BR112017004704A2 - composto, composição farmacêutica, e, método para tratar uma doença ou distúrbio em um indivíduo - Google Patents

composto, composição farmacêutica, e, método para tratar uma doença ou distúrbio em um indivíduo

Info

Publication number
BR112017004704A2
BR112017004704A2 BR112017004704A BR112017004704A BR112017004704A2 BR 112017004704 A2 BR112017004704 A2 BR 112017004704A2 BR 112017004704 A BR112017004704 A BR 112017004704A BR 112017004704 A BR112017004704 A BR 112017004704A BR 112017004704 A2 BR112017004704 A2 BR 112017004704A2
Authority
BR
Brazil
Prior art keywords
disorder
disease
treating
individual
compound
Prior art date
Application number
BR112017004704A
Other languages
English (en)
Inventor
Ben Kita David
Michael Short Kevin
De Los Angeles Estiarte-Martinez Maria
Minh Pham Son
Original Assignee
Verseon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Verseon Corp filed Critical Verseon Corp
Publication of BR112017004704A2 publication Critical patent/BR112017004704A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

a presente invenção se refere inter alia a compostos de piridona substituídos por pirazolila, que exibem atividade biológica, por exemplo, ação inibitória, contra serina protease, que inclui trombina e várias calicreínas. as composições farmacêuticas são fornecidas adicionalmente. os métodos de tratar e prevenir certas doenças ou distúrbios são adicionalmente fornecidos, cuja doença ou cujo distúrbio é suscetível ao tratamento ou prevenção pela inibição de serina protease, que inclui trombina e várias calicreínas.
BR112017004704A 2014-09-17 2015-09-17 composto, composição farmacêutica, e, método para tratar uma doença ou distúrbio em um indivíduo BR112017004704A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462051511P 2014-09-17 2014-09-17
US201462051585P 2014-09-17 2014-09-17
PCT/US2015/050809 WO2016044662A1 (en) 2014-09-17 2015-09-17 Pyrazolyl-substituted pyridone compounds as serine protease inhibitors

Publications (1)

Publication Number Publication Date
BR112017004704A2 true BR112017004704A2 (pt) 2018-01-23

Family

ID=55533876

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017004704A BR112017004704A2 (pt) 2014-09-17 2015-09-17 composto, composição farmacêutica, e, método para tratar uma doença ou distúrbio em um indivíduo

Country Status (14)

Country Link
US (2) US10189810B2 (pt)
EP (1) EP3194369A4 (pt)
JP (2) JP2017528486A (pt)
KR (1) KR20170048410A (pt)
CN (1) CN106687445A (pt)
AU (2) AU2015317522A1 (pt)
BR (1) BR112017004704A2 (pt)
CA (1) CA2960790A1 (pt)
IL (1) IL250965A0 (pt)
MX (1) MX2017003624A (pt)
RU (1) RU2017112739A (pt)
SG (1) SG11201701940UA (pt)
WO (1) WO2016044662A1 (pt)
ZA (1) ZA201701799B (pt)

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CN110386932A (zh) 2018-04-20 2019-10-29 艾科思莱德制药公司 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂
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KR20170048410A (ko) 2017-05-08
MX2017003624A (es) 2017-07-13
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US20190359586A1 (en) 2019-11-28
AU2020202167A1 (en) 2020-04-30
WO2016044662A1 (en) 2016-03-24
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