JP4638735B2 - 絹糸生体材料およびその使用方法 - Google Patents

絹糸生体材料およびその使用方法 Download PDF

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Publication number
JP4638735B2
JP4638735B2 JP2004530973A JP2004530973A JP4638735B2 JP 4638735 B2 JP4638735 B2 JP 4638735B2 JP 2004530973 A JP2004530973 A JP 2004530973A JP 2004530973 A JP2004530973 A JP 2004530973A JP 4638735 B2 JP4638735 B2 JP 4638735B2
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Prior art keywords
silk
peo
fiber
solution
aqueous solution
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Expired - Lifetime
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JP2004530973A
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English (en)
Japanese (ja)
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JP2006504450A (ja
Inventor
デイビッド エル． カプラン
ヒョウン−ジョーン ジン
グレゴリー ラトリッジ
セルゲイ フリードリッヒ
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Massachusetts Institute of Technology
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Massachusetts Institute of Technology
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    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/0007—Electro-spinning
    • D01D5/0015—Electro-spinning characterised by the initial state of the material
    • D01D5/003—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion
    • D01D5/0038—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion the fibre formed by solvent evaporation, i.e. dry electro-spinning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F1/00—General methods for the manufacture of artificial filaments or the like
    • D01F1/02—Addition of substances to the spinning solution or to the melt
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F4/00—Monocomponent artificial filaments or the like of proteins; Manufacture thereof
    • D01F4/02—Monocomponent artificial filaments or the like of proteins; Manufacture thereof from fibroin
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
    • D01F6/88—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from mixtures of polycondensation products as major constituent with other polymers or low-molecular-weight compounds
    • D01F6/94—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from mixtures of polycondensation products as major constituent with other polymers or low-molecular-weight compounds of other polycondensation products
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
    • D06M13/10—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
    • D06M13/165—Ethers
    • D06M13/17—Polyoxyalkyleneglycol ethers
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M15/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment
    • D06M15/01—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment with natural macromolecular compounds or derivatives thereof
    • D06M15/03—Polysaccharides or derivatives thereof
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M15/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment
    • D06M15/01—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment with natural macromolecular compounds or derivatives thereof
    • D06M15/03—Polysaccharides or derivatives thereof
    • D06M15/11—Starch or derivatives thereof

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Textile Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Manufacturing & Machinery (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Nonwoven Fabrics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
JP2004530973A 2002-06-24 2003-06-24 絹糸生体材料およびその使用方法 Expired - Lifetime JP4638735B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US39092902P 2002-06-24 2002-06-24
US40273802P 2002-08-12 2002-08-12
US43029102P 2002-12-02 2002-12-02
PCT/US2003/019968 WO2004000915A2 (en) 2002-06-24 2003-06-24 Silk biomaterials and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010183530A Division JP2011019923A (ja) 2002-06-24 2010-08-19 絹糸生体材料およびその使用方法

Publications (2)

Publication Number Publication Date
JP2006504450A JP2006504450A (ja) 2006-02-09
JP4638735B2 true JP4638735B2 (ja) 2011-02-23

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
JP2004530973A Expired - Lifetime JP4638735B2 (ja) 2002-06-24 2003-06-24 絹糸生体材料およびその使用方法
JP2010183530A Withdrawn JP2011019923A (ja) 2002-06-24 2010-08-19 絹糸生体材料およびその使用方法
JP2014043805A Expired - Lifetime JP5855151B2 (ja) 2002-06-24 2014-03-06 絹糸生体材料およびその使用方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2010183530A Withdrawn JP2011019923A (ja) 2002-06-24 2010-08-19 絹糸生体材料およびその使用方法
JP2014043805A Expired - Lifetime JP5855151B2 (ja) 2002-06-24 2014-03-06 絹糸生体材料およびその使用方法

Country Status (6)

Country Link
US (2) US7674882B2 (enExample)
EP (4) EP1558444B1 (enExample)
JP (3) JP4638735B2 (enExample)
AU (1) AU2003249366A1 (enExample)
CA (1) CA2525994C (enExample)
WO (1) WO2004000915A2 (enExample)

Cited By (7)

* Cited by examiner, † Cited by third party
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WO2018207827A1 (ja) 2017-05-10 2018-11-15 Ｓｐｉｂｅｒ株式会社 ポリペプチド溶液、及びポリペプチド繊維の製造方法、並びに人造ポリペプチド
WO2019022163A1 (ja) 2017-07-26 2019-01-31 Ｓｐｉｂｅｒ株式会社 改変フィブロイン
WO2019194146A1 (ja) 2018-04-03 2019-10-10 Ｓｐｉｂｅｒ株式会社 成形体及びその製造方法
WO2020145363A1 (ja) 2019-01-09 2020-07-16 Ｓｐｉｂｅｒ株式会社 改変フィブロイン
WO2020250904A1 (ja) 2019-06-11 2020-12-17 Ｓｐｉｂｅｒ株式会社 吸水速乾性付与剤、及び吸水速乾性を付与する方法
WO2021065769A1 (ja) 2019-09-30 2021-04-08 Ｓｐｉｂｅｒ株式会社 接触冷感性及び吸水速乾性付与剤、並びに物品に接触冷感性及び吸水速乾性を付与する方法
WO2023038153A1 (ja) 2021-09-13 2023-03-16 Ｓｐｉｂｅｒ株式会社 消臭材、消臭性付与剤並びに消臭性の付与方法

Families Citing this family (254)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE466072T1 (de) * 2000-06-29 2010-05-15 Mount Sinai Hospital Corp Bandscheibe
US20110009960A1 (en) * 2001-11-16 2011-01-13 Allergan, Inc. Prosthetic fabric structure
US6902932B2 (en) * 2001-11-16 2005-06-07 Tissue Regeneration, Inc. Helically organized silk fibroin fiber bundles for matrices in tissue engineering
JP4638735B2 (ja) * 2002-06-24 2011-02-23 タフツ ユニバーシティー 絹糸生体材料およびその使用方法
US7842780B2 (en) 2003-01-07 2010-11-30 Trustees Of Tufts College Silk fibroin materials and use thereof
JP4698596B2 (ja) 2003-04-10 2011-06-08 タフツ ユニバーシティー 濃縮された水性シルクフィブロイン溶液およびそれらの使用
US8383158B2 (en) 2003-04-15 2013-02-26 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
WO2005000483A1 (en) 2003-06-06 2005-01-06 Tufts University Method for forming inorganic coatings
BRPI0508098A (pt) 2004-02-27 2007-07-17 Amgen Inc compostos, composições farmacêuticas e métodos para uso no tratamento de distúrbios metabólicos
GB0405045D0 (en) 2004-03-05 2004-04-07 Spinox Ltd Composite materials
JP4526851B2 (ja) * 2004-03-31 2010-08-18 明彦 谷岡 多糖類のナノスケールの繊維および成形体
US7622367B1 (en) 2004-06-04 2009-11-24 The Board Of Trustees Of The University Of Illinois Methods and devices for fabricating and assembling printable semiconductor elements
EP1773240B1 (en) 2004-06-11 2019-11-20 Trustees of the Tufts College Silk-based drug delivery system
DE602005013979D1 (de) * 2004-09-14 2009-05-28 Neurotex Ltd Verfahren und gerät für verstärktes wachstum von peripheren nerven und nervengewebe
GB2417904A (en) * 2004-09-14 2006-03-15 Spinox Ltd Tubular prosthesis for nerve regeneration
WO2006099332A2 (en) 2005-03-11 2006-09-21 Wake Forest University Health Sciences Production of tissue engineered digits and limbs
EP1863546B1 (en) 2005-03-11 2015-10-07 Wake Forest University Health Sciences Production of tissue engineered heart valves
CA2602029C (en) 2005-03-11 2014-07-15 Wake Forest University Health Sciences Tissue engineered blood vessels
US20060204539A1 (en) * 2005-03-11 2006-09-14 Anthony Atala Electrospun cell matrices
CN100577720C (zh) * 2005-03-21 2010-01-06 中国科学院化学研究所 可生物降解及吸收的聚合物纳米纤维膜材料及制法和用途
US9539410B2 (en) 2005-04-19 2017-01-10 Abbott Cardiovascular Systems Inc. Methods and compositions for treating post-cardial infarction damage
US20080125745A1 (en) 2005-04-19 2008-05-29 Shubhayu Basu Methods and compositions for treating post-cardial infarction damage
EP1915436B1 (en) 2005-08-02 2011-09-28 Trustees Of Tufts College Methods for stepwise deposition of silk fibroin coatings
DE102005042455A1 (de) * 2005-09-06 2007-04-12 Medizinische Hochschule Hannover Nervenimplantat
CN100382772C (zh) * 2005-09-28 2008-04-23 南通大学 含蚕丝丝素的医用神经移植物的制备方法
ES2787501T3 (es) * 2005-12-02 2020-10-16 Sunstar Suisse Sa Material biocompatible que presenta un tejido de nano- o microfibras no tejidas producido por procedimiento de electrohilado
WO2007103442A1 (en) * 2006-03-06 2007-09-13 Board Of Supervisors Of Louisiana State Universityand Agricultural And Mechanical College Biocompatible scaffolds and adipose-derived stem cells
EP1852470A1 (en) * 2006-05-03 2007-11-07 Technische Universität München Multilayer Silk Protein Films
CN100404081C (zh) * 2006-06-09 2008-07-23 浙江大学 一种网状组织工程支架
US9242005B1 (en) 2006-08-21 2016-01-26 Abbott Cardiovascular Systems Inc. Pro-healing agent formulation compositions, methods and treatments
CN100364619C (zh) * 2006-08-30 2008-01-30 郑军 人造血管丝素、胶原蛋白共混预凝涂层
CN100364621C (zh) * 2006-08-30 2008-01-30 黄福华 人造血管丝素蛋白预凝涂层
US20110180951A1 (en) * 2006-09-18 2011-07-28 Wee Eong Teo Fiber structures and process for their preparation
US9969134B2 (en) 2006-11-03 2018-05-15 Trustees Of Tufts College Nanopatterned biopolymer optical device and method of manufacturing the same
CA2704304C (en) 2006-11-03 2015-01-13 Trustees Of Trufts College Biopolymer optical waveguide and method of manufacturing the same
EP2101975A2 (en) 2006-11-03 2009-09-23 Trustees of Tufts College Biopolymer sensor and method of manufacturing the same
WO2008118211A2 (en) 2006-11-03 2008-10-02 Trustees Of Tufts College Biopolymer photonic crystals and method of manufacturing the same
US20080112998A1 (en) * 2006-11-14 2008-05-15 Hongjun Wang Innovative bottom-up cell assembly approach to three-dimensional tissue formation using nano-or micro-fibers
US9005672B2 (en) 2006-11-17 2015-04-14 Abbott Cardiovascular Systems Inc. Methods of modifying myocardial infarction expansion
US8192760B2 (en) 2006-12-04 2012-06-05 Abbott Cardiovascular Systems Inc. Methods and compositions for treating tissue using silk proteins
US9011754B2 (en) 2006-12-05 2015-04-21 Nanyang Technological University Manufacturing three-dimensional scaffolds using electrospinning at low temperatures
WO2008069761A1 (en) 2006-12-05 2008-06-12 Nanyang Technological University Manufacturing three-dimensional scaffolds using cryogenic prototyping
WO2008069020A1 (ja) * 2006-12-06 2008-06-12 Toyo Boseki Kabushiki Kaisha タンパク質の溶解性改善方法、タンパク質含有水溶液の溶状を安定化する方法、及び、組成物
EP2097117B1 (en) * 2006-12-11 2013-05-22 Medizinische Hochschule Hannover Implant of cross-linked spider silk threads
EP2129772B1 (en) 2007-02-27 2016-07-27 Trustees Of Tufts College Tissue-engineered silk organs
CA2682701A1 (en) 2007-03-20 2008-09-25 Serica Technologies, Inc. Prosthetic device and method of manufacturing the same
HRP20141265T1 (hr) 2007-05-29 2015-04-10 Trustees Of Tufts College Postupak geliranja fibroina svile pomoä†u ultrazvuka
US9599891B2 (en) 2007-11-05 2017-03-21 Trustees Of Tufts College Fabrication of silk fibroin photonic structures by nanocontact imprinting
WO2009099570A2 (en) * 2008-02-01 2009-08-13 Wake Forest University Health Sciences Aligned scaffolding system for skeletal muscle regeneration
EP2249886A4 (en) 2008-02-07 2013-05-22 Tufts College 3-DIMENSIONAL SILK HYDROXYLAPATITE COMPOSITIONS
EP2299988A4 (en) 2008-05-15 2013-10-16 Tufts College SILK-POLYMER-BASED ADENOSINE RELEASE, THERAPEUTIC POTENTIAL IN EPILEPSY
US8242073B2 (en) * 2008-07-10 2012-08-14 The Hong Kong Polytechnic University Biodegradable and bioabsorbable biomaterials and keratin fibrous articles for medical applications
CN102176905A (zh) * 2008-08-08 2011-09-07 巴斯夫欧洲公司 具有受控释放的活性成分的含活性成分的纤维层状结构，其用途及其生产方法
WO2010015419A2 (de) 2008-08-08 2010-02-11 Basf Se Wirkstoffhaltige fasernflächengebilde auf basis von biopolymeren, ihre anwendungen und verfahren zu ihrer herstellung
KR100937736B1 (ko) * 2008-09-23 2010-01-21 동국대학교 산학협력단 유도 조직 재생을 위한 다공성 지지체 및 그의 제조방법
US9492593B2 (en) * 2008-09-24 2016-11-15 Poly-Med, Inc. Absorbable, permeability-modulated barrier composites and applications thereof
EP2349366B1 (en) * 2008-09-26 2013-08-28 Trustees Of Tufts College Active silk muco-adhesives, silk electrogelation process, and devices
US8501172B2 (en) 2008-09-26 2013-08-06 Trustees Of Tufts College pH-induced silk gels and uses thereof
US8097926B2 (en) 2008-10-07 2012-01-17 Mc10, Inc. Systems, methods, and devices having stretchable integrated circuitry for sensing and delivering therapy
US8389862B2 (en) 2008-10-07 2013-03-05 Mc10, Inc. Extremely stretchable electronics
US8886334B2 (en) 2008-10-07 2014-11-11 Mc10, Inc. Systems, methods, and devices using stretchable or flexible electronics for medical applications
US8372726B2 (en) 2008-10-07 2013-02-12 Mc10, Inc. Methods and applications of non-planar imaging arrays
EP2349440B1 (en) 2008-10-07 2019-08-21 Mc10, Inc. Catheter balloon having stretchable integrated circuitry and sensor array
CA2739487A1 (en) * 2008-10-09 2010-04-15 Trustees Of Tufts College Modified silk films containing glycerol
WO2010057142A2 (en) * 2008-11-17 2010-05-20 Trustees Of Tufts College Surface modification of silk fibroin matrices with poly(ethylene glycol) useful as anti adhesion barriers and anti thrombotic materials
EP2438442B1 (en) 2008-12-01 2017-08-09 Laboratory Corporation of America Holdings Methods and assays for measuring p95 and/or p95 complexes in a sample and antibodies specific for p95
US9204953B2 (en) 2008-12-15 2015-12-08 Allergan, Inc. Biocompatible surgical scaffold with varying stretch
US9326840B2 (en) 2008-12-15 2016-05-03 Allergan, Inc. Prosthetic device and method of manufacturing the same
US9308070B2 (en) 2008-12-15 2016-04-12 Allergan, Inc. Pliable silk medical device
US9204954B2 (en) * 2008-12-15 2015-12-08 Allergan, Inc. Knitted scaffold with diagonal yarn
MX2011006289A (es) 2008-12-15 2011-06-27 Allergan Inc Dispositivo protesico y metodo de elaborar el mismo.
JP5186671B2 (ja) * 2008-12-25 2013-04-17 国立大学法人信州大学 絹タンパク質ナノファイバー及びその製造方法、並びに絹タンパク質複合体ナノファイバー及びその製造方法
CN101474430B (zh) * 2009-01-13 2013-01-09 武汉大学 一种生物活性组织再生膜及其制备方法
CN101476172B (zh) * 2009-01-14 2010-08-11 天津工业大学 一种医用纤维及其制造方法
AU2010242010B2 (en) 2009-02-12 2015-06-18 Trustees Of Tufts College Nanoimprinting of silk fibroin structures for biomedical and biophotonic applications
MX345864B (es) * 2009-03-10 2017-02-20 Medprin Regenerative Medical Tech Co Ltd Duramadre artificial sintética.
US20110111031A1 (en) * 2009-04-20 2011-05-12 Guang-Liang Jiang Drug Delivery Platforms Comprising Silk Fibroin Hydrogels and Uses Thereof
US8420077B2 (en) * 2009-04-20 2013-04-16 Allergan, Inc. Silk fibroin hydrogels and uses thereof
US20110052695A1 (en) * 2009-04-20 2011-03-03 Allergan, Inc. Drug delivery platforms comprising silk fibroin hydrogels and uses thereof
US20110189292A1 (en) * 2009-04-20 2011-08-04 Allergan, Inc. Dermal fillers comprising silk fibroin hydrogels and uses thereof
WO2011005381A2 (en) 2009-06-01 2011-01-13 Trustees Of Tufts College Vortex-induced silk fibroin gelation for encapsulation and delivery
US8728498B2 (en) 2009-07-14 2014-05-20 Trustees Of Tufts College Electrospun silk material systems for wound healing
WO2011046652A2 (en) 2009-07-20 2011-04-21 Trustees Of Tufts College All-protein implantable, resorbable reflectors
US9211377B2 (en) 2009-07-30 2015-12-15 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
KR101116237B1 (ko) * 2009-08-12 2012-03-09 서울대학교산학협력단 실크 나노섬유 신경도관 및 이의 제조방법
JP5789799B2 (ja) * 2009-08-21 2015-10-07 国立研究開発法人農業生物資源研究所 多孔質体の製造方法、細胞又は組織供給用支持体の製造方法、及び組織供給体の製造方法
EP2474054A4 (en) 2009-08-31 2013-03-13 Tufts University Trustees Of Tufts College SILK TRANSISTOR DEVICES
AU2010292237A1 (en) * 2009-09-11 2012-04-05 Allergan, Inc. Prosthetic device and method of manufacturing the same
EP2483460B1 (en) 2009-09-28 2015-09-02 Trustees Of Tufts College Method to prepare drawn silk egel fibers
EP2483199B1 (en) 2009-09-29 2017-04-26 Trustees Of Tufts College Silk nanospheres and microspheres and methods of making same
US20110218756A1 (en) * 2009-10-01 2011-09-08 Mc10, Inc. Methods and apparatus for conformal sensing of force and/or acceleration at a person's head
WO2011041727A1 (en) 2009-10-01 2011-04-07 Mc10, Inc. Protective cases with integrated electronics
KR101186004B1 (ko) * 2009-10-14 2012-09-25 한림대학교 산학협력단 생분해성 실크 나노섬유 막 및 그 제조방법, 이를 이용한 생분해성 지지체
EP2513953B1 (en) 2009-12-16 2017-10-18 The Board of Trustees of the University of Illionis Electrophysiology using conformal electronics
US9936574B2 (en) 2009-12-16 2018-04-03 The Board Of Trustees Of The University Of Illinois Waterproof stretchable optoelectronics
US10441185B2 (en) 2009-12-16 2019-10-15 The Board Of Trustees Of The University Of Illinois Flexible and stretchable electronic systems for epidermal electronics
US9603971B2 (en) 2010-03-05 2017-03-28 Trustees Of Tufts College Silk-based ionomeric compositions
WO2011113446A1 (en) * 2010-03-17 2011-09-22 Amsilk Gmbh Method for production of polypeptide containing fibres
KR101837481B1 (ko) 2010-03-17 2018-03-13 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 생체흡수성 기판 상 이식가능한 바이오의료 장치
JP5298316B2 (ja) * 2010-03-23 2013-09-25 国立大学法人信州大学 水生昆虫由来のシルクナノファイバー及びシルク複合ナノファイバー、並びにその製造方法
JP5470569B2 (ja) * 2010-03-26 2014-04-16 国立大学法人信州大学 シルク複合ナノファイバー及びその製造方法
KR101142103B1 (ko) * 2010-04-09 2012-05-07 조선대학교산학협력단 실크 피브로인 분말을 이용하여 제조된 바이오복합재료 및 이를 이용한 인공도관
CN103181025A (zh) 2010-04-12 2013-06-26 塔夫茨大学 丝电子部件
US8697057B2 (en) 2010-08-19 2014-04-15 Allergan, Inc. Compositions and soft tissue replacement methods
EP2611473A4 (en) * 2010-09-01 2014-08-13 Tufts College SILK FIBROIN AND POLYETHYLENE GLYCOL BIOMATERIALS
US9517357B2 (en) 2010-09-03 2016-12-13 Tufts University Plasmonic nanoparticle-doped silk materials
EP2619356A4 (en) * 2010-09-22 2014-04-09 Univ Virginia Commonwealth PREPARATION WITH A HIGH SHARE OF FIBER MATRICES ON A GROWTH FACTOR BASIS FOR TISSUE ENGINEERING, GROWTH FACTOR LEAKAGE AND WOUND HEALING
US8470967B2 (en) 2010-09-24 2013-06-25 Duke University Phase transition biopolymers and methods of use
EP2622663A4 (en) 2010-09-27 2014-12-24 Tufts University Trustees Of Tufts College PIEZOELECTRIC MATERIALS BASED ON SILK
EP4218891A1 (en) 2010-10-19 2023-08-02 Trustees Of Tufts College Silk fibroin-based microneedles and methods of making the same
JP2012171124A (ja) * 2011-02-18 2012-09-10 Sekisui Chem Co Ltd 製管用部材、及び既設管の更生方法
WO2013105997A2 (en) 2011-02-23 2013-07-18 Allergan, Inc. Compositions and improved soft tissue replacement methods
KR101380786B1 (ko) * 2011-03-11 2014-04-04 포항공과대학교 산학협력단 말미잘 유래 재조합 실크 단백질, 이의 생산방법 및 이를 포함하는 실크 섬유 제조용 조성물
WO2012145652A1 (en) 2011-04-20 2012-10-26 Trustees Of Tufts College Dynamic silk coatings for implantable devices
ITMI20110758A1 (it) * 2011-05-05 2012-11-06 Stazione Sperimentale Per La Seta Film di fibroina e pectina, in particolare per applicazioni medicali e di ingegneria tissutale, e relativo metodo di preparazione
WO2012158709A1 (en) 2011-05-16 2012-11-22 The Board Of Trustees Of The University Of Illinois Thermally managed led arrays assembled by printing
US9159635B2 (en) 2011-05-27 2015-10-13 Mc10, Inc. Flexible electronic structure
US8934965B2 (en) 2011-06-03 2015-01-13 The Board Of Trustees Of The University Of Illinois Conformable actively multiplexed high-density surface electrode array for brain interfacing
CN102293688B (zh) * 2011-06-03 2013-09-04 浙江星月生物科技股份有限公司 一种蚕丝支架及其制备与应用
EP2537538A1 (en) 2011-06-22 2012-12-26 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH Bioresorbable Wound Dressing
WO2013044067A1 (en) * 2011-09-23 2013-03-28 Trustees Of Tufts College Methods for treatment of cervical insufficiency
US20140370094A1 (en) 2011-11-08 2014-12-18 Tufts University Silk-based scaffold platform for engineering tissue constructs
CN104203292B (zh) 2011-11-09 2019-05-31 塔夫茨大学信托人 可注射丝素蛋白泡沫及其用途
KR20200093073A (ko) 2011-11-09 2020-08-04 트러스티즈 오브 터프츠 칼리지 주사가능한 실크 피브로인 입자 및 그의 용도
JP6231489B2 (ja) 2011-12-01 2017-11-15 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ プログラム可能な変化を被るように設計された遷移デバイス
US10126467B2 (en) 2011-12-05 2018-11-13 Tufts University Signal enhancement by silk photonic crystals
US20130149351A1 (en) * 2011-12-09 2013-06-13 University Of Southern California Polymer scaffolds and their use in the treatment of vision loss
JP2013135740A (ja) * 2011-12-28 2013-07-11 Kyocera Medical Corp 医療用材料
WO2013102193A1 (en) 2011-12-29 2013-07-04 Trustees Of Tufts College Functionalization of biomaterials to control regeneration and inflammation responses
EP3884931A3 (en) 2012-02-06 2021-12-01 Children's Medical Center, Corp. Multi-layer biomaterial for tissue regeneration and wound healing
WO2013123272A1 (en) 2012-02-16 2013-08-22 Allergan, Inc. Compositions and improved soft tissue replacement methods
WO2013123275A1 (en) 2012-02-16 2013-08-22 Allergan, Inc. Compositions and improved soft tissue replacement methods
EP2814482A1 (en) 2012-02-16 2014-12-24 Allergan, Inc. Compositions and improved soft tissue replacement methods
WO2013123274A1 (en) 2012-02-16 2013-08-22 Allergan, Inc. Compositions and improved soft tissue replacement methods
KR20150004819A (ko) 2012-03-30 2015-01-13 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 표면에 상응하는 부속체 장착가능한 전자 장치
IN2014DN07958A (enExample) * 2012-04-04 2015-05-01 Pepsico Inc
US9925301B2 (en) 2012-04-06 2018-03-27 Trustees Of Tufts College Methods of producing and using silk microfibers
EP2841108A4 (en) 2012-04-25 2015-11-25 Tufts College SILK MICRO BEADS AND METHOD OF SURFACE LUBRICATION
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US10034945B2 (en) 2012-07-13 2018-07-31 Trustees Of Tufts College Silk powder compaction for production of constructs with high mechanical strength and stiffness
WO2014035798A1 (en) 2012-08-30 2014-03-06 Sanofi Silk lyogels for sustained release of protein therapeutics and methods of making and uses
US9171794B2 (en) 2012-10-09 2015-10-27 Mc10, Inc. Embedding thin chips in polymer
US10899803B2 (en) 2012-10-17 2021-01-26 Nanyang Technological University Compounds and methods for the production of suckerin and uses thereof
CN102936794B (zh) * 2012-11-20 2015-01-21 东华大学 基于天然材料丝素蛋白和壳聚糖复合纳米纤维膜的制备
WO2014085725A1 (en) 2012-11-27 2014-06-05 Tufts University Biopolymer-based inks and use thereof
CN102949751A (zh) * 2012-11-28 2013-03-06 川北医学院第二临床医学院 组织工程胶原—透明质酸—硫酸软骨素静电纺丝支架制备方法
EP2940066B1 (en) 2012-12-26 2020-02-05 Spiber Inc. Spider silk protein film, and method for producing same
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
WO2014197093A2 (en) 2013-03-15 2014-12-11 Tufts University All water-based nanopatterning
US11376329B2 (en) 2013-03-15 2022-07-05 Trustees Of Tufts College Low molecular weight silk compositions and stabilizing silk compositions
WO2014144971A1 (en) 2013-03-15 2014-09-18 Tufts University Silk water lithography
CA2905090C (en) 2013-03-15 2022-10-25 Trustees Of Tufts College Low molecular weight silk compositions and stabilizing silk compositions
US10292263B2 (en) 2013-04-12 2019-05-14 The Board Of Trustees Of The University Of Illinois Biodegradable materials for multilayer transient printed circuit boards
AU2014250792B2 (en) 2013-04-12 2018-05-10 The Board Of Trustees Of The University Of Illinois Materials, electronic systems and modes for active and passive transience
US9314549B2 (en) 2013-04-24 2016-04-19 University Of South Carolina Bone tissue biomimetic materials
WO2014176458A2 (en) 2013-04-24 2014-10-30 Trustees Of Tufts College Bioresorbable biopolymer anastomosis devices
JP2014221011A (ja) * 2013-05-13 2014-11-27 独立行政法人物質・材料研究機構 細胞培養用支持体の製造方法、細胞培養用支持体および細胞培養方法
US10364451B2 (en) 2013-05-30 2019-07-30 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
US10392611B2 (en) 2013-05-30 2019-08-27 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
US20150047532A1 (en) * 2013-08-13 2015-02-19 Utah State University Synthetic spider silk protein compositions and methods
WO2015048344A2 (en) * 2013-09-27 2015-04-02 Tufts University Silk/platelet composition and use thereof
CA3137437A1 (en) 2013-09-30 2015-04-02 Evolved By Nature, Inc. Silk protein fragment compositions and articles manufactured therefrom
US10092679B2 (en) 2013-10-18 2018-10-09 Wake Forest University Health Sciences Laminous vascular constructs combining cell sheet engineering and electrospinning technologies
US10227566B2 (en) 2013-10-30 2019-03-12 University Of South Carolina Three dimensional matrix for cancer stem cells
US20150202651A1 (en) * 2013-12-17 2015-07-23 Utah State University Recombinant Spider Silk Protein Film and Method of Synthesizing
EP3180044B1 (en) 2014-06-09 2020-08-05 Cornell University Implantable therapeutic delivery system and methods thereof
CN104043148B (zh) * 2014-06-17 2016-01-20 武汉纺织大学 一种韧带支架及其制备方法
KR101629204B1 (ko) * 2014-08-19 2016-06-10 전북대학교산학협력단 초박막 실크피브로인/콜라겐 복합이식체 및 이의 제조방법
JP6402984B2 (ja) * 2014-09-01 2018-10-10 国立研究開発法人物質・材料研究機構 透明フィブロインナノファイバー不織布、細胞培養用基材、細胞シート及び透明フィブロインナノファイバー不織布の製造方法
CN104231283B (zh) * 2014-09-25 2016-11-09 苏州印丝特纺织数码科技有限公司 一种用活性peg制备丝素纳米颗粒的方法
US9165742B1 (en) 2014-10-10 2015-10-20 Kla-Tencor Corporation Inspection site preparation
KR101582202B1 (ko) * 2014-11-05 2016-01-05 대한민국 누에고치를 이용한 혈관용 패치 및 이의 제조방법
EA035551B1 (ru) 2014-12-02 2020-07-06 Силк Терапьютикс, Инк. Изделие
WO2016154530A1 (en) 2015-03-26 2016-09-29 Duke University Targeted therapeutic agents comprising multivalent protein-biopolymer fusions
WO2016164923A1 (en) * 2015-04-10 2016-10-13 Lewis Randolph V Spider silk and synthetic polymer fiber blends
RU2585893C1 (ru) * 2015-04-28 2016-06-10 Наталья Павловна Михайлова Многокомпонентная мезонить, содержащая гиалуроновую кислоту, и способ её получения (варианты)
CN104947320B (zh) * 2015-05-28 2017-11-14 清华大学深圳研究生院 一种生物医用储能调温纤维膜及其制备方法
CN107851208B (zh) 2015-06-01 2021-09-10 伊利诺伊大学评议会 具有无线供电和近场通信能力的小型化电子系统
MX2017015587A (es) 2015-06-01 2018-08-23 Univ Illinois Metodo alternativo para sensor uv.
WO2017011679A1 (en) 2015-07-14 2017-01-19 Silk Therapeutics, Inc. Silk performance apparel and products and methods of preparing the same
WO2017024182A1 (en) 2015-08-04 2017-02-09 Duke University Genetically encoded intrinsically disordered stealth polymers for delivery and methods of using same
EP3766686A1 (en) * 2015-09-17 2021-01-20 Roberto Velozzi Jerez Load-bearing composite panels, materials, products, and processes to make and use same
WO2017051926A1 (ja) * 2015-09-24 2017-03-30 日立化成株式会社 ファイバー、スキンケアシート、創傷被覆材、再生医療用材料及び不織布
KR101602791B1 (ko) * 2015-10-21 2016-03-11 대한민국 평면견을 이용한 혈관용 패치 및 이의 제조방법
US10925543B2 (en) 2015-11-11 2021-02-23 The Board Of Trustees Of The University Of Illinois Bioresorbable silicon electronics for transient implants
US11752213B2 (en) 2015-12-21 2023-09-12 Duke University Surfaces having reduced non-specific binding and antigenicity
EP3395860A4 (en) * 2015-12-25 2019-05-29 Spiber Inc. PROCESS FOR PRODUCING POLYMER AGGREGATE
WO2017138002A1 (en) 2016-02-11 2017-08-17 Seevix Material Sciences Ltd. Composite materials comprising synthetic dragline spider silk
CN105803676A (zh) * 2016-03-23 2016-07-27 天津工业大学 一种高比例角蛋白含量的角蛋白/peo纳米纤维膜的制备方法
US11467156B2 (en) 2016-06-01 2022-10-11 Duke University Nonfouling biosensors
WO2018006037A1 (en) * 2016-07-01 2018-01-04 Trustees Of Tufts College Innervated artificial skin
CN106283399A (zh) * 2016-08-11 2017-01-04 东华大学 一种排列有序的改性纳米纤维膜及其制备和应用
JP6758707B2 (ja) * 2016-09-05 2020-09-23 国立大学法人信州大学 シルク多孔質繊維立体構造体の製造方法
RU2019110848A (ru) 2016-09-14 2020-10-15 Дьюк Юниверсити Наночастицы на основе триблочных полипептидов для доставки гидрофильных лекарственных средств
JP2020500150A (ja) 2016-09-23 2020-01-09 デューク ユニバーシティ 下限臨界溶液温度挙動を有する非反復かつ非構造的ポリペプチド
WO2018081815A2 (en) 2016-10-31 2018-05-03 Sofregen Medical, Inc. Compositions comprising silk fibroin particles and uses thereof
CN108210987B (zh) * 2016-12-14 2021-01-22 沈阳何氏眼产业集团有限公司 白内障手术切口用粘合剂及其制备方法
RU2644633C1 (ru) * 2016-12-28 2018-02-13 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ восстановления кожного покрова
WO2018132732A1 (en) 2017-01-12 2018-07-19 Duke University Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
WO2018213320A1 (en) 2017-05-15 2018-11-22 Duke University Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
IT201700064613A1 (it) * 2017-06-12 2018-12-12 Univ Bologna Alma Mater Studiorum Scaffold multiscala elettrofilato per la rigenerazione e/o sostituzione del tessuto tendineo/legamentoso e metodo di produzione
WO2019006374A1 (en) 2017-06-30 2019-01-03 Duke University ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-SENSITIVE BIOPOLYMER NETWORKS
US10894019B2 (en) 2017-08-15 2021-01-19 University Of South Carolina Drug delivery system and method for targeting cancer stem cells
US11208736B2 (en) 2017-09-25 2021-12-28 Bolt Threads, Inc. Methods of generating highly-crystalline recombinant spider silk protein fibers
WO2019067745A1 (en) 2017-09-27 2019-04-04 Silk, Inc. SILK-COATED FABRICS, PRODUCTS AND PREPARATION METHODS THEREFOR
US20210236644A1 (en) 2017-11-10 2021-08-05 Cocoon Biotech Inc. Ocular applications of silk-based products
WO2019147954A1 (en) 2018-01-26 2019-08-01 Duke University Albumin binding peptide-drug (aibiped) conjugates and methods of making and using same
CN108144116A (zh) * 2018-02-26 2018-06-12 丁文铃 一种新型抗菌人工韧带
CN108261563A (zh) * 2018-02-26 2018-07-10 丁文铃 一种增强增韧仿生韧带
JP7323766B2 (ja) * 2018-02-28 2023-08-09 セントラル硝子株式会社 タンパク質溶液の調製方法およびそれを用いた分子量測定方法
CN108295315A (zh) * 2018-03-09 2018-07-20 中科国思生物科技研究（广州）有限公司 一种蚕丝内固定组合支架的制备方法
AU2019233651B2 (en) 2018-03-13 2022-01-27 Institut Químic De Sarrià Cets Fundació Privada Vascular repair patch
CA3096036A1 (en) 2018-04-03 2019-10-10 Vaxess Technologies, Inc. Microneedle comprising silk fibroin applied to a dissolvable base
US12257308B2 (en) 2018-04-30 2025-03-25 Duke University Stimuli-responsive PEG-like polymer-based drug delivery platform
US11649275B2 (en) 2018-08-02 2023-05-16 Duke University Dual agonist fusion proteins
CN109187960A (zh) * 2018-09-10 2019-01-11 浙江理工大学 一种基于免疫层析技术的检测古代丝织品的方法
CN111228578A (zh) * 2018-11-09 2020-06-05 沈阳药科大学 载药丝素蛋白骨修复螺钉及其制备方法
CN109289082A (zh) * 2018-11-22 2019-02-01 李忠 一种吸收性医用止血纤维材料及其制备方法
CN109731139B (zh) * 2018-11-28 2021-06-18 山东省科学院能源研究所 一种小口径人工血管及其制备方法
CN109568635B (zh) * 2018-12-17 2021-11-16 河南省医疗器械检验所 一种原位膨胀高吸水性止血材料及其制备方法
CN109620797B (zh) * 2019-01-24 2023-02-03 东南大学 一种耐受胃液胁迫的纳米纤维缓释固体剂及其制备方法
JP2020121962A (ja) * 2019-01-31 2020-08-13 Ｓｐｉｂｅｒ株式会社 タンパク質フィルム及びタンパク質フィルムの製造方法
JP7503842B2 (ja) 2019-02-07 2024-06-21 Ｓｐｉｂｅｒ株式会社 人造構造タンパク質繊維の製造方法
KR102185580B1 (ko) * 2019-02-15 2020-12-03 성균관대학교산학협력단 전기수력학 기반 3d 프린팅 공정을 이용한 다공성 3차원 섬유구조체 제조방법 및 이의 용도
JP6905717B2 (ja) * 2019-03-25 2021-07-21 国立大学法人大阪大学 ３ｄプリンティングシステム用インク
CN110124109B (zh) * 2019-05-13 2022-07-15 华东数字医学工程研究院 人工血管支架及其制备方法和应用
US11672767B2 (en) 2019-05-13 2023-06-13 University Of South Carolina Enzymatically cleavable self-assembled nanoparticles for morphogen delivery
CN110106634B (zh) * 2019-05-13 2021-08-10 天津工业大学 一种角蛋白peo复合生物纳米纤维膜及其制备方法和创口贴
AU2020288624B2 (en) 2019-06-04 2025-09-25 Cocoon Biotech Inc. Silk-based products, formulations, and methods of use
US20220273526A1 (en) * 2019-07-12 2022-09-01 Bolt Threads, Inc. Recombinant spider silk extrudate formulations
US11512314B2 (en) 2019-07-12 2022-11-29 Duke University Amphiphilic polynucleotides
JP7503287B2 (ja) * 2019-09-30 2024-06-20 Ｓｐｉｂｅｒ株式会社 難燃性組成物
CN112410976B (zh) * 2019-10-12 2022-06-14 深圳市珂莱蒂尔服饰有限公司 一种吸水复合丝绸面料
US11738174B2 (en) 2019-10-15 2023-08-29 Sofregen Medical, Inc. Delivery devices for delivering and methods of delivering compositions
CN110540404B (zh) * 2019-10-17 2022-06-10 广州润虹医药科技股份有限公司 一种具有中空贯通结构的磷酸钙骨水泥、制备方法及其应用
CN113005532B (zh) * 2019-12-19 2022-07-19 武汉大学 一种连续制备蚕丝纳米纤维与甲壳素或壳聚糖复合纤维的方法
CN111265722B (zh) * 2020-04-03 2021-08-03 东华大学 一种用于糖尿病骨修复的双层结构骨膜及其制备方法
AU2021258592A1 (en) 2020-04-23 2022-10-06 Seevix Material Sciences Ltd. Modified spider silk fiber and use thereof
CN111558093B (zh) * 2020-05-19 2022-09-13 温州医科大学附属眼视光医院 一种中长期可降解的泪道栓及其制备方法
US20230212798A1 (en) * 2020-05-28 2023-07-06 Shinwa Corp. Nonwoven Fabric, and Method for Producing Same
CN112030297B (zh) * 2020-09-08 2021-09-14 安徽新虹纺织有限公司 一种阻燃耐磨的抗菌纱线及其生产工艺
KR102840628B1 (ko) * 2020-10-26 2025-08-01 (주)메디코스바이오텍 재조합 실크 단백질을 포함하는 골 조직 재생용 조성물 및 이를 포함하는 다공성 스캐폴드
EP3991762A1 (en) 2020-11-02 2022-05-04 Medizinische Hochschule Hannover Implant for nerve regeneration
KR102385695B1 (ko) 2021-04-15 2022-04-12 남기준 세미-아이피엔 구조를 이루는 연조직 수복 및 확대를 위한 신규한 히알루론-복합 아미노 하이드로 겔 조성물 및 이의 용도
WO2022236168A1 (en) * 2021-05-07 2022-11-10 Trustees Of Tufts College Systems, kits, and methods for forming in situ silk fibroin fibers and/or aerosols
CN113663128B (zh) * 2021-09-29 2022-05-10 东华大学 一种高强度复合涂层人工韧带及其制备方法和应用
CN114481356B (zh) * 2021-10-10 2024-02-09 南京大学 一种仿蚕茧支架及其制备方法和应用
CN114569790B (zh) * 2022-03-14 2022-09-02 新乡医学院 具有促内皮化及抗凝双功能的人工血管及制备方法、用途
CA3260638A1 (en) 2022-06-24 2023-12-28 Vaxess Technologies, Inc. MEDICATION TAMP APPLICATOR
CN115122690B (zh) * 2022-06-28 2023-09-29 奥精医疗科技股份有限公司 一种神经导管的制备方法
WO2024263835A1 (en) 2023-06-23 2024-12-26 Vaxess Technologies, Inc. Applicator for medicament patch
WO2025141008A1 (en) 2023-12-29 2025-07-03 Hyspinlab Sa Process for purifying high molecular weight hyaluronic acid
GB202320146D0 (en) 2023-12-29 2024-02-14 Hyspinlab Sa Silk biomaterials
CN118441414A (zh) * 2024-03-28 2024-08-06 苏州贝彩纳米科技有限公司 一种丝素蛋白肽纳米纤维面膜及其制备方法

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US387413A (en) 1888-08-07 Wire fence
BE380083A (enExample) 1929-12-23
JPS5838449B2 (ja) 1979-04-17 1983-08-23 カネボウ株式会社 微粉末状絹フィプロインの製造法
JPS5581589A (en) * 1978-12-15 1980-06-19 Kanebo Ltd Enzyme-containing film and method of making the same
JPS56166235A (en) 1980-05-24 1981-12-21 Kanebo Ltd Hydrophilic porous body and its preparation
JPS5838449A (ja) 1981-08-31 1983-03-05 Matsushita Electronics Corp 高圧ナトリウムランプ装置
US4806355A (en) 1983-06-06 1989-02-21 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US5263992A (en) 1986-10-17 1993-11-23 Bio-Metric Systems, Inc. Biocompatible device with covalently bonded biocompatible agent
CA1340581C (en) * 1986-11-20 1999-06-08 Joseph P. Vacanti Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices
JPS63190604A (ja) * 1987-02-03 1988-08-08 Agency Of Ind Science & Technol 新規の水−アルコ−ル分離膜
DK530787D0 (da) * 1987-10-09 1987-10-09 Bukh Meditec Indretning til indfoering i en legemshulhed
US5606019A (en) * 1987-10-29 1997-02-25 Protien Polymer Technologies, Inc. Synthetic protein as implantables
GB8800078D0 (en) 1988-01-05 1988-02-10 Ciba Geigy Ag Novel antibodies
EP0330134A1 (de) 1988-02-25 1989-08-30 Akzo Nobel N.V. Modifizierte Cellulose für biocompatible Dialysemembranen IV und Verfahren zu deren Herstellung
US5015476A (en) 1989-08-11 1991-05-14 Paravax, Inc. Immunization implant and method
US5270419A (en) 1990-01-19 1993-12-14 Nova Pharmaceutical Corporation Polyanhydrides of oligomerized unsaturated aliphatic acids
US5290494A (en) * 1990-03-05 1994-03-01 Board Of Regents, The University Of Texas System Process of making a resorbable implantation device
US5245012A (en) 1990-04-19 1993-09-14 The United States Of America As Represented By The Secretary Of The Army Method to achieve solubilization of spider silk proteins
JPH055275A (ja) 1991-06-27 1993-01-14 Kanebo Ltd 絹フイブロイン加工布帛の製造方法
JP2580422B2 (ja) 1992-01-21 1997-02-12 増実株式会社 絹繊維製品の機能性付与加工方法
JPH06346314A (ja) 1993-06-02 1994-12-20 Toyobo Co Ltd 再生絹フィブロイン繊維およびその製造方法
CN1200145A (zh) 1995-08-22 1998-11-25 阿格里科拉技术有限公司 高强度蛛丝蛋白的克隆方法
US5576881A (en) 1995-08-29 1996-11-19 Lucent Technologies Inc. Multi-frequency optical signal source having reduced distortion and crosstalk
US5855613A (en) 1995-10-13 1999-01-05 Islet Sheet Medical, Inc. Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change
JPH1036676A (ja) 1996-07-26 1998-02-10 Kanebo Ltd タンパク質水溶液の濃縮方法
US5814328A (en) 1997-01-13 1998-09-29 Gunasekaran; Subramanian Preparation of collagen using papain and a reducing agent
DE69837141T2 (de) 1997-05-12 2007-10-31 Metabolix, Inc., Cambridge Polyhydroxyalkanoate für in vivo anwendungen
JP2990239B2 (ja) * 1997-06-18 1999-12-13 農林水産省蚕糸・昆虫農業技術研究所長 絹フィブロインおよび絹セリシンを主成分とする創傷被覆材並びにその製造方法
CA2301064A1 (en) * 1997-07-01 1999-01-14 Brown University Research Foundation Implantable prosthetic devices coated with bioactive molecules
JP3111216B2 (ja) * 1997-08-08 2000-11-20 農林水産省蚕糸・昆虫農業技術研究所長 抗菌性ブレンド塊状物およびその製造方法
US5932552A (en) 1997-11-26 1999-08-03 Keraplast Technologies Ltd. Keratin-based hydrogel for biomedical applications and method of production
JP2955653B2 (ja) * 1998-02-16 1999-10-04 農林水産省蚕糸・昆虫農業技術研究所長 絹蛋白質／コラーゲン複合体およびその製造方法
US5902800A (en) 1998-03-27 1999-05-11 Glenpharma Dextran formulations and method for treatment of inflammatory joint disorders
US6110590A (en) * 1998-04-15 2000-08-29 The University Of Akron Synthetically spun silk nanofibers and a process for making the same
JPH11323735A (ja) 1998-05-12 1999-11-26 Tango Orimono Kogyo Kumiai 絹糸の改質加工方法
CO5031249A1 (es) 1998-05-29 2001-04-27 Sugen Inc Pirrol substituido-2-indolinonas inhibidoras de proteinci-nasas
US7662409B2 (en) * 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
US6302848B1 (en) 1999-07-01 2001-10-16 Sonotech, Inc. In vivo biocompatible acoustic coupling media
US6592623B1 (en) * 1999-08-31 2003-07-15 Virginia Commonwealth University Intellectual Property Foundation Engineered muscle
JP3151665B2 (ja) * 1999-03-23 2001-04-03 農林水産省蚕糸・昆虫農業技術研究所長 生体高分子／ポリアリルアミン複合体およびその製造方法
US6103255A (en) 1999-04-16 2000-08-15 Rutgers, The State University Porous polymer scaffolds for tissue engineering
US6267776B1 (en) 1999-05-03 2001-07-31 O'connell Paul T. Vena cava filter and method for treating pulmonary embolism
US6325810B1 (en) 1999-06-30 2001-12-04 Ethicon, Inc. Foam buttress for stapling apparatus
US6277392B1 (en) * 1999-09-16 2001-08-21 Carbon Medical Technologies, Inc. Tissue injectable composition
ATE367473T1 (de) 1999-10-01 2007-08-15 Canon Kk Druckverfahren und damit hergestellte drucke sowie mit diesem verfahren hergestellter artikel
WO2001036531A1 (fr) * 1999-11-15 2001-05-25 Zaidan-Houjin Ueda Sen-I Kagaku Shinkoukai Materiau polymere moleculairement composite en fibroine/cellulose et procede de production de ce materiau
US6310188B1 (en) 2000-01-24 2001-10-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method for producing chitin or chitosan
WO2001056626A1 (en) * 2000-02-03 2001-08-09 Nexia Biotechnologies, Inc. Surgical sutures containing spider silk
US6423252B1 (en) 2000-06-23 2002-07-23 Ethicon, Inc. Methods of making micropatterned foams
IT1316885B1 (it) 2000-10-02 2003-05-13 Consorzio Per Gli Studi Uni Procedimento per la preparazione di un tessuto non tessuto in fibroinadi seta.
JP2002128691A (ja) 2000-10-24 2002-05-09 National Institute Of Agrobiological Sciences セリシン含有素材、その製造方法およびその使用方法
JP4485124B2 (ja) 2000-11-17 2010-06-16 ヴァージニア コモンウェルス ユニバーシティ インテレクチュアル プロパティー ファンデーション 電気処理されたコラーゲン
JPWO2002072931A1 (ja) 2001-03-14 2004-07-02 東京農工大学長 絹及び絹様材料の繊維及びフィルムの製造方法
WO2003004254A1 (en) 2001-07-03 2003-01-16 The Regents Of The University Of California Microfabricated biopolymer scaffolds and method of making same
GB0121985D0 (en) 2001-09-11 2001-10-31 Isis Innovation Tissue engineering scaffolds
ITVR20010098A1 (it) 2001-09-11 2003-03-11 Consorzio Per Gli Studi Uni Procedimento per l'ottenimento di idrogeli di fibroina di seta.
US6902932B2 (en) * 2001-11-16 2005-06-07 Tissue Regeneration, Inc. Helically organized silk fibroin fiber bundles for matrices in tissue engineering
US7057023B2 (en) * 2002-01-11 2006-06-06 Nexia Biotechnologies Inc. Methods and apparatus for spinning spider silk protein
JP3772207B2 (ja) 2002-06-19 2006-05-10 独立行政法人農業生物資源研究所 生分解性生体高分子材料、その製造方法、およびこの高分子材料からなる機能性素材
JP4638735B2 (ja) * 2002-06-24 2011-02-23 タフツ ユニバーシティー 絹糸生体材料およびその使用方法
US7572894B2 (en) 2002-11-01 2009-08-11 Trustees Of Tufts College Templated native silk smectic gels
US7169898B2 (en) * 2002-12-04 2007-01-30 Alexander Steinkasserer Soluble CD83 proteins and use thereof for the treatment or prevention of a disease or medical condition caused by dysfunction or undesired function of a cellular immune response involving T cells
US7842780B2 (en) 2003-01-07 2010-11-30 Trustees Of Tufts College Silk fibroin materials and use thereof
JP4698596B2 (ja) * 2003-04-10 2011-06-08 タフツ ユニバーシティー 濃縮された水性シルクフィブロイン溶液およびそれらの使用
WO2005000483A1 (en) 2003-06-06 2005-01-06 Tufts University Method for forming inorganic coatings
EP1773240B1 (en) 2004-06-11 2019-11-20 Trustees of the Tufts College Silk-based drug delivery system
WO2006076711A2 (en) 2005-01-14 2006-07-20 Trustees Of Tufts College Fibrous protein fusions and use thereof in the formation of advanced organic/inorganic composite materials
US9290579B2 (en) 2005-04-20 2016-03-22 Trustees Of Tufts College Covalently immobilized protein gradients in three-dimensional porous scaffolds
EP1915436B1 (en) 2005-08-02 2011-09-28 Trustees Of Tufts College Methods for stepwise deposition of silk fibroin coatings
US20100028451A1 (en) 2006-09-26 2010-02-04 Trustees Of Tufts College Silk microspheres for encapsulation and controlled release
EP2101975A2 (en) 2006-11-03 2009-09-23 Trustees of Tufts College Biopolymer sensor and method of manufacturing the same
US9969134B2 (en) 2006-11-03 2018-05-15 Trustees Of Tufts College Nanopatterned biopolymer optical device and method of manufacturing the same
WO2008127405A2 (en) 2006-11-03 2008-10-23 Trustees Of Tufts College Microfluidic device with a cylindrical microchannel and a method for fabricating same
CA2704304C (en) 2006-11-03 2015-01-13 Trustees Of Trufts College Biopolymer optical waveguide and method of manufacturing the same
WO2008118211A2 (en) 2006-11-03 2008-10-02 Trustees Of Tufts College Biopolymer photonic crystals and method of manufacturing the same
EP2129772B1 (en) 2007-02-27 2016-07-27 Trustees Of Tufts College Tissue-engineered silk organs
HRP20141265T1 (hr) 2007-05-29 2015-04-10 Trustees Of Tufts College Postupak geliranja fibroina svile pomoä†u ultrazvuka
US8206774B2 (en) 2008-03-13 2012-06-26 Trustees Of Tufts College Diazonium salt modification of silk polymer
JP2010067203A (ja) * 2008-09-12 2010-03-25 Fujitsu Ltd 生産順決定支援方法、生産順決定支援装置、およびコンピュータプログラム

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018207827A1 (ja) 2017-05-10 2018-11-15 Ｓｐｉｂｅｒ株式会社 ポリペプチド溶液、及びポリペプチド繊維の製造方法、並びに人造ポリペプチド
WO2019022163A1 (ja) 2017-07-26 2019-01-31 Ｓｐｉｂｅｒ株式会社 改変フィブロイン
WO2019194146A1 (ja) 2018-04-03 2019-10-10 Ｓｐｉｂｅｒ株式会社 成形体及びその製造方法
WO2020145363A1 (ja) 2019-01-09 2020-07-16 Ｓｐｉｂｅｒ株式会社 改変フィブロイン
WO2020250904A1 (ja) 2019-06-11 2020-12-17 Ｓｐｉｂｅｒ株式会社 吸水速乾性付与剤、及び吸水速乾性を付与する方法
WO2021065769A1 (ja) 2019-09-30 2021-04-08 Ｓｐｉｂｅｒ株式会社 接触冷感性及び吸水速乾性付与剤、並びに物品に接触冷感性及び吸水速乾性を付与する方法
WO2023038153A1 (ja) 2021-09-13 2023-03-16 Ｓｐｉｂｅｒ株式会社 消臭材、消臭性付与剤並びに消臭性の付与方法

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