JP2011212029A5 - - Google Patents
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- JP2011212029A5 JP2011212029A5 JP2011170533A JP2011170533A JP2011212029A5 JP 2011212029 A5 JP2011212029 A5 JP 2011212029A5 JP 2011170533 A JP2011170533 A JP 2011170533A JP 2011170533 A JP2011170533 A JP 2011170533A JP 2011212029 A5 JP2011212029 A5 JP 2011212029A5
- Authority
- JP
- Japan
- Prior art keywords
- nutrient media
- taxane
- silver
- medium
- nutrient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 27
- 235000015097 nutrients Nutrition 0.000 claims 15
- 229940123237 Taxane Drugs 0.000 claims 12
- 238000004519 manufacturing process Methods 0.000 claims 9
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 9
- 229910052709 silver Inorganic materials 0.000 claims 8
- 239000004332 silver Substances 0.000 claims 8
- ZNJFBWYDHIGLCU-HWKXXFMVSA-N jasmonic acid Chemical compound CC\C=C/C[C@@H]1[C@@H](CC(O)=O)CCC1=O ZNJFBWYDHIGLCU-HWKXXFMVSA-N 0.000 claims 7
- 239000002609 medium Substances 0.000 claims 7
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 6
- 229930012538 Paclitaxel Natural products 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 229960001592 paclitaxel Drugs 0.000 claims 5
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 5
- OVMSOCFBDVBLFW-VHLOTGQHSA-N 5beta,20-epoxy-1,7beta,13alpha-trihydroxy-9-oxotax-11-ene-2alpha,4alpha,10beta-triyl 4,10-diacetate 2-benzoate Chemical compound O([C@@H]1[C@@]2(C[C@H](O)C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)O)C(=O)C1=CC=CC=C1 OVMSOCFBDVBLFW-VHLOTGQHSA-N 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- 230000015572 biosynthetic process Effects 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- ZNJFBWYDHIGLCU-UHFFFAOYSA-N jasmonic acid Natural products CCC=CCC1C(CC(O)=O)CCC1=O ZNJFBWYDHIGLCU-UHFFFAOYSA-N 0.000 claims 4
- 239000006143 cell culture medium Substances 0.000 claims 3
- 239000003623 enhancer Substances 0.000 claims 3
- 238000004114 suspension culture Methods 0.000 claims 3
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims 2
- 229930192334 Auxin Natural products 0.000 claims 2
- 239000005715 Fructose Substances 0.000 claims 2
- 229930091371 Fructose Natural products 0.000 claims 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims 2
- 229930006000 Sucrose Natural products 0.000 claims 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
- 241001149649 Taxus wallichiana var. chinensis Species 0.000 claims 2
- 239000002363 auxin Substances 0.000 claims 2
- 229930014667 baccatin III Natural products 0.000 claims 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 239000008103 glucose Substances 0.000 claims 2
- 239000003630 growth substance Substances 0.000 claims 2
- SEOVTRFCIGRIMH-UHFFFAOYSA-N indole-3-acetic acid Chemical compound C1=CC=C2C(CC(=O)O)=CNC2=C1 SEOVTRFCIGRIMH-UHFFFAOYSA-N 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- -1 silver ions Chemical class 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- GEWDNTWNSAZUDX-WQMVXFAESA-N (-)-methyl jasmonate Chemical compound CC\C=C/C[C@@H]1[C@@H](CC(=O)OC)CCC1=O GEWDNTWNSAZUDX-WQMVXFAESA-N 0.000 claims 1
- HTCSFFGLRQDZDE-SECBINFHSA-N (2r)-2-azaniumyl-2-phenylpropanoate Chemical group OC(=O)[C@@](N)(C)C1=CC=CC=C1 HTCSFFGLRQDZDE-SECBINFHSA-N 0.000 claims 1
- UJOYFRCOTPUKAK-MRVPVSSYSA-N (R)-3-ammonio-3-phenylpropanoate Chemical compound OC(=O)C[C@@H](N)C1=CC=CC=C1 UJOYFRCOTPUKAK-MRVPVSSYSA-N 0.000 claims 1
- 239000005971 1-naphthylacetic acid Substances 0.000 claims 1
- IIDAJRNSZSFFCB-UHFFFAOYSA-N 4-amino-5-methoxy-2-methylbenzenesulfonamide Chemical compound COC1=CC(S(N)(=O)=O)=C(C)C=C1N IIDAJRNSZSFFCB-UHFFFAOYSA-N 0.000 claims 1
- 238000002965 ELISA Methods 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- 206010020649 Hyperkeratosis Diseases 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- ZSILVJLXKHGNPL-UHFFFAOYSA-L S(=S)(=O)([O-])[O-].[Ag+2] Chemical compound S(=S)(=O)([O-])[O-].[Ag+2] ZSILVJLXKHGNPL-UHFFFAOYSA-L 0.000 claims 1
- 241001116500 Taxus Species 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- 238000010923 batch production Methods 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 210000004748 cultured cell Anatomy 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- GEWDNTWNSAZUDX-UHFFFAOYSA-N methyl 7-epi-jasmonate Natural products CCC=CCC1C(CC(=O)OC)CCC1=O GEWDNTWNSAZUDX-UHFFFAOYSA-N 0.000 claims 1
- 150000003378 silver Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65303696A | 1996-05-24 | 1996-05-24 | |
| US08/653,036 | 1996-05-24 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008043232A Division JP2008167764A (ja) | 1996-05-24 | 2008-02-25 | タキサス種の細胞培養によるタキサンの増強生産 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012267338A Division JP2013046643A (ja) | 1996-05-24 | 2012-12-06 | タキサス種の細胞培養によるタキサンの増強生産 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011212029A JP2011212029A (ja) | 2011-10-27 |
| JP2011212029A5 true JP2011212029A5 (https=) | 2013-01-31 |
Family
ID=24619244
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54282497A Expired - Fee Related JP4047929B2 (ja) | 1996-05-24 | 1997-05-27 | タキサス種の細胞培養によるタキサンの増強生産 |
| JP2007028425A Withdrawn JP2007143557A (ja) | 1996-05-24 | 2007-02-07 | タキサス種の細胞培養によるタキサンの増強生産 |
| JP2008043232A Withdrawn JP2008167764A (ja) | 1996-05-24 | 2008-02-25 | タキサス種の細胞培養によるタキサンの増強生産 |
| JP2011170533A Pending JP2011212029A (ja) | 1996-05-24 | 2011-08-03 | タキサス種の細胞培養によるタキサンの増強生産 |
| JP2012267338A Pending JP2013046643A (ja) | 1996-05-24 | 2012-12-06 | タキサス種の細胞培養によるタキサンの増強生産 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54282497A Expired - Fee Related JP4047929B2 (ja) | 1996-05-24 | 1997-05-27 | タキサス種の細胞培養によるタキサンの増強生産 |
| JP2007028425A Withdrawn JP2007143557A (ja) | 1996-05-24 | 2007-02-07 | タキサス種の細胞培養によるタキサンの増強生産 |
| JP2008043232A Withdrawn JP2008167764A (ja) | 1996-05-24 | 2008-02-25 | タキサス種の細胞培養によるタキサンの増強生産 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012267338A Pending JP2013046643A (ja) | 1996-05-24 | 2012-12-06 | タキサス種の細胞培養によるタキサンの増強生産 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8338143B2 (https=) |
| EP (3) | EP1398384A1 (https=) |
| JP (5) | JP4047929B2 (https=) |
| KR (7) | KR20140062179A (https=) |
| AT (1) | ATE315097T1 (https=) |
| AU (1) | AU727425B2 (https=) |
| BR (1) | BR9709361B1 (https=) |
| CA (2) | CA2638292A1 (https=) |
| DE (1) | DE69735059T2 (https=) |
| DK (1) | DK0954596T3 (https=) |
| ES (1) | ES2256887T3 (https=) |
| HU (2) | HU223267B1 (https=) |
| IL (1) | IL127062A (https=) |
| PT (1) | PT954596E (https=) |
| TR (1) | TR199802426T2 (https=) |
| WO (1) | WO1997044476A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7264951B1 (en) | 1992-02-20 | 2007-09-04 | Phyton, Inc. | Enhanced production of taxol and taxanes by cell cultures of Taxus species |
| KR20140062179A (ko) * | 1996-05-24 | 2014-05-22 | 디에프비 바이오테크 인코포레이티드 | 탁수스종의 세포 배양에 의한 탁산의 생산 증진 방법 |
| KR100287465B1 (ko) * | 1997-06-25 | 2001-05-02 | 나까니시 히로유끼 | 탁산형 디테르펜의 제조방법 |
| TW200304947A (en) | 2002-02-08 | 2003-10-16 | Bristol Myers Squibb Co | Compositions and methods for latering biosynthesis of taxanes and taxane-related compounds |
| WO2006129988A1 (en) | 2005-06-03 | 2006-12-07 | Samyang Genex Corporation | Mass production of secondary metabolite in plant cell culture by treatment of saccharide mixture in medicum |
| EP2386626B1 (en) * | 2005-10-31 | 2016-10-26 | Unhwa Corporation | Stability of secondary metabolite mass production through syncronized plant cell cultures |
| US8053238B2 (en) | 2005-10-31 | 2011-11-08 | Unhwa Corporation | Isolated population of plant single cells and method of preparing the same |
| KR101064518B1 (ko) | 2007-09-21 | 2011-09-19 | 주식회사 운화 | 저장근을 가지는 초본식물의 형성층 유래 식물줄기세포주 및 이의 분리방법 |
| KR101100867B1 (ko) * | 2008-05-14 | 2012-01-02 | 주식회사 운화 | 주목의 형성층 또는 전형성층 유래 식물줄기세포주를 유효성분으로 함유하는 항산화, 항염증 또는 항노화용 조성물 |
| US8877501B2 (en) | 2009-06-18 | 2014-11-04 | Phyton Holdings, Llc | Production of alkaloids by liliaceae cell culture |
| FR2952072B1 (fr) * | 2009-11-05 | 2013-09-27 | Pf Medicament | Procede de production de triptolide |
| WO2013164834A1 (en) * | 2012-05-04 | 2013-11-07 | Phyto Biotech Pvt. Ltd. | Cost-effective process for commercial production of paclitaxel |
| CN103570647A (zh) * | 2013-11-06 | 2014-02-12 | 湖南农业大学 | 从红豆杉细胞培养液中制备高纯度紫杉醇的方法 |
| KR20160093040A (ko) | 2013-12-02 | 2016-08-05 | 파이톤 홀딩스, 엘엘씨 | 탑시아 세포 현탁 배양에 의한 탑시가르긴의 생산 |
| US10058542B1 (en) | 2014-09-12 | 2018-08-28 | Thioredoxin Systems Ab | Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith |
| US10172306B2 (en) | 2015-03-20 | 2019-01-08 | Phyton Holdings, Llc | Production of ingenol, ingenol esters and/or tiglian-3-one derivatives by euphorbiaceae plant cell suspension cultures |
| CN105349592B (zh) * | 2015-12-09 | 2018-11-27 | 天津艾赛博生物技术有限公司 | 代谢互补的植物细胞系混种培养生产次级代谢产物的方法 |
| CN106636242A (zh) * | 2016-12-20 | 2017-05-10 | 天津艾赛博生物技术有限公司 | 一种红豆杉细胞长期培养生产紫杉烷的调控方法 |
| JP7359527B2 (ja) * | 2017-05-31 | 2023-10-11 | トヨタ自動車株式会社 | 電池搭載構造 |
| AU2021318553A1 (en) | 2020-07-28 | 2023-03-23 | Impello Biosciences Inc. | Methods and compositions for altering secondary metabolites in plants |
| CN113416689B (zh) * | 2021-08-04 | 2023-01-10 | 海南鑫开源医药科技有限公司 | 一种利用植物细胞发酵技术生产高丽槐素的方法 |
| CN115948494B (zh) * | 2022-09-12 | 2024-07-16 | 昆明理工大学 | 一种利用三七细胞合成齐墩果烷型皂苷的方法 |
| WO2025058703A1 (en) * | 2023-09-13 | 2025-03-20 | Bedoukian Research, Inc | Method of controlling or reducing senescencein plants and seeds |
| CN117379425A (zh) * | 2023-11-14 | 2024-01-12 | 广州日聚商贸发展有限公司 | 喹啉-4-羧酸在抗衰老产品以及保护肝脏、促进肝脏再生产品制备中的应用 |
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1997
- 1997-05-27 KR KR1020147011093A patent/KR20140062179A/ko not_active Ceased
- 1997-05-27 BR BRPI9709361-0A patent/BR9709361B1/pt not_active IP Right Cessation
- 1997-05-27 CA CA002638292A patent/CA2638292A1/en not_active Abandoned
- 1997-05-27 EP EP20030026211 patent/EP1398384A1/en not_active Ceased
- 1997-05-27 DK DK97926731T patent/DK0954596T3/da active
- 1997-05-27 HU HU0302357A patent/HU223267B1/hu not_active IP Right Cessation
- 1997-05-27 KR KR1020077020228A patent/KR20070094867A/ko not_active Ceased
- 1997-05-27 ES ES97926731T patent/ES2256887T3/es not_active Expired - Lifetime
- 1997-05-27 KR KR1020087030132A patent/KR20090005241A/ko not_active Ceased
- 1997-05-27 AU AU31430/97A patent/AU727425B2/en not_active Ceased
- 1997-05-27 HU HU9901788A patent/HUP9901788A3/hu unknown
- 1997-05-27 TR TR1998/02426T patent/TR199802426T2/xx unknown
- 1997-05-27 AT AT97926731T patent/ATE315097T1/de not_active IP Right Cessation
- 1997-05-27 EP EP05002665A patent/EP1538214A1/en not_active Ceased
- 1997-05-27 PT PT97926731T patent/PT954596E/pt unknown
- 1997-05-27 JP JP54282497A patent/JP4047929B2/ja not_active Expired - Fee Related
- 1997-05-27 KR KR1020107012489A patent/KR20100070388A/ko not_active Ceased
- 1997-05-27 KR KR1020107012491A patent/KR20100070389A/ko not_active Ceased
- 1997-05-27 EP EP97926731A patent/EP0954596B1/en not_active Expired - Lifetime
- 1997-05-27 WO PCT/US1997/008907 patent/WO1997044476A1/en not_active Ceased
- 1997-05-27 IL IL12706297A patent/IL127062A/xx not_active IP Right Cessation
- 1997-05-27 KR KR1019980709509A patent/KR100897457B1/ko not_active Expired - Lifetime
- 1997-05-27 KR KR1020127032650A patent/KR20120138251A/ko not_active Ceased
- 1997-05-27 DE DE69735059T patent/DE69735059T2/de not_active Expired - Lifetime
- 1997-05-27 CA CA002256357A patent/CA2256357C/en not_active Expired - Lifetime
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2007
- 2007-02-07 JP JP2007028425A patent/JP2007143557A/ja not_active Withdrawn
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2008
- 2008-02-25 JP JP2008043232A patent/JP2008167764A/ja not_active Withdrawn
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2010
- 2010-12-17 US US12/972,064 patent/US8338143B2/en not_active Expired - Fee Related
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2011
- 2011-08-03 JP JP2011170533A patent/JP2011212029A/ja active Pending
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2012
- 2012-09-14 US US13/618,284 patent/US20130017582A1/en not_active Abandoned
- 2012-12-06 JP JP2012267338A patent/JP2013046643A/ja active Pending
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