EA201100300A1 - Композиции и способы, предназначенные для направленного воздействия антител на белок c5 системы комплемента - Google Patents

Композиции и способы, предназначенные для направленного воздействия антител на белок c5 системы комплемента

Info

Publication number
EA201100300A1
EA201100300A1 EA201100300A EA201100300A EA201100300A1 EA 201100300 A1 EA201100300 A1 EA 201100300A1 EA 201100300 A EA201100300 A EA 201100300A EA 201100300 A EA201100300 A EA 201100300A EA 201100300 A1 EA201100300 A1 EA 201100300A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibodies
compositions
complement system
methods intended
directed impact
Prior art date
Application number
EA201100300A
Other languages
English (en)
Other versions
EA027575B1 (ru
Inventor
Беате Дифенбах-Штрайбер
Адина Эберт
Брейдон Чарлз Гилд
Ён-Ин Ким
Майкл Рогуска
Игор Сплавски
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201100300A1 publication Critical patent/EA201100300A1/ru
Publication of EA027575B1 publication Critical patent/EA027575B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

В заявке описаны антитела, оказывающие направленное воздействие на белок С5 системы комплемента, и содержащие их композиции и способы их применения.
EA201100300A 2008-08-05 2009-08-03 Антитело или его антигенсвязывающий фрагмент, связывающий человеческий белок с5, содержащая их композиция, нуклеиновая кислота, кодирующая антитело или его антигенсвязывающий фрагмент, содержащие эту кислоту вектор и клетка-хозяин и применение антитела или его антигенсвязывающего фрагмента EA027575B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8635508P 2008-08-05 2008-08-05
PCT/EP2009/060052 WO2010015608A1 (en) 2008-08-05 2009-08-03 Compositions and methods for antibodies targeting complement protein c5

Publications (2)

Publication Number Publication Date
EA201100300A1 true EA201100300A1 (ru) 2011-12-30
EA027575B1 EA027575B1 (ru) 2017-08-31

Family

ID=41227252

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201100300A EA027575B1 (ru) 2008-08-05 2009-08-03 Антитело или его антигенсвязывающий фрагмент, связывающий человеческий белок с5, содержащая их композиция, нуклеиновая кислота, кодирующая антитело или его антигенсвязывающий фрагмент, содержащие эту кислоту вектор и клетка-хозяин и применение антитела или его антигенсвязывающего фрагмента

Country Status (38)

Country Link
US (5) US8241628B2 (ru)
EP (3) EP2328616B1 (ru)
JP (2) JP5815403B2 (ru)
KR (1) KR101463296B1 (ru)
CN (2) CN104177495B (ru)
AR (1) AR072897A1 (ru)
AU (1) AU2009279197B2 (ru)
BR (1) BRPI0916668B1 (ru)
CA (1) CA2732782C (ru)
CL (1) CL2011000233A1 (ru)
CO (1) CO6351750A2 (ru)
CR (2) CR20110035A (ru)
CU (1) CU23978B1 (ru)
DK (1) DK2328616T3 (ru)
EA (1) EA027575B1 (ru)
EC (1) ECSP11010805A (ru)
ES (2) ES2541142T3 (ru)
HK (4) HK1203156A1 (ru)
HN (1) HN2011000357A (ru)
HR (1) HRP20150799T1 (ru)
HU (1) HUE026179T2 (ru)
IL (1) IL210768B (ru)
JO (1) JO3118B1 (ru)
MA (1) MA32535B1 (ru)
MX (2) MX356218B (ru)
MY (1) MY159396A (ru)
NZ (2) NZ600622A (ru)
PE (1) PE20110225A1 (ru)
PL (1) PL2328616T3 (ru)
PT (1) PT2328616E (ru)
RS (1) RS54113B1 (ru)
SG (1) SG10201405377XA (ru)
SI (1) SI2328616T1 (ru)
SV (1) SV2011003834A (ru)
TW (2) TWI417107B (ru)
UA (1) UA105009C2 (ru)
WO (1) WO2010015608A1 (ru)
ZA (1) ZA201100375B (ru)

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US11046784B2 (en) 2006-03-31 2021-06-29 Chugai Seiyaku Kabushiki Kaisha Methods for controlling blood pharmacokinetics of antibodies
US11248053B2 (en) 2007-09-26 2022-02-15 Chugai Seiyaku Kabushiki Kaisha Method of modifying isoelectric point of antibody via amino acid substitution in CDR
US11359194B2 (en) 2008-04-11 2022-06-14 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding two or more antigen molecules repeatedly
US11597760B2 (en) 2014-12-19 2023-03-07 Chugai Seiyaku Kabushiki Kaisha Method of detecting the presence of complement C5
US11780912B2 (en) 2016-08-05 2023-10-10 Chugai Seiyaku Kabushiki Kaisha Composition for prophylaxis or treatment of IL-8 related diseases
US11891434B2 (en) 2010-11-30 2024-02-06 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly

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US10407496B2 (en) 2019-09-10
KR20110038173A (ko) 2011-04-13
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PL2328616T3 (pl) 2015-10-30
BRPI0916668B1 (pt) 2021-12-28
HK1156226A1 (en) 2012-06-08
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CR20110035A (es) 2011-03-08
CA2732782C (en) 2019-02-26
NZ590634A (en) 2012-07-27
AR072897A1 (es) 2010-09-29
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US20130064836A1 (en) 2013-03-14
DK2328616T3 (en) 2015-07-20
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MX356218B (es) 2018-05-18
ZA201100375B (en) 2011-10-26
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IL210768B (en) 2018-02-28
MA32535B1 (fr) 2011-08-01
UA105009C2 (ru) 2014-04-10
EP2815766B1 (en) 2017-07-05
US20100034809A1 (en) 2010-02-11
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AU2009279197B2 (en) 2013-12-12

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