AR080466A1 - Enriquecimiento selectivo de anticuerpos - Google Patents

Enriquecimiento selectivo de anticuerpos

Info

Publication number
AR080466A1
AR080466A1 ARP110100705A ARP110100705A AR080466A1 AR 080466 A1 AR080466 A1 AR 080466A1 AR P110100705 A ARP110100705 A AR P110100705A AR P110100705 A ARP110100705 A AR P110100705A AR 080466 A1 AR080466 A1 AR 080466A1
Authority
AR
Argentina
Prior art keywords
binding
selective enrichment
antibodies
protein
target protein
Prior art date
Application number
ARP110100705A
Other languages
English (en)
Inventor
Philine Dobberthien
Maria-Katharina Hoyer
Michael Dieterle
Dorothee Ambrosius
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR080466A1 publication Critical patent/AR080466A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/32—Extraction; Separation; Purification by precipitation as complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Un procedimiento para el enriquecimiento selectivo de inmunoglobulinas u otras proteínas que contienen un dominio Fc (proteína diana), con las etapas: e. proporcionar una solucion que contiene la proteína diana; f. incorporar una proteína de union de Fc con exactamente dos sitios de union en condiciones que posibilitan una union; g. separar el precipitado de la fase líquida; h. liberar la union de la proteína diana con la proteína de union de Fc.
ARP110100705A 2010-03-05 2011-03-04 Enriquecimiento selectivo de anticuerpos AR080466A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10155647 2010-03-05

Publications (1)

Publication Number Publication Date
AR080466A1 true AR080466A1 (es) 2012-04-11

Family

ID=42470646

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110100705A AR080466A1 (es) 2010-03-05 2011-03-04 Enriquecimiento selectivo de anticuerpos

Country Status (11)

Country Link
US (3) US20120071637A1 (es)
EP (1) EP2542567B1 (es)
JP (1) JP5917417B2 (es)
KR (1) KR101855714B1 (es)
CN (1) CN102791728B (es)
AR (1) AR080466A1 (es)
AU (1) AU2011222991B2 (es)
CA (1) CA2791918C (es)
SG (1) SG183920A1 (es)
TW (1) TW201144325A (es)
WO (1) WO2011107518A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11566082B2 (en) 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
CN106084062B (zh) * 2015-04-28 2021-04-02 荣昌生物制药（烟台）有限公司 桥连的双特异性融合蛋白
US10654887B2 (en) 2016-05-11 2020-05-19 Ge Healthcare Bio-Process R&D Ab Separation matrix
ES2909833T3 (es) 2016-05-11 2022-05-10 Cytiva Bioprocess R & D Ab Método de limpieza y/o desinfección de una matriz de separación
US10703774B2 (en) 2016-09-30 2020-07-07 Ge Healthcare Bioprocess R&D Ab Separation method
US10730908B2 (en) 2016-05-11 2020-08-04 Ge Healthcare Bioprocess R&D Ab Separation method
ES2914278T3 (es) * 2016-05-11 2022-06-08 Cytiva Bioprocess R & D Ab Polipéptidos de unión a inmunoglobulina mutados
CN109311949B (zh) 2016-05-11 2022-09-16 思拓凡生物工艺研发有限公司 储存分离基质的方法
EP3455243B1 (en) 2016-05-11 2021-03-24 Cytiva BioProcess R&D AB Separation matrix
JP7031934B2 (ja) 2016-05-11 2022-03-08 サイティバ・バイオプロセス・アールアンドディ・アクチボラグ 分離マトリックス
US10889615B2 (en) 2016-05-11 2021-01-12 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
US12448411B2 (en) 2016-09-30 2025-10-21 Cytiva Bioprocess R&D Ab Separation method
JP7053577B2 (ja) * 2017-03-31 2022-04-12 株式会社カネカ 免疫グロブリン精製用アフィニティー分離マトリックス
WO2020018732A1 (en) * 2018-07-19 2020-01-23 Ab Studio Inc. Novel systems for screening internalizing antibody and uses thereof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0560807A1 (en) * 1990-11-26 1993-09-22 The Public Health Laboratory Service Board Immunoglobulin-binding proteins and recombinant dna molecules coding therefor
JP2584697B2 (ja) * 1991-08-23 1997-02-26 オリエンタル酵母工業株式会社 ＩｇＧ精製用組換え型プロテインＡ
WO1995006125A1 (en) * 1993-08-23 1995-03-02 Applied Immune Sciences, Inc. CHIMERIC RECEPTOR CONTAINING ONE IgG BINDING DOMAIN OF BOTH PROTEIN A AND PROTEIN G
US6949244B1 (en) 1995-12-20 2005-09-27 The Board Of Trustees Of The University Of Kentucky Murine monoclonal anti-idiotype antibody 11D10 and methods of use thereof
SE9901379D0 (sv) 1999-04-19 1999-04-19 Pharmacia & Upjohn Ab Receptor structures
US20040077017A1 (en) * 2001-01-12 2004-04-22 Amelie Karlstrom Detection methods
US7709209B2 (en) * 2002-03-25 2010-05-04 Ge Healthcare Bio-Sciences Ab Protein ligands
EP1592970A4 (en) * 2003-02-11 2007-09-19 Univ Washington REAGENT RESPONSE POLYMER CONJUGATES AND ASSOCIATED METHODS
IL157086A0 (en) 2003-07-24 2004-02-08 Guy Patchornik Multivalent ligand complexes
CA2586803C (en) 2004-12-14 2012-12-11 Ge Healthcare Bio-Sciences Ab Purification of immunoglobulins
US8728828B2 (en) * 2004-12-22 2014-05-20 Ge Healthcare Bio-Sciences Ab Purification of immunoglobulins
CN101213211A (zh) * 2005-06-17 2008-07-02 惠氏公司 纯化含Fc区蛋白的方法
CN102989018A (zh) * 2005-08-03 2013-03-27 Rq生物科技有限公司 用于诊断IgA和IgM介导的肾脏疾病的方法和组合物
JP4481260B2 (ja) * 2006-03-16 2010-06-16 株式会社カネカ 抗体結合性ペプチド
EP2066419B1 (en) 2006-09-29 2015-11-11 GE Healthcare Bio-Sciences AB Chromatography ligand comprising domain c from staphyloccocus aureus protein a for antibody isolation
WO2008067547A2 (en) * 2006-11-30 2008-06-05 Research Development Foundation Improved immunoglobulin libraries
US7691608B2 (en) 2006-12-06 2010-04-06 Repligen Corporation Nucleic acids encoding recombinant protein A
PL2220107T3 (pl) 2007-11-12 2017-05-31 Chreto Aps Polipeptydy o podwójnym powinowactwie do oczyszczania
US8592555B2 (en) * 2008-08-11 2013-11-26 Emd Millipore Corporation Immunoglobulin-binding proteins with improved specificity
US20120149875A1 (en) * 2009-01-12 2012-06-14 Ge Healthcare Bio-Sciences Ab Affinity chromatography matrix

Also Published As

Publication number Publication date
WO2011107518A1 (de) 2011-09-09
AU2011222991B2 (en) 2015-07-16
KR20130004476A (ko) 2013-01-10
TW201144325A (en) 2011-12-16
CA2791918A1 (en) 2011-09-09
US20140128578A1 (en) 2014-05-08
KR101855714B1 (ko) 2018-05-10
JP5917417B2 (ja) 2016-05-11
US10894806B2 (en) 2021-01-19
JP2013521258A (ja) 2013-06-10
CN102791728B (zh) 2015-04-01
SG183920A1 (en) 2012-10-30
EP2542567A2 (de) 2013-01-09
AU2011222991A1 (en) 2012-09-20
EP2542567B1 (de) 2020-02-12
US20210107937A1 (en) 2021-04-15
CA2791918C (en) 2019-11-19
US20120071637A1 (en) 2012-03-22
CN102791728A (zh) 2012-11-21

Similar Documents

Publication Publication Date Title
AR080466A1 (es) Enriquecimiento selectivo de anticuerpos
CL2018000461A1 (es) Anticuerpos biespecíficos con tetravalencia para un receptor de fnt coestimulador.
CY1124108T1 (el) Μορια συνδεσης που αναστελουν την αναπτυξη καρκινου
CY1123518T1 (el) Ανθρωπινα αντισωματα enanti-tau
MX2023006482A (es) Anticuerpos biespecificos especificos para un receptor de tnf coestimulador.
CY1120951T1 (el) Ανθρωπινα αντισωματα enanti-tau
EA201100300A1 (ru) Композиции и способы, предназначенные для направленного воздействия антител на белок c5 системы комплемента
EA201690492A1 (ru) Проникающие в клетку конъюгаты и способы их применения
WO2012142515A3 (en) Fc fusion proteins comprising novel linkers or arrangements
EA201201016A1 (ru) Антидоты антикоагулянтов
SG195073A1 (en) Deimmunized serum-binding domains and their use for extending serum half-life
EA201170030A1 (ru) Il-6-опосредованная иммунотерапия
EA201391564A1 (ru) Полипептиды антитела, которые антагонизируют cd40
CR20110544A (es) Anticuerpo antagonista específico para el heterodímero de alfa-4-beta-7
BR112014008382A2 (pt) anticorpo especificamente ligando a epítope no domínio sema do c-met
BR112014028785A2 (pt) proteínas de ligação a antígeno de st2
BR112015017354A2 (pt) método para detectar pelo menos uma base modificada
WO2013115410A3 (en) Anti-phospholipase d4 antibody
MX2021001418A (es) Produccion de proteinas heteromultimericas usando celulas de mamifero.
MX377780B (es) Sobreexpresion de reguladores de la ruta de n-glicosilacion para modular la glicosilacion de proteinas recombinantes.
BR112014019773A8 (pt) Ligantes para anticorpo e proteína de fusão fc para cromatografia de afinidade
CL2014000434A1 (es) Metodo para determinar la presencia o ausencia de un anticuerpo que se enlaza de manera específica a una proteína e (rns) de virus de diarrea viral bovina (bvdv); equipo de diagnostico que comprende los reactivos.
HK1220456A1 (zh) 6-乙酰吗啡类似物，和其合成方法和用途
WO2011133608A3 (en) Engineering surface epitopes to improve protein crystallization
CY1120686T1 (el) Αντισωματα ειδικα για το ανθρωπινο πολυπεπτιδιο αμυλοειδους των νησιδιων (ηιαρρ) και χρησεις αυτων

Legal Events

Date Code Title Description
FB Suspension of granting procedure