EA201100868A1 - Противоопухолевые комбинации, содержащие антитела, специфически распознающие cd38, и цитарабин - Google Patents

Противоопухолевые комбинации, содержащие антитела, специфически распознающие cd38, и цитарабин

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Publication number
EA201100868A1
EA201100868A1 EA201100868A EA201100868A EA201100868A1 EA 201100868 A1 EA201100868 A1 EA 201100868A1 EA 201100868 A EA201100868 A EA 201100868A EA 201100868 A EA201100868 A EA 201100868A EA 201100868 A1 EA201100868 A1 EA 201100868A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cytarabines
antibodies specifically
specifically recognizing
containing antibodies
combinations containing
Prior art date
Application number
EA201100868A
Other languages
English (en)
Other versions
EA027070B1 (ru
Inventor
Паскаль Лежен
Патрисья Вриньо
Original Assignee
Санофи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40627502&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201100868(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Санофи filed Critical Санофи
Publication of EA201100868A1 publication Critical patent/EA201100868A1/ru
Publication of EA027070B1 publication Critical patent/EA027070B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)

Abstract

Фармацевтическая композиция/ содержащая антитело, специфически распознающее CD38, и цитарабин.
EA201100868A 2008-11-28 2009-11-27 Противоопухолевые комбинации, содержащие антитела, специфически распознающие cd38, и цитарабин EA027070B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08291118A EP2191842A1 (en) 2008-11-28 2008-11-28 Antitumor combinations containing antibodies recognizing specifically CD38 and cytarabine
PCT/IB2009/055391 WO2010061359A1 (en) 2008-11-28 2009-11-27 Antitumor combinations containing antibodies recognizing specifically cd38 and cytarabine

Publications (2)

Publication Number Publication Date
EA201100868A1 true EA201100868A1 (ru) 2011-10-31
EA027070B1 EA027070B1 (ru) 2017-06-30

Family

ID=40627502

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201100868A EA027070B1 (ru) 2008-11-28 2009-11-27 Противоопухолевые комбинации, содержащие антитела, специфически распознающие cd38, и цитарабин

Country Status (38)

Country Link
US (1) US20120093806A1 (ru)
EP (2) EP2191842A1 (ru)
JP (2) JP2012510463A (ru)
KR (1) KR101715958B1 (ru)
CN (2) CN102264386A (ru)
AR (1) AR073425A1 (ru)
AU (1) AU2009321251B2 (ru)
BR (1) BRPI0921858B1 (ru)
CA (1) CA2745005C (ru)
CL (1) CL2011001232A1 (ru)
CO (1) CO6440556A2 (ru)
CR (1) CR20110282A (ru)
DK (1) DK2370096T5 (ru)
EA (1) EA027070B1 (ru)
EC (1) ECSP11011071A (ru)
ES (1) ES2638926T3 (ru)
HN (1) HN2011001423A (ru)
HR (1) HRP20171301T1 (ru)
HU (1) HUE035910T2 (ru)
IL (2) IL213115A (ru)
LT (1) LT2370096T (ru)
MA (1) MA32899B1 (ru)
MX (1) MX344973B (ru)
NI (1) NI201100107A (ru)
NZ (1) NZ593085A (ru)
PA (1) PA8849901A1 (ru)
PE (1) PE20120205A1 (ru)
PL (1) PL2370096T3 (ru)
PT (1) PT2370096T (ru)
RS (1) RS56248B1 (ru)
SG (1) SG171821A1 (ru)
SI (1) SI2370096T1 (ru)
TN (1) TN2011000242A1 (ru)
TW (1) TWI436770B (ru)
UA (1) UA104160C2 (ru)
UY (1) UY32266A (ru)
WO (1) WO2010061359A1 (ru)
ZA (1) ZA201104064B (ru)

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HUE031956T2 (en) 2010-09-27 2017-08-28 Morphosys Ag Anti-CD38 antibody and lenalidomide or bortezomib for the treatment of multiple myeloma and NHL
UA112170C2 (uk) * 2010-12-10 2016-08-10 Санофі Протипухлинна комбінація, що містить антитіло, яке специфічно розпізнає cd38, і бортезоміб
JOP20210044A1 (ar) 2010-12-30 2017-06-16 Takeda Pharmaceuticals Co الأجسام المضادة لـ cd38
MX368288B (es) 2012-09-25 2019-09-27 Morphosys Ag Una combinación de anticuerpos anti-cd38 y melfalán para usarse en el tratamiento de mieloma múltiple.
RU2723937C2 (ru) 2013-03-13 2020-06-18 Санофи Композиции, включающие антитела к cd38 и карфилзомиб
KR20160077155A (ko) * 2013-10-31 2016-07-01 사노피 인간 암을 치료하기 위한 특이적 항-ｃｄ38 항체
US9732154B2 (en) 2014-02-28 2017-08-15 Janssen Biotech, Inc. Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia
US9603927B2 (en) 2014-02-28 2017-03-28 Janssen Biotech, Inc. Combination therapies with anti-CD38 antibodies
JP6707531B2 (ja) 2014-09-09 2020-06-10 ヤンセン バイオテツク，インコーポレーテツド 抗ｃｄ３８抗体による併用療法
JP6802791B2 (ja) 2014-12-04 2020-12-23 ヤンセン バイオテツク，インコーポレーテツド 急性骨髄性白血病の治療のための抗ｃｄ３８抗体
CR20170526A (es) 2015-05-20 2018-04-03 Janssen Biotech Inc ANTICUERPOS ANTI-CD38 PARA EL TRATAMIENTO DE AMILOIDOSIS DE CADENA LIGERA y OTRAS ENFERMEDADES MALIGNAS HEMATOLÓGICAS POSITIVAS PARA CD38
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EP3350595B1 (en) * 2015-09-14 2021-08-04 Leukemia Therapeutics, LLC Identification of novel diagnostics and therapeutics by modulating rhoh
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US10781261B2 (en) 2015-11-03 2020-09-22 Janssen Biotech, Inc. Subcutaneous formulations of anti-CD38 antibodies and their uses
WO2019035938A1 (en) 2017-08-16 2019-02-21 Elstar Therapeutics, Inc. MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF
KR20200079293A (ko) 2017-10-31 2020-07-02 얀센 바이오테크 인코포레이티드 고위험 다발성 골수종을 치료하는 방법
CA3130132A1 (en) 2019-03-15 2020-09-24 Morphosys Ag Anti-cd38 antibodies and pharmaceutical compositions thereof for the treatment of autoantibody-mediated autoimmune disease
US11655302B2 (en) 2019-06-10 2023-05-23 Sanofi Anti-CD38 antibodies and formulations
CN112876563B (zh) * 2019-11-29 2022-08-16 康诺亚生物医药科技（成都）有限公司 药物组合物及其制备方法和应用
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CA3204187A1 (en) 2021-01-14 2022-07-21 Stefan Steidl Anti-cd38 antibodies and their uses
TW202302642A (zh) 2021-03-01 2023-01-16 德商莫菲西斯公司 用於治療抗體介導移植物排斥用途之抗ｃｄ３８抗體
CN113278075B (zh) * 2021-06-18 2021-12-14 芜湖森爱驰生物科技有限公司 一种炎症检测试剂盒
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Also Published As

Publication number Publication date
LT2370096T (lt) 2017-09-25
EP2191842A1 (en) 2010-06-02
EP2370096B1 (en) 2017-05-31
IL213118A0 (en) 2011-07-31
WO2010061359A1 (en) 2010-06-03
CA2745005C (en) 2020-08-11
PA8849901A1 (es) 2010-07-27
MX344973B (es) 2017-01-12
KR101715958B1 (ko) 2017-03-14
HUE035910T2 (en) 2018-05-28
BRPI0921858B1 (pt) 2022-11-16
CR20110282A (es) 2011-09-20
PT2370096T (pt) 2017-09-08
SI2370096T1 (sl) 2017-10-30
CN102264386A (zh) 2011-11-30
MA32899B1 (fr) 2011-12-01
HN2011001423A (es) 2014-01-13
IL213115A0 (en) 2011-07-31
ECSP11011071A (es) 2011-07-29
CO6440556A2 (es) 2012-05-15
BRPI0921858A2 (pt) 2018-10-09
CL2011001232A1 (es) 2012-02-10
PL2370096T3 (pl) 2017-10-31
CA2745005A1 (en) 2010-06-03
IL213118A (en) 2017-08-31
AU2009321251B2 (en) 2016-06-09
TWI436770B (zh) 2014-05-11
AU2009321251A1 (en) 2010-06-03
JP2015205893A (ja) 2015-11-19
EA027070B1 (ru) 2017-06-30
NZ593085A (en) 2012-12-21
IL213115A (en) 2017-08-31
JP2012510463A (ja) 2012-05-10
PE20120205A1 (es) 2012-03-03
ZA201104064B (en) 2012-09-26
AR073425A1 (es) 2010-11-03
KR20110096551A (ko) 2011-08-30
TN2011000242A1 (en) 2012-12-17
RS56248B1 (sr) 2017-11-30
UA104160C2 (ru) 2014-01-10
DK2370096T5 (en) 2017-09-18
EP2370096A1 (en) 2011-10-05
NI201100107A (es) 2011-09-26
US20120093806A1 (en) 2012-04-19
TW201023863A (en) 2010-07-01
CN107096022A (zh) 2017-08-29
ES2638926T3 (es) 2017-10-24
HRP20171301T1 (hr) 2017-10-20
MX2011005666A (es) 2011-09-30
JP6072854B2 (ja) 2017-02-01
DK2370096T3 (en) 2017-07-17
UY32266A (es) 2010-06-30
SG171821A1 (en) 2011-07-28

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