DK3077523T3 - Produktion af thapsigarginer ved hjælp af Thapsia cellesuspensionskultur - Google Patents

Produktion af thapsigarginer ved hjælp af Thapsia cellesuspensionskultur Download PDF

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Publication number
DK3077523T3
DK3077523T3 DK14835563.9T DK14835563T DK3077523T3 DK 3077523 T3 DK3077523 T3 DK 3077523T3 DK 14835563 T DK14835563 T DK 14835563T DK 3077523 T3 DK3077523 T3 DK 3077523T3
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DK
Denmark
Prior art keywords
thapsia
argins
production
cell suspension
suspension culture
Prior art date
Application number
DK14835563.9T
Other languages
English (en)
Inventor
Harald Heckenmüller
Jens Stefan Wilke
Yantree Devi Sankar-Thomas
Gilbert Gorr
David Alexander Ullisch
Original Assignee
Phyton Holdings Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phyton Holdings Llc filed Critical Phyton Holdings Llc
Application granted granted Critical
Publication of DK3077523T3 publication Critical patent/DK3077523T3/da

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/04Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01HNEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H4/00Plant reproduction by tissue culture techniques ; Tissue culture techniques therefor
    • A01H4/005Methods for micropropagation; Vegetative plant propagation using cell or tissue culture techniques
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018Culture media for cell or tissue culture
    • C12N5/0025Culture media for plant cell or plant tissue culture
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/04Plant cells or tissues
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes

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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Environmental Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK14835563.9T 2013-12-02 2014-12-02 Produktion af thapsigarginer ved hjælp af Thapsia cellesuspensionskultur DK3077523T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361910919P 2013-12-02 2013-12-02
PCT/IB2014/002638 WO2015082978A1 (en) 2013-12-02 2014-12-02 Production of thapsigargins by thapsia cell suspension culture

Publications (1)

Publication Number Publication Date
DK3077523T3 true DK3077523T3 (da) 2020-07-20

Family

ID=52462944

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14835563.9T DK3077523T3 (da) 2013-12-02 2014-12-02 Produktion af thapsigarginer ved hjælp af Thapsia cellesuspensionskultur

Country Status (11)

Country Link
US (1) US10822628B2 (da)
EP (1) EP3077523B1 (da)
JP (1) JP2016538887A (da)
KR (1) KR20160093040A (da)
CN (1) CN105992823A (da)
AU (2) AU2014358838B2 (da)
CA (1) CA2930767C (da)
DK (1) DK3077523T3 (da)
ES (1) ES2806553T3 (da)
HK (1) HK1223979A1 (da)
WO (1) WO2015082978A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017144065A1 (en) 2016-02-26 2017-08-31 University Of Copenhagen Sustainable and industrial production of guaianolides based on organ tissue culture
CN110511910B (zh) * 2019-09-12 2021-08-20 河北医科大学第一医院 一种LncRNA MALAT1的表达上调剂及其应用
WO2023066885A1 (en) 2021-10-19 2023-04-27 Glaxosmithkline Biologicals Sa Saponin production
WO2023242187A1 (en) 2022-06-15 2023-12-21 Glaxosmithkline Biologicals Sa Enzymatic modification of saponins
WO2024011263A2 (en) * 2022-07-08 2024-01-11 Cibus Us Llc Producing sesquiterpenes and other terpenes using plant-based biomasses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1209168A (zh) * 1995-12-12 1999-02-24 施凯姆公司 由植物细胞培养物生产植物化学物质的生产和筛选方法
KR20090005241A (ko) 1996-05-24 2009-01-12 디에프비 바이오테크 인코포레이티드 탁수스종의 세포 배양에 의한 탁산의 생산 증진 방법
US7468345B2 (en) 2006-09-29 2008-12-23 Eco Holdings, Llc Graffiti cleaning solution including a non-aqueous concentrate and diluted aqueous solution
FR2952072B1 (fr) * 2009-11-05 2013-09-27 Pf Medicament Procede de production de triptolide

Also Published As

Publication number Publication date
WO2015082978A1 (en) 2015-06-11
US20160312255A1 (en) 2016-10-27
HK1223979A1 (zh) 2017-08-11
JP2016538887A (ja) 2016-12-15
ES2806553T3 (es) 2021-02-18
AU2017202062A1 (en) 2017-04-20
AU2014358838A1 (en) 2016-06-23
EP3077523A1 (en) 2016-10-12
CN105992823A (zh) 2016-10-05
US10822628B2 (en) 2020-11-03
AU2014358838B2 (en) 2017-01-05
EP3077523B1 (en) 2020-05-06
KR20160093040A (ko) 2016-08-05
CA2930767C (en) 2018-09-18
CA2930767A1 (en) 2015-06-11

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