2020-10-30 | Geron Corporation | Metode priprave polinukleotida, z uporabo sestavkov multivalentne kationske soli |
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2016
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2018
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2021
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2022
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