MX369263B - Toxinas de clostridium degradables. - Google Patents
Toxinas de clostridium degradables.Info
- Publication number
- MX369263B MX369263B MX2015015117A MX2015015117A MX369263B MX 369263 B MX369263 B MX 369263B MX 2015015117 A MX2015015117 A MX 2015015117A MX 2015015117 A MX2015015117 A MX 2015015117A MX 369263 B MX369263 B MX 369263B
- Authority
- MX
- Mexico
- Prior art keywords
- toxins
- chimeras
- clostridial toxins
- degradable clostridial
- degradable
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
Abstract
La presente invención se refiere a toxinas de Clostridium o quimeras de toxinas de Clostridium que comprenden un sitio de inactivación de escisión, moléculas de polinucleótidos que codifican las toxinas o quimeras, composiciones que comprenden las toxinas o quimeras, y método para producir las toxinas o quimeras.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34657810P | 2010-05-20 | 2010-05-20 | |
PCT/US2011/037131 WO2011146704A1 (en) | 2010-05-20 | 2011-05-19 | Degradable clostridial toxins |
Publications (1)
Publication Number | Publication Date |
---|---|
MX369263B true MX369263B (es) | 2019-11-04 |
Family
ID=44484018
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012013381A MX2012013381A (es) | 2010-05-20 | 2011-05-19 | Toxinas de clostridium degradables. |
MX2015015117A MX369263B (es) | 2010-05-20 | 2011-05-19 | Toxinas de clostridium degradables. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012013381A MX2012013381A (es) | 2010-05-20 | 2011-05-19 | Toxinas de clostridium degradables. |
Country Status (21)
Country | Link |
---|---|
US (13) | US8512992B2 (es) |
EP (3) | EP2571509B1 (es) |
JP (4) | JP6148979B2 (es) |
KR (4) | KR101942106B1 (es) |
CN (1) | CN103228286B (es) |
AR (1) | AR081407A1 (es) |
AU (1) | AU2011255525B2 (es) |
BR (1) | BR112012029666A2 (es) |
CA (1) | CA2799969C (es) |
DK (3) | DK2650003T3 (es) |
ES (3) | ES2600463T3 (es) |
HK (1) | HK1180592A1 (es) |
IL (1) | IL223100B (es) |
MX (2) | MX2012013381A (es) |
NZ (2) | NZ604322A (es) |
RU (1) | RU2561465C2 (es) |
SG (2) | SG10201506567UA (es) |
TW (1) | TWI516594B (es) |
UA (1) | UA108646C2 (es) |
WO (1) | WO2011146704A1 (es) |
ZA (1) | ZA201208753B (es) |
Families Citing this family (39)
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SG10201506567UA (en) | 2010-05-20 | 2015-10-29 | Allergan Inc | Degradable Clostridial Toxins |
JP6148676B2 (ja) * | 2011-11-04 | 2017-06-14 | リポテック, エセ.ア. | 活性化受容体を阻害するペプチド、および化粧品組成物または薬学的組成物におけるそれらの使用 |
EP3279335B1 (en) | 2011-12-31 | 2021-03-10 | Allergan, Inc. | Highly sensitive cell-based assay to detect the presence of active botulinum neurotoxin serotype-a |
RS59670B1 (sr) | 2012-01-12 | 2020-01-31 | Bioverativ Therapeutics Inc | Himerni polipeptidi faktora viii i njihove upotrebe |
EP3549953A1 (en) | 2012-02-15 | 2019-10-09 | Bioverativ Therapeutics Inc. | Recombinant factor viii proteins |
MY188897A (en) | 2012-02-15 | 2022-01-12 | Bioverativ Therapeutics Inc | Factor viii compositions and methods of making and using same |
WO2013181471A2 (en) * | 2012-05-30 | 2013-12-05 | The University Of Utah Research Foundation | Matrix metalloproteinase cleavable protein polymers for cancer gene therapy |
SG10201913893XA (en) | 2012-07-11 | 2020-03-30 | Bioverativ Therapeutics Inc | Factor viii complex with xten and von willebrand factor protein, and uses thereof |
US20140170132A1 (en) | 2012-12-18 | 2014-06-19 | Allergan, Inc. | Prophylatic treatment of herpes recurrence |
CN104212833A (zh) * | 2013-05-30 | 2014-12-17 | 江苏大学 | 一种新型转基因质粒载体及其构建方法、体内含新型重组基因家蚕的培育方法 |
WO2014210547A1 (en) * | 2013-06-28 | 2014-12-31 | Biogen Idec Ma Inc. | Thrombin cleavable linker |
GB201312317D0 (en) * | 2013-07-09 | 2013-08-21 | Syntaxin Ltd | Cationic neurotoxins |
WO2015023891A2 (en) | 2013-08-14 | 2015-02-19 | Biogen Idec Ma Inc. | Factor viii-xten fusions and uses thereof |
US20150087810A1 (en) * | 2013-09-25 | 2015-03-26 | Cytomx Therapeutics, Inc. | Matrix Metalloproteinase Substrates And Other Cleavable Moieties And Methods Of Use Thereof |
US9216210B2 (en) | 2013-12-23 | 2015-12-22 | Dublin City University | Multiprotease therapeutics for chronic pain |
CN117106095A (zh) | 2014-01-10 | 2023-11-24 | 比奥贝拉蒂治疗公司 | 因子viii嵌合蛋白及其用途 |
CA2937370A1 (en) * | 2014-01-31 | 2015-08-06 | Cytomx Therapeutics, Inc. | Matriptase and u-plasminogen activator substrates and other cleavable moieties and methods of use thereof |
EP3137053B1 (en) | 2014-04-30 | 2020-06-17 | Allergan, Inc. | Formulations of biologics for intravesical instillation |
US20160030570A1 (en) | 2014-07-31 | 2016-02-04 | Allergan, Inc. | Formulations of biologics for intravesical instillation |
RU2585494C2 (ru) * | 2014-09-17 | 2016-05-27 | Федеральное государственное бюджетное учреждение "Государственный научный центр Институт иммунологии" Федерального медико-биологического агентства России | Рекомбинантный белок rec-mp, содержащий в своем составе последовательности миелопептидов для лечения вторичных иммунодефицитных состояний |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
MA41374A (fr) | 2015-01-20 | 2017-11-28 | Cytomx Therapeutics Inc | Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci |
PT3274364T (pt) | 2015-03-26 | 2021-11-05 | Harvard College | Neurotoxina botulínica manipulada |
GB201505306D0 (en) * | 2015-03-27 | 2015-05-13 | Ipsen Biopharm Ltd | Chimeric polypeptides |
GB201607901D0 (en) * | 2016-05-05 | 2016-06-22 | Ipsen Biopharm Ltd | Chimeric neurotoxins |
IL263754B2 (en) * | 2016-07-08 | 2023-04-01 | Childrens Medical Center | A new botulinum neurotoxin and its derivatives |
EP3504226A1 (en) | 2016-08-24 | 2019-07-03 | President and Fellows of Harvard College | Engineered botulinum neurotoxin |
WO2018053111A1 (en) | 2016-09-15 | 2018-03-22 | University Of Utah Research Foundation | In situ gelling compositions for the treatment or prevention of inflammation and tissue damage |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US10849914B2 (en) | 2017-06-12 | 2020-12-01 | University Of Utah Research Foundation | Methods for producing chemoembolic agents for the delivery of anti-cancer agents |
CA3072884A1 (en) * | 2017-08-11 | 2019-02-14 | University Of Kentucky Research Foundation | Anti-neurodegenerative therapeutic, method of manufacture, and use |
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2011
- 2011-05-19 SG SG10201506567UA patent/SG10201506567UA/en unknown
- 2011-05-19 SG SG2012085114A patent/SG185663A1/en unknown
- 2011-05-19 DK DK13176290.8T patent/DK2650003T3/da active
- 2011-05-19 WO PCT/US2011/037131 patent/WO2011146704A1/en active Application Filing
- 2011-05-19 RU RU2012154862/10A patent/RU2561465C2/ru active
- 2011-05-19 ES ES13176290.8T patent/ES2600463T3/es active Active
- 2011-05-19 AU AU2011255525A patent/AU2011255525B2/en not_active Ceased
- 2011-05-19 KR KR1020127033131A patent/KR101942106B1/ko active IP Right Grant
- 2011-05-19 KR KR1020197001617A patent/KR102164166B1/ko active IP Right Grant
- 2011-05-19 KR KR1020207028393A patent/KR102321664B1/ko active IP Right Grant
- 2011-05-19 ES ES11724483.0T patent/ES2596128T3/es active Active
- 2011-05-19 NZ NZ604322A patent/NZ604322A/en not_active IP Right Cessation
- 2011-05-19 EP EP11724483.0A patent/EP2571509B1/en active Active
- 2011-05-19 DK DK16181227.6T patent/DK3106170T3/da active
- 2011-05-19 CN CN201180035613.3A patent/CN103228286B/zh not_active Expired - Fee Related
- 2011-05-19 KR KR1020217035259A patent/KR20210132753A/ko active Application Filing
- 2011-05-19 NZ NZ703378A patent/NZ703378A/en not_active IP Right Cessation
- 2011-05-19 ES ES16181227T patent/ES2813650T3/es active Active
- 2011-05-19 EP EP13176290.8A patent/EP2650003B1/en active Active
- 2011-05-19 CA CA2799969A patent/CA2799969C/en not_active Expired - Fee Related
- 2011-05-19 MX MX2012013381A patent/MX2012013381A/es active IP Right Grant
- 2011-05-19 UA UAA201214593A patent/UA108646C2/ru unknown
- 2011-05-19 DK DK11724483.0T patent/DK2571509T3/en active
- 2011-05-19 EP EP16181227.6A patent/EP3106170B1/en active Active
- 2011-05-19 MX MX2015015117A patent/MX369263B/es unknown
- 2011-05-19 JP JP2013511353A patent/JP6148979B2/ja not_active Expired - Fee Related
- 2011-05-19 BR BR112012029666-3A patent/BR112012029666A2/pt not_active Application Discontinuation
- 2011-05-20 AR ARP110101742A patent/AR081407A1/es not_active Application Discontinuation
- 2011-05-20 US US13/112,844 patent/US8512992B2/en active Active
- 2011-05-20 TW TW100117869A patent/TWI516594B/zh not_active IP Right Cessation
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2012
- 2012-11-18 IL IL223100A patent/IL223100B/en active IP Right Grant
- 2012-11-21 ZA ZA2012/08753A patent/ZA201208753B/en unknown
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2013
- 2013-03-18 US US13/846,307 patent/US8685692B2/en active Active
- 2013-03-18 US US13/846,338 patent/US8685693B2/en active Active
- 2013-03-18 US US13/846,364 patent/US8841111B2/en active Active
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2015
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2016
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