JP2011019923A5 - - Google Patents

Info

Publication number

JP2011019923A5

JP2011019923A5 JP2010183530A JP2010183530A JP2011019923A5 JP 2011019923 A5 JP2011019923 A5 JP 2011019923A5 JP 2010183530 A JP2010183530 A JP 2010183530A JP 2010183530 A JP2010183530 A JP 2010183530A JP 2011019923 A5 JP2011019923 A5 JP 2011019923A5

Authority

JP

Japan

Prior art keywords

silk

growth factor

composition

acid

group

Prior art date

2010-08-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 239000000203 mixture Substances 0.000 claims 13
• 229920000249 biocompatible polymer Polymers 0.000 claims 7
• 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 6
• 239000002202 Polyethylene glycol Substances 0.000 claims 6
• 229920001223 polyethylene glycol Polymers 0.000 claims 6
• 108010022355 Fibroins Proteins 0.000 claims 5
• 229920001872 Spider silk Polymers 0.000 claims 5
• 239000000243 solution Substances 0.000 claims 5
• 241000255789 Bombyx mori Species 0.000 claims 4
• 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims 4
• 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims 4
• 229940035676 analgesics Drugs 0.000 claims 4
• 239000000730 antalgic agent Substances 0.000 claims 4
• 230000001760 anti-analgesic effect Effects 0.000 claims 4
• 239000007864 aqueous solution Substances 0.000 claims 4
• 229940112869 bone morphogenetic protein Drugs 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 4
• 229940124597 therapeutic agent Drugs 0.000 claims 4
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 3
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 3
• 229920002101 Chitin Polymers 0.000 claims 3
• 229920001661 Chitosan Polymers 0.000 claims 3
• 102000008186 Collagen Human genes 0.000 claims 3
• 108010035532 Collagen Proteins 0.000 claims 3
• 229920002307 Dextran Polymers 0.000 claims 3
• 102000016359 Fibronectins Human genes 0.000 claims 3
• 108010067306 Fibronectins Proteins 0.000 claims 3
• 108010076876 Keratins Proteins 0.000 claims 3
• 102000011782 Keratins Human genes 0.000 claims 3
• 229920002732 Polyanhydride Polymers 0.000 claims 3
• 229920000805 Polyaspartic acid Polymers 0.000 claims 3
• 229920000954 Polyglycolide Polymers 0.000 claims 3
• 108010039918 Polylysine Proteins 0.000 claims 3
• 229940072056 alginate Drugs 0.000 claims 3
• 229920000615 alginic acid Polymers 0.000 claims 3
• 235000010443 alginic acid Nutrition 0.000 claims 3
• 229920001436 collagen Polymers 0.000 claims 3
• 229920002674 hyaluronan Polymers 0.000 claims 3
• 229960003160 hyaluronic acid Drugs 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 229920001277 pectin Polymers 0.000 claims 3
• 239000001814 pectin Substances 0.000 claims 3
• 235000010987 pectin Nutrition 0.000 claims 3
• 239000005014 poly(hydroxyalkanoate) Substances 0.000 claims 3
• 229920000747 poly(lactic acid) Polymers 0.000 claims 3
• 108010064470 polyaspartate Proteins 0.000 claims 3
• 229920001610 polycaprolactone Polymers 0.000 claims 3
• 239000004632 polycaprolactone Substances 0.000 claims 3
• 239000004633 polyglycolic acid Substances 0.000 claims 3
• 229920000903 polyhydroxyalkanoate Polymers 0.000 claims 3
• 239000004626 polylactic acid Substances 0.000 claims 3
• 229920000656 polylysine Polymers 0.000 claims 3
• 239000002904 solvent Substances 0.000 claims 3
• 102000009024 Epidermal Growth Factor Human genes 0.000 claims 2
• 101800003838 Epidermal growth factor Proteins 0.000 claims 2
• 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 2
• 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 2
• 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 2
• 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims 2
• 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims 2
• 102000013275 Somatomedins Human genes 0.000 claims 2
• 108010009583 Transforming Growth Factors Proteins 0.000 claims 2
• 102000009618 Transforming Growth Factors Human genes 0.000 claims 2
• 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 2
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 2
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 2
• 239000003242 anti bacterial agent Substances 0.000 claims 2
• 230000002924 anti-infective effect Effects 0.000 claims 2
• 229940121363 anti-inflammatory agent Drugs 0.000 claims 2
• 239000002260 anti-inflammatory agent Substances 0.000 claims 2
• 230000003409 anti-rejection Effects 0.000 claims 2
• 229940088710 antibiotic agent Drugs 0.000 claims 2
• 229960005475 antiinfective agent Drugs 0.000 claims 2
• 239000003443 antiviral agent Substances 0.000 claims 2
• 229940116977 epidermal growth factor Drugs 0.000 claims 2
• 229940126864 fibroblast growth factor Drugs 0.000 claims 2
• 239000003102 growth factor Substances 0.000 claims 2
• 229940088597 hormone Drugs 0.000 claims 2
• 239000005556 hormone Substances 0.000 claims 2
• 150000003431 steroids Chemical class 0.000 claims 2
• VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 2
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
• 239000012620 biological material Substances 0.000 claims 1
• 238000001035 drying Methods 0.000 claims 1