CO2017009217A2 - Métodos de preparación de polinucleótidos de tiofosforamidato n3’→p5’ usando composiciones salinas de cationes multivalentes - Google Patents
Métodos de preparación de polinucleótidos de tiofosforamidato n3’→p5’ usando composiciones salinas de cationes multivalentesInfo
- Publication number
- CO2017009217A2 CO2017009217A2 CONC2017/0009217A CO2017009217A CO2017009217A2 CO 2017009217 A2 CO2017009217 A2 CO 2017009217A2 CO 2017009217 A CO2017009217 A CO 2017009217A CO 2017009217 A2 CO2017009217 A2 CO 2017009217A2
- Authority
- CO
- Colombia
- Prior art keywords
- polynucleotide
- salt
- multivalent cation
- thiophosphoramidate
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
- C12N15/101—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by chromatography, e.g. electrophoresis, ion-exchange, reverse phase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/314—Phosphoramidates
- C12N2310/3145—Phosphoramidates with the nitrogen in 3' or 5'-position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07049—RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Los aspectos de la descripción incluyen métodos para la preparación de un polinucleótido. En algunas modalidades, el método incluye poner en contacto una primera composición de polinucleótidos que incluye: un polinucleótido que tiene una secuencia de 7 o más subunidades nucleósido donde al menos dos de las subunidades nucleósido están unidas por un enlace entre subunidades de tiofosforamidato N3'→P5'; y reactivos y productos sintéticos no objetivo; con una sal de cationes multivalente para precipitar una primera sal de polinucleótidos que incluye al menos un contraión de cationes multivalente; y separar la sal de polinucleótidos de la primera composición de polinucleótidos en contacto para producir una segunda composición de polinucleótidos que incluye la primera sal de polinucleótidos. En determinadas modalidades, el método incluye además poner en contacto la primera sal de polinucleótidos con un soporte de cromatografía de fase inversa; y eluir a partir del soporte de cromatografía una tercera composición de polinucleótidos que incluye una segunda sal de polinucleótidos. También se proporcionan composiciones que incluyen una sal del polinucleótido que incluye al menos un contraión de cationes multivalentes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562151891P | 2015-04-23 | 2015-04-23 | |
PCT/US2016/028657 WO2016172346A1 (en) | 2015-04-23 | 2016-04-21 | Methods of polynucleotide preparation using multivalent cation salt compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2017009217A2 true CO2017009217A2 (es) | 2018-02-20 |
Family
ID=55911083
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2017/0009217A CO2017009217A2 (es) | 2015-04-23 | 2017-09-12 | Métodos de preparación de polinucleótidos de tiofosforamidato n3’→p5’ usando composiciones salinas de cationes multivalentes |
Country Status (36)
Country | Link |
---|---|
US (2) | US10745687B2 (es) |
EP (1) | EP3286203B1 (es) |
JP (3) | JP2018513127A (es) |
KR (1) | KR102401252B1 (es) |
CN (2) | CN113564168A (es) |
AU (2) | AU2016250576C1 (es) |
BR (1) | BR112017019627B1 (es) |
CA (1) | CA2978191C (es) |
CL (1) | CL2017002314A1 (es) |
CO (1) | CO2017009217A2 (es) |
CY (1) | CY1123197T1 (es) |
DK (1) | DK3286203T3 (es) |
EA (1) | EA035885B1 (es) |
ES (1) | ES2798270T3 (es) |
HK (1) | HK1251234A1 (es) |
HR (1) | HRP20201218T1 (es) |
HU (1) | HUE051148T2 (es) |
IL (1) | IL254222A0 (es) |
LT (1) | LT3286203T (es) |
MA (2) | MA42569B1 (es) |
MD (1) | MD3286203T2 (es) |
ME (1) | ME03811B (es) |
MX (1) | MX2017011642A (es) |
MY (1) | MY187804A (es) |
PE (2) | PE20171785A1 (es) |
PH (1) | PH12017501927A1 (es) |
PT (1) | PT3286203T (es) |
RS (1) | RS60645B1 (es) |
SA (1) | SA517390103B1 (es) |
SG (2) | SG10201909816PA (es) |
SI (1) | SI3286203T1 (es) |
TN (1) | TN2017000411A1 (es) |
TW (1) | TWI736532B (es) |
UA (1) | UA124521C2 (es) |
WO (1) | WO2016172346A1 (es) |
ZA (1) | ZA201706041B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG10201909816PA (en) | 2015-04-23 | 2019-11-28 | Geron Corp | Methods of polynucleotide preparation using multivalent cation salt compositions |
US11384352B2 (en) | 2016-12-13 | 2022-07-12 | Modernatx, Inc. | RNA affinity purification |
EP3554556B1 (en) | 2016-12-19 | 2022-03-09 | Ventana Medical Systems, Inc. | Peptide nucleic acid conjugates |
EP3668977A4 (en) * | 2017-08-18 | 2021-04-21 | Modernatx, Inc. | HPLC ANALYTICAL PROCESSES |
CN111542606A (zh) * | 2017-09-22 | 2020-08-14 | 科罗拉多州立大学董事会法人团体 | 硫吗啉代寡核苷酸用于治疗肌肉营养不良 |
EP3727470A1 (en) * | 2017-12-18 | 2020-10-28 | Ventana Medical Systems, Inc. | Peptide nucleic acid conjugates |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4046720A (en) | 1974-01-17 | 1977-09-06 | California Institute Of Technology | Crosslinked, porous, polyacrylate beads |
US4678814A (en) | 1981-03-30 | 1987-07-07 | California Institute Of Technology | Polyacrolein microspheres |
US4413070A (en) | 1981-03-30 | 1983-11-01 | California Institute Of Technology | Polyacrolein microspheres |
US5185444A (en) | 1985-03-15 | 1993-02-09 | Anti-Gene Deveopment Group | Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages |
US4659774A (en) | 1985-11-01 | 1987-04-21 | American Hoechst Corporation | Support for solid-phase oligonucleotide synthesis |
EP0801082B1 (en) | 1990-08-31 | 2003-04-09 | Regents Of The University Of Minnesota | Method for making graft resins for solid-phase peptide synthesis |
US5281701A (en) | 1991-07-12 | 1994-01-25 | Applied Biosystems, Inc. | Process and compounds for RNA synthesis |
US5476925A (en) | 1993-02-01 | 1995-12-19 | Northwestern University | Oligodeoxyribonucleotides including 3'-aminonucleoside-phosphoramidate linkages and terminal 3'-amino groups |
CA2184375C (en) | 1994-03-18 | 2006-05-02 | Sergei M. Gryaznov | Oligonucleotide n3'-p5' phosphoramidates: synthesis and compounds; hybridization and nuclease resistance properties |
US5726297A (en) | 1994-03-18 | 1998-03-10 | Lynx Therapeutics, Inc. | Oligodeoxyribonucleotide N3' P5' phosphoramidates |
US5599922A (en) | 1994-03-18 | 1997-02-04 | Lynx Therapeutics, Inc. | Oligonucleotide N3'-P5' phosphoramidates: hybridization and nuclease resistance properties |
US5684143A (en) | 1996-02-21 | 1997-11-04 | Lynx Therapeutics, Inc. | Oligo-2'-fluoronucleotide N3'->P5' phosphoramidates |
US5859233A (en) | 1996-02-21 | 1999-01-12 | Lynx Therapeutics, Inc. | Synthons for synthesis of oligonucleotide N3-P5 phosphoramidates |
CA2274586A1 (en) | 1996-12-20 | 1998-07-02 | Geron Corporation | Methods for detecting and inhibiting the rna component of telomerase |
US5998604A (en) | 1997-09-15 | 1999-12-07 | The Perkin-Elmer Corporation | Polynucleotide purification method |
US6114519A (en) | 1997-10-15 | 2000-09-05 | Isis Pharmaceuticals, Inc. | Synthesis of sulfurized oligonucleotides |
US6465628B1 (en) | 1999-02-04 | 2002-10-15 | Isis Pharmaceuticals, Inc. | Process for the synthesis of oligomeric compounds |
WO2001018015A1 (en) | 1999-09-10 | 2001-03-15 | Geron Corporation | Oligonucleotide n3'→p5' thiophosphoramidates: their synthesis and use |
JP2002060341A (ja) * | 2000-08-21 | 2002-02-26 | Terumo Corp | 止血剤 |
JP4854913B2 (ja) | 2001-03-23 | 2012-01-18 | ジェロン・コーポレーション | オリゴヌクレオチド結合体 |
US7563618B2 (en) | 2001-03-23 | 2009-07-21 | Geron Corporation | Oligonucleotide conjugates |
PL3342425T3 (pl) * | 2003-09-09 | 2020-06-15 | Geron Corporation | Zmodyfikowane oligonukleotydy do hamowania telomerazy |
US20120329858A1 (en) | 2010-08-04 | 2012-12-27 | Geron Corporation | Modified oligonucleotides for telomerase inhibition |
WO2005116207A1 (ja) | 2004-05-28 | 2005-12-08 | Sankyo Company, Limited | テロメラーゼ阻害enaオリゴヌクレオチド |
CN100558739C (zh) | 2004-07-02 | 2009-11-11 | 杰龙公司 | 合成被保护的3’-氨基核苷单体 |
JP5438320B2 (ja) * | 2005-10-03 | 2014-03-12 | アプライド バイオシステムズ リミテッド ライアビリティー カンパニー | 核酸を増幅するための組成物、方法およびキット |
CA2666607C (en) * | 2006-11-01 | 2015-02-10 | Biogen Idec Ma Inc. | Method of isolating biomacromolecules using low ph and divalent cations |
HUE029521T2 (en) | 2010-08-20 | 2017-03-28 | Replicor Inc | Oligonucleotide chelate complexes |
US9106103B2 (en) | 2011-09-23 | 2015-08-11 | Eaton Corporation | Unintteruptible power supply systems and methods employing on-demand energy storage |
US9006630B2 (en) | 2012-01-13 | 2015-04-14 | Altasens, Inc. | Quality of optically black reference pixels in CMOS iSoCs |
AR091065A1 (es) | 2012-05-18 | 2014-12-30 | Replicor Inc | Una formulacion farmaceutica que comprende un quelato de oligonucleotidos antiviral para el tratamiento de una infeccion antiviral |
CN104487596B (zh) * | 2012-06-14 | 2020-03-13 | 生命技术公司 | 用于聚合酶链式反应(pcr)的新型组合物、方法和试剂盒 |
MA45504B1 (fr) | 2012-12-07 | 2021-10-29 | Geron Corp | Utilisation d'inhibiteurs de télomérase pour le traitement de troubles myéloprolifératifs et de néoplasies myéloprolifératives |
JOP20200257A1 (ar) | 2014-05-01 | 2017-06-16 | Geron Corp | تركيبات أوليجو نوكليوتيد وطرق لتحضيرها |
SG10201909816PA (en) | 2015-04-23 | 2019-11-28 | Geron Corp | Methods of polynucleotide preparation using multivalent cation salt compositions |
-
2016
- 2016-04-21 SG SG10201909816P patent/SG10201909816PA/en unknown
- 2016-04-21 CN CN202110878917.1A patent/CN113564168A/zh active Pending
- 2016-04-21 DK DK16720636.6T patent/DK3286203T3/da active
- 2016-04-21 EP EP16720636.6A patent/EP3286203B1/en active Active
- 2016-04-21 MY MYPI2017703910A patent/MY187804A/en unknown
- 2016-04-21 ES ES16720636T patent/ES2798270T3/es active Active
- 2016-04-21 PE PE2017001516A patent/PE20171785A1/es unknown
- 2016-04-21 CA CA2978191A patent/CA2978191C/en active Active
- 2016-04-21 BR BR112017019627-1A patent/BR112017019627B1/pt active IP Right Grant
- 2016-04-21 MA MA42569A patent/MA42569B1/fr unknown
- 2016-04-21 PE PE2022001164A patent/PE20221275A1/es unknown
- 2016-04-21 PT PT167206366T patent/PT3286203T/pt unknown
- 2016-04-21 US US15/134,740 patent/US10745687B2/en active Active
- 2016-04-21 MD MDE20180204T patent/MD3286203T2/ro unknown
- 2016-04-21 JP JP2017548279A patent/JP2018513127A/ja not_active Withdrawn
- 2016-04-21 CN CN201680014382.0A patent/CN107429247B/zh active Active
- 2016-04-21 EA EA201791753A patent/EA035885B1/ru unknown
- 2016-04-21 SG SG11201707893RA patent/SG11201707893RA/en unknown
- 2016-04-21 TN TNP/2017/000411A patent/TN2017000411A1/en unknown
- 2016-04-21 SI SI201630771T patent/SI3286203T1/sl unknown
- 2016-04-21 RS RS20200935A patent/RS60645B1/sr unknown
- 2016-04-21 ME MEP-2020-161A patent/ME03811B/me unknown
- 2016-04-21 LT LTEP16720636.6T patent/LT3286203T/lt unknown
- 2016-04-21 AU AU2016250576A patent/AU2016250576C1/en active Active
- 2016-04-21 MA MA042157A patent/MA42157A/fr unknown
- 2016-04-21 WO PCT/US2016/028657 patent/WO2016172346A1/en active Application Filing
- 2016-04-21 HU HUE16720636A patent/HUE051148T2/hu unknown
- 2016-04-21 UA UAA201708890A patent/UA124521C2/uk unknown
- 2016-04-21 KR KR1020177025835A patent/KR102401252B1/ko active IP Right Grant
- 2016-04-21 TW TW105112455A patent/TWI736532B/zh active
- 2016-04-21 MX MX2017011642A patent/MX2017011642A/es unknown
-
2017
- 2017-08-30 IL IL254222A patent/IL254222A0/en active IP Right Grant
- 2017-09-05 ZA ZA201706041A patent/ZA201706041B/en unknown
- 2017-09-12 CO CONC2017/0009217A patent/CO2017009217A2/es unknown
- 2017-09-13 CL CL2017002314A patent/CL2017002314A1/es unknown
- 2017-10-04 SA SA517390103A patent/SA517390103B1/ar unknown
- 2017-10-20 PH PH12017501927A patent/PH12017501927A1/en unknown
-
2018
- 2018-08-18 HK HK18110626.1A patent/HK1251234A1/zh unknown
-
2020
- 2020-07-09 CY CY20201100632T patent/CY1123197T1/el unknown
- 2020-07-10 US US16/926,340 patent/US11441144B2/en active Active
- 2020-08-03 HR HRP20201218TT patent/HRP20201218T1/hr unknown
-
2021
- 2021-05-04 AU AU2021202803A patent/AU2021202803A1/en not_active Abandoned
- 2021-07-01 JP JP2021110090A patent/JP2021152079A/ja active Pending
-
2022
- 2022-09-02 JP JP2022140111A patent/JP2022168017A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO2017009217A2 (es) | Métodos de preparación de polinucleótidos de tiofosforamidato n3’→p5’ usando composiciones salinas de cationes multivalentes | |
CL2016002010A1 (es) | Métodos y sistemas para generar mapas colaborativos compartidos | |
BR112019007288A2 (pt) | proteína heterodimérica biespecífica, composições de ácido nucleico e de vetor de expressão, vetor de expressão, célula hospedeira, e, métodos para produzir proteína heterodimérica biespecífica e para tratar câncer em um paciente | |
CL2018003136A1 (es) | Proteínas de unión específica y usos de las mismas. | |
UY37340A (es) | Antianticuerpos gprc5d, moléculas de unión al antígeno biespecíficas que se unen a gprc5d y cd3, y usos de estas | |
CO2018002196A2 (es) | Proteínas de fusión de factor ix y métodos para producirlas y utilizarlas | |
BR112014009066B8 (pt) | molécula de ácido nucleico, método para a sintetização de uma molécula de dna de triciclo-fosforotioato e composição farmacêutica | |
ECSP14013132A (es) | Anticuerpos anti-psgl-1 y usos de los mismos | |
BR112017000135B8 (pt) | Processo para a preparação de ácidos 4-alcóxi-3-hidroxipicolínico | |
BR112016025196A2 (pt) | composições de oligonucleotídeo e métodos de fazê-las | |
BR112017015414A2 (pt) | máquina fresadora e método de aplicação da máquina fresadora | |
BR102016023568B8 (pt) | Método para produzir lignina sólida a partir de material de partida rico em lignina | |
BR112014020929A2 (pt) | alinhamento de imagem de imagens de mama | |
BR112017007411A2 (pt) | método em a máquina de plantio de mudas e máquina de plantio de mudas | |
BR112014015288A2 (pt) | máquina e processo para tornear pelo menos ressaltos planos de um eixo de manivela que circunda pinos de manivela | |
BR112016024466A2 (pt) | método para a síntese de clofarabina | |
CR20130662A (es) | Anticuerpos a adp-ribosil ciclasa 2 | |
BR112017026203A2 (pt) | método de geração de uma estratégia de produção para a explotação de um reservatório de hidrocarbonetos em um ambiente natural | |
DOP2015000294A (es) | Preparado farmacéutico | |
BR112015030065A2 (pt) | sistema de deslocamento de fase | |
BR112017028547A2 (pt) | um método de junção de uma liga de fecral com uma liga de fenicr utilizando um metal de preenchimento por soldagem | |
BR112023000227A2 (pt) | Processo para preparação de dismina | |
RU2015154015A (ru) | Способ получения нефтяных сульфонатов | |
CO2020008886A2 (es) | Métodos para el procesamiento de materias primas de hidrocarburos | |
MX2020007707A (es) | Proceso para preparar nanoemulsiones transparentes que comprenden aceite laurico. |