PL2328616T3 - Kompozycje i sposoby dla przeciwciał celujących białko dopełniacza C5 - Google Patents
Kompozycje i sposoby dla przeciwciał celujących białko dopełniacza C5Info
- Publication number
- PL2328616T3 PL2328616T3 PL09737379T PL09737379T PL2328616T3 PL 2328616 T3 PL2328616 T3 PL 2328616T3 PL 09737379 T PL09737379 T PL 09737379T PL 09737379 T PL09737379 T PL 09737379T PL 2328616 T3 PL2328616 T3 PL 2328616T3
- Authority
- PL
- Poland
- Prior art keywords
- compositions
- methods
- antibodies against
- complement protein
- against complement
- Prior art date
Links
- 102000000989 Complement System Proteins Human genes 0.000 title 1
- 108010069112 Complement System Proteins Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8635508P | 2008-08-05 | 2008-08-05 | |
| PCT/EP2009/060052 WO2010015608A1 (en) | 2008-08-05 | 2009-08-03 | Compositions and methods for antibodies targeting complement protein c5 |
| EP09737379.9A EP2328616B1 (en) | 2008-08-05 | 2009-08-03 | Compositions and methods for antibodies against complement protein c5 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2328616T3 true PL2328616T3 (pl) | 2015-10-30 |
Family
ID=41227252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09737379T PL2328616T3 (pl) | 2008-08-05 | 2009-08-03 | Kompozycje i sposoby dla przeciwciał celujących białko dopełniacza C5 |
Country Status (38)
| Country | Link |
|---|---|
| US (5) | US8241628B2 (pl) |
| EP (3) | EP2837388A1 (pl) |
| JP (2) | JP5815403B2 (pl) |
| KR (1) | KR101463296B1 (pl) |
| CN (2) | CN104177495B (pl) |
| AR (1) | AR072897A1 (pl) |
| AU (1) | AU2009279197B2 (pl) |
| BR (1) | BRPI0916668B1 (pl) |
| CA (1) | CA2732782C (pl) |
| CL (1) | CL2011000233A1 (pl) |
| CO (1) | CO6351750A2 (pl) |
| CR (2) | CR20110035A (pl) |
| CU (1) | CU23978B1 (pl) |
| DK (1) | DK2328616T3 (pl) |
| EA (1) | EA027575B1 (pl) |
| EC (1) | ECSP11010805A (pl) |
| ES (2) | ES2541142T3 (pl) |
| HK (1) | HK1203156A1 (pl) |
| HN (1) | HN2011000357A (pl) |
| HR (1) | HRP20150799T1 (pl) |
| HU (1) | HUE026179T2 (pl) |
| IL (1) | IL210768B (pl) |
| JO (1) | JO3118B1 (pl) |
| MA (1) | MA32535B1 (pl) |
| MX (2) | MX2011001371A (pl) |
| MY (1) | MY159396A (pl) |
| NZ (2) | NZ590634A (pl) |
| PE (1) | PE20110225A1 (pl) |
| PL (1) | PL2328616T3 (pl) |
| PT (1) | PT2328616E (pl) |
| RS (1) | RS54113B1 (pl) |
| SG (1) | SG10201405377XA (pl) |
| SI (1) | SI2328616T1 (pl) |
| SV (1) | SV2011003834A (pl) |
| TW (2) | TWI417107B (pl) |
| UA (1) | UA105009C2 (pl) |
| WO (1) | WO2010015608A1 (pl) |
| ZA (1) | ZA201100375B (pl) |
Families Citing this family (157)
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| WO2009023184A2 (en) * | 2007-08-10 | 2009-02-19 | Protelix, Inc. | Universal fibronectin type iii binding-domain libraries |
| US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
| US8680019B2 (en) * | 2007-08-10 | 2014-03-25 | Protelica, Inc. | Universal fibronectin Type III binding-domain libraries |
| EP3127921A1 (en) | 2007-09-26 | 2017-02-08 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substition in cdr |
| HUE067049T2 (hu) | 2008-04-11 | 2024-09-28 | Chugai Pharmaceutical Co Ltd | Két vagy több antigén-molekulát ismétlõdõen megkötni képes antigénkötõ molekula |
| AR072897A1 (es) * | 2008-08-05 | 2010-09-29 | Novartis Ag | Composiciones y metodos para anticuerpos que se dirigen a la proteina de complemento c5 |
| NZ614351A (en) | 2008-11-10 | 2015-05-29 | Alexion Pharma Inc | Methods and compositions for treating complement-associated disorders |
| AR076284A1 (es) * | 2009-04-29 | 2011-06-01 | Bayer Schering Pharma Ag | Inmunoconjugados de antimesotelina y usos de los mismos |
| ME01699B (me) | 2009-07-02 | 2014-09-20 | Musc Found For Res Dev | Metode za stimulaciju regeneracije jetre |
| NZ600393A (en) | 2009-11-05 | 2014-08-29 | Alexion Cambridge Corp | Treatment of paroxysmal nocturnal hemoglobinuria, hemolytic anemias and disease states involving intravascular and extravascular hemolysis |
| BR112012029067A2 (pt) | 2010-05-14 | 2019-09-24 | Univ Colorado Regents | grupos-alvo de receptor do complemento 2 (cr2) melhorados. |
| MX2012014975A (es) | 2010-06-22 | 2013-03-12 | Univ Colorado Regents | Anticuerpos al fragmento c3d de componente 3 de complemento. |
| CN103328632A (zh) | 2010-11-30 | 2013-09-25 | 中外制药株式会社 | 与多分子的抗原重复结合的抗原结合分子 |
| CA2822288A1 (en) * | 2010-12-22 | 2012-06-28 | Medimmune, Llc | Anti-c5/c5a/c5adesr antibodies and fragments |
| EP3604330A1 (en) | 2011-02-25 | 2020-02-05 | Chugai Seiyaku Kabushiki Kaisha | Fcgammariib-specific fc antibody |
| EP2731970B1 (en) | 2011-07-15 | 2018-11-28 | MorphoSys AG | Antibodies that are cross-reactive for macrophage migration inhibitory factor (mif) and d-dopachrome tautomerase (d-dt) |
| WO2013047748A1 (ja) | 2011-09-30 | 2013-04-04 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| SG10201609301QA (en) | 2011-11-30 | 2016-12-29 | Chugai Pharmaceutical Co Ltd | Drug containing carrier into cell for forming immune complex |
| SG10201703249PA (en) * | 2011-12-21 | 2017-05-30 | Novartis Ag | Compositions and methods for antibodies targeting factor p |
| HK1201296A1 (en) | 2012-02-09 | 2015-08-28 | 中外制药株式会社 | Modified fc region of antibody |
| MY167232A (en) * | 2012-02-20 | 2018-08-14 | Swedish Orphan Biovitrum Ab Publ | Polypeptides binding to human complement c5 |
| EP2854760B1 (en) | 2012-05-25 | 2018-10-17 | Novartis AG | Aqueous pharmaceutical composition containing a biologic therapeutic agent and l-arginine derivative and an injection including the composition |
| US10413620B2 (en) | 2012-08-17 | 2019-09-17 | The Regents Of The University Of Colorado, A Body Corporate | Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging |
| AU2013302441B2 (en) | 2012-08-17 | 2018-05-10 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for detecting complement activation |
| SG11201500873XA (en) | 2012-08-24 | 2015-04-29 | Chugai Pharmaceutical Co Ltd | Fcgriib-specific fc region variant |
| CN110818798A (zh) | 2012-10-25 | 2020-02-21 | 美国比奥维拉迪维股份有限公司 | 抗补体C1s抗体和其用途 |
| GB2509260B (en) | 2012-11-02 | 2016-05-04 | True North Therapeutics Inc | Anti-complement C1s antibodies and uses thereof |
| WO2014074905A1 (en) | 2012-11-08 | 2014-05-15 | Eleven Biotherapeutics, Inc. | Il-6 antagonists and uses thereof |
| LT2928921T (lt) * | 2012-12-05 | 2021-04-26 | Novartis Ag | Kompozicijos ir būdai, skirti antikūnams nukreipti į epo |
| RU2663349C2 (ru) * | 2013-01-31 | 2018-08-03 | СЕУЛ НЭШНЛ ЮНИВЕРСИТИ Ар энд ДиБи ФАУНДЕЙШН | Антитело против с5 и способ предупреждения и лечения обусловленных комплементом заболеваний |
| WO2014160958A1 (en) | 2013-03-29 | 2014-10-02 | Alexion Pharmaceuticals, Inc. | Compositions and methods for increasing the serum half-life of a therapeutic agent targeting complement c5 |
| KR102318483B1 (ko) | 2013-04-02 | 2021-10-27 | 추가이 세이야쿠 가부시키가이샤 | Ｆｃ영역 개변체 |
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| PL3039033T3 (pl) | 2013-08-28 | 2020-01-31 | Affibody Ab | Polipeptydy wiążące o zmutowanym rusztowaniu |
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| WO2016094834A2 (en) | 2014-12-12 | 2016-06-16 | Alexion Pharmaceuticals, Inc. | A method for treating a complement mediated disorder caused by an infectious agent in a patient |
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| TWI779010B (zh) | 2014-12-19 | 2022-10-01 | 日商中外製藥股份有限公司 | 抗肌抑素之抗體、含變異Ｆｃ區域之多胜肽及使用方法 |
| CN113956354A (zh) | 2015-01-22 | 2022-01-21 | 中外制药株式会社 | 两种以上抗-c5抗体的组合与使用方法 |
| US20180311299A1 (en) * | 2015-05-01 | 2018-11-01 | Alexion Pharmaceuticals, Inc. | Efficacy of an anti-c5 antibody in the prevention of antibody mediated rejection in sensitized recipients of a kidney transplant |
| US20180230540A1 (en) | 2015-08-12 | 2018-08-16 | Novartis Ag | Methods of treating ophthalmic disorders |
| WO2017035401A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Amide compounds for treatment of immune and inflammatory disorders |
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| JP7221691B2 (ja) | 2015-10-30 | 2023-02-14 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | Ｔ細胞媒介性同種移植片血管障害の増悪を抑制する方法 |
| CN109069623A (zh) * | 2015-12-18 | 2018-12-21 | 诺华股份有限公司 | 靶向CD32b的抗体及其使用方法 |
| SI3390442T1 (sl) * | 2015-12-18 | 2024-01-31 | Chugai Seiyaku Kabushiki Kaisha | Protitelesa proti c5 in postopki uporabe |
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| US20190225678A1 (en) * | 2016-06-07 | 2019-07-25 | Novartis Ag | Anti-c5 antibody for treating patients with complement c5 polymorphism |
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| FI3525583T3 (fi) | 2016-10-12 | 2025-10-31 | Bioverativ Usa Inc | Anti-c1s-vasta-aineita ja niiden käyttömenetelmiä |
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