MX357403B - Polipeptidos de factor viii quimericos y usos de los mismos. - Google Patents

Polipeptidos de factor viii quimericos y usos de los mismos.

Info

Publication number
MX357403B
MX357403B MX2014008512A MX2014008512A MX357403B MX 357403 B MX357403 B MX 357403B MX 2014008512 A MX2014008512 A MX 2014008512A MX 2014008512 A MX2014008512 A MX 2014008512A MX 357403 B MX357403 B MX 357403B
Authority
MX
Mexico
Prior art keywords
vwf
vwf fragment
fviii
protein
fragment
Prior art date
Application number
MX2014008512A
Other languages
English (en)
Other versions
MX2014008512A (es
Inventor
Jiang Haiyan
Peters Robert
Seth Chhabra Ekta
Liu Tongyao
Original Assignee
Bioverativ Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioverativ Therapeutics Inc filed Critical Bioverativ Therapeutics Inc
Publication of MX2014008512A publication Critical patent/MX2014008512A/es
Publication of MX357403B publication Critical patent/MX357403B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a un fragmento de VWF que comprende el dominio D´ y el dominio D3 de VWF, una proteína quimérica que comprende el fragmento de VWF y un resto heterólogo, o una proteína quimérica que comprende el fragmento de VWF y una proteína de FVIII y métodos para usarlos. Una cadena de polipéptidos que comprende un fragmento de VWF de la invención se une o está asociada a una cadena de polipéptidos que comprende una proteína de FVIII y la cadena de polipéptidos que comprende el fragmento de VWF puede evitar o inhibir la unión de VWF endógeno a la proteína de FVIII. Al evitar o inhibir la unión de VWF endógeno a FVIII, que es un factor limitante de la semivida para FVIII, el fragmento de VWF puede inducir la extensión de la semivida de la proteína de FVIII. La invención también incluye nucleótidos, vectores, células hospedadoras, métodos para usar el fragmento de VWF o las proteínas quiméricas.
MX2014008512A 2012-01-12 2013-01-12 Polipeptidos de factor viii quimericos y usos de los mismos. MX357403B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261586099P 2012-01-12 2012-01-12
US201261586654P 2012-01-13 2012-01-13
US201261667901P 2012-07-03 2012-07-03
US201261734954P 2012-12-07 2012-12-07
PCT/US2013/021330 WO2013106787A1 (en) 2012-01-12 2013-01-12 Chimeric factor viii polypeptides and uses thereof

Publications (2)

Publication Number Publication Date
MX2014008512A MX2014008512A (es) 2014-11-25
MX357403B true MX357403B (es) 2018-07-09

Family

ID=48781968

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014008512A MX357403B (es) 2012-01-12 2013-01-12 Polipeptidos de factor viii quimericos y usos de los mismos.

Country Status (29)

Country Link
US (2) US11370827B2 (es)
EP (2) EP2804623B1 (es)
JP (4) JP6255630B2 (es)
KR (1) KR102212098B1 (es)
CN (4) CN104271150A (es)
AU (2) AU2016202875B2 (es)
BR (1) BR112014017165B1 (es)
CA (1) CA2863328A1 (es)
CO (1) CO7010788A2 (es)
CY (1) CY1122509T1 (es)
DK (1) DK2804623T3 (es)
EA (2) EA035323B1 (es)
ES (1) ES2753124T3 (es)
HK (1) HK1202799A1 (es)
HR (1) HRP20191920T1 (es)
HU (1) HUE046396T2 (es)
IL (2) IL233463B (es)
LT (1) LT2804623T (es)
MX (1) MX357403B (es)
MY (1) MY201293A (es)
NZ (1) NZ626945A (es)
PH (2) PH12014501602B1 (es)
PL (1) PL2804623T3 (es)
PT (1) PT2804623T (es)
RS (1) RS59670B1 (es)
SG (2) SG10201610193RA (es)
SI (1) SI2804623T1 (es)
TW (3) TWI826778B (es)
WO (1) WO2013106787A1 (es)

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