BR9709361A - Produção aumentada de taxanos por culturas de espécie taxus - Google Patents

Produção aumentada de taxanos por culturas de espécie taxus

Info

Publication number
BR9709361A
BR9709361A BR9709361A BR9709361A BR9709361A BR 9709361 A BR9709361 A BR 9709361A BR 9709361 A BR9709361 A BR 9709361A BR 9709361 A BR9709361 A BR 9709361A BR 9709361 A BR9709361 A BR 9709361A
Authority
BR
Brazil
Prior art keywords
taxus species
taxane production
taxus
crops
increased
Prior art date
Application number
BR9709361A
Other languages
English (en)
Other versions
BR9709361B1 (pt
Inventor
Venkataraman Bringi
Prakash G Kadkade
Christopher L Prince
Braden L Roach
Original Assignee
Phyton Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24619244&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9709361(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Phyton Inc filed Critical Phyton Inc
Publication of BR9709361A publication Critical patent/BR9709361A/pt
Publication of BR9709361B1 publication Critical patent/BR9709361B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0025—Culture media for plant cell or plant tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/04—Plant cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
BRPI9709361-0A 1996-05-24 1997-05-27 produção aumentada de taxanos por culturas de células de espécie taxus. BR9709361B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65303696A 1996-05-24 1996-05-24
PCT/US1997/008907 WO1997044476A1 (en) 1996-05-24 1997-05-27 Enhanced production of taxanes by cell cultures of taxus species

Publications (2)

Publication Number Publication Date
BR9709361A true BR9709361A (pt) 1999-08-10
BR9709361B1 BR9709361B1 (pt) 2009-05-05

Family

ID=24619244

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9709361-0A BR9709361B1 (pt) 1996-05-24 1997-05-27 produção aumentada de taxanos por culturas de células de espécie taxus.

Country Status (16)

Country Link
US (2) US8338143B2 (pt)
EP (3) EP1398384A1 (pt)
JP (5) JP4047929B2 (pt)
KR (7) KR20090005241A (pt)
AT (1) ATE315097T1 (pt)
AU (1) AU727425B2 (pt)
BR (1) BR9709361B1 (pt)
CA (2) CA2256357C (pt)
DE (1) DE69735059T2 (pt)
DK (1) DK0954596T3 (pt)
ES (1) ES2256887T3 (pt)
HU (2) HUP9901788A3 (pt)
IL (1) IL127062A (pt)
PT (1) PT954596E (pt)
TR (1) TR199802426T2 (pt)
WO (1) WO1997044476A1 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9901788A3 (en) * 1996-05-24 2002-07-29 Phyton Inc Ithaca Enhanced production of taxanes by cell cultures of taxus species
KR100287465B1 (ko) * 1997-06-25 2001-05-02 나까니시 히로유끼 탁산형 디테르펜의 제조방법
TW200304947A (en) * 2002-02-08 2003-10-16 Bristol Myers Squibb Co Compositions and methods for latering biosynthesis of taxanes and taxane-related compounds
WO2006129988A1 (en) * 2005-06-03 2006-12-07 Samyang Genex Corporation Mass production of secondary metabolite in plant cell culture by treatment of saccharide mixture in medicum
CN101297028B (zh) * 2005-10-31 2016-01-20 云火公司 通过同步化植物细胞培养的次级代谢产物批量生产的稳定化方法
US8053238B2 (en) 2005-10-31 2011-11-08 Unhwa Corporation Isolated population of plant single cells and method of preparing the same
KR101064518B1 (ko) 2007-09-21 2011-09-19 주식회사 운화 저장근을 가지는 초본식물의 형성층 유래 식물줄기세포주 및 이의 분리방법
KR101100867B1 (ko) * 2008-05-14 2012-01-02 주식회사 운화 주목의 형성층 또는 전형성층 유래 식물줄기세포주를 유효성분으로 함유하는 항산화, 항염증 또는 항노화용 조성물
DK2443229T3 (da) 2009-06-18 2020-03-30 Phyton Holdings Llc Fremstilling af alkaloider med cellekultur fra Veratrum californicum
FR2952072B1 (fr) * 2009-11-05 2013-09-27 Pf Medicament Procede de production de triptolide
WO2013164834A1 (en) * 2012-05-04 2013-11-07 Phyto Biotech Pvt. Ltd. Cost-effective process for commercial production of paclitaxel
CN103570647A (zh) * 2013-11-06 2014-02-12 湖南农业大学 从红豆杉细胞培养液中制备高纯度紫杉醇的方法
EP3077523B1 (en) 2013-12-02 2020-05-06 Phyton Holdings, LLC Production of thapsigargins by thapsia cell suspension culture
US10058542B1 (en) 2014-09-12 2018-08-28 Thioredoxin Systems Ab Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith
DK3270686T3 (da) 2015-03-20 2020-03-09 Phyton Holdings Llc Fremstilling af ingenol, ingenolestere og/eller tiglian-3-on-derivater ved hjælp af Euphorbiaceae-plantecellesuspensions-kulturer
CN105349592B (zh) * 2015-12-09 2018-11-27 天津艾赛博生物技术有限公司 代谢互补的植物细胞系混种培养生产次级代谢产物的方法
CN106636242A (zh) * 2016-12-20 2017-05-10 天津艾赛博生物技术有限公司 一种红豆杉细胞长期培养生产紫杉烷的调控方法
JP7359527B2 (ja) * 2017-05-31 2023-10-11 トヨタ自動車株式会社 電池搭載構造
EP4188090A2 (en) * 2020-07-28 2023-06-07 Impello Biosciences, Inc. Methods and compositions for altering secondary metabolites in plants
CN113416689B (zh) * 2021-08-04 2023-01-10 海南鑫开源医药科技有限公司 一种利用植物细胞发酵技术生产高丽槐素的方法
CN115948494A (zh) * 2022-09-12 2023-04-11 昆明理工大学 一种利用三七细胞合成齐墩果烷型皂苷的方法

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0071999B1 (en) * 1981-08-11 1986-03-26 Mitsui Petrochemical Industries, Ltd. Method for producing secondary metabolites of plants
WO1986002463A1 (fr) 1984-10-19 1986-04-24 Alain Zarudiansky Systeme de lunettes
JPH0833258B2 (ja) 1987-10-09 1996-03-29 三洋電機株式会社 吸収冷凍装置
DE3801023A1 (de) 1988-01-13 1989-07-27 Schering Ag Verfahren zur steigerung von enzym-aktivitaeten und der syntheseleistung von organismen
EP0378921A3 (en) 1988-12-21 1990-09-19 Idaho Research Foundation, Inc. Enhancement of plant metabolite production by timed elicitation
US5019504A (en) * 1989-03-23 1991-05-28 The United States Of America As Represented By The Secretary Of Agriculture Production of taxol or taxol-like compounds in cell culture
US5334529A (en) * 1989-06-27 1994-08-02 Escagenetics Corporation Stably transformed coffee plant cells and plantlets
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
ATE142420T1 (de) 1990-05-25 1996-09-15 Univ Washington Verfahren zur auslösung pflanzenschützender mechanismen
ATE146527T1 (de) 1991-02-12 1997-01-15 Nippon Steel Corp Verfahren zur herstellung von taxol mittels taxusspezies-zellkultur
US5244775A (en) * 1991-03-20 1993-09-14 Hitachi, Ltd. Method of manufacturing an optical disc
EP0580759B1 (en) 1991-04-19 1999-05-26 The University Of Mississippi Methods and compositions for isolating taxanes
US5248625A (en) * 1991-06-06 1993-09-28 Lsi Logic Corporation Techniques for forming isolation structures
WO1993002067A1 (fr) 1991-07-17 1993-02-04 Nippon Steel Corporation Compose antitumoral nsc-lsc1 et son procede de production
US5344775A (en) 1991-11-15 1994-09-06 Escagenetics Corporation Synthesis of taxanes in culture using pseudocalluscells
US5407816A (en) * 1992-02-20 1995-04-18 Phyton Catalytic, Inc. Enhanced production of taxol and taxanes by cell cultures of taxus species
US5451392A (en) * 1992-03-03 1995-09-19 The Research And Development Institute At Montana State University Production of taxol
US5445809A (en) * 1992-03-03 1995-08-29 Research And Development Institute At Montana State University Production of taxol from the yew tree
JPH05244971A (ja) 1992-03-06 1993-09-24 Nippon Oil Co Ltd タキサン類化合物の製造方法
CA2131532A1 (en) 1992-04-01 1993-10-14 Steven R. Wann Induction of somatic embryogenesis in taxus, and the production of taxane-ring containing alkaloids therefrom
US5850032A (en) * 1992-04-01 1998-12-15 Union Camp Corporation Method for production of plant biological products in precocious neomorphic embryoids
CA2434692A1 (en) 1992-04-07 1993-10-08 Paul M. Cino Callus cell induction and the preparation of taxanes
US5322779A (en) * 1992-04-16 1994-06-21 The Research And Development Institute, Inc. At Montana State University Taxol production by taxomyces andreanae
EP0642586A4 (en) 1992-05-21 1995-11-29 Penn State Res Found CULTURAL -i (TAXUS) FABRIC AS A SOURCE OF TAXOL, RELATED TAXANS AND OTHER NEW ANTI-TUMOR / ANTI-VIRAL SUBSTANCES (01/20/94).
JP2967532B2 (ja) 1992-06-11 1999-10-25 日石三菱株式会社 タキサン類化合物の製造方法
US5279953A (en) * 1992-06-24 1994-01-18 Esca Genetics Corporation In vivo production of taxanes
JP3162217B2 (ja) 1992-12-24 2001-04-25 三井化学株式会社 タキサン型ジテルペンの製造方法
JP3144947B2 (ja) 1993-04-08 2001-03-12 三井化学株式会社 タキサン型ジテルペンの製造方法
JPH06296493A (ja) 1993-04-14 1994-10-25 Nippon Steel Corp タキソールの生産方法
KR950005081B1 (ko) 1993-07-06 1995-05-18 산림청임목육종연구소 주목 종자의 씨눈 유래의 체세포배 및 체세포배성세포 혹은 그 배양배지로부터 택솔(Taxol) 및 그 유도체를 생산하는 방법
JP3488492B2 (ja) 1993-11-15 2004-01-19 三井化学株式会社 タキサン型ジテルペン高産生培養細胞の取得方法
JPH0856680A (ja) * 1994-08-25 1996-03-05 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
EP0683232B1 (en) 1993-11-15 2001-02-14 Mitsui Chemicals, Inc. Process for producing taxane diterpene and method of harvesting cultred cell capable of producing taxane diterpene in high yield
JPH07308197A (ja) 1994-05-18 1995-11-28 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JP3434892B2 (ja) 1994-06-28 2003-08-11 三井化学株式会社 タキサン型ジテルペンの製造方法
JPH08116981A (ja) 1994-10-18 1996-05-14 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JPH07308196A (ja) 1994-05-18 1995-11-28 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JPH0856681A (ja) 1994-08-25 1996-03-05 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JP2967034B2 (ja) 1994-03-07 1999-10-25 三井化学株式会社 タキサン型ジテルペンの製造方法
JPH07255495A (ja) 1994-03-28 1995-10-09 Ishikawajima Harima Heavy Ind Co Ltd タキソールの製造方法
US5547866A (en) * 1994-07-20 1996-08-20 The Regents Of The University Of California Taxane production in haploid-derived cell cultures
JPH0870880A (ja) 1994-09-05 1996-03-19 Osaka Organic Chem Ind Ltd タキソールの培養生産法
JP3549594B2 (ja) 1994-11-25 2004-08-04 三井化学株式会社 タキサン型ジテルペンの製造方法
CA2163614C (en) * 1994-11-25 2002-12-31 Yukihito Yukimune Method of producing a taxane-type diterpene
JPH08163991A (ja) 1994-12-15 1996-06-25 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JPH08149984A (ja) 1994-11-30 1996-06-11 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JP3746550B2 (ja) 1994-12-05 2006-02-15 三井化学株式会社 タキサン型ジテルペンの製造方法
JPH08205881A (ja) * 1994-12-05 1996-08-13 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JPH08154693A (ja) 1994-12-05 1996-06-18 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JP3019736B2 (ja) 1994-12-07 2000-03-13 三井化学株式会社 タキサン型ジテルペンの製造方法
JPH08198863A (ja) * 1995-01-25 1996-08-06 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
US5620875A (en) * 1995-02-17 1997-04-15 University Of Portland Transfer of taxol from yew tree cuttings into a culture medium over time
KR960037826A (ko) 1995-04-27 1996-11-19 김경환 택서스속 식물세포의 반연속식 배양방법
US6248572B1 (en) * 1995-04-27 2001-06-19 Samyang, Genex, Corporation Production of taxol from taxus plant cell culture adding silver nitrate
US5900367A (en) 1995-04-29 1999-05-04 Samyang Genex Co., Ltd. Method for purifying taxol from taxus biomass
JPH08298993A (ja) 1995-05-02 1996-11-19 Nippon Steel Corp イチイの組織培養によるタキサン化合物の製造法
US5965438A (en) 1995-06-07 1999-10-12 Phyton, Inc. Cryopreservation of plant cells
JPH0928392A (ja) 1995-07-17 1997-02-04 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
JPH0956387A (ja) 1995-08-22 1997-03-04 Mitsui Petrochem Ind Ltd タキサン型ジテルペンの製造方法
US5670663A (en) * 1996-02-14 1997-09-23 Regents Of The University Of California Recovery of taxanes from conifers
HUP9901788A3 (en) * 1996-05-24 2002-07-29 Phyton Inc Ithaca Enhanced production of taxanes by cell cultures of taxus species
JPH1042888A (ja) 1996-07-30 1998-02-17 Jumoku Seiri Kinousei Butsushitsu Gijutsu Kenkyu Kumiai タキソールの培養生産方法
JPH1052295A (ja) 1996-08-09 1998-02-24 Nippon Oil Co Ltd タキサン類化合物の製造方法（ｉｉ）
JPH1052294A (ja) 1996-08-09 1998-02-24 Nippon Oil Co Ltd タキサン類化合物の製造方法（ｉ）
JPH1052296A (ja) 1996-08-09 1998-02-24 Nippon Oil Co Ltd タキサン類化合物の製造方法（ｉｉｉ）
AU727388B2 (en) * 1997-02-19 2000-12-14 Phytobiotech Inc. Method for increasing the growth of plant cell cultures
KR100287465B1 (ko) * 1997-06-25 2001-05-02 나까니시 히로유끼 탁산형 디테르펜의 제조방법
JPH1146782A (ja) 1997-08-05 1999-02-23 Mitsui Chem Inc ラジカル発生剤処理による植物二次代謝産物の生産促進方法
US6030818A (en) * 1997-12-22 2000-02-29 Bcm Developpement, Inc. Bacterial mass production of taxanes and paclitaxel
JP3897267B2 (ja) 1998-03-26 2007-03-22 三井化学株式会社 タキサン型ジテルペンの製造方法
JP2000106893A (ja) 1998-10-06 2000-04-18 Kobe Tennenbutsu Kagaku Kk タキサン型ジテルペン類の製造方法
JP3815919B2 (ja) 1999-05-26 2006-08-30 三井化学株式会社 タキサン型ジテルペンの製造方法
US6365407B1 (en) * 2001-03-05 2002-04-02 Council Of Scientific & Industrial Research Culture medium composition useful for induction and proliferation of Taxus calli

Also Published As

Publication number Publication date
DE69735059T2 (de) 2006-08-31
HU0302357D0 (en) 2003-09-29
IL127062A0 (en) 1999-09-22
KR20120138251A (ko) 2012-12-24
ATE315097T1 (de) 2006-02-15
PT954596E (pt) 2006-05-31
DE69735059D1 (de) 2006-03-30
JP2013046643A (ja) 2013-03-07
US20110086397A1 (en) 2011-04-14
AU3143097A (en) 1997-12-09
KR20140062179A (ko) 2014-05-22
KR20100070389A (ko) 2010-06-25
WO1997044476A1 (en) 1997-11-27
KR20100070388A (ko) 2010-06-25
HUP9901788A2 (hu) 1999-09-28
EP1398384A1 (en) 2004-03-17
US20130017582A1 (en) 2013-01-17
ES2256887T3 (es) 2006-07-16
DK0954596T3 (da) 2006-05-15
EP1538214A1 (en) 2005-06-08
KR100897457B1 (ko) 2009-12-18
CA2256357A1 (en) 1997-11-27
US8338143B2 (en) 2012-12-25
EP0954596B1 (en) 2006-01-04
CA2256357C (en) 2008-08-12
JP2000511420A (ja) 2000-09-05
EP0954596A1 (en) 1999-11-10
IL127062A (en) 2005-09-25
JP2008167764A (ja) 2008-07-24
KR20070094867A (ko) 2007-09-21
HUP9901788A3 (en) 2002-07-29
TR199802426T2 (xx) 2001-01-22
HU223267B1 (hu) 2004-04-28
CA2638292A1 (en) 1997-11-27
JP2007143557A (ja) 2007-06-14
JP2011212029A (ja) 2011-10-27
AU727425B2 (en) 2000-12-14
JP4047929B2 (ja) 2008-02-13
BR9709361B1 (pt) 2009-05-05
KR20000015952A (ko) 2000-03-25
KR20090005241A (ko) 2009-01-12

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B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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