CY1123450T1 - Μεθοδος καθαρισμου συζευγματων βασει il-15/il-15ra - Google Patents

Μεθοδος καθαρισμου συζευγματων βασει il-15/il-15ra

Info

Publication number
CY1123450T1
CY1123450T1 CY20201100650T CY201100650T CY1123450T1 CY 1123450 T1 CY1123450 T1 CY 1123450T1 CY 20201100650 T CY20201100650 T CY 20201100650T CY 201100650 T CY201100650 T CY 201100650T CY 1123450 T1 CY1123450 T1 CY 1123450T1
Authority
CY
Cyprus
Prior art keywords
purification method
polypeptide
derivatives
amino acid
acid sequence
Prior art date
Application number
CY20201100650T
Other languages
English (en)
Inventor
David Bechard
Guy De Martynoff
Original Assignee
Cytune Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytune Pharma filed Critical Cytune Pharma
Publication of CY1123450T1 publication Critical patent/CY1123450T1/el

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/20—Anion exchangers for chromatographic processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5443—IL-15
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2086—IL-13 to IL-16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/14—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε μία μέθοδο για την παρασκευή μίας σύνθεσης που περιλαμβάνει μονομερή συζεύγματα από ένα δείγμα, όπου το εν λόγω σύζευγμα περιλαμβάνει (a) ένα πολυπεπτίδιο που περιλαμβάνει την αλληλουχία αμινοξέων της ιντερλευκίνης 15 ή παραγώγων αυτής και (b) ένα πολυπεπτίδιο που περιλαμβάνει την αλληλουχία αμινοξέων του πεδίου sushi του IL-15Rα ή παραγώγων αυτού• όπου η εν λόγω μέθοδος περιλαμβάνει τη χρήση χρωματογραφίας ανταλλαγής ανιόντων που ακολουθείται από χρωματογραφία υδρόφοβης αλληλεπίδρασης• και σε μία φαρμακευτική σύνθεση που μπορεί να ληφθεί από αυτή τη μέθοδο.
CY20201100650T 2014-03-03 2020-07-16 Μεθοδος καθαρισμου συζευγματων βασει il-15/il-15ra CY1123450T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14000742.8A EP2915569A1 (en) 2014-03-03 2014-03-03 IL-15/IL-15Ralpha based conjugates purification method
PCT/EP2015/000473 WO2015131994A1 (en) 2014-03-03 2015-03-03 Il-15/il-15ralpha based conjugates purification method

Publications (1)

Publication Number Publication Date
CY1123450T1 true CY1123450T1 (el) 2022-03-24

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Family Applications (1)

Application Number Title Priority Date Filing Date
CY20201100650T CY1123450T1 (el) 2014-03-03 2020-07-16 Μεθοδος καθαρισμου συζευγματων βασει il-15/il-15ra

Country Status (20)

Country Link
US (2) US10808022B2 (el)
EP (2) EP2915569A1 (el)
JP (2) JP2017509618A (el)
KR (1) KR102361954B1 (el)
CN (2) CN106457070B (el)
AU (2) AU2015226504B2 (el)
CA (1) CA2938649C (el)
CY (1) CY1123450T1 (el)
DK (1) DK3113858T3 (el)
ES (1) ES2807758T3 (el)
HR (1) HRP20201122T1 (el)
HU (1) HUE050138T2 (el)
IL (1) IL247469B (el)
LT (1) LT3113858T (el)
PL (1) PL3113858T3 (el)
PT (1) PT3113858T (el)
RS (1) RS60627B1 (el)
RU (1) RU2701301C2 (el)
SI (1) SI3113858T1 (el)
WO (1) WO2015131994A1 (el)

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HRP20201122T1 (hr) 2021-01-22
HUE050138T2 (hu) 2020-11-30
IL247469A0 (en) 2016-11-30
PL3113858T3 (pl) 2020-11-02
WO2015131994A1 (en) 2015-09-11
RU2016138469A (ru) 2018-04-04
US10808022B2 (en) 2020-10-20
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AU2015226504A1 (en) 2016-09-08
IL247469B (en) 2022-03-01
JP7086920B2 (ja) 2022-06-20
PT3113858T (pt) 2020-07-24
JP2017509618A (ja) 2017-04-06
CN111018946A (zh) 2020-04-17
US20170056874A1 (en) 2017-03-02
KR102361954B1 (ko) 2022-02-11
JP2020063288A (ja) 2020-04-23
EP3113858B1 (en) 2020-05-06
ES2807758T3 (es) 2021-02-24
SI3113858T1 (sl) 2020-10-30
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LT3113858T (lt) 2020-08-10
CA2938649C (en) 2023-10-17
AU2019203422B2 (en) 2020-04-30
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DK3113858T3 (da) 2020-07-27
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EP3113858A1 (en) 2017-01-11
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