PT954596E - Producao melhorada de taxanos atraves de culturas de celulas da especie taxus - Google Patents

Producao melhorada de taxanos atraves de culturas de celulas da especie taxus

Info

Publication number
PT954596E
PT954596E PT97926731T PT97926731T PT954596E PT 954596 E PT954596 E PT 954596E PT 97926731 T PT97926731 T PT 97926731T PT 97926731 T PT97926731 T PT 97926731T PT 954596 E PT954596 E PT 954596E
Authority
PT
Portugal
Prior art keywords
taxans
cell cultures
improved production
taxus species
species cell
Prior art date
Application number
PT97926731T
Other languages
English (en)
Inventor
Bringi Venkataraman
Prakash G Kadkade
Christopher L Prince
Braden L Roach
Original Assignee
Phyton Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24619244&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT954596(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Phyton Inc filed Critical Phyton Inc
Publication of PT954596E publication Critical patent/PT954596E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0025—Culture media for plant cell or plant tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/04—Plant cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
PT97926731T 1996-05-24 1997-05-27 Producao melhorada de taxanos atraves de culturas de celulas da especie taxus PT954596E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65303696A 1996-05-24 1996-05-24

Publications (1)

Publication Number Publication Date
PT954596E true PT954596E (pt) 2006-05-31

Family

ID=24619244

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97926731T PT954596E (pt) 1996-05-24 1997-05-27 Producao melhorada de taxanos atraves de culturas de celulas da especie taxus

Country Status (16)

Country Link
US (2) US8338143B2 (pt)
EP (3) EP0954596B1 (pt)
JP (5) JP4047929B2 (pt)
KR (7) KR20100070388A (pt)
AT (1) ATE315097T1 (pt)
AU (1) AU727425B2 (pt)
BR (1) BR9709361B1 (pt)
CA (2) CA2638292A1 (pt)
DE (1) DE69735059T2 (pt)
DK (1) DK0954596T3 (pt)
ES (1) ES2256887T3 (pt)
HU (2) HUP9901788A3 (pt)
IL (1) IL127062A (pt)
PT (1) PT954596E (pt)
TR (1) TR199802426T2 (pt)
WO (1) WO1997044476A1 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100070388A (ko) * 1996-05-24 2010-06-25 디에프비 바이오테크 인코포레이티드 탁수스종의 세포 배양에 의한 탁산의 생산 증진 방법
KR100287465B1 (ko) * 1997-06-25 2001-05-02 나까니시 히로유끼 탁산형 디테르펜의 제조방법
TW200304947A (en) * 2002-02-08 2003-10-16 Bristol Myers Squibb Co Compositions and methods for latering biosynthesis of taxanes and taxane-related compounds
WO2006129988A1 (en) * 2005-06-03 2006-12-07 Samyang Genex Corporation Mass production of secondary metabolite in plant cell culture by treatment of saccharide mixture in medicum
US8053238B2 (en) 2005-10-31 2011-11-08 Unhwa Corporation Isolated population of plant single cells and method of preparing the same
US8017397B2 (en) * 2005-10-31 2011-09-13 Unhwa Corporation Isolated population of plant single cells and method of preparing same
KR101064518B1 (ko) 2007-09-21 2011-09-19 주식회사 운화 저장근을 가지는 초본식물의 형성층 유래 식물줄기세포주 및 이의 분리방법
KR101100867B1 (ko) * 2008-05-14 2012-01-02 주식회사 운화 주목의 형성층 또는 전형성층 유래 식물줄기세포주를 유효성분으로 함유하는 항산화, 항염증 또는 항노화용 조성물
WO2010148338A1 (en) 2009-06-18 2010-12-23 Phyton Holdings, Llc Production of alkaloids by liliaceae cell culture
FR2952072B1 (fr) 2009-11-05 2013-09-27 Pf Medicament Procede de production de triptolide
WO2013164834A1 (en) * 2012-05-04 2013-11-07 Phyto Biotech Pvt. Ltd. Cost-effective process for commercial production of paclitaxel
CN103570647A (zh) * 2013-11-06 2014-02-12 湖南农业大学 从红豆杉细胞培养液中制备高纯度紫杉醇的方法
DK3077523T3 (da) 2013-12-02 2020-07-20 Phyton Holdings Llc Produktion af thapsigarginer ved hjælp af Thapsia cellesuspensionskultur
US10058542B1 (en) 2014-09-12 2018-08-28 Thioredoxin Systems Ab Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith
WO2016150860A1 (en) 2015-03-20 2016-09-29 Phyton Biotech Gmbh Production of ingenol, ingenol esters and/or tiglian-3-one derivatives by euphorbiaceae plant cell suspension cultures
CN105349592B (zh) * 2015-12-09 2018-11-27 天津艾赛博生物技术有限公司 代谢互补的植物细胞系混种培养生产次级代谢产物的方法
CN106636242A (zh) * 2016-12-20 2017-05-10 天津艾赛博生物技术有限公司 一种红豆杉细胞长期培养生产紫杉烷的调控方法
JP7359527B2 (ja) * 2017-05-31 2023-10-11 トヨタ自動車株式会社 電池搭載構造
WO2022026613A2 (en) * 2020-07-28 2022-02-03 Impello Biosciences, Inc. Methods and compositions for altering secondary metabolites in plants
CN113416689B (zh) * 2021-08-04 2023-01-10 海南鑫开源医药科技有限公司 一种利用植物细胞发酵技术生产高丽槐素的方法
CN115948494B (zh) * 2022-09-12 2024-07-16 昆明理工大学 一种利用三七细胞合成齐墩果烷型皂苷的方法

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3270112D1 (en) 1981-08-11 1986-04-30 Mitsui Petrochemical Ind Method for producing secondary metabolites of plants
WO1986002463A1 (fr) 1984-10-19 1986-04-24 Alain Zarudiansky Systeme de lunettes
JPH0833258B2 (ja) 1987-10-09 1996-03-29 三洋電機株式会社 吸収冷凍装置
DE3801023A1 (de) 1988-01-13 1989-07-27 Schering Ag Verfahren zur steigerung von enzym-aktivitaeten und der syntheseleistung von organismen
EP0378921A3 (en) 1988-12-21 1990-09-19 Idaho Research Foundation, Inc. Enhancement of plant metabolite production by timed elicitation
US5019504A (en) * 1989-03-23 1991-05-28 The United States Of America As Represented By The Secretary Of Agriculture Production of taxol or taxol-like compounds in cell culture
US5334529A (en) 1989-06-27 1994-08-02 Escagenetics Corporation Stably transformed coffee plant cells and plantlets
US5015744A (en) 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
CA2083595C (en) 1990-05-25 2003-03-25 Clarence A. Ryan, Jr. Method of inducing plant defense mechanisms
JPH05507629A (ja) 1991-02-12 1993-11-04 新日本製鐵株式会社 イチイの組織培養によるタキソールの生産方法
US5244775A (en) * 1991-03-20 1993-09-14 Hitachi, Ltd. Method of manufacturing an optical disc
JP3222466B2 (ja) 1991-04-19 2001-10-29 ザ・ユニバーシティ・オブ・ミシシッピー タクサン類を単離するための方法および組成物
US5248625A (en) 1991-06-06 1993-09-28 Lsi Logic Corporation Techniques for forming isolation structures
KR930702323A (ko) 1991-07-17 1993-09-08 하지메 나까가와 항종양 활성을 가진 화합물(nsc-lsc1) 및 그의 제조방법
US5344775A (en) 1991-11-15 1994-09-06 Escagenetics Corporation Synthesis of taxanes in culture using pseudocalluscells
US5407816A (en) 1992-02-20 1995-04-18 Phyton Catalytic, Inc. Enhanced production of taxol and taxanes by cell cultures of taxus species
US5445809A (en) 1992-03-03 1995-08-29 Research And Development Institute At Montana State University Production of taxol from the yew tree
US5451392A (en) 1992-03-03 1995-09-19 The Research And Development Institute At Montana State University Production of taxol
JPH05244971A (ja) 1992-03-06 1993-09-24 Nippon Oil Co Ltd タキサン類化合物の製造方法
WO1993019585A1 (en) 1992-04-01 1993-10-14 Union Camp Corporation Induction of somatic embryogenesis in taxus, and the production of taxane-ring containing alkaloids therefrom
US5850032A (en) 1992-04-01 1998-12-15 Union Camp Corporation Method for production of plant biological products in precocious neomorphic embryoids
CA2434692A1 (en) 1992-04-07 1993-10-08 Paul M. Cino Callus cell induction and the preparation of taxanes
US5322779A (en) 1992-04-16 1994-06-21 The Research And Development Institute, Inc. At Montana State University Taxol production by taxomyces andreanae
CA2136213A1 (en) 1992-05-21 1993-11-25 Richard N. Arteca Cultured taxu tissues as a source of taxol, related taxanes and other novel anti-tumor/anti-viral compounds
JP2967532B2 (ja) 1992-06-11 1999-10-25 日石三菱株式会社 タキサン類化合物の製造方法
US5279953A (en) 1992-06-24 1994-01-18 Esca Genetics Corporation In vivo production of taxanes
JP3162217B2 (ja) 1992-12-24 2001-04-25 三井化学株式会社 タキサン型ジテルペンの製造方法
JP3144947B2 (ja) 1993-04-08 2001-03-12 三井化学株式会社 タキサン型ジテルペンの製造方法
JPH06296493A (ja) 1993-04-14 1994-10-25 Nippon Steel Corp タキソールの生産方法
KR950005081B1 (ko) 1993-07-06 1995-05-18 산림청임목육종연구소 주목 종자의 씨눈 유래의 체세포배 및 체세포배성세포 혹은 그 배양배지로부터 택솔(Taxol) 및 그 유도체를 생산하는 방법
JP3434892B2 (ja) 1994-06-28 2003-08-11 三井化学株式会社 タキサン型ジテルペンの製造方法
WO1995014103A1 (fr) 1993-11-15 1995-05-26 Mitsui Petrochemical Industries, Ltd. Procede de production de diterpene de taxane et procede de recolte de cellules de culture capables de produire du diterpene de taxane a haut rendement
JPH07308197A (ja) 1994-05-18 1995-11-28 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JPH0856680A (ja) * 1994-08-25 1996-03-05 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JPH0856681A (ja) 1994-08-25 1996-03-05 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JPH08116981A (ja) 1994-10-18 1996-05-14 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JPH07308196A (ja) 1994-05-18 1995-11-28 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JP3488492B2 (ja) 1993-11-15 2004-01-19 三井化学株式会社 タキサン型ジテルペン高産生培養細胞の取得方法
JP2967034B2 (ja) 1994-03-07 1999-10-25 三井化学株式会社 タキサン型ジテルペンの製造方法
JPH07255495A (ja) 1994-03-28 1995-10-09 Ishikawajima Harima Heavy Ind Co Ltd タキソールの製造方法
US5547866A (en) 1994-07-20 1996-08-20 The Regents Of The University Of California Taxane production in haploid-derived cell cultures
JPH0870880A (ja) 1994-09-05 1996-03-19 Osaka Organic Chem Ind Ltd タキソールの培養生産法
CA2163614C (en) * 1994-11-25 2002-12-31 Yukihito Yukimune Method of producing a taxane-type diterpene
JP3549594B2 (ja) 1994-11-25 2004-08-04 三井化学株式会社 タキサン型ジテルペンの製造方法
JPH08163991A (ja) 1994-12-15 1996-06-25 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JPH08149984A (ja) 1994-11-30 1996-06-11 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JPH08205881A (ja) * 1994-12-05 1996-08-13 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JPH08154693A (ja) 1994-12-05 1996-06-18 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JP3746550B2 (ja) 1994-12-05 2006-02-15 三井化学株式会社 タキサン型ジテルペンの製造方法
JP3019736B2 (ja) 1994-12-07 2000-03-13 三井化学株式会社 タキサン型ジテルペンの製造方法
JPH08198863A (ja) * 1995-01-25 1996-08-06 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
US5620875A (en) 1995-02-17 1997-04-15 University Of Portland Transfer of taxol from yew tree cuttings into a culture medium over time
US6248572B1 (en) 1995-04-27 2001-06-19 Samyang, Genex, Corporation Production of taxol from taxus plant cell culture adding silver nitrate
KR960037826A (ko) 1995-04-27 1996-11-19 김경환 택서스속 식물세포의 반연속식 배양방법
US5900367A (en) 1995-04-29 1999-05-04 Samyang Genex Co., Ltd. Method for purifying taxol from taxus biomass
JPH08298993A (ja) 1995-05-02 1996-11-19 Nippon Steel Corp イチイの組織培養によるタキサン化合物の製造法
US5965438A (en) 1995-06-07 1999-10-12 Phyton, Inc. Cryopreservation of plant cells
JPH0928392A (ja) 1995-07-17 1997-02-04 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JPH0956387A (ja) 1995-08-22 1997-03-04 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
US5670663A (en) 1996-02-14 1997-09-23 Regents Of The University Of California Recovery of taxanes from conifers
KR20100070388A (ko) * 1996-05-24 2010-06-25 디에프비 바이오테크 인코포레이티드 탁수스종의 세포 배양에 의한 탁산의 생산 증진 방법
JPH1042888A (ja) 1996-07-30 1998-02-17 Jumoku Seiri Kinousei Butsushitsu Gijutsu Kenkyu Kumiai タキソールの培養生産方法
JPH1052294A (ja) 1996-08-09 1998-02-24 Nippon Oil Co Ltd タキサン類化合物の製造方法（ｉ）
JPH1052295A (ja) 1996-08-09 1998-02-24 Nippon Oil Co Ltd タキサン類化合物の製造方法（ｉｉ）
JPH1052296A (ja) 1996-08-09 1998-02-24 Nippon Oil Co Ltd タキサン類化合物の製造方法（ｉｉｉ）
ATE258594T1 (de) 1997-02-19 2004-02-15 Phytobiotech Inc Verfahren zur steigerung des wachstums von pflanzenzellkulturen
KR100287465B1 (ko) 1997-06-25 2001-05-02 나까니시 히로유끼 탁산형 디테르펜의 제조방법
JPH1146782A (ja) 1997-08-05 1999-02-23 Mitsui Chem Inc ラジカル発生剤処理による植物二次代謝産物の生産促進方法
US6030818A (en) 1997-12-22 2000-02-29 Bcm Developpement, Inc. Bacterial mass production of taxanes and paclitaxel
JP3897267B2 (ja) 1998-03-26 2007-03-22 三井化学株式会社 タキサン型ジテルペンの製造方法
JP2000106893A (ja) 1998-10-06 2000-04-18 Kobe Tennenbutsu Kagaku Kk タキサン型ジテルペン類の製造方法
JP3815919B2 (ja) 1999-05-26 2006-08-30 三井化学株式会社 タキサン型ジテルペンの製造方法
US6365407B1 (en) 2001-03-05 2002-04-02 Council Of Scientific & Industrial Research Culture medium composition useful for induction and proliferation of Taxus calli

Also Published As

Publication number Publication date
BR9709361A (pt) 1999-08-10
HU0302357D0 (en) 2003-09-29
ATE315097T1 (de) 2006-02-15
US20130017582A1 (en) 2013-01-17
EP1538214A1 (en) 2005-06-08
DK0954596T3 (da) 2006-05-15
HUP9901788A2 (hu) 1999-09-28
DE69735059D1 (de) 2006-03-30
US8338143B2 (en) 2012-12-25
CA2256357C (en) 2008-08-12
HU223267B1 (hu) 2004-04-28
KR20120138251A (ko) 2012-12-24
KR20070094867A (ko) 2007-09-21
BR9709361B1 (pt) 2009-05-05
JP2011212029A (ja) 2011-10-27
EP0954596A1 (en) 1999-11-10
AU727425B2 (en) 2000-12-14
KR20000015952A (ko) 2000-03-25
US20110086397A1 (en) 2011-04-14
CA2638292A1 (en) 1997-11-27
KR20100070388A (ko) 2010-06-25
CA2256357A1 (en) 1997-11-27
JP4047929B2 (ja) 2008-02-13
KR20100070389A (ko) 2010-06-25
EP1398384A1 (en) 2004-03-17
WO1997044476A1 (en) 1997-11-27
ES2256887T3 (es) 2006-07-16
TR199802426T2 (xx) 2001-01-22
HUP9901788A3 (en) 2002-07-29
IL127062A (en) 2005-09-25
AU3143097A (en) 1997-12-09
JP2008167764A (ja) 2008-07-24
IL127062A0 (en) 1999-09-22
EP0954596B1 (en) 2006-01-04
KR20140062179A (ko) 2014-05-22
JP2007143557A (ja) 2007-06-14
JP2000511420A (ja) 2000-09-05
JP2013046643A (ja) 2013-03-07
DE69735059T2 (de) 2006-08-31
KR100897457B1 (ko) 2009-12-18
KR20090005241A (ko) 2009-01-12

Similar Documents

Publication Publication Date Title
PT954596E (pt) Producao melhorada de taxanos atraves de culturas de celulas da especie taxus
DK0672162T3 (da) Forøget produktion af taxol og taxaner ved hjælp af cellekulturer af Taxus-arter
CA2264270A1 (en) Mass production of paclitaxel by changing the temperature of the medium during the plant cell culture
PT95088A (pt) Processo para a preparacao de zeaxantina e de composicoes que contem zeaxantina
EP1130043A3 (en) Polyhydroxyalkanoate containing 3-hydroxythienylalkanoic acid as monomer unit and method for producing the same
BR9805900B1 (pt) processo para integrar um fragmento de dna no genoma de uma célula de uma planta manocotiledÈnea.
ATE537265T1 (de) Verfahren zur vitaminherstellung
ES2165500T3 (es) Proceso para producir 1,3-propanodiol a partir de carbohidratos usando cultivos microbiologicos.
DK0568821T3 (da) Calluscelleinduktion og fremstilling af taxaner
BR9806934A (pt) Método para produzir um óxido, meio de cultura e óxido
FI964208A (fi) Menetelmä metallofosfaatin saostumisen kontrolloimiseksi fermentoinneissa, joissa solutiheys on suuri
ATE5199T1 (de) Verfahren zur gewinnung von glucosedehydrogenase und hierfuer geeignete mikroorganismen.
AU1364895A (en) Pilocarpin production process
AU2001251065A1 (en) Method for screening of microorganisms under nutrient limited conditions
IT1275575B (it) Caledotricine
KR910012252A (ko) 폴리-3-히드록시부티르산의 생합성 방법
UA24126A (uk) Живильне середовище для росту штаму м-81 hirschioporus laricinus - продуценту молокозсідного ферменту
JPS5588695A (en) Removal of methylguanidine