MX2017003624A - Compuestos de piridona sustituida con pirazolilo como inhibidores de serina proteasas. - Google Patents
Compuestos de piridona sustituida con pirazolilo como inhibidores de serina proteasas.Info
- Publication number
- MX2017003624A MX2017003624A MX2017003624A MX2017003624A MX2017003624A MX 2017003624 A MX2017003624 A MX 2017003624A MX 2017003624 A MX2017003624 A MX 2017003624A MX 2017003624 A MX2017003624 A MX 2017003624A MX 2017003624 A MX2017003624 A MX 2017003624A
- Authority
- MX
- Mexico
- Prior art keywords
- pyrazolyl
- pyridone compounds
- protease inhibitors
- serine protease
- substituted pyridone
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epidemiology (AREA)
Abstract
Se proporcionan, entre otros, compuestos de piridona sustituida con pirazolilo, que exhiben actividad biológica, por ejemplo, acción inhibidora, contra serina proteasas, que incluyen trombina y diversas calicreínas; adicionalmente, se proporcionan composiciones farmacéuticas; además, se proporcionan métodos para tratar y prevenir algunas enfermedades y trastornos, en donde la enfermedad o el trastorno pueden responder al tratamiento o a la prevención mediante la inhibición de serina proteasas, que incluyen trombina y diversas calicreínas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462051511P | 2014-09-17 | 2014-09-17 | |
US201462051585P | 2014-09-17 | 2014-09-17 | |
PCT/US2015/050809 WO2016044662A1 (en) | 2014-09-17 | 2015-09-17 | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017003624A true MX2017003624A (es) | 2017-07-13 |
Family
ID=55533876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017003624A MX2017003624A (es) | 2014-09-17 | 2015-09-17 | Compuestos de piridona sustituida con pirazolilo como inhibidores de serina proteasas. |
Country Status (14)
Country | Link |
---|---|
US (2) | US10189810B2 (es) |
EP (1) | EP3194369A4 (es) |
JP (2) | JP2017528486A (es) |
KR (1) | KR20170048410A (es) |
CN (1) | CN106687445A (es) |
AU (2) | AU2015317522A1 (es) |
BR (1) | BR112017004704A2 (es) |
CA (1) | CA2960790A1 (es) |
IL (1) | IL250965A0 (es) |
MX (1) | MX2017003624A (es) |
RU (1) | RU2017112739A (es) |
SG (1) | SG11201701940UA (es) |
WO (1) | WO2016044662A1 (es) |
ZA (1) | ZA201701799B (es) |
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KR20150132148A (ko) * | 2013-03-15 | 2015-11-25 | 베르선 코포레이션 | 세린 프로타아제 억제제로서의 다중 치환된 방향족 화합물 |
TWI636047B (zh) | 2013-08-14 | 2018-09-21 | 英商卡爾維斯塔製藥有限公司 | 雜環衍生物 |
KR20170048410A (ko) * | 2014-09-17 | 2017-05-08 | 베르선 코포레이션 | 세린 프로테아제 저해제로서의 피라졸릴-치환된 피리돈 화합물 |
GB201421083D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | Enzyme inhibitors |
GB201421085D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | New enzyme inhibitors |
PT3416945T (pt) * | 2016-02-19 | 2020-09-11 | Sprint Bioscience Ab | Compostos de 6-aril-4-(morfolin-4-il)-1h-piridina-2-ona úteis para o tratamento do cancro e da diabetes |
CN108884067B (zh) | 2016-02-19 | 2021-01-08 | 思普瑞特生物科学公司 | 可用于治疗癌症和糖尿病的6-杂环基-4-吗啉-4-基吡啶-2-酮化合物 |
CN106008362B (zh) * | 2016-05-24 | 2018-08-10 | 杰达维(上海)医药科技发展有限公司 | 一种嘧啶衍生物的制备方法 |
CN109311847B (zh) | 2016-05-31 | 2021-07-06 | 卡尔维斯塔制药有限公司 | 作为血浆激肽释放酶抑制剂的吡唑衍生物 |
GB201609607D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts |
GB201609603D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide |
JP7037507B2 (ja) * | 2017-01-26 | 2022-03-16 | 三井化学アグロ株式会社 | ピリドン化合物およびそれを有効成分とする農園芸用殺菌剤 |
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US11234939B2 (en) | 2017-11-29 | 2022-02-01 | Kalvista Pharmaceuticals Limited | Dosage forms comprising a plasma kallikrein inhibitor |
GB201719881D0 (en) | 2017-11-29 | 2018-01-10 | Kalvista Pharmaceuticals Ltd | Solid forms of plasma kallikrein inhibitor and salts thereof |
CN110386932A (zh) | 2018-04-20 | 2019-10-29 | 艾科思莱德制药公司 | 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂 |
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EP4010333A1 (en) | 2019-08-09 | 2022-06-15 | Kalvista Pharmaceuticals Limited | Plasma kallikrein inhibitors |
CN110467601B (zh) * | 2019-08-29 | 2021-07-02 | 杭州市西溪医院 | 一种吡唑联吡啶酮类化合物、中间体及其制备方法及应用 |
DE102020103516B4 (de) | 2020-02-11 | 2023-12-07 | Universität Zu Lübeck | Antivirale Wirkstoffe mit breiter Aktivität |
BR102020009679A2 (pt) | 2020-05-14 | 2021-11-23 | Fundação Universidade Federal Do Abc - Ufabc | Anticorpos recombinantes humanos para inibição da calicreína tecidual humana 7 (klk7) e uso em doenças relacionadas ao processo de descamação da pele |
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-
2015
- 2015-09-17 KR KR1020177007352A patent/KR20170048410A/ko unknown
- 2015-09-17 JP JP2017514899A patent/JP2017528486A/ja active Pending
- 2015-09-17 RU RU2017112739A patent/RU2017112739A/ru not_active Application Discontinuation
- 2015-09-17 WO PCT/US2015/050809 patent/WO2016044662A1/en active Application Filing
- 2015-09-17 US US15/512,037 patent/US10189810B2/en active Active
- 2015-09-17 SG SG11201701940UA patent/SG11201701940UA/en unknown
- 2015-09-17 EP EP15841577.8A patent/EP3194369A4/en not_active Withdrawn
- 2015-09-17 AU AU2015317522A patent/AU2015317522A1/en not_active Abandoned
- 2015-09-17 CN CN201580050088.0A patent/CN106687445A/zh active Pending
- 2015-09-17 BR BR112017004704A patent/BR112017004704A2/pt not_active Application Discontinuation
- 2015-09-17 MX MX2017003624A patent/MX2017003624A/es unknown
- 2015-09-17 CA CA2960790A patent/CA2960790A1/en not_active Abandoned
-
2017
- 2017-03-06 IL IL250965A patent/IL250965A0/en unknown
- 2017-03-13 ZA ZA2017/01799A patent/ZA201701799B/en unknown
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2018
- 2018-12-07 US US16/213,272 patent/US20190359586A1/en not_active Abandoned
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2020
- 2020-03-26 AU AU2020202167A patent/AU2020202167A1/en not_active Abandoned
- 2020-05-19 JP JP2020087253A patent/JP2020143112A/ja active Pending
Also Published As
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US20170267656A1 (en) | 2017-09-21 |
KR20170048410A (ko) | 2017-05-08 |
JP2017528486A (ja) | 2017-09-28 |
CA2960790A1 (en) | 2016-03-24 |
US20190359586A1 (en) | 2019-11-28 |
ZA201701799B (en) | 2019-06-26 |
AU2015317522A1 (en) | 2017-03-23 |
EP3194369A1 (en) | 2017-07-26 |
SG11201701940UA (en) | 2017-04-27 |
RU2017112739A3 (es) | 2019-04-01 |
JP2020143112A (ja) | 2020-09-10 |
AU2020202167A1 (en) | 2020-04-30 |
EP3194369A4 (en) | 2018-02-28 |
US10189810B2 (en) | 2019-01-29 |
CN106687445A (zh) | 2017-05-17 |
RU2017112739A (ru) | 2018-10-17 |
WO2016044662A1 (en) | 2016-03-24 |
IL250965A0 (en) | 2017-04-30 |
BR112017004704A2 (pt) | 2018-01-23 |
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