CO6351750A2 - Composiciones y métodos para anticuerpos que se dirigen a la proteina de complementos c5 - Google Patents

Composiciones y métodos para anticuerpos que se dirigen a la proteina de complementos c5

Info

Publication number
CO6351750A2
CO6351750A2 CO11011416A CO11011416A CO6351750A2 CO 6351750 A2 CO6351750 A2 CO 6351750A2 CO 11011416 A CO11011416 A CO 11011416A CO 11011416 A CO11011416 A CO 11011416A CO 6351750 A2 CO6351750 A2 CO 6351750A2
Authority
CO
Colombia
Prior art keywords
antibodies
compositions
methods
complement protein
complement
Prior art date
Application number
CO11011416A
Other languages
English (en)
Inventor
Streiber Beate Diefenbach
Adina Eberth
Braydon Charles Guild
Yong-In Kim
Igor Splawski
Original Assignee
Novartis Ag
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Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CO6351750A2 publication Critical patent/CO6351750A2/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a anticuerpos que se dirigen a la proteína de complemento C5, ácidos nucléicos, vectores, y a composiciones y métodos de uso de los mismos.
CO11011416A 2008-08-05 2011-02-01 Composiciones y métodos para anticuerpos que se dirigen a la proteina de complementos c5 CO6351750A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8635508P 2008-08-05 2008-08-05

Publications (1)

Publication Number Publication Date
CO6351750A2 true CO6351750A2 (es) 2011-12-20

Family

ID=41227252

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11011416A CO6351750A2 (es) 2008-08-05 2011-02-01 Composiciones y métodos para anticuerpos que se dirigen a la proteina de complementos c5

Country Status (38)

Country Link
US (5) US8241628B2 (es)
EP (3) EP2328616B1 (es)
JP (2) JP5815403B2 (es)
KR (1) KR101463296B1 (es)
CN (2) CN104177495B (es)
AR (1) AR072897A1 (es)
AU (1) AU2009279197B2 (es)
BR (1) BRPI0916668B1 (es)
CA (1) CA2732782C (es)
CL (1) CL2011000233A1 (es)
CO (1) CO6351750A2 (es)
CR (2) CR20110035A (es)
CU (1) CU23978B1 (es)
DK (1) DK2328616T3 (es)
EA (1) EA027575B1 (es)
EC (1) ECSP11010805A (es)
ES (2) ES2541142T3 (es)
HK (4) HK1202269A1 (es)
HN (1) HN2011000357A (es)
HR (1) HRP20150799T1 (es)
HU (1) HUE026179T2 (es)
IL (1) IL210768B (es)
JO (1) JO3118B1 (es)
MA (1) MA32535B1 (es)
MX (2) MX2011001371A (es)
MY (1) MY159396A (es)
NZ (2) NZ600622A (es)
PE (1) PE20110225A1 (es)
PL (1) PL2328616T3 (es)
PT (1) PT2328616E (es)
RS (1) RS54113B1 (es)
SG (1) SG10201405377XA (es)
SI (1) SI2328616T1 (es)
SV (1) SV2011003834A (es)
TW (2) TWI417107B (es)
UA (1) UA105009C2 (es)
WO (1) WO2010015608A1 (es)
ZA (1) ZA201100375B (es)

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