JP2017121244A5 - - Google Patents
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- Publication number
- JP2017121244A5 JP2017121244A5 JP2017018370A JP2017018370A JP2017121244A5 JP 2017121244 A5 JP2017121244 A5 JP 2017121244A5 JP 2017018370 A JP2017018370 A JP 2017018370A JP 2017018370 A JP2017018370 A JP 2017018370A JP 2017121244 A5 JP2017121244 A5 JP 2017121244A5
- Authority
- JP
- Japan
- Prior art keywords
- guanosine
- polynucleotide
- composition
- composition according
- open reading
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 11
- 108091033319 polynucleotide Proteins 0.000 claims 9
- 239000002157 polynucleotide Substances 0.000 claims 9
- 102000040430 polynucleotide Human genes 0.000 claims 9
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 6
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 6
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 6
- 150000002632 lipids Chemical class 0.000 claims 5
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 229930024421 Adenine Natural products 0.000 claims 3
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 3
- 229960000643 adenine Drugs 0.000 claims 3
- 229940104302 cytosine Drugs 0.000 claims 3
- 210000004962 mammalian cell Anatomy 0.000 claims 3
- 239000002105 nanoparticle Substances 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 229940035893 uracil Drugs 0.000 claims 3
- 108700026244 Open Reading Frames Proteins 0.000 claims 2
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical class O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 claims 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 2
- 239000002777 nucleoside Substances 0.000 claims 2
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 2
- RVHYPUORVDKRTM-UHFFFAOYSA-N 1-[2-[bis(2-hydroxydodecyl)amino]ethyl-[2-[4-[2-[bis(2-hydroxydodecyl)amino]ethyl]piperazin-1-yl]ethyl]amino]dodecan-2-ol Chemical compound CCCCCCCCCCC(O)CN(CC(O)CCCCCCCCCC)CCN(CC(O)CCCCCCCCCC)CCN1CCN(CCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)CC1 RVHYPUORVDKRTM-UHFFFAOYSA-N 0.000 claims 1
- UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 claims 1
- UTAIYTHAJQNQDW-KQYNXXCUSA-N 1-methylguanosine Chemical compound C1=NC=2C(=O)N(C)C(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O UTAIYTHAJQNQDW-KQYNXXCUSA-N 0.000 claims 1
- UVBYMVOUBXYSFV-XUTVFYLZSA-N 1-methylpseudouridine Chemical group O=C1NC(=O)N(C)C=C1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 UVBYMVOUBXYSFV-XUTVFYLZSA-N 0.000 claims 1
- LRFJOIPOPUJUMI-KWXKLSQISA-N 2-[2,2-bis[(9z,12z)-octadeca-9,12-dienyl]-1,3-dioxolan-4-yl]-n,n-dimethylethanamine Chemical compound CCCCC\C=C/C\C=C/CCCCCCCCC1(CCCCCCCC\C=C/C\C=C/CCCCC)OCC(CCN(C)C)O1 LRFJOIPOPUJUMI-KWXKLSQISA-N 0.000 claims 1
- JRYMOPZHXMVHTA-DAGMQNCNSA-N 2-amino-7-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1h-pyrrolo[2,3-d]pyrimidin-4-one Chemical compound C1=CC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O JRYMOPZHXMVHTA-DAGMQNCNSA-N 0.000 claims 1
- BGTXMQUSDNMLDW-AEHJODJJSA-N 2-amino-9-[(2r,3s,4r,5r)-3-fluoro-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purin-6-one Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](CO)[C@@H](O)[C@]1(O)F BGTXMQUSDNMLDW-AEHJODJJSA-N 0.000 claims 1
- 108020005345 3' Untranslated Regions Proteins 0.000 claims 1
- HXVVOLDXHIMZJZ-UHFFFAOYSA-N 3-[2-[2-[2-[bis[3-(dodecylamino)-3-oxopropyl]amino]ethyl-[3-(dodecylamino)-3-oxopropyl]amino]ethylamino]ethyl-[3-(dodecylamino)-3-oxopropyl]amino]-n-dodecylpropanamide Chemical compound CCCCCCCCCCCCNC(=O)CCN(CCC(=O)NCCCCCCCCCCCC)CCN(CCC(=O)NCCCCCCCCCCCC)CCNCCN(CCC(=O)NCCCCCCCCCCCC)CCC(=O)NCCCCCCCCCCCC HXVVOLDXHIMZJZ-UHFFFAOYSA-N 0.000 claims 1
- 108020003589 5' Untranslated Regions Proteins 0.000 claims 1
- HCAJQHYUCKICQH-VPENINKCSA-N 8-Oxo-7,8-dihydro-2'-deoxyguanosine Chemical compound C1=2NC(N)=NC(=O)C=2NC(=O)N1[C@H]1C[C@H](O)[C@@H](CO)O1 HCAJQHYUCKICQH-VPENINKCSA-N 0.000 claims 1
- 241000180579 Arca Species 0.000 claims 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 1
- 108020004705 Codon Proteins 0.000 claims 1
- UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical class C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 claims 1
- 229930010555 Inosine Natural products 0.000 claims 1
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 claims 1
- NRLNQCOGCKAESA-KWXKLSQISA-N [(6z,9z,28z,31z)-heptatriaconta-6,9,28,31-tetraen-19-yl] 4-(dimethylamino)butanoate Chemical compound CCCCC\C=C/C\C=C/CCCCCCCCC(OC(=O)CCCN(C)C)CCCCCCCC\C=C/C\C=C/CCCCC NRLNQCOGCKAESA-KWXKLSQISA-N 0.000 claims 1
- 229960005305 adenosine Drugs 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 claims 1
- 229940029575 guanosine Drugs 0.000 claims 1
- 229960003786 inosine Drugs 0.000 claims 1
- GLGLUQVVDHRLQK-WRBBJXAJSA-N n,n-dimethyl-2,3-bis[(z)-octadec-9-enoxy]propan-1-amine Chemical compound CCCCCCCC\C=C/CCCCCCCCOCC(CN(C)C)OCCCCCCCC\C=C/CCCCCCCC GLGLUQVVDHRLQK-WRBBJXAJSA-N 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018204593A JP6921797B2 (ja) | 2012-04-02 | 2018-10-31 | ヒト疾患に関連する生物製剤およびタンパク質の産生のための修飾ポリヌクレオチド |
Applications Claiming Priority (100)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261618866P | 2012-04-02 | 2012-04-02 | |
| US201261618953P | 2012-04-02 | 2012-04-02 | |
| US201261618885P | 2012-04-02 | 2012-04-02 | |
| US201261618911P | 2012-04-02 | 2012-04-02 | |
| US201261618945P | 2012-04-02 | 2012-04-02 | |
| US201261618873P | 2012-04-02 | 2012-04-02 | |
| US201261618870P | 2012-04-02 | 2012-04-02 | |
| US201261618922P | 2012-04-02 | 2012-04-02 | |
| US201261618878P | 2012-04-02 | 2012-04-02 | |
| US201261618957P | 2012-04-02 | 2012-04-02 | |
| US201261618868P | 2012-04-02 | 2012-04-02 | |
| US201261618896P | 2012-04-02 | 2012-04-02 | |
| US201261618961P | 2012-04-02 | 2012-04-02 | |
| US201261618862P | 2012-04-02 | 2012-04-02 | |
| US61/618,862 | 2012-04-02 | ||
| US61/618,896 | 2012-04-02 | ||
| US61/618,878 | 2012-04-02 | ||
| US61/618,873 | 2012-04-02 | ||
| US61/618,866 | 2012-04-02 | ||
| US61/618,911 | 2012-04-02 | ||
| US61/618,961 | 2012-04-02 | ||
| US61/618,945 | 2012-04-02 | ||
| US61/618,885 | 2012-04-02 | ||
| US61/618,922 | 2012-04-02 | ||
| US61/618,957 | 2012-04-02 | ||
| US61/618,870 | 2012-04-02 | ||
| US61/618,868 | 2012-04-02 | ||
| US61/618,953 | 2012-04-02 | ||
| US201261648286P | 2012-05-17 | 2012-05-17 | |
| US201261648244P | 2012-05-17 | 2012-05-17 | |
| US61/648,286 | 2012-05-17 | ||
| US61/648,244 | 2012-05-17 | ||
| US201261668157P | 2012-07-05 | 2012-07-05 | |
| US61/668,157 | 2012-07-05 | ||
| US201261681720P | 2012-08-10 | 2012-08-10 | |
| US201261681675P | 2012-08-10 | 2012-08-10 | |
| US201261681712P | 2012-08-10 | 2012-08-10 | |
| US201261681667P | 2012-08-10 | 2012-08-10 | |
| US201261681661P | 2012-08-10 | 2012-08-10 | |
| US201261681645P | 2012-08-10 | 2012-08-10 | |
| US201261681704P | 2012-08-10 | 2012-08-10 | |
| US201261681658P | 2012-08-10 | 2012-08-10 | |
| US201261681696P | 2012-08-10 | 2012-08-10 | |
| US201261681742P | 2012-08-10 | 2012-08-10 | |
| US201261681649P | 2012-08-10 | 2012-08-10 | |
| US201261681647P | 2012-08-10 | 2012-08-10 | |
| US201261681650P | 2012-08-10 | 2012-08-10 | |
| US201261681654P | 2012-08-10 | 2012-08-10 | |
| US201261681648P | 2012-08-10 | 2012-08-10 | |
| US201261681687P | 2012-08-10 | 2012-08-10 | |
| US61/681,645 | 2012-08-10 | ||
| US61/681,650 | 2012-08-10 | ||
| US61/681,648 | 2012-08-10 | ||
| US61/681,720 | 2012-08-10 | ||
| US61/681,661 | 2012-08-10 | ||
| US61/681,658 | 2012-08-10 | ||
| US61/681,647 | 2012-08-10 | ||
| US61/681,687 | 2012-08-10 | ||
| US61/681,712 | 2012-08-10 | ||
| US61/681,654 | 2012-08-10 | ||
| US61/681,667 | 2012-08-10 | ||
| US61/681,704 | 2012-08-10 | ||
| US61/681,742 | 2012-08-10 | ||
| US61/681,675 | 2012-08-10 | ||
| US61/681,696 | 2012-08-10 | ||
| US61/681,649 | 2012-08-10 | ||
| US201261696381P | 2012-09-04 | 2012-09-04 | |
| US61/696,381 | 2012-09-04 | ||
| US201261709303P | 2012-10-03 | 2012-10-03 | |
| US61/709,303 | 2012-10-03 | ||
| US201261712490P | 2012-10-11 | 2012-10-11 | |
| US61/712,490 | 2012-10-11 | ||
| US201261737168P | 2012-12-14 | 2012-12-14 | |
| US201261737135P | 2012-12-14 | 2012-12-14 | |
| US201261737134P | 2012-12-14 | 2012-12-14 | |
| US201261737203P | 2012-12-14 | 2012-12-14 | |
| US201261737213P | 2012-12-14 | 2012-12-14 | |
| US201261737147P | 2012-12-14 | 2012-12-14 | |
| US201261737130P | 2012-12-14 | 2012-12-14 | |
| US201261737139P | 2012-12-14 | 2012-12-14 | |
| US201261737191P | 2012-12-14 | 2012-12-14 | |
| US201261737155P | 2012-12-14 | 2012-12-14 | |
| US201261737152P | 2012-12-14 | 2012-12-14 | |
| US201261737174P | 2012-12-14 | 2012-12-14 | |
| US201261737184P | 2012-12-14 | 2012-12-14 | |
| US201261737160P | 2012-12-14 | 2012-12-14 | |
| US61/737,160 | 2012-12-14 | ||
| US61/737,191 | 2012-12-14 | ||
| US61/737,147 | 2012-12-14 | ||
| US61/737,130 | 2012-12-14 | ||
| US61/737,213 | 2012-12-14 | ||
| US61/737,134 | 2012-12-14 | ||
| US61/737,135 | 2012-12-14 | ||
| US61/737,203 | 2012-12-14 | ||
| US61/737,155 | 2012-12-14 | ||
| US61/737,168 | 2012-12-14 | ||
| US61/737,184 | 2012-12-14 | ||
| US61/737,152 | 2012-12-14 | ||
| US61/737,174 | 2012-12-14 | ||
| US61/737,139 | 2012-12-14 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015504565A Division JP2015518705A (ja) | 2012-04-02 | 2013-03-09 | ヒト疾患に関連する生物製剤およびタンパク質の産生のための修飾ポリヌクレオチド |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018204593A Division JP6921797B2 (ja) | 2012-04-02 | 2018-10-31 | ヒト疾患に関連する生物製剤およびタンパク質の産生のための修飾ポリヌクレオチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017121244A JP2017121244A (ja) | 2017-07-13 |
| JP2017121244A5 true JP2017121244A5 (enExample) | 2017-11-09 |
| JP6430552B2 JP6430552B2 (ja) | 2018-11-28 |
Family
ID=49301149
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015504565A Pending JP2015518705A (ja) | 2012-04-02 | 2013-03-09 | ヒト疾患に関連する生物製剤およびタンパク質の産生のための修飾ポリヌクレオチド |
| JP2017018370A Active JP6430552B2 (ja) | 2012-04-02 | 2017-02-03 | ヒト疾患に関連する生物製剤およびタンパク質の産生のための修飾ポリヌクレオチド |
| JP2018204593A Active JP6921797B2 (ja) | 2012-04-02 | 2018-10-31 | ヒト疾患に関連する生物製剤およびタンパク質の産生のための修飾ポリヌクレオチド |
| JP2021122947A Pending JP2021192606A (ja) | 2012-04-02 | 2021-07-28 | ヒト疾患に関連する生物製剤およびタンパク質の産生のための修飾ポリヌクレオチド |
| JP2023114173A Pending JP2023130471A (ja) | 2012-04-02 | 2023-07-12 | ヒト疾患に関連する生物製剤およびタンパク質の産生のための修飾ポリヌクレオチド |
| JP2025097708A Pending JP2025169942A (ja) | 2012-04-02 | 2025-06-11 | ヒト疾患に関連する生物製剤およびタンパク質の産生のための修飾ポリヌクレオチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015504565A Pending JP2015518705A (ja) | 2012-04-02 | 2013-03-09 | ヒト疾患に関連する生物製剤およびタンパク質の産生のための修飾ポリヌクレオチド |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018204593A Active JP6921797B2 (ja) | 2012-04-02 | 2018-10-31 | ヒト疾患に関連する生物製剤およびタンパク質の産生のための修飾ポリヌクレオチド |
| JP2021122947A Pending JP2021192606A (ja) | 2012-04-02 | 2021-07-28 | ヒト疾患に関連する生物製剤およびタンパク質の産生のための修飾ポリヌクレオチド |
| JP2023114173A Pending JP2023130471A (ja) | 2012-04-02 | 2023-07-12 | ヒト疾患に関連する生物製剤およびタンパク質の産生のための修飾ポリヌクレオチド |
| JP2025097708A Pending JP2025169942A (ja) | 2012-04-02 | 2025-06-11 | ヒト疾患に関連する生物製剤およびタンパク質の産生のための修飾ポリヌクレオチド |
Country Status (6)
| Country | Link |
|---|---|
| JP (6) | JP2015518705A (enExample) |
| CN (2) | CN108949772A (enExample) |
| AU (4) | AU2013243949A1 (enExample) |
| CA (1) | CA2868391A1 (enExample) |
| HK (1) | HK1206612A1 (enExample) |
| WO (1) | WO2013151666A2 (enExample) |
Families Citing this family (296)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3338765T3 (pl) | 2009-12-01 | 2019-06-28 | Translate Bio, Inc. | Pochodna steroidowa dla dostarczania mrna w ludzkich chorobach genetycznych |
| ES2646669T3 (es) | 2010-07-06 | 2017-12-14 | Glaxosmithkline Biologicals Sa | Procedimientos de aumento de una respuesta inmunitaria mediante el suministro de ARN |
| SI2591114T1 (sl) | 2010-07-06 | 2016-10-28 | Glaxosmithkline Biologicals S.A. | Imunizacija velikih sesalcev z majhnimi odmerki RNA |
| AU2011276234B2 (en) | 2010-07-06 | 2016-02-25 | Glaxosmithkline Biologicals S.A. | Liposomes with lipids having an advantageous pKa- value for RNA delivery |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| WO2012031043A1 (en) | 2010-08-31 | 2012-03-08 | Novartis Ag | Pegylated liposomes for delivery of immunogen-encoding rna |
| ES3005233T3 (en) | 2010-10-01 | 2025-03-14 | Modernatx Inc | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| EP3520813B1 (en) | 2010-10-11 | 2023-04-19 | GlaxoSmithKline Biologicals S.A. | Antigen delivery platforms |
| US8853377B2 (en) | 2010-11-30 | 2014-10-07 | Shire Human Genetic Therapies, Inc. | mRNA for use in treatment of human genetic diseases |
| JP2014511687A (ja) | 2011-03-31 | 2014-05-19 | モデルナ セラピューティクス インコーポレイテッド | 工学操作された核酸の送達および製剤 |
| PT2717893T (pt) | 2011-06-08 | 2019-08-20 | Translate Bio Inc | Composições de nanopartículas lipídicas e métodos para transferência de arnm |
| EP3854413A1 (en) | 2011-07-06 | 2021-07-28 | GlaxoSmithKline Biologicals SA | Immunogenic combination compositions and uses thereof |
| EP2763701B1 (en) | 2011-10-03 | 2018-12-19 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| JP2015501844A (ja) | 2011-12-16 | 2015-01-19 | モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 修飾ヌクレオシド、ヌクレオチドおよび核酸組成物 |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US10501513B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides for the production of oncology-related proteins and peptides |
| WO2013151663A1 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of membrane proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| WO2013185067A1 (en) | 2012-06-08 | 2013-12-12 | Shire Human Genetic Therapies, Inc. | Nuclease resistant polynucleotides and uses thereof |
| WO2013185069A1 (en) | 2012-06-08 | 2013-12-12 | Shire Human Genetic Therapies, Inc. | Pulmonary delivery of mrna to non-lung target cells |
| WO2014028429A2 (en) | 2012-08-14 | 2014-02-20 | Moderna Therapeutics, Inc. | Enzymes and polymerases for the synthesis of rna |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
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2013
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- 2013-03-09 HK HK15107193.3A patent/HK1206612A1/xx unknown
- 2013-03-09 CN CN201380028773.4A patent/CN104411338A/zh active Pending
- 2013-03-09 WO PCT/US2013/030062 patent/WO2013151666A2/en not_active Ceased
- 2013-03-09 AU AU2013243949A patent/AU2013243949A1/en not_active Abandoned
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