JP2013523763A5 - - Google Patents
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- Publication number
- JP2013523763A5 JP2013523763A5 JP2013502815A JP2013502815A JP2013523763A5 JP 2013523763 A5 JP2013523763 A5 JP 2013523763A5 JP 2013502815 A JP2013502815 A JP 2013502815A JP 2013502815 A JP2013502815 A JP 2013502815A JP 2013523763 A5 JP2013523763 A5 JP 2013523763A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- compound
- disorder
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 32
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 18
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 239000003814 drug Substances 0.000 claims 13
- 125000003118 aryl group Chemical group 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 11
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- 201000010099 disease Diseases 0.000 claims 9
- 208000035475 disorder Diseases 0.000 claims 9
- 208000007536 Thrombosis Diseases 0.000 claims 8
- 125000002947 alkylene group Chemical group 0.000 claims 8
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 8
- 150000002431 hydrogen Chemical class 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 125000004474 heteroalkylene group Chemical group 0.000 claims 5
- 125000004404 heteroalkyl group Chemical group 0.000 claims 4
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000004476 Acute Coronary Syndrome Diseases 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 208000005189 Embolism Diseases 0.000 claims 2
- 206010014513 Embolism arterial Diseases 0.000 claims 2
- 206010014522 Embolism venous Diseases 0.000 claims 2
- 208000001435 Thromboembolism Diseases 0.000 claims 2
- 230000001269 cardiogenic effect Effects 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- 208000004043 venous thromboembolism Diseases 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 208000009190 disseminated intravascular coagulation Diseases 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- -1 pyridyl compound Chemical class 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31917510P | 2010-03-30 | 2010-03-30 | |
| US61/319,175 | 2010-03-30 | ||
| PCT/US2011/030585 WO2011126903A2 (en) | 2010-03-30 | 2011-03-30 | Multisubstituted aromatic compounds as inhibitors of thrombin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016021856A Division JP6411390B2 (ja) | 2010-03-30 | 2016-02-08 | トロンビンの阻害剤としての多置換芳香族化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013523763A JP2013523763A (ja) | 2013-06-17 |
| JP2013523763A5 true JP2013523763A5 (enExample) | 2014-05-15 |
| JP6155187B2 JP6155187B2 (ja) | 2017-06-28 |
Family
ID=44763506
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013502815A Active JP6155187B2 (ja) | 2010-03-30 | 2011-03-30 | トロンビンの阻害剤としての多置換芳香族化合物 |
| JP2016021856A Expired - Fee Related JP6411390B2 (ja) | 2010-03-30 | 2016-02-08 | トロンビンの阻害剤としての多置換芳香族化合物 |
| JP2018180211A Active JP6650983B2 (ja) | 2010-03-30 | 2018-09-26 | トロンビンの阻害剤としての多置換芳香族化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016021856A Expired - Fee Related JP6411390B2 (ja) | 2010-03-30 | 2016-02-08 | トロンビンの阻害剤としての多置換芳香族化合物 |
| JP2018180211A Active JP6650983B2 (ja) | 2010-03-30 | 2018-09-26 | トロンビンの阻害剤としての多置換芳香族化合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US9533967B2 (enExample) |
| EP (1) | EP2560966B1 (enExample) |
| JP (3) | JP6155187B2 (enExample) |
| KR (3) | KR101955691B1 (enExample) |
| CN (3) | CN110269856A (enExample) |
| AU (3) | AU2011238616B2 (enExample) |
| BR (1) | BR112012024678A2 (enExample) |
| CA (1) | CA2829790C (enExample) |
| IL (3) | IL222019A (enExample) |
| MX (1) | MX355038B (enExample) |
| NZ (3) | NZ700332A (enExample) |
| RU (2) | RU2017144535A (enExample) |
| SG (2) | SG10201502484SA (enExample) |
| WO (1) | WO2011126903A2 (enExample) |
| ZA (2) | ZA201507923B (enExample) |
Families Citing this family (116)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR077975A1 (es) | 2009-08-28 | 2011-10-05 | Irm Llc | Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina |
| JP6155187B2 (ja) * | 2010-03-30 | 2017-06-28 | ヴァーセオン コーポレイション | トロンビンの阻害剤としての多置換芳香族化合物 |
| GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
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| US8815271B2 (en) | 2010-11-03 | 2014-08-26 | Dow Agrosciences, Llc. | Pesticidal compositions and processes related thereto |
| GB201020179D0 (en) | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
| CN102898386B (zh) | 2011-07-27 | 2015-07-29 | 上海医药集团股份有限公司 | 喹唑啉衍生物、其制备方法、中间体、组合物及其应用 |
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| UA111754C2 (uk) | 2011-10-06 | 2016-06-10 | Байєр Фарма Акцієнгезелльшафт | Заміщені бензиліндазоли для застосування як інгібіторів bub1-кінази для лікування гіперпроліферативних захворювань |
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