|
US7235537B2
(en)
*
|
2002-03-13 |
2007-06-26 |
Array Biopharma, Inc. |
N3 alkylated benzimidazole derivatives as MEK inhibitors
|
|
CA2478374C
(en)
*
|
2002-03-13 |
2009-01-06 |
Eli M. Wallace |
N3 alkylated benzimidazole derivatives as mek inhibitors
|
|
US20060084682A1
(en)
*
|
2002-12-13 |
2006-04-20 |
Heerding Dirk A |
Thrombopoietin mimetics
|
|
EP1598079B1
(en)
*
|
2003-02-26 |
2009-04-22 |
Kowa Co., Ltd. |
Remedies for allergic contact dermatitis
|
|
WO2005009975A2
(en)
|
2003-07-24 |
2005-02-03 |
Warner-Lambert Company Llc |
Benzimidazole derivatives as mek inhibitors
|
|
US7144907B2
(en)
|
2003-09-03 |
2006-12-05 |
Array Biopharma Inc. |
Heterocyclic inhibitors of MEK and methods of use thereof
|
|
US7538120B2
(en)
|
2003-09-03 |
2009-05-26 |
Array Biopharma Inc. |
Method of treating inflammatory diseases
|
|
MY142589A
(en)
|
2003-09-22 |
2010-12-15 |
S Bio Pte Ltd |
Benzimidazole derivatives : preparation and pharmaceutical applications
|
|
US7517994B2
(en)
*
|
2003-11-19 |
2009-04-14 |
Array Biopharma Inc. |
Heterocyclic inhibitors of MEK and methods of use thereof
|
|
US7732616B2
(en)
*
|
2003-11-19 |
2010-06-08 |
Array Biopharma Inc. |
Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
|
|
JP4869075B2
(ja)
*
|
2003-11-19 |
2012-02-01 |
アレイ バイオファーマ、インコーポレイテッド |
Ｍｅｋの複素環阻害剤及びその使用方法
|
|
BRPI0416852A
(pt)
*
|
2003-11-21 |
2007-02-27 |
Array Biopharma Inc |
inibidores da quinase akt
|
|
US20050171182A1
(en)
*
|
2003-12-11 |
2005-08-04 |
Roger Briesewitz |
Methods and compositions for use in the treatment of mutant receptor tyrosine kinase driven cellular proliferative diseases
|
|
AR051248A1
(es)
|
2004-10-20 |
2007-01-03 |
Applied Research Systems |
Derivados de 3-arilamino piridina
|
|
ATE443063T1
(de)
*
|
2004-12-01 |
2009-10-15 |
Merck Serono Sa |
Ä1,2,4ütriazoloä4,3-aüpyridin-derivative zur behandlung hyperproliferativer erkrankungen
|
|
US7429667B2
(en)
*
|
2005-01-20 |
2008-09-30 |
Ardea Biosciences, Inc. |
Phenylamino isothiazole carboxamidines as MEK inhibitors
|
|
RU2500673C2
(ru)
*
|
2005-05-18 |
2013-12-10 |
Астразенека Аб |
Гетероциклические ингибиторы мек и способы их применения
|
|
ES2567133T3
(es)
*
|
2005-06-23 |
2016-04-20 |
Array Biopharma, Inc. |
Proceso para preparar compuestos de benzoimidazol
|
|
BRPI0612306A2
(pt)
*
|
2005-06-23 |
2010-11-03 |
Array Biopharma Inc |
processo snar para preparar composto de benzimidazol
|
|
US8101799B2
(en)
|
2005-07-21 |
2012-01-24 |
Ardea Biosciences |
Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
|
|
AU2012261703B2
(en)
*
|
2005-10-07 |
2015-08-13 |
Exelixis, Inc. |
Azetidines as MEK inhibitors for the treatment of proliferative diseases
|
|
EP1934174B1
(en)
|
2005-10-07 |
2011-04-06 |
Exelixis, Inc. |
Azetidines as mek inhibitors for the treatment of proliferative diseases
|
|
AU2013203939B2
(en)
*
|
2005-10-07 |
2015-08-13 |
Exelixis, Inc. |
Azetidines as MEK inhibitors for the treatment of proliferative diseases
|
|
US7968108B2
(en)
*
|
2005-10-25 |
2011-06-28 |
Metbro Distributing L.P. |
Hydrogen cyanamide pesticide formulations
|
|
US7572460B2
(en)
*
|
2005-10-25 |
2009-08-11 |
Rodrigo Rodriguez-Kabana |
Hydrogen cyanamide pesticide formulations
|
|
TWI405756B
(zh)
|
2005-12-21 |
2013-08-21 |
Array Biopharma Inc |
新穎硫酸氫鹽
|
|
CN101341132A
(zh)
*
|
2005-12-21 |
2009-01-07 |
阿斯利康(瑞典)有限公司 |
作为mek抑制剂用于治疗癌症的6-(4-溴-2-氯-苯基氨基)-7-氟-n-(2-羟基乙氧基)-3-甲基-3h-苯并咪唑-5-甲酰胺的甲苯磺酸盐
|
|
RU2418790C3
(ru)
*
|
2005-12-21 |
2022-03-14 |
Астразенека Аб |
Новая гидросульфатная соль
|
|
CA2534243A1
(fr)
|
2006-01-25 |
2007-07-25 |
Hydro Quebec |
Particules d'oxyde metallique enrobees a faible taux de dissolution, procedes de preparation et utilisation dans les systemes electrochimiques
|
|
GB0601962D0
(en)
|
2006-01-31 |
2006-03-15 |
Ucb Sa |
Therapeutic agents
|
|
US7842836B2
(en)
|
2006-04-11 |
2010-11-30 |
Ardea Biosciences |
N-aryl-N'alkyl sulfamides as MEK inhibitors
|
|
CN101454004B
(zh)
*
|
2006-04-18 |
2013-12-04 |
阿迪亚生命科学公司 |
作为mek抑制剂的吡啶酮磺酰胺类和吡啶酮硫酰胺类
|
|
US8063050B2
(en)
*
|
2006-07-06 |
2011-11-22 |
Array Biopharma Inc. |
Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
|
|
PL2049500T3
(pl)
*
|
2006-07-06 |
2012-02-29 |
Array Biopharma Inc |
Cyklopenta[d]pirymidyny jako inhibitory kinaz białkowych AKT
|
|
WO2008006039A1
(en)
|
2006-07-06 |
2008-01-10 |
Array Biopharma Inc. |
Dihydrothieno pyrimidines as akt protein kinase inhibitors
|
|
WO2008006025A1
(en)
|
2006-07-06 |
2008-01-10 |
Array Biopharma Inc. |
Dihydrofuro pyrimidines as akt protein kinase inhibitors
|
|
US8492378B2
(en)
|
2006-08-03 |
2013-07-23 |
Takeda Pharmaceutical Company Limited |
GSK-3β inhibitor
|
|
CA2660963A1
(en)
*
|
2006-08-21 |
2008-02-28 |
Genentech, Inc. |
Aza-benzothiophenyl compounds and methods of use
|
|
WO2008024725A1
(en)
*
|
2006-08-21 |
2008-02-28 |
Genentech, Inc. |
Aza-benzofuranyl compounds and methods of use
|
|
ZA200901009B
(en)
*
|
2006-08-21 |
2010-05-26 |
Genentech Inc |
Aza-benzothiophenyl compounds and methods of use
|
|
JP5311673B2
(ja)
|
2006-12-14 |
2013-10-09 |
エグゼリクシス， インコーポレイテッド |
Ｍｅｋ阻害剤の使用方法
|
|
JO2985B1
(ar)
|
2006-12-20 |
2016-09-05 |
Takeda Pharmaceuticals Co |
مثبطات كينازmapk/erk
|
|
CN101678001A
(zh)
*
|
2007-04-13 |
2010-03-24 |
阿斯利康(瑞典)有限公司 |
包含azd2171和azd6244或mek-抑制剂ⅱ的组合治疗
|
|
US8509487B2
(en)
*
|
2007-04-19 |
2013-08-13 |
Avago Technologies General Ip (Singapore) Pte. Ltd. |
System and method for optically measuring a parameter of an object
|
|
JP5580735B2
(ja)
|
2007-06-12 |
2014-08-27 |
ジェネンテック， インコーポレイテッド |
Ｎ−置換アザインドール類及び使用方法
|
|
US8846683B2
(en)
|
2007-07-05 |
2014-09-30 |
Array Biopharma, Inc. |
Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
|
|
EP2404907B1
(en)
*
|
2007-07-05 |
2015-01-14 |
Array Biopharma, Inc. |
Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
|
|
BRPI0813999A2
(pt)
|
2007-07-05 |
2019-10-01 |
Array Biopharma Inc |
ciclopentanos de pirimidil como inibidores de akt proteína cinase
|
|
US9409886B2
(en)
|
2007-07-05 |
2016-08-09 |
Array Biopharma Inc. |
Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
|
|
GB0714384D0
(en)
|
2007-07-23 |
2007-09-05 |
Ucb Pharma Sa |
theraputic agents
|
|
BRPI0818426A2
(pt)
*
|
2007-10-15 |
2017-06-13 |
Astrazeneca Ab |
produto de combinação, uso de um produto de combinação, e, método para tratar câncer
|
|
WO2009064675A1
(en)
|
2007-11-12 |
2009-05-22 |
Takeda Pharmaceutical Company Limited |
Mapk/erk kinase inhibitors
|
|
PL2222675T3
(pl)
|
2007-12-19 |
2014-02-28 |
Genentech Inc |
5-anilinoimidazopirydyny i sposoby zastosowania
|
|
CA2704125A1
(en)
|
2007-12-19 |
2009-07-09 |
Genentech, Inc. |
8-anilinoimidazopyridines and their use as anti-cancer and/or anti-inflammatory agents
|
|
WO2009080523A1
(en)
|
2007-12-20 |
2009-07-02 |
F. Hoffmann-La Roche Ag |
Substituted hydantoins as mek kinase inhibitors
|
|
KR20100099185A
(ko)
|
2007-12-21 |
2010-09-10 |
제넨테크, 인크. |
아자인돌리진 및 이용 방법
|
|
KR101624753B1
(ko)
*
|
2008-01-09 |
2016-05-26 |
어레이 바이오파마 인크. |
Ａｋｔ 단백질 키나제 저해물질로서의 수산화된 피리미딜 시클로펜탄
|
|
AU2009204019B2
(en)
*
|
2008-01-09 |
2014-02-20 |
Array Biopharma Inc. |
Hydroxylated pyrimidyl cyclopentane as AKT protein kinase inhibitor
|
|
EP2240494B1
(en)
|
2008-01-21 |
2016-03-30 |
UCB Biopharma SPRL |
Thieno-pyridine derivatives as mek inhibitors
|
|
SA109300195B1
(ar)
|
2008-03-28 |
2013-04-20 |
Astrazeneca Ab |
تركيبة صيدلانية جديدة مضادة للسرطان
|
|
GB0811304D0
(en)
|
2008-06-19 |
2008-07-30 |
Ucb Pharma Sa |
Therapeutic agents
|
|
WO2009157167A1
(ja)
|
2008-06-23 |
2009-12-30 |
パナソニック株式会社 |
無線通信基地局装置および参照信号割当方法
|
|
US8492427B2
(en)
*
|
2008-07-01 |
2013-07-23 |
Genentech, Inc. |
Isoindolones derivatives as MEK kinase inhibitors and methods of use
|
|
US8841462B2
(en)
|
2008-07-01 |
2014-09-23 |
Robert A. Heald |
Bicyclic heterocycles as MEK kinase inhibitors
|
|
DK2307376T3
(en)
|
2008-08-04 |
2016-01-11 |
Merck Patent Gmbh |
NOVEL phenylamino ISONIKOTINAMIDFORBINDELSER
|
|
CN101653607B
(zh)
*
|
2008-08-19 |
2013-02-13 |
鼎泓国际投资（香港）有限公司 |
含有肝细胞生长因子受体抑制剂和丝裂原细胞外激酶抑制剂的药物组合物及其用途
|
|
US8470819B2
(en)
*
|
2008-11-03 |
2013-06-25 |
Merck Sharp & Dohme Corp. |
Benzimidazole and aza-benzimidazole carboxamides
|
|
WO2010051933A2
(en)
|
2008-11-10 |
2010-05-14 |
Bayer Schering Pharma Aktiengesellschaft |
Substituted sulphonamido phenoxybenzamides
|
|
JO3002B1
(ar)
|
2009-08-28 |
2016-09-05 |
Irm Llc |
مركبات و تركيبات كمثبطات كيناز بروتين
|
|
US8242260B2
(en)
|
2009-08-28 |
2012-08-14 |
Novartis Ag |
Compounds and compositions as protein kinase inhibitors
|
|
CA2777071A1
(en)
|
2009-10-21 |
2011-04-28 |
Bayer Pharma Aktiengesellschaft |
Substituted halophenoxybenzamide derivatives
|
|
CA2777430A1
(en)
|
2009-10-21 |
2011-04-28 |
Bayer Pharma Aktiengesellschaft |
Substituted benzosulphonamides
|
|
US8962606B2
(en)
|
2009-10-21 |
2015-02-24 |
Bayer Intellectual Property Gmbh |
Substituted benzosulphonamides
|
|
WO2011095807A1
(en)
|
2010-02-07 |
2011-08-11 |
Astrazeneca Ab |
Combinations of mek and hh inhibitors
|
|
EP2560640A1
(en)
|
2010-04-19 |
2013-02-27 |
Synta Pharmaceuticals Corp. |
Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor
|
|
JP5945532B2
(ja)
|
2010-04-21 |
2016-07-05 |
プロビオドルグ エージー |
グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
|
|
CA2803055A1
(en)
|
2010-06-25 |
2011-12-29 |
Novartis Ag |
Heteroaryl compounds and compositions as protein kinase inhibitors
|
|
US20150141380A1
(en)
|
2010-08-05 |
2015-05-21 |
Case Western Reserve University |
Inhibitors of erk for developmental disorders of neuronal connectivity
|
|
PE20140192A1
(es)
|
2010-10-06 |
2014-02-24 |
Glaxosmithkline Llc |
Derivados de bencimidazol como inhibidores de cinasa pi3
|
|
US9045429B2
(en)
|
2010-10-29 |
2015-06-02 |
Bayer Intellectual Property Gmbh |
Substituted phenoxypyridines
|
|
CN102020651B
(zh)
|
2010-11-02 |
2012-07-18 |
北京赛林泰医药技术有限公司 |
6-芳基氨基吡啶酮甲酰胺mek抑制剂
|
|
CN106893692B
(zh)
|
2010-12-22 |
2021-11-26 |
菲特治疗公司 |
用于单细胞分选与增强ipsc重新编程的细胞培养平台
|
|
HUE024504T2
(en)
|
2010-12-23 |
2016-01-28 |
Sanofi Sa |
Pyrimidine derivatives, a process for their preparation and their use in medicine
|
|
CA2831922C
(en)
|
2011-04-01 |
2019-12-31 |
Genentech, Inc. |
Combinations of akt inhibitor compounds and vemurafenib, and methods of use
|
|
BR112013025397A2
(pt)
|
2011-04-01 |
2019-09-24 |
Deepak Sampath |
combinação de um composto, composto de fórmula i ou um sal farmaceuticamente aceitável do mesmo, uso, kit, produto, método para tratamento de um distúrbio hiperproliferativo e método para tratamento de uma doença ou afecção modulada por quinase akt em um mamífero
|
|
WO2012145503A1
(en)
|
2011-04-21 |
2012-10-26 |
Novartis Ag |
Pharmaceutical combinations
|
|
US20140228418A1
(en)
*
|
2011-05-23 |
2014-08-14 |
Synta Pharmaceuticals Corp. |
Combination therapy of hsp90 inhibitory compounds with mek inhibitors
|
|
ES2597052T3
(es)
|
2011-05-25 |
2017-01-13 |
Université Paris Descartes |
Inhibidores de ERK para su uso en el tratamiento de atrofia muscular espinal
|
|
US9416132B2
(en)
|
2011-07-21 |
2016-08-16 |
Tolero Pharmaceuticals, Inc. |
Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors
|
|
AR087405A1
(es)
|
2011-08-01 |
2014-03-19 |
Genentech Inc |
Metodos para tratar el cancer por el uso de antagonistas de union al eje pd-1 e inhibidores de mek
|
|
US10307167B2
(en)
|
2012-12-14 |
2019-06-04 |
Corquest Medical, Inc. |
Assembly and method for left atrial appendage occlusion
|
|
US10813630B2
(en)
|
2011-08-09 |
2020-10-27 |
Corquest Medical, Inc. |
Closure system for atrial wall
|
|
US10314594B2
(en)
|
2012-12-14 |
2019-06-11 |
Corquest Medical, Inc. |
Assembly and method for left atrial appendage occlusion
|
|
WO2013066483A1
(en)
|
2011-08-31 |
2013-05-10 |
Novartis Ag |
Synergistic combinations of pi3k- and mek-inhibitors
|
|
EP2750672A1
(en)
|
2011-09-01 |
2014-07-09 |
Novartis AG |
Use of organic compound for the treatment of noonan syndrome
|
|
EP2570127A1
(en)
|
2011-09-16 |
2013-03-20 |
Sanofi |
Compositions and methods for treating cancer using PI3KB beta inhibitor and MAPK pathway inhibitor, including MEK and RAF inhibitors
|
|
UA116875C2
(uk)
|
2011-10-14 |
2018-05-25 |
Еррей Біофарма Інк. |
Поліморфи arry-380 селективного інгібітору erbb2 і фармацевтичні композиції, що їх містять
|
|
CA2853799A1
(en)
|
2011-11-02 |
2013-05-10 |
Synta Pharmaceuticals Corp. |
Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors
|
|
AU2012332424A1
(en)
|
2011-11-02 |
2014-06-05 |
Synta Pharmaceuticals Corp. |
Combination therapy of Hsp90 inhibitors with platinum-containing agents
|
|
WO2013074594A1
(en)
|
2011-11-14 |
2013-05-23 |
Synta Pharmaceuticals Corp. |
Combination therapy of hsp90 inhibitors with braf inhibitors
|
|
MX350957B
(es)
|
2011-11-23 |
2017-09-27 |
Medimmune Llc |
Moleculas de union especificas para her3 y usos de las mismas.
|
|
WO2013082511A1
(en)
|
2011-12-02 |
2013-06-06 |
Genentech, Inc. |
Methods for overcoming tumor resistance to vegf antagonists
|
|
BR112014016870A2
(pt)
|
2012-01-09 |
2017-06-27 |
Huesken Dieter |
composições orgânicas para tratar doenças relacionadas com beta-catenina
|
|
WO2013109142A1
(en)
|
2012-01-16 |
2013-07-25 |
Stichting Het Nederlands Kanker Instituut |
Combined pdk and mapk/erk pathway inhibition in neoplasia
|
|
CN103204827B
(zh)
|
2012-01-17 |
2014-12-03 |
上海科州药物研发有限公司 |
作为蛋白激酶抑制剂的苯并噻二唑化合物及其制备方法和用途
|
|
GB201201332D0
(en)
|
2012-01-26 |
2012-03-14 |
Imp Innovations Ltd |
Method
|
|
KR102088469B1
(ko)
*
|
2012-03-20 |
2020-03-17 |
노파르티스 아게 |
Mek 억제제 및 igf1r 억제제의 병용 요법
|
|
WO2013152425A1
(en)
|
2012-04-09 |
2013-10-17 |
Switch Materials , Inc. |
Switching materials, and compositions and methods for making same
|
|
US9588358B2
(en)
|
2012-05-29 |
2017-03-07 |
Switch Materials, Inc. |
Optical filter comprising a variable transmittance layer
|
|
CA2874905A1
(en)
|
2012-05-31 |
2013-12-05 |
Bayer Pharma Aktiengesellschaft |
Biomarkers for determining effective response of treatments of hepatocellular carcinoma (hcc) patients
|
|
AR091876A1
(es)
*
|
2012-07-26 |
2015-03-04 |
Novartis Ag |
Combinaciones farmaceuticas para el tratamiento de enfermedades proliferativas
|
|
KR20240146112A
(ko)
|
2012-08-17 |
2024-10-07 |
에프. 호프만-라 로슈 아게 |
코비메티닙 및 베무라피닙을 투여함을 포함하는 흑색종의 조합 치료법
|
|
MX2015003959A
(es)
|
2012-10-02 |
2015-11-16 |
Epitherapeutics Aps |
Inhibidores de histona demetilasas.
|
|
HRP20180670T1
(hr)
|
2012-10-12 |
2018-07-13 |
Exelixis Inc. |
Novi postupak dobivanja spojeva namijenjenih upotrebi u liječenju raka
|
|
JP6243918B2
(ja)
|
2012-10-16 |
2017-12-06 |
トレロ ファーマシューティカルズ， インコーポレイテッド |
Ｐｋｍ２調節因子およびそれらの使用方法
|
|
AR099630A1
(es)
|
2012-10-19 |
2016-08-10 |
Novartis Ag |
Preparación de un inhibidor de mek y formulación que lo comprende
|
|
US20140142689A1
(en)
|
2012-11-21 |
2014-05-22 |
Didier De Canniere |
Device and method of treating heart valve malfunction
|
|
PL2925366T3
(pl)
|
2012-11-29 |
2018-08-31 |
Novartis Ag |
Kombinacje farmaceutyczne
|
|
WO2014097125A1
(en)
|
2012-12-20 |
2014-06-26 |
Novartis Ag |
Pharmaceutical combination comprising binimetinib
|
|
EP2752191A1
(en)
|
2013-01-07 |
2014-07-09 |
Sanofi |
Compositions and methods using hdm2 antagonist and mek inhibitor
|
|
CN105229144A
(zh)
|
2013-02-22 |
2016-01-06 |
细胞动力学国际有限公司 |
通过组合的遗传工程和化学工程经由正向编程产生肝细胞
|
|
US10139415B2
(en)
|
2013-02-27 |
2018-11-27 |
Daiichi Sankyo Company, Limited |
Method for predicting responsiveness to compound inhibiting MAPK signal transduction pathway
|
|
ES2670864T3
(es)
|
2013-02-27 |
2018-06-01 |
Gilead Sciences, Inc. |
Inhibidores de histonas desmetilasas
|
|
DK2970205T3
(da)
|
2013-03-14 |
2019-07-29 |
Tolero Pharmaceuticals Inc |
JAK2- og ALK2-inhibitorer og fremgangsmåder til anvendelse deraf
|
|
PT2976106T
(pt)
|
2013-03-21 |
2021-05-26 |
Array Biopharma Inc |
Terapia de combinação que compreende um inibidor de b-raf e um segundo inibidor
|
|
AR097617A1
(es)
|
2013-09-13 |
2016-04-06 |
Actelion Pharmaceuticals Ltd |
Derivados antibacterianos del 2h-indazol
|
|
WO2015041534A1
(en)
|
2013-09-20 |
2015-03-26 |
Stichting Het Nederlands Kanker Instituut |
P90rsk in combination with raf/erk/mek
|
|
EP3046557A1
(en)
|
2013-09-20 |
2016-07-27 |
Stichting Het Nederlands Kanker Instituut |
Rock in combination with mapk-pathway
|
|
EP3757130A1
(en)
|
2013-09-26 |
2020-12-30 |
Costim Pharmaceuticals Inc. |
Methods for treating hematologic cancers
|
|
US9566443B2
(en)
|
2013-11-26 |
2017-02-14 |
Corquest Medical, Inc. |
System for treating heart valve malfunction including mitral regurgitation
|
|
TR201807881T4
(tr)
|
2013-12-19 |
2018-06-21 |
Idorsia Pharmaceuticals Ltd |
Antibakteriyel 1h-ındazol ve 1h-ındol türevleri.
|
|
EP3094736A4
(en)
|
2014-01-14 |
2017-10-25 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for identification, assessment, prevention, and treatment of melanoma using pd-l1 isoforms
|
|
CN104788365B
(zh)
*
|
2014-01-16 |
2018-08-10 |
上海艾力斯医药科技有限公司 |
异烟酰胺衍生物、其制备方法及应用
|
|
JOP20200094A1
(ar)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
جزيئات جسم مضاد لـ pd-1 واستخداماتها
|
|
JOP20200096A1
(ar)
|
2014-01-31 |
2017-06-16 |
Children’S Medical Center Corp |
جزيئات جسم مضاد لـ tim-3 واستخداماتها
|
|
AR099612A1
(es)
|
2014-03-04 |
2016-08-03 |
Actelion Pharmaceuticals Ltd |
Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona
|
|
SG10201807292YA
(en)
|
2014-03-04 |
2018-09-27 |
Fate Therapeutics Inc |
Improved reprogramming methods and cell culture platforms
|
|
ME03558B
(me)
|
2014-03-14 |
2020-07-20 |
Novartis Ag |
Molekuli anti-lag-3 antiтela i njihove upotrebe
|
|
AR099890A1
(es)
|
2014-03-31 |
2016-08-24 |
Epitherapeutics Aps |
Inhibidores de histona demetilasas
|
|
US20170107486A1
(en)
|
2014-04-21 |
2017-04-20 |
Cellular Dynamics International, Inc. |
Hepatocyte production via forward programming by combined genetic and chemical engineering
|
|
JP2017515906A
(ja)
|
2014-05-16 |
2017-06-15 |
アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ |
抗菌性キナゾロン−４（３ｈ）−オン誘導体
|
|
US10023879B2
(en)
|
2014-06-04 |
2018-07-17 |
Fate Therapeutics, Inc. |
Minimal volume reprogramming of mononuclear cells
|
|
AR101210A1
(es)
|
2014-07-15 |
2016-11-30 |
Genentech Inc |
Métodos de tratamiento de cáncer usando antagonistas de unión al eje pd-1 e inhibidores de mek
|
|
MX2017002451A
(es)
|
2014-08-27 |
2017-05-23 |
Gilead Sciences Inc |
Compuestos y metodos para inhibir histona desmetilasas.
|
|
KR20170060042A
(ko)
|
2014-09-13 |
2017-05-31 |
노파르티스 아게 |
Alk 억제제의 조합 요법
|
|
EA201790737A1
(ru)
|
2014-10-03 |
2017-08-31 |
Новартис Аг |
Комбинированная терапия
|
|
AU2015328411C1
(en)
|
2014-10-06 |
2022-03-03 |
Dana-Farber Cancer Institute, Inc. |
Angiopoietin-2 biomarkers predictive of anti-immune checkpoint response
|
|
MA41044A
(fr)
|
2014-10-08 |
2017-08-15 |
Novartis Ag |
Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
|
|
MX389663B
(es)
|
2014-10-14 |
2025-03-20 |
Novartis Ag |
Moleculas de anticuerpo que se unen a pd-l1 y usos de las mismas.
|
|
US10842626B2
(en)
|
2014-12-09 |
2020-11-24 |
Didier De Canniere |
Intracardiac device to correct mitral regurgitation
|
|
WO2016100882A1
(en)
|
2014-12-19 |
2016-06-23 |
Novartis Ag |
Combination therapies
|
|
ES2722048T3
(es)
|
2014-12-23 |
2019-08-07 |
Novartis Ag |
Compuestos de triazolopirimidina y usos de los mismos
|
|
US10626372B1
(en)
|
2015-01-26 |
2020-04-21 |
Fate Therapeutics, Inc. |
Methods and compositions for inducing hematopoietic cell differentiation
|
|
CN105566225A
(zh)
*
|
2015-02-16 |
2016-05-11 |
苏州晶云药物科技有限公司 |
一种口服丝裂原活化蛋白激酶抑制剂的晶型及其制备方法
|
|
JP2016155776A
(ja)
*
|
2015-02-24 |
2016-09-01 |
学校法人兵庫医科大学 |
抗腫瘍効果増強剤および抗腫瘍剤
|
|
US10449211B2
(en)
|
2015-03-10 |
2019-10-22 |
Aduro Biotech, Inc. |
Compositions and methods for activating “stimulator of interferon gene”—dependent signalling
|
|
RU2017134379A
(ru)
|
2015-03-25 |
2019-04-03 |
Новартис Аг |
Формилированные n-гетероциклические производные в качестве ингибиторов fgfr4
|
|
MA41866A
(fr)
|
2015-03-31 |
2018-02-06 |
Massachusetts Gen Hospital |
Molécules à auto-assemblage pour l'administration ciblée de médicaments
|
|
EP3878465A1
(en)
|
2015-07-29 |
2021-09-15 |
Novartis AG |
Combination therapies comprising antibody molecules to tim-3
|
|
US20180222982A1
(en)
|
2015-07-29 |
2018-08-09 |
Novartis Ag |
Combination therapies comprising antibody molecules to pd-1
|
|
DK3317301T3
(da)
|
2015-07-29 |
2021-06-28 |
Immutep Sas |
Kombinationsterapier omfattende antistofmolekyler mod lag-3
|
|
AR105646A1
(es)
|
2015-08-11 |
2017-10-25 |
Actelion Pharmaceuticals Ltd |
Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
|
|
WO2017033113A1
(en)
|
2015-08-21 |
2017-03-02 |
Acerta Pharma B.V. |
Therapeutic combinations of a mek inhibitor and a btk inhibitor
|
|
AU2016314082B2
(en)
|
2015-08-28 |
2019-07-25 |
Novartis Ag |
Mdm2 inhibitors and combinations thereof
|
|
AR105889A1
(es)
|
2015-09-03 |
2017-11-22 |
Actelion Pharmaceuticals Ltd |
Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
|
|
AU2016338680B2
(en)
|
2015-10-16 |
2022-11-17 |
Fate Therapeutics, Inc. |
Platform for the induction and maintenance of ground state pluripotency
|
|
SI3370768T1
(sl)
|
2015-11-03 |
2022-04-29 |
Janssen Biotech, Inc. |
Protitelesa, ki se specifično vežejo na PD-1, in njihove uporabe
|
|
KR20250141836A
(ko)
|
2015-11-04 |
2025-09-29 |
페이트 세러퓨틱스, 인코포레이티드 |
만능 세포의 유전자 조작
|
|
CN108473961B
(zh)
|
2015-11-04 |
2022-11-29 |
菲特治疗公司 |
用于诱导造血细胞分化的方法和组合物
|
|
EP3389712B1
(en)
|
2015-12-17 |
2024-04-10 |
Novartis AG |
Antibody molecules to pd-1 and uses thereof
|
|
WO2017127755A1
(en)
|
2016-01-20 |
2017-07-27 |
Fate Therapeutics, Inc. |
Compositions and methods for immune cell modulation in adoptive immunotherapies
|
|
CA3010236A1
(en)
|
2016-01-20 |
2017-07-27 |
Fate Therapeutics, Inc. |
Compositions and methods for immune cell modulation in adoptive immunotherapies
|
|
KR20180118719A
(ko)
|
2016-03-04 |
2018-10-31 |
다이호야쿠힌고교 가부시키가이샤 |
악성 종양 치료용 제제 및 조성물
|
|
US11883404B2
(en)
|
2016-03-04 |
2024-01-30 |
Taiho Pharmaceuticals Co., Ltd. |
Preparation and composition for treatment of malignant tumors
|
|
AR108257A1
(es)
|
2016-05-02 |
2018-08-01 |
Mei Pharma Inc |
Formas polimórficas de 3-[2-butil-1-(2-dietilamino-etil)-1h-bencimidazol-5-il]-n-hidroxi-acrilamida y usos de las mismas
|
|
MX387795B
(es)
|
2016-06-03 |
2025-03-19 |
Array Biopharma Inc |
Combinaciones farmaceuticas.
|
|
US11091489B2
(en)
|
2016-06-20 |
2021-08-17 |
Novartis Ag |
Crystalline forms of a triazolopyrimidine compound
|
|
EP3472166A1
(en)
|
2016-06-20 |
2019-04-24 |
Novartis AG |
Imidazopyrimidine compounds useful for the treatment of cancer
|
|
EP3472161B1
(en)
|
2016-06-20 |
2020-03-25 |
Novartis AG |
Triazolopyridine compounds and uses thereof
|
|
US11098077B2
(en)
|
2016-07-05 |
2021-08-24 |
Chinook Therapeutics, Inc. |
Locked nucleic acid cyclic dinucleotide compounds and uses thereof
|
|
WO2018065924A1
(en)
*
|
2016-10-04 |
2018-04-12 |
Sun Pharmaceutical Industries Limited |
Intermediates of mitogen-activated protein kinase kinase (map2k or mek) inhibitors and process for their preparation
|
|
WO2018092064A1
(en)
|
2016-11-18 |
2018-05-24 |
Novartis Ag |
Combinations of mdm2 inhibitors and bcl-xl inhibitors
|
|
CN108084078B
(zh)
*
|
2016-11-24 |
2021-07-30 |
中山大学 |
一种治疗银屑病性关节炎疾病的药物阿普斯特的合成方法
|
|
JP7098615B2
(ja)
|
2016-12-05 |
2022-07-11 |
フェイト セラピューティクス，インコーポレイテッド |
養子免疫療法における免疫細胞調節のための組成物および方法
|
|
EP3372624A1
(en)
|
2017-03-06 |
2018-09-12 |
Henkel AG & Co. KGaA |
One component composition based on compounds with at least two exo-vinylene cyclic carbonate units
|
|
UY37695A
(es)
|
2017-04-28 |
2018-11-30 |
Novartis Ag |
Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
|
|
CN109438362B
(zh)
*
|
2017-11-14 |
2020-07-21 |
深圳市塔吉瑞生物医药有限公司 |
一种取代的苯并咪唑化合物及包含该化合物的组合物
|
|
AU2018368731A1
(en)
|
2017-11-16 |
2020-05-14 |
Novartis Ag |
Combination therapies
|
|
TW201938165A
(zh)
|
2017-12-18 |
2019-10-01 |
美商輝瑞股份有限公司 |
治療癌症的方法及組合療法
|
|
US12398209B2
(en)
|
2018-01-22 |
2025-08-26 |
Janssen Biotech, Inc. |
Methods of treating cancers with antagonistic anti-PD-1 antibodies
|
|
AU2019239404B2
(en)
|
2018-03-19 |
2021-12-23 |
Taiho Pharmaceutical Co., Ltd. |
Pharmaceutical composition including sodium alkyl sulfate
|
|
WO2019195753A1
(en)
|
2018-04-05 |
2019-10-10 |
Tolero Pharmaceuticals, Inc. |
Axl kinase inhibitors and use of the same
|
|
JOP20200303A1
(ar)
|
2018-05-24 |
2020-11-23 |
Janssen Biotech Inc |
عوامل ربط psma واستخداماتها
|
|
AR116109A1
(es)
|
2018-07-10 |
2021-03-31 |
Novartis Ag |
Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
|
|
WO2020021465A1
(en)
|
2018-07-25 |
2020-01-30 |
Advanced Accelerator Applications (Italy) S.R.L. |
Method of treatment of neuroendocrine tumors
|
|
PT3826686T
(pt)
|
2018-07-25 |
2025-08-04 |
Advanced Accelerator Applications S A |
Soluções estáveis de complexo de radionuclídeo concentrado
|
|
CN112512597A
(zh)
|
2018-07-26 |
2021-03-16 |
大日本住友制药肿瘤公司 |
用于治疗与acvr1表达异常相关的疾病的方法以及用于此的acvr1抑制剂
|
|
ES2946060T3
(es)
|
2018-08-17 |
2023-07-12 |
Novartis Ag |
Compuestos y composiciones de urea como inhibidores de SMARCA2/BRM-ATPASA
|
|
JP7358484B2
(ja)
|
2018-09-25 |
2023-10-10 |
アドヴァンスド・アクセラレーター・アプリケーションズ・（イタリー）・エッセエッレエッレ |
併用療法
|
|
WO2020106305A1
(en)
|
2018-11-20 |
2020-05-28 |
Nflection Therapeutics, Inc. |
Thienyl-aniline compounds for treatment of dermal disorders
|
|
EP3883552B1
(en)
|
2018-11-20 |
2025-04-09 |
NFlection Therapeutics, Inc. |
Cyanoaryl-aniline compounds for treatment of dermal disorders
|
|
MA55144A
(fr)
|
2018-11-20 |
2021-09-29 |
Nflection Therapeutics Inc |
Composés naphthyridinone-aniline destinés au traitement d'affections de la peau
|
|
WO2020128972A1
(en)
|
2018-12-20 |
2020-06-25 |
Novartis Ag |
Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives
|
|
BR112021011894A2
(pt)
|
2018-12-21 |
2021-09-08 |
Daiichi Sankyo Company, Limited |
Composição farmacêutica
|
|
CA3127502A1
(en)
|
2019-02-12 |
2020-08-20 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Formulations comprising heterocyclic protein kinase inhibitors
|
|
ES3032659T3
(en)
|
2019-02-15 |
2025-07-23 |
Novartis Ag |
3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
|
|
ES2982474T3
(es)
|
2019-02-15 |
2024-10-16 |
Novartis Ag |
Derivados de 3-(1-oxoisoindolin-2-il)piperidin-1,6-diona sustituidos y usos de estos
|
|
AU2020242287A1
(en)
|
2019-03-21 |
2021-09-02 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
A Dbait molecule in combination with kinase inhibitor for the treatment of cancer
|
|
WO2020198077A1
(en)
|
2019-03-22 |
2020-10-01 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Compositions comprising pkm2 modulators and methods of treatment using the same
|
|
WO2020212832A1
(en)
*
|
2019-04-16 |
2020-10-22 |
Alembic Pharmaceuticals Limited |
Process of preparation of benzimidazole compounds
|
|
KR20220002899A
(ko)
|
2019-04-19 |
2022-01-07 |
얀센 바이오테크 인코포레이티드 |
항-psma/cd3 항체로 전립선암을 치료하는 방법
|
|
TWI817018B
(zh)
|
2019-06-28 |
2023-10-01 |
美商艾瑞生藥股份有限公司 |
用於治療ｂｒａｆ相關的疾病和失調症之化合物
|
|
US11529350B2
(en)
|
2019-07-03 |
2022-12-20 |
Sumitomo Pharma Oncology, Inc. |
Tyrosine kinase non-receptor 1 (TNK1) inhibitors and uses thereof
|
|
WO2021057853A1
(en)
|
2019-09-26 |
2021-04-01 |
Novartis Ag |
Aza-quinoline compounds and uses thereof
|
|
KR20220098759A
(ko)
|
2019-11-08 |
2022-07-12 |
인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) |
키나제 억제제에 대해 내성을 획득한 암의 치료 방법
|
|
WO2021116901A1
(en)
*
|
2019-12-09 |
2021-06-17 |
Biocon Limited |
Forms of binimetinib and process for preparation thereof
|
|
MX2022007759A
(es)
|
2019-12-20 |
2022-07-19 |
Novartis Ag |
Combinacion del anticuerpo anti tim-3 mbg453 y anticuerpo anti tgf-beta nis793, con o sin decitabina o el anticuerpo anti pd-1 spartalizumab, para el tratamiento de mielofibrosis y sindrome mielodisplasico.
|
|
WO2021148581A1
(en)
|
2020-01-22 |
2021-07-29 |
Onxeo |
Novel dbait molecule and its use
|
|
WO2021185291A1
(zh)
*
|
2020-03-17 |
2021-09-23 |
南京明德新药研发有限公司 |
蛋白降解调节剂与其使用方法
|
|
JPWO2021206167A1
(OSRAM)
|
2020-04-10 |
2021-10-14 |
|
|
|
US12303509B2
(en)
|
2020-06-09 |
2025-05-20 |
Pfizer Inc. |
Compounds for the treatment of BRAF-associated diseases and disorders
|
|
MX2022015852A
(es)
|
2020-06-23 |
2023-01-24 |
Novartis Ag |
Regimen de dosificacion que comprende derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona.
|
|
AR123185A1
(es)
|
2020-08-10 |
2022-11-09 |
Novartis Ag |
Compuestos y composiciones para inhibir ezh2
|
|
WO2022043556A1
(en)
|
2020-08-31 |
2022-03-03 |
Novartis Ag |
Stable radiopharmaceutical composition
|
|
US20230321285A1
(en)
|
2020-08-31 |
2023-10-12 |
Advanced Accelerator Applications International Sa |
Method of treating psma-expressing cancers
|
|
EP4204020A1
(en)
|
2020-08-31 |
2023-07-05 |
Advanced Accelerator Applications International S.A. |
Method of treating psma-expressing cancers
|
|
EP4225307A1
(en)
|
2020-10-05 |
2023-08-16 |
Pierre Fabre Medicament |
Combination of encorafenib and binimetinib as adjuvant treatment for resected stage ii melanoma
|
|
TW202237119A
(zh)
|
2020-12-10 |
2022-10-01 |
美商住友製藥腫瘤公司 |
Ａｌｋ﹘５抑制劑和彼之用途
|
|
CN112759552A
(zh)
*
|
2020-12-31 |
2021-05-07 |
武汉九州钰民医药科技有限公司 |
司美替尼的合成方法
|
|
CN112679438A
(zh)
*
|
2020-12-31 |
2021-04-20 |
武汉九州钰民医药科技有限公司 |
制备司美替尼的方法
|
|
US12141240B2
(en)
|
2021-01-20 |
2024-11-12 |
Rutgers, The State University Of New Jersey |
Method of calibration using master calibration function
|
|
EP4281069A4
(en)
*
|
2021-01-21 |
2025-09-17 |
Nflection Therapeutics Inc |
PROCESSES FOR THE PREPARATION OF PYRROLOPYRIDINE-ANILINE COMPOUNDS
|
|
AU2022214491A1
(en)
|
2021-01-28 |
2023-09-14 |
Janssen Biotech, Inc. |
Psma binding proteins and uses thereof
|
|
AU2022218128A1
(en)
|
2021-02-02 |
2023-08-17 |
Les Laboratoires Servier |
Selective bcl-xl protac compounds and methods of use
|
|
WO2022195551A1
(en)
|
2021-03-18 |
2022-09-22 |
Novartis Ag |
Biomarkers for cancer and methods of use thereof
|
|
TW202304979A
(zh)
|
2021-04-07 |
2023-02-01 |
瑞士商諾華公司 |
抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途
|
|
EP4323356A1
(en)
|
2021-04-13 |
2024-02-21 |
Nuvalent, Inc. |
Amino-substituted heterocycles for treating cancers with egfr mutations
|
|
WO2022221586A1
(en)
*
|
2021-04-15 |
2022-10-20 |
Ideaya Biosciences, Inc. |
Combination therapy comprising a pkc inhibitor and a mek inhibitor
|
|
AR125874A1
(es)
|
2021-05-18 |
2023-08-23 |
Novartis Ag |
Terapias de combinación
|
|
WO2022251193A1
(en)
|
2021-05-27 |
2022-12-01 |
Mirati Therapeutics, Inc. |
Combination therapies
|
|
BR112023025916A2
(pt)
|
2021-06-09 |
2024-02-27 |
Chugai Pharmaceutical Co Ltd |
Combinação de um inibidor de braf e um inibidor de mek, uso de uma combinação, método para o tratamento ou profilaxia de câncer, composições farmacêuticas e invenção
|
|
CN115490640B
(zh)
*
|
2021-06-17 |
2024-11-26 |
深圳市塔吉瑞生物医药有限公司 |
取代的苯并咪唑类化合物及包含该化合物的组合物及其用途
|
|
WO2023283425A1
(en)
|
2021-07-09 |
2023-01-12 |
Plexium, Inc. |
Aryl compounds and pharmaceutical compositions that modulate ikzf2
|
|
IL312171A
(en)
|
2021-11-04 |
2024-06-01 |
Hoffmann La Roche |
Innovative use of the quinazolinone compound for cancer treatment
|
|
WO2023084489A1
(en)
|
2021-11-15 |
2023-05-19 |
Pfizer Inc. |
Methods of treating coronavirus disease 2019
|
|
TW202342018A
(zh)
|
2022-03-04 |
2023-11-01 |
美商奇奈特生物製藥公司 |
Mek激酶抑制劑
|
|
US20250339547A1
(en)
|
2022-05-20 |
2025-11-06 |
Novartis Ag |
Met bcl-xl inhibitor antibody-drug conjugates and methods of use thereof
|
|
EP4525925A1
(en)
|
2022-05-20 |
2025-03-26 |
Novartis AG |
Epha2 bcl-xl inhibitor antibody-drug conjugates and methods of use thereof
|
|
EP4536226A1
(en)
*
|
2022-06-06 |
2025-04-16 |
Alivus Life Sciences Limited |
Process for preparation of selumetinib and salts thereof
|
|
EP4618994A1
(en)
|
2022-11-18 |
2025-09-24 |
F. Hoffmann-La Roche AG |
Quinazolinone compound as braf inhibitor for the treatment of advanced solid cancer or metastases
|
|
WO2024189481A1
(en)
|
2023-03-10 |
2024-09-19 |
Novartis Ag |
Panras inhibitor antibody-drug conjugates and methods of use thereof
|
|
WO2024209717A1
(ja)
|
2023-04-06 |
2024-10-10 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
腫瘍治療用医薬組成物
|
|
WO2025073765A1
(en)
|
2023-10-03 |
2025-04-10 |
Institut National de la Santé et de la Recherche Médicale |
Methods of prognosis and treatment of patients suffering from melanoma
|
|
WO2025111450A1
(en)
|
2023-11-22 |
2025-05-30 |
Les Laboratoires Servier |
Anti-cd74 antibody-drug conjugates and methods of use thereof
|
|
FR3159741A1
(fr)
|
2024-03-04 |
2025-09-05 |
Pierre Fabre Medicament |
Formulation topique comprenant du binimetinib
|
|
WO2025215536A1
(en)
|
2024-04-10 |
2025-10-16 |
Novartis Ag |
Macrocyclic panras inhibitors for the treatment of cancer
|
|
PL451047A1
(pl)
*
|
2025-01-27 |
2025-08-18 |
Politechnika Lubelska |
Kompozytowa konstrukcja przekładkowa
|
|
PL451049A1
(pl)
*
|
2025-01-27 |
2025-08-04 |
Politechnika Lubelska |
Kompozytowa konstrukcja przekładkowa
|
|
PL451048A1
(pl)
*
|
2025-01-27 |
2025-08-04 |
Politechnika Lubelska |
Kompozytowa konstrukcja przekładkowa
|
|
PL451050A1
(pl)
*
|
2025-01-27 |
2025-08-04 |
Politechnika Lubelska |
Kompozytowa konstrukcja przekładkowa
|
|
PL451045A1
(pl)
*
|
2025-01-27 |
2025-06-09 |
Politechnika Lubelska |
Kompozytowa konstrukcja przekładkowa
|
|
PL451046A1
(pl)
*
|
2025-01-27 |
2025-06-09 |
Politechnika Lubelska |
Kompozytowa konstrukcja przekładkowa
|