HRP20141265T1 - Postupak geliranja fibroina svile pomoä†u ultrazvuka - Google Patents
Postupak geliranja fibroina svile pomoä†u ultrazvuka Download PDFInfo
- Publication number
- HRP20141265T1 HRP20141265T1 HRP20141265AT HRP20141265T HRP20141265T1 HR P20141265 T1 HRP20141265 T1 HR P20141265T1 HR P20141265A T HRP20141265A T HR P20141265AT HR P20141265 T HRP20141265 T HR P20141265T HR P20141265 T1 HRP20141265 T1 HR P20141265T1
- Authority
- HR
- Croatia
- Prior art keywords
- silk fibroin
- solution
- agent
- gelation
- concentration
- Prior art date
Links
- 108010022355 Fibroins Proteins 0.000 title claims 24
- 238000000034 method Methods 0.000 title claims 17
- 238000001879 gelation Methods 0.000 title claims 12
- 238000000527 sonication Methods 0.000 title claims 2
- 239000012266 salt solution Substances 0.000 claims 10
- 239000003795 chemical substances by application Substances 0.000 claims 9
- 239000000243 solution Substances 0.000 claims 8
- 239000012620 biological material Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000011591 potassium Substances 0.000 claims 2
- 229910052700 potassium Inorganic materials 0.000 claims 2
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 2
- 229910001414 potassium ion Inorganic materials 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 238000009210 therapy by ultrasound Methods 0.000 claims 2
- 238000002604 ultrasonography Methods 0.000 claims 2
- 108091023037 Aptamer Proteins 0.000 claims 1
- 101001007348 Arachis hypogaea Galactose-binding lectin Proteins 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
- 230000000845 anti-microbial effect Effects 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229910052802 copper Inorganic materials 0.000 claims 1
- 239000010949 copper Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000011701 zinc Substances 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/24—Mucus; Mucous glands; Bursa; Synovial fluid; Arthral fluid; Excreta; Spinal fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
- C07K14/43586—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from silkworms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Insects & Arthropods (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Inorganic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
Claims (15)
1. Postupak brzog formiranja geliranog fibroina svile, obuhvaća izlaganje fibroina svile obradi koja se sastoji u primjeni ultrazvuka kroz vrijeme od oko 5 sekundi do oko 60 sekundi kako bi počelo geliranje, gdje u biti do formiranja geliranog fibroina svile dolazi u manje od 24 sata nakon obrade ultrazvukom.
2. Postupak prema zahtjevu 1, gdje do formiranja geliranog fibroina svile dolazi u manje od dva sata nakon obrade ultrazvukom.
3. Postupak prema zahtjevu 1, gdje se fibroin svile gelira u vremenskom razdoblju u rasponu od oko pet minuta do oko dva sata nakon obrade ultrazvukom.
4. Postupak prema zahtjevu 1, 2 ili 3, gdje obrada dalje obuhvaća otopinu soli, gdje otopina soli po izboru sadrži ione izabrane iz skupine koja obuhvaća kalij, kalcij, natrij, magnezij, bakar, cink i njihove kombinacije.
5. Postupak prema zahtjevu 1, gdje je fibroin svile u obliku vodene otopine čiji je pH oko pH 4 ili niži ili je oko pH 7,5 ili više.
6. Postupak prema zahtjevu 4, gdje je sol kalij, koncentracija soli je manja od 100mM, i pH otopine soli je oko pH 4 ili manje.
7. Postupak kontrole vremena geliranja fibroina svile pomoću uporabe postupka prema bilo kojem od zahtjeva 1 do 4 gdje fibroin svile prolazi značajno geliranje u roku od oko dva sata.
8. Postupak prema zahtjevu 7, gdje se vrijeme geliranja kontrolira preko amplitude ultrazvuka i koncentracije otopine fibroina svile.
9. Postupak prema zahtjevu 7 ili 8, gdje se vrijeme geliranja kontrolira preko koncentracije otopine fibroina svile i koncentracije otopine soli, i po izboru,
gdje je koncentracija fibroina svile 4wt% ili niža, otopina soli sadrži ione kalija i koncentracija otopine kalijeve soli je u rasponu od 20mM do 100mM.
10. Postupak prema zahtjevu 7, gdje se vrijeme geliranja kontrolira preko koncentracije i pH otopine soli, i po izboru,
gdje otopina soli sadrži ione kalija, koncentracija otopine kalijeve soli je u rasponu od 20mM do 100mM i pH otopine je pH 4 ili niži.
11. Postupak kapsuliranja barem jednog sredstva u fibroin svile, obuhvaća:
dovođenje u doticaj otopine fibroina svile s obradom pomoću ultrazvukom kroz vrijeme od oko 5 sekundi do oko 60 sekundi radi započinjanja geliranja; i
uvođenje sredst(a)va u otopinu fibroina svile prije nego što dođe do značajnijeg geliranja u otopini fibroina svile;
kako bi se dobilo sredstvo kapsulirano u fibroinu svile.
12. Postupak kapsuliranja barem jednog sredstva u fibroin svile, obuhvaća:
uvođenje sredst(a)va u otopinu fibroina svile; i
dovođenje u doticaj otopine fibroina svile s obradom pomoću ultrazvukom kroz vrijeme od oko 5 sekundi do oko 60 sekundi radi započinjanja geliranja;
kako bi se dobilo sredstvo kapsulirano u fibroinu svile.
13. Postupak prema zahtjevu 11 ili 12, gdje je sredstvo terapijsko sredstvo ili biološki materijal, ili oboje, i/ili
gdje je sredstvo barem jedan biološki materijal izabran iz skupine koja obuhvaća stanice, proteine, peptide, nukleinske kiseline, PNA, aptamere, protutijela, hormone, faktore rasta, citokine, enzime, antimikrobne spojeve i njihove kombinacije, i/ili
gdje je stanica ne-embrionska matična stanica, i/ili
gdje se medij za stanični rast uvodi u fibroin svile s biološkim materijalom, i/ili
gdje je sredstvo terapijsko sredstvo izabrano iz skupine koja obuhvaća male molekule, lijekove i njihove kombinacije.
14. Postupak prema zahtjevu 12 ili 13, gdje se u biti geliranje događa u roku od oko 2 sata, i/ili
gdje se u biti geliranje događa u vremenu u rasponu od oko pet minuta do oko dva sata, i/ili
gdje obrada dalje obuhvaća otopinu soli, i/ili
gdje je fibroin svile u obliku vodene otopine čiji je pH oko pH 4 ili niže ili je oko pH 7,5 ili više.
15. Biološki materijal kapsuliran u fibroin svile na način prema postupku iz zahtjeva 12 i 13, za uporabu kao proizvod za dopremu bioloških tvari.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94055407P | 2007-05-29 | 2007-05-29 | |
| PCT/US2008/065076 WO2008150861A1 (en) | 2007-05-29 | 2008-05-29 | Method for silk fibroin gelation using sonication |
| EP08756432.4A EP2211876B1 (en) | 2007-05-29 | 2008-05-29 | Method for silk fibroin gelation using sonication |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20141265T1 true HRP20141265T1 (hr) | 2015-04-10 |
Family
ID=40094093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20141265AT HRP20141265T1 (hr) | 2007-05-29 | 2014-12-29 | Postupak geliranja fibroina svile pomoä†u ultrazvuka |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US8187616B2 (hr) |
| EP (1) | EP2211876B1 (hr) |
| JP (2) | JP2010529230A (hr) |
| KR (2) | KR101839659B1 (hr) |
| CN (2) | CN104013598A (hr) |
| AU (1) | AU2008260156B2 (hr) |
| BR (1) | BRPI0813312A2 (hr) |
| CA (1) | CA2688431C (hr) |
| CY (1) | CY1116090T1 (hr) |
| DK (1) | DK2211876T3 (hr) |
| EA (1) | EA019118B1 (hr) |
| ES (1) | ES2527125T3 (hr) |
| HK (1) | HK1201470A1 (hr) |
| HR (1) | HRP20141265T1 (hr) |
| IL (1) | IL202354A (hr) |
| MX (1) | MX2009012978A (hr) |
| PL (1) | PL2211876T3 (hr) |
| PT (1) | PT2211876E (hr) |
| SI (1) | SI2211876T1 (hr) |
| WO (1) | WO2008150861A1 (hr) |
Families Citing this family (106)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6092337A (ja) * | 1983-10-26 | 1985-05-23 | Sekisui Plastics Co Ltd | 発泡フエノ−ル樹脂成形物の製造方法 |
| WO2004000915A2 (en) * | 2002-06-24 | 2003-12-31 | Tufts University | Silk biomaterials and methods of use thereof |
| US7842780B2 (en) | 2003-01-07 | 2010-11-30 | Trustees Of Tufts College | Silk fibroin materials and use thereof |
| EP1613796B1 (en) | 2003-04-10 | 2017-03-22 | Tufts University | Concentrated aqueous silk fibroin solution and use thereof |
| WO2005000483A1 (en) * | 2003-06-06 | 2005-01-06 | Tufts University | Method for forming inorganic coatings |
| CN101120433B (zh) | 2004-06-04 | 2010-12-08 | 伊利诺伊大学评议会 | 用于制造并组装可印刷半导体元件的方法 |
| JP2010509593A (ja) | 2006-11-03 | 2010-03-25 | トラスティーズ オブ タフツ カレッジ | バイオポリマーセンサーおよびその製造方法 |
| CA2704769C (en) | 2006-11-03 | 2016-01-12 | Trustees Of Tufts College | Nanopatterned biopolymer optical device and method of manufacturing the same |
| US8195021B2 (en) * | 2006-11-03 | 2012-06-05 | Tufts University/Trustees Of Tufts College | Biopolymer optical waveguide and method of manufacturing the same |
| EP2129772B1 (en) * | 2007-02-27 | 2016-07-27 | Trustees Of Tufts College | Tissue-engineered silk organs |
| KR101839659B1 (ko) | 2007-05-29 | 2018-03-16 | 트러스티즈 오브 터프츠 칼리지 | 음파 처리를 이용한 실크 피브로인 겔화 방법 |
| EP2249886A4 (en) * | 2008-02-07 | 2013-05-22 | Tufts College | THREE DIMENSIONAL HYDROXYAPATITIS AND SILK COMPOSITIONS |
| GB0807868D0 (en) * | 2008-04-30 | 2008-06-04 | Knight David P | Cartilage repair material and a method for the preparation thereof |
| JP5727366B2 (ja) * | 2008-05-15 | 2015-06-03 | タフツ ユニバーシティー／トラスティーズ オブ タフツ カレッジ | 絹ポリマーに基づくアデノシン放出：てんかんに対する潜在的治療能力 |
| WO2010042798A2 (en) * | 2008-10-09 | 2010-04-15 | Trustees Of Tufts College | Modified silk films containing glycerol |
| US8501172B2 (en) | 2008-09-26 | 2013-08-06 | Trustees Of Tufts College | pH-induced silk gels and uses thereof |
| JP5646492B2 (ja) | 2008-10-07 | 2014-12-24 | エムシー１０ インコーポレイテッドＭｃ１０，Ｉｎｃ． | 伸縮可能な集積回路およびセンサアレイを有する装置 |
| US8886334B2 (en) | 2008-10-07 | 2014-11-11 | Mc10, Inc. | Systems, methods, and devices using stretchable or flexible electronics for medical applications |
| US8372726B2 (en) | 2008-10-07 | 2013-02-12 | Mc10, Inc. | Methods and applications of non-planar imaging arrays |
| US8097926B2 (en) | 2008-10-07 | 2012-01-17 | Mc10, Inc. | Systems, methods, and devices having stretchable integrated circuitry for sensing and delivering therapy |
| US8389862B2 (en) | 2008-10-07 | 2013-03-05 | Mc10, Inc. | Extremely stretchable electronics |
| EP2403551A4 (en) * | 2009-03-04 | 2014-02-26 | Tufts College | FIBROIN SILK SYSTEMS FOR ANTIBIOTIC DELIVERY |
| WO2011005381A2 (en) * | 2009-06-01 | 2011-01-13 | Trustees Of Tufts College | Vortex-induced silk fibroin gelation for encapsulation and delivery |
| US8728498B2 (en) | 2009-07-14 | 2014-05-20 | Trustees Of Tufts College | Electrospun silk material systems for wound healing |
| CN102482497B (zh) * | 2009-07-31 | 2014-07-30 | 科学与工业研究委员会 | 再生丝心蛋白的加速凝胶化 |
| EP2483460B1 (en) | 2009-09-28 | 2015-09-02 | Trustees Of Tufts College | Method to prepare drawn silk egel fibers |
| JP5730317B2 (ja) | 2009-09-29 | 2015-06-10 | タフツ ユニバーシティー／トラスティーズ オブ タフツ カレッジ | 絹ナノスフェアおよび絹マイクロスフェアならびにこれらを作製する方法 |
| WO2011041727A1 (en) | 2009-10-01 | 2011-04-07 | Mc10, Inc. | Protective cases with integrated electronics |
| US9936574B2 (en) | 2009-12-16 | 2018-04-03 | The Board Of Trustees Of The University Of Illinois | Waterproof stretchable optoelectronics |
| US10441185B2 (en) | 2009-12-16 | 2019-10-15 | The Board Of Trustees Of The University Of Illinois | Flexible and stretchable electronic systems for epidermal electronics |
| JP6046491B2 (ja) | 2009-12-16 | 2016-12-21 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ | コンフォーマル電子機器を使用した生体内での電気生理学 |
| US9603971B2 (en) | 2010-03-05 | 2017-03-28 | Trustees Of Tufts College | Silk-based ionomeric compositions |
| CN105496423A (zh) | 2010-03-17 | 2016-04-20 | 伊利诺伊大学评议会 | 基于生物可吸收基质的可植入生物医学装置 |
| CN103181025A (zh) | 2010-04-12 | 2013-06-26 | 塔夫茨大学 | 丝电子部件 |
| JP6081358B2 (ja) | 2010-09-01 | 2017-02-15 | トラスティーズ・オブ・タフツ・カレッジＴｒｕｓｔｅｅｓ Ｏｆ Ｔｕｆｔｓ Ｃｏｌｌｅｇｅ | 絹フィブロインおよびポリエチレングリコールをベースとする生体材料 |
| CA2847590A1 (en) | 2010-09-03 | 2012-03-08 | Tufts University/Trustees Of Tufts College | Plasmonic nanoparticle-doped silk materials |
| JP2014502416A (ja) | 2010-09-27 | 2014-01-30 | タフツ ユニバーシティー／トラスティーズ オブ タフツ カレッジ | 絹ベースの圧電性材料 |
| EP4218891A1 (en) | 2010-10-19 | 2023-08-02 | Trustees Of Tufts College | Silk fibroin-based microneedles and methods of making the same |
| JP2012171124A (ja) * | 2011-02-18 | 2012-09-10 | Sekisui Chem Co Ltd | 製管用部材、及び既設管の更生方法 |
| US10335519B2 (en) | 2011-04-20 | 2019-07-02 | Trustees Of Tufts College | Dynamic silk coatings for implantable devices |
| US20140287043A1 (en) | 2011-04-21 | 2014-09-25 | Trustees Of Tufts College | Compositions and methods for stabilization of active agents |
| US9765934B2 (en) | 2011-05-16 | 2017-09-19 | The Board Of Trustees Of The University Of Illinois | Thermally managed LED arrays assembled by printing |
| US9159635B2 (en) | 2011-05-27 | 2015-10-13 | Mc10, Inc. | Flexible electronic structure |
| WO2012167096A2 (en) | 2011-06-03 | 2012-12-06 | The Board Of Trustees Of The University Of Illinois | Conformable actively multiplexed high-density surface electrode array for brain interfacing |
| WO2013103424A2 (en) * | 2011-10-11 | 2013-07-11 | Tufts University | Silk-based multifunctional biomedical platform |
| WO2013070907A1 (en) | 2011-11-08 | 2013-05-16 | Tufts University | A silk-based scaffold platform for engineering tissue constructs |
| ES2953309T3 (es) | 2011-11-09 | 2023-11-10 | Tufts College | Partículas de fibroína de seda inyectables y usos de las mismas |
| KR102176406B1 (ko) | 2011-11-09 | 2020-11-09 | 트러스티즈 오브 터프츠 칼리지 | 주사가능한 실크 피브로인 발포체 및 그의 용도 |
| KR101979354B1 (ko) | 2011-12-01 | 2019-08-29 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 프로그램 변형을 실행하도록 설계된 과도 장치 |
| WO2013130156A2 (en) | 2011-12-05 | 2013-09-06 | Tufts University | Signal enhancement by silk photonic crystals |
| WO2013102193A1 (en) | 2011-12-29 | 2013-07-04 | Trustees Of Tufts College | Functionalization of biomaterials to control regeneration and inflammation responses |
| ES2856873T3 (es) | 2012-02-06 | 2021-09-28 | Childrens Medical Center | Biomaterial multicapa para la regeneración de tejidos y la cicatrización de las heridas |
| EP2817031A4 (en) * | 2012-02-22 | 2015-08-05 | Tufts College | COMPOSITIONS AND METHODS FOR OCULAR DELIVERY OF A THERAPEUTIC AGENT |
| JP2015510818A (ja) | 2012-03-20 | 2015-04-13 | トラスティーズ オブ タフツ カレッジ | 薬物送達のための絹リザーバー |
| EP2830492B1 (en) | 2012-03-30 | 2021-05-19 | The Board of Trustees of the University of Illinois | Appendage mountable electronic devices conformable to surfaces and method of making the same |
| WO2013152265A1 (en) | 2012-04-06 | 2013-10-10 | Trustees Of Tufts College | Methods of producing and using silk microfibers |
| AU2013245785A1 (en) | 2012-04-13 | 2014-10-23 | Trustees Of Tufts College | Methods and compositions for preparing a silk microsphere |
| WO2013163407A1 (en) | 2012-04-25 | 2013-10-31 | Trustees Of Tufts College | Silk microspheres and methods for surface lubrication |
| WO2014012101A1 (en) | 2012-07-13 | 2014-01-16 | Trustees Of Tufts College | Silk powder compaction for production of constructs with high mechanical strength and stiffness |
| CN104684540A (zh) * | 2012-07-13 | 2015-06-03 | 塔夫茨大学 | 在丝纤蛋白生物材料中对不相混溶的相的包封 |
| EP2712955A1 (en) * | 2012-09-27 | 2014-04-02 | Ludwig Boltzmann Gesellschaft GmbH | Product made of silk |
| US9171794B2 (en) | 2012-10-09 | 2015-10-27 | Mc10, Inc. | Embedding thin chips in polymer |
| CN104837500A (zh) * | 2012-10-11 | 2015-08-12 | 塔夫茨大学 | 用于持续递送胰高血糖素样肽(glp-1)受体激动剂治疗剂的组合物和方法 |
| EP2925822A4 (en) | 2012-11-27 | 2016-10-12 | Univ Tufts | INKS BASED ON BIOPOLYMERS AND THEIR USE |
| ES2935659T3 (es) | 2013-03-15 | 2023-03-09 | Tufts College | Composiciones de seda de bajo peso molecular y composiciones de seda estabilizadoras |
| US11009792B2 (en) | 2013-03-15 | 2021-05-18 | Tufts University | All water-based nanopatterning |
| US10464361B2 (en) | 2013-03-15 | 2019-11-05 | Tufts University | Silk water lithography |
| US11376329B2 (en) | 2013-03-15 | 2022-07-05 | Trustees Of Tufts College | Low molecular weight silk compositions and stabilizing silk compositions |
| WO2014176458A2 (en) | 2013-04-24 | 2014-10-30 | Trustees Of Tufts College | Bioresorbable biopolymer anastomosis devices |
| US20150047532A1 (en) * | 2013-08-13 | 2015-02-19 | Utah State University | Synthetic spider silk protein compositions and methods |
| EA036027B1 (ru) | 2013-09-30 | 2020-09-15 | Силк Терапьютикс, Инк. | Композиция из фрагментов белков шелка (варианты) и изделия, изготовленные из них |
| US10925999B2 (en) | 2013-10-08 | 2021-02-23 | Trustees Of Tufts College | Tunable covalently crosslinked hydrogels and methods of making the same |
| US10513802B2 (en) | 2013-11-08 | 2019-12-24 | Tufts University | Peptide-based nanofibrillar materials |
| WO2016029034A1 (en) * | 2014-08-20 | 2016-02-25 | Silk Technologies, Ltd. | Fibroin-derived protein composition |
| EA035551B1 (ru) | 2014-12-02 | 2020-07-06 | Силк Терапьютикс, Инк. | Изделие |
| ES2915384T3 (es) | 2015-03-12 | 2022-06-22 | Univ Tufts | Materiales de seda con memoria de forma |
| MX2017015586A (es) | 2015-06-01 | 2018-08-23 | Univ Illinois | Sistemas electronicos miniaturizados con capacidades de energia inalambrica y comunicacion de campo cercano. |
| US11029198B2 (en) | 2015-06-01 | 2021-06-08 | The Board Of Trustees Of The University Of Illinois | Alternative approach for UV sensing |
| CA2992462A1 (en) | 2015-07-14 | 2017-01-19 | Silk Therapeutics, Inc. | Silk performance apparel and products and methods of preparing the same |
| US10925543B2 (en) | 2015-11-11 | 2021-02-23 | The Board Of Trustees Of The University Of Illinois | Bioresorbable silicon electronics for transient implants |
| WO2017123383A2 (en) | 2015-12-17 | 2017-07-20 | Trustees Of Tufts College | Silk-fibroin hydrogels, methods of forming, and uses thereof |
| CN108431094A (zh) * | 2015-12-25 | 2018-08-21 | 丝芭博株式会社 | 高分子凝集体的制造方法 |
| RU2614694C1 (ru) * | 2015-12-31 | 2017-03-28 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Средство, обладающее нейропротекторными свойствами в эксперименте и способ его получения |
| RU2616509C1 (ru) * | 2015-12-31 | 2017-04-17 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Способ нейропротекции в эксперименте |
| CN109563474B (zh) * | 2016-02-12 | 2023-02-28 | 思百博技术股份公司 | 整合的细胞 |
| WO2017189832A1 (en) | 2016-04-29 | 2017-11-02 | Trustees Of Tufts College | An artificial silk based innervated cornea |
| WO2017192227A1 (en) | 2016-05-04 | 2017-11-09 | Trustees Of Tufts College | Silk nanofibrils and uses thereof |
| WO2018006037A1 (en) | 2016-07-01 | 2018-01-04 | Trustees Of Tufts College | Innervated artificial skin |
| US11248313B2 (en) | 2016-08-01 | 2022-02-15 | Trustees Of Tufts College | Biomimetic mechanical tension driven fabrication of nanofibrillar architecture |
| EP3496662A4 (en) | 2016-08-12 | 2019-10-30 | Silk Technologies Ltd. | PROTEIN DERIVED FROM SILK FOR THE TREATMENT OF INFLAMMATION |
| WO2018081805A1 (en) | 2016-10-31 | 2018-05-03 | Sofregen Medical, Inc. | Compositions comprising low molecular weight silk fibroin fragments and plasticizers |
| EP3688018A4 (en) | 2017-09-27 | 2021-07-07 | Evolved by Nature, Inc. | SILK COVERED FABRICS, RELATED PRODUCTS AND PREPARATION PROCESSES |
| KR102017948B1 (ko) | 2017-10-30 | 2019-09-03 | 단국대학교 천안캠퍼스 산학협력단 | 콜라겐 및 실크 피브로인을 포함하는 세포 캡슐화용 복합 하이드로겔 및 이의 제조방법 |
| CN107892755B (zh) * | 2017-11-17 | 2019-04-02 | 苏州大学 | 一种生理条件下蚕丝蛋白溶液快速凝胶化的方法 |
| RU2692578C1 (ru) * | 2017-12-29 | 2019-06-25 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Имплантат для регенерации костной ткани и способ его получения |
| US20210052822A1 (en) * | 2018-03-22 | 2021-02-25 | National University Corporation Tokyo Medical And Dental University | Glucose responsive composite gel composition, method for producing same, insulin delivery microneedle including said glucose responsive composite gel composition, and production method thereof |
| AU2019247655A1 (en) | 2018-04-03 | 2020-10-01 | Vaxess Technologies, Inc. | Microneedle comprising silk fibroin applied to a dissolvable base |
| CN110066418B (zh) * | 2019-04-16 | 2021-08-31 | 苏州大学 | 一种活性丝素多孔材料或活性丝素膜及其制备方法 |
| CN110150672A (zh) * | 2019-06-03 | 2019-08-23 | 武汉轻工大学 | 硒补充剂及其制备方法 |
| WO2021076798A1 (en) | 2019-10-15 | 2021-04-22 | Sofregen Medical, Inc. | Delivery devices for delivering and methods of delivering compositions |
| CN112322609A (zh) * | 2020-11-25 | 2021-02-05 | 苏州大学 | 一种基于丝素蛋白的微藻固定化方法 |
| CN112957521B (zh) * | 2021-04-01 | 2022-06-10 | 浙江理工大学 | 一种载青蒿素脂质体的海藻酸盐-丝素蛋白复合水凝胶的制备方法 |
| CN113842505A (zh) * | 2021-09-13 | 2021-12-28 | 南通大学 | 用于神经修复的多孔双网络纳米导电水凝胶神经支架的制备方法 |
| CN114958009B (zh) * | 2022-05-24 | 2024-01-16 | 浙江理工大学 | 一种蚕丝基高强度离子凝胶柔性传感材料的制备方法 |
| WO2023250117A2 (en) | 2022-06-24 | 2023-12-28 | Vaxess Technologies, Inc. | Applicator for medicament patch |
| CN115260531B (zh) * | 2022-08-04 | 2024-03-22 | 重庆科技学院 | 一种可自卷曲双层水凝胶片的制备方法 |
Family Cites Families (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE374905A (hr) | 1929-12-23 | |||
| US3424164A (en) | 1966-05-20 | 1969-01-28 | Ethicon Inc | Silk suture |
| JPS5838449B2 (ja) * | 1979-04-17 | 1983-08-23 | カネボウ株式会社 | 微粉末状絹フィプロインの製造法 |
| JPS5645961A (en) * | 1979-09-20 | 1981-04-25 | Kanebo Ltd | Preparation of fibroin-coated pigment |
| JPS56163658A (en) * | 1980-05-21 | 1981-12-16 | Kanebo Ltd | Manufacture of solid aromatic |
| JPS56166235A (en) | 1980-05-24 | 1981-12-21 | Kanebo Ltd | Hydrophilic porous body and its preparation |
| JPS5765155A (en) | 1980-10-09 | 1982-04-20 | Kyowa Hakko Kogyo Co Ltd | Preparation of powdery protein of soybean |
| JPS5838449A (ja) | 1981-08-31 | 1983-03-05 | Matsushita Electronics Corp | 高圧ナトリウムランプ装置 |
| JPS60142259A (ja) | 1983-12-29 | 1985-07-27 | Kanebo Ltd | 固定化抗体 |
| JPS60259677A (ja) | 1984-05-31 | 1985-12-21 | 水島 繁三郎 | 動物蛋白吸着再生繊維からなる原糸、織物、編物及びその製造方法 |
| US4798722A (en) | 1986-11-12 | 1989-01-17 | Zotos International, Inc. | Permanent waving composition |
| CA1340581C (en) | 1986-11-20 | 1999-06-08 | Joseph P. Vacanti | Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices |
| JPS63190604A (ja) | 1987-02-03 | 1988-08-08 | Agency Of Ind Science & Technol | 新規の水−アルコ−ル分離膜 |
| US5606019A (en) | 1987-10-29 | 1997-02-25 | Protien Polymer Technologies, Inc. | Synthetic protein as implantables |
| JPH0694518B2 (ja) | 1987-11-02 | 1994-11-24 | 工業技術院長 | 絹フィブロイン多孔質体の製造方法 |
| GB8800078D0 (en) | 1988-01-05 | 1988-02-10 | Ciba Geigy Ag | Novel antibodies |
| JPH0284503A (ja) * | 1988-09-20 | 1990-03-26 | Agency Of Ind Science & Technol | 絹フィブロインの凝固方法 |
| JPH0296512A (ja) | 1988-09-29 | 1990-04-09 | Seiwa Kasei:Kk | パーマネントウェーブ用第一剤 |
| US5290494A (en) | 1990-03-05 | 1994-03-01 | Board Of Regents, The University Of Texas System | Process of making a resorbable implantation device |
| US5989894A (en) | 1990-04-20 | 1999-11-23 | University Of Wyoming | Isolated DNA coding for spider silk protein, a replicable vector and a transformed cell containing the DNA |
| GB2245279B (en) | 1990-06-20 | 1993-04-07 | Unilever Plc | Shampoo composition |
| JP2854687B2 (ja) * | 1990-07-30 | 1999-02-03 | 鐘紡株式会社 | 染色絹フィブロイン粉末の製造法 |
| JPH04263611A (ja) | 1991-02-16 | 1992-09-18 | Pola Chem Ind Inc | 水不溶性固形フィブロイン成形物及びその製造法 |
| JPH0543600A (ja) | 1991-08-08 | 1993-02-23 | Kanebo Ltd | 抗体または抗原固定化絹フイブロイン膜および免疫測定用センサー |
| JPH05163132A (ja) | 1991-12-13 | 1993-06-29 | Kanebo Ltd | 皮膚化粧料 |
| JPH0694518A (ja) | 1992-09-10 | 1994-04-05 | Toshiba Lighting & Technol Corp | 日照センサ |
| JPH06346314A (ja) | 1993-06-02 | 1994-12-20 | Toyobo Co Ltd | 再生絹フィブロイン繊維およびその製造方法 |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| JPH08295697A (ja) | 1995-04-26 | 1996-11-12 | Kanebo Ltd | 高濃度絹フィブロイン水溶液の製造方法 |
| JPH1036676A (ja) | 1996-07-26 | 1998-02-10 | Kanebo Ltd | タンパク質水溶液の濃縮方法 |
| WO1998057676A1 (fr) | 1997-06-18 | 1998-12-23 | Japan As Represented By Director General Of National Institute Of Sericultural And Entomological Science Ministry Of Agriculture, Forestry And Fisheries | Matiere de recouvrement de plaie contenant de la fibroine de soie et de la sericine de soie comme composants principaux et son procede de production |
| WO1999001089A1 (en) | 1997-07-01 | 1999-01-14 | Brown University Research Foundation | Implantable prosthetic devices coated with bioactive molecules |
| DE19732046A1 (de) | 1997-07-25 | 1999-01-28 | Abb Patent Gmbh | Prozeßdiagnosesystem und Verfahren zur Diagnose von Vorgängen und Zuständen eines technischen Prozesses |
| US6123819A (en) | 1997-11-12 | 2000-09-26 | Protiveris, Inc. | Nanoelectrode arrays |
| US5994099A (en) | 1997-12-31 | 1999-11-30 | The University Of Wyoming | Extremely elastic spider silk protein and DNA coding therefor |
| PT1411075E (pt) | 1998-03-12 | 2008-08-05 | Nektar Therapeutics Al Corp | Método para a preparação de conjugados de polímeros |
| US6110590A (en) | 1998-04-15 | 2000-08-29 | The University Of Akron | Synthetically spun silk nanofibers and a process for making the same |
| US20030007991A1 (en) | 1998-09-25 | 2003-01-09 | Masters David B. | Devices including protein matrix materials and methods of making and using thereof |
| US7662409B2 (en) | 1998-09-25 | 2010-02-16 | Gel-Del Technologies, Inc. | Protein matrix materials, devices and methods of making and using thereof |
| JP2000202484A (ja) | 1999-01-13 | 2000-07-25 | Fuji Electric Co Ltd | 有機性汚水の生物処理方法 |
| US6592623B1 (en) | 1999-08-31 | 2003-07-15 | Virginia Commonwealth University Intellectual Property Foundation | Engineered muscle |
| JP3151665B2 (ja) | 1999-03-23 | 2001-04-03 | 農林水産省蚕糸・昆虫農業技術研究所長 | 生体高分子／ポリアリルアミン複合体およびその製造方法 |
| JP2000342902A (ja) | 1999-06-07 | 2000-12-12 | Ube Gosei Kogyo Kk | 潮解を遅くした潮解性無機塩結晶の製造方法及び反応装置 |
| WO2001036531A1 (fr) | 1999-11-15 | 2001-05-25 | Zaidan-Houjin Ueda Sen-I Kagaku Shinkoukai | Materiau polymere moleculairement composite en fibroine/cellulose et procede de production de ce materiau |
| EP1251888A1 (en) | 2000-02-03 | 2002-10-30 | Nexia Biotechnologies, Inc. | Surgical sutures containing spider silk |
| IT1316885B1 (it) | 2000-10-02 | 2003-05-13 | Consorzio Per Gli Studi Uni | Procedimento per la preparazione di un tessuto non tessuto in fibroinadi seta. |
| JP2002128691A (ja) | 2000-10-24 | 2002-05-09 | National Institute Of Agrobiological Sciences | セリシン含有素材、その製造方法およびその使用方法 |
| US7265186B2 (en) | 2001-01-19 | 2007-09-04 | Nektar Therapeutics Al, Corporation | Multi-arm block copolymers as drug delivery vehicles |
| WO2002072931A1 (fr) | 2001-03-14 | 2002-09-19 | Japan As Represented By President Of Tokyo University Of Agriculture And Technology | Procede de production d'une fibre ou d'une bande de soie et de matiere de type soie |
| ITVR20010098A1 (it) | 2001-09-11 | 2003-03-11 | Consorzio Per Gli Studi Uni | Procedimento per l'ottenimento di idrogeli di fibroina di seta. |
| AU2002337793A1 (en) | 2001-10-02 | 2003-05-12 | Northwestern University | Protein and peptide nanoarrays |
| GB0126118D0 (en) | 2001-10-31 | 2002-01-02 | Vollrath Friedrich W L | Precursor feedstock for forming filaments |
| US6902932B2 (en) | 2001-11-16 | 2005-06-07 | Tissue Regeneration, Inc. | Helically organized silk fibroin fiber bundles for matrices in tissue engineering |
| US7364343B2 (en) | 2001-12-07 | 2008-04-29 | Philips Lumileds Lighting Company Llc | Compact lighting system and display device |
| JP3803962B2 (ja) | 2001-12-28 | 2006-08-02 | 独立行政法人科学技術振興機構 | 絹タンパク質フィルムとその製造方法 |
| US7057023B2 (en) | 2002-01-11 | 2006-06-06 | Nexia Biotechnologies Inc. | Methods and apparatus for spinning spider silk protein |
| JP3772207B2 (ja) | 2002-06-19 | 2006-05-10 | 独立行政法人農業生物資源研究所 | 生分解性生体高分子材料、その製造方法、およびこの高分子材料からなる機能性素材 |
| WO2004000915A2 (en) | 2002-06-24 | 2003-12-31 | Tufts University | Silk biomaterials and methods of use thereof |
| US7572894B2 (en) | 2002-11-01 | 2009-08-11 | Trustees Of Tufts College | Templated native silk smectic gels |
| US7842780B2 (en) | 2003-01-07 | 2010-11-30 | Trustees Of Tufts College | Silk fibroin materials and use thereof |
| EP1613796B1 (en) | 2003-04-10 | 2017-03-22 | Tufts University | Concentrated aqueous silk fibroin solution and use thereof |
| WO2005000483A1 (en) | 2003-06-06 | 2005-01-06 | Tufts University | Method for forming inorganic coatings |
| CN1243059C (zh) * | 2004-03-04 | 2006-02-22 | 苏州大学 | 纳米丝素颗粒的制造方法 |
| CA2608862C (en) | 2004-06-11 | 2020-05-05 | Trustees Of Tufts College | Silk-based drug delivery system |
| EP1773864A4 (en) | 2004-07-31 | 2009-02-18 | Biogrand Co Ltd | SILKEPEPTIDE THAT IMPROVES NEUROPROTECTIVE AND NEUROFUNCTIONAL EFFECTS, AND METHOD FOR THE PRODUCTION THEREOF |
| WO2006042287A2 (en) | 2004-10-12 | 2006-04-20 | Trustees Of Tufts College | Method for producing biomaterial scaffolds |
| WO2006076711A2 (en) | 2005-01-14 | 2006-07-20 | Trustees Of Tufts College | Fibrous protein fusions and use thereof in the formation of advanced organic/inorganic composite materials |
| US9290579B2 (en) | 2005-04-20 | 2016-03-22 | Trustees Of Tufts College | Covalently immobilized protein gradients in three-dimensional porous scaffolds |
| US8354501B2 (en) | 2005-08-02 | 2013-01-15 | Trustees Of Tufts College | Methods for stepwise deposition of silk fibroin coatings |
| GB0516846D0 (en) | 2005-08-17 | 2005-09-21 | Knight David P | Meniscal repair device |
| US20080058400A1 (en) | 2006-08-29 | 2008-03-06 | Fujifilm Corporation | Skin external preparation |
| WO2008118133A2 (en) | 2006-09-26 | 2008-10-02 | Trustees Of Tufts College | Silk microspheres for encapsulation and controlled release |
| GB2443401A (en) | 2006-10-30 | 2008-05-07 | Spin'tec Engineering Gmbh | Producing fibres by extruding onto a treatment device |
| US20110121485A1 (en) | 2006-10-30 | 2011-05-26 | Spintec Engineering Gmbh | Method and apparatus for the manufacture of a fiber |
| EP2089343B1 (en) | 2006-10-31 | 2011-07-06 | baseclick GmbH | Click chemistry for the production of reporter molecules |
| JP2010509593A (ja) | 2006-11-03 | 2010-03-25 | トラスティーズ オブ タフツ カレッジ | バイオポリマーセンサーおよびその製造方法 |
| US20100068740A1 (en) | 2006-11-03 | 2010-03-18 | Trustees Of Tufts College | Microfluidic device with a cylindrical microchannel and a method for fabricating same |
| US8195021B2 (en) | 2006-11-03 | 2012-06-05 | Tufts University/Trustees Of Tufts College | Biopolymer optical waveguide and method of manufacturing the same |
| CA2704769C (en) | 2006-11-03 | 2016-01-12 | Trustees Of Tufts College | Nanopatterned biopolymer optical device and method of manufacturing the same |
| WO2008118211A2 (en) | 2006-11-03 | 2008-10-02 | Trustees Of Tufts College | Biopolymer photonic crystals and method of manufacturing the same |
| JP5163132B2 (ja) | 2007-02-16 | 2013-03-13 | ソニー株式会社 | 光ピックアップ装置、光ディスク装置、対物レンズの設計方法、光ピックアップ装置の設計方法、及び、光ディスク装置の設計方法 |
| EP2129772B1 (en) | 2007-02-27 | 2016-07-27 | Trustees Of Tufts College | Tissue-engineered silk organs |
| CN101657839B (zh) | 2007-03-23 | 2013-02-06 | 汤姆森许可贸易公司 | 用于对2d图像进行区域分类以进行2d至3d转换的系统和方法 |
| KR101839659B1 (ko) | 2007-05-29 | 2018-03-16 | 트러스티즈 오브 터프츠 칼리지 | 음파 처리를 이용한 실크 피브로인 겔화 방법 |
| WO2009023615A1 (en) | 2007-08-10 | 2009-02-19 | Trustees Of Tufts College | Tubular silk compositions and methods of use thereof |
| WO2009061823A1 (en) | 2007-11-05 | 2009-05-14 | Trustees Of Tufts College | Fabrication of silk fibroin photonic structures by nanocontact imprinting |
| EP2249886A4 (en) | 2008-02-07 | 2013-05-22 | Tufts College | THREE DIMENSIONAL HYDROXYAPATITIS AND SILK COMPOSITIONS |
| US8206774B2 (en) | 2008-03-13 | 2012-06-26 | Trustees Of Tufts College | Diazonium salt modification of silk polymer |
| US9068282B2 (en) | 2008-04-08 | 2015-06-30 | Trustees Of Tufts College | System and method for making biomaterial structures |
| JP5727366B2 (ja) | 2008-05-15 | 2015-06-03 | タフツ ユニバーシティー／トラスティーズ オブ タフツ カレッジ | 絹ポリマーに基づくアデノシン放出：てんかんに対する潜在的治療能力 |
| US20090297588A1 (en) | 2008-05-28 | 2009-12-03 | Spin'tec Engineering Gmbh | Antibiotic dressing for the treatment of infected wounds |
| JP2011525254A (ja) | 2008-06-18 | 2011-09-15 | トラスティーズ オブ タフツ カレッジ | 食用のホログラフィック絹製品 |
| GB2461125A (en) | 2008-06-25 | 2009-12-30 | Spintec Engineering Gmbh | A silk membrane for bone graft material |
| US8501172B2 (en) | 2008-09-26 | 2013-08-06 | Trustees Of Tufts College | pH-induced silk gels and uses thereof |
| GB2464348A (en) | 2008-10-17 | 2010-04-21 | Spintec Engineering Gmbh | Applying a liquid protein onto a permeable surface, and silk mono-filament having specific properties |
| EP2191867A1 (en) | 2008-11-27 | 2010-06-02 | KPSS-Kao Professional Salon Services GmbH | Bleaching/Highlighting composition |
| EP2253336A1 (en) | 2009-05-15 | 2010-11-24 | Spintec Engineering GmbH | A silk medical device with antimicrobial properties and a method of manufacture thereof |
| EP2451953A4 (en) | 2009-07-10 | 2013-07-03 | Tufts College | GEN-MANIPULATED SILK PROTEIN-BASED NUCLEIC ACID DELIVERY SYSTEMS |
| KR101317420B1 (ko) | 2010-03-11 | 2013-10-10 | 한국과학기술원 | 고분자량의 재조합 실크 또는 실크 유사 단백질 및 이를 이용하여 제조된 마이크로 또는 나노 크기의 거미줄 또는 거미줄 유사 섬유 |
| JP6094518B2 (ja) * | 2014-03-24 | 2017-03-15 | 株式会社富士通ゼネラル | ヒートポンプ式暖房給湯装置 |
-
2008
- 2008-05-29 KR KR1020157020146A patent/KR101839659B1/ko active IP Right Grant
- 2008-05-29 CN CN201410072156.0A patent/CN104013598A/zh active Pending
- 2008-05-29 PT PT87564324T patent/PT2211876E/pt unknown
- 2008-05-29 PL PL08756432T patent/PL2211876T3/pl unknown
- 2008-05-29 WO PCT/US2008/065076 patent/WO2008150861A1/en active Application Filing
- 2008-05-29 SI SI200831355T patent/SI2211876T1/sl unknown
- 2008-05-29 US US12/601,845 patent/US8187616B2/en active Active
- 2008-05-29 BR BRPI0813312-3A2A patent/BRPI0813312A2/pt not_active Application Discontinuation
- 2008-05-29 EA EA200971116A patent/EA019118B1/ru not_active IP Right Cessation
- 2008-05-29 EP EP08756432.4A patent/EP2211876B1/en active Active
- 2008-05-29 CN CN200880100926.0A patent/CN101772348B/zh active Active
- 2008-05-29 KR KR1020097027152A patent/KR20100029217A/ko active Application Filing
- 2008-05-29 JP JP2010510483A patent/JP2010529230A/ja not_active Withdrawn
- 2008-05-29 MX MX2009012978A patent/MX2009012978A/es active IP Right Grant
- 2008-05-29 CA CA2688431A patent/CA2688431C/en active Active
- 2008-05-29 ES ES08756432.4T patent/ES2527125T3/es active Active
- 2008-05-29 AU AU2008260156A patent/AU2008260156B2/en active Active
- 2008-05-29 DK DK08756432.4T patent/DK2211876T3/en active
-
2009
- 2009-11-26 IL IL202354A patent/IL202354A/en not_active IP Right Cessation
-
2012
- 2012-04-27 US US13/457,705 patent/US8722067B2/en active Active
-
2014
- 2014-04-07 US US14/246,672 patent/US20140303346A1/en not_active Abandoned
- 2014-12-29 HR HRP20141265AT patent/HRP20141265T1/hr unknown
- 2014-12-30 CY CY20141101092T patent/CY1116090T1/el unknown
-
2015
- 2015-01-23 US US14/604,568 patent/US9254333B2/en active Active
- 2015-03-02 HK HK15102079.3A patent/HK1201470A1/xx unknown
- 2015-03-17 JP JP2015053556A patent/JP6091540B2/ja active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20141265T1 (hr) | Postupak geliranja fibroina svile pomoä†u ultrazvuka | |
| JP2015145500A5 (hr) | ||
| Rodrigo-Navarro et al. | Engineered living biomaterials | |
| JP2010529230A5 (hr) | ||
| US20060270037A1 (en) | Collagen-coated carrier and method for manufacturing collagen-coated carrier | |
| WO2008006544A3 (de) | Verwendung von gelatine und einem vernetzungsmittel zur herstellung einer vernetzenden therapeutischen zusammensetzung | |
| CN103040727A (zh) | 一种药物和蛋白质缓释海藻酸盐杂化凝胶的制备方法 | |
| JP2009542383A5 (hr) | ||
| BRPI0416779B8 (pt) | formulação farmacêutica líquida para a liberação prolongada de princípio(s) ativo(s), processo para a preparação desta formulação, e processo para a preparação de um pó derivado desta formulação | |
| Holzmeister et al. | Artificial inorganic biohybrids: The functional combination of microorganisms and cells with inorganic materials | |
| JPS6244919B2 (hr) | ||
| CN101130107B (zh) | 含羟基磷灰石纳米粒的壳聚糖/聚乙烯醇凝胶的制备方法 | |
| WO2008065756A1 (en) | Bone filler for cartilage tissue regeneration treatment | |
| WO2009101518A3 (en) | Gellan gum based hydrogels for regenerative medicine and tissue engineering applications, its system, and processing devices | |
| JP2008099565A (ja) | 心筋培養用のスポンジ状シート | |
| CN102408575A (zh) | 一种可注射多肽水凝胶的制备方法 | |
| CN104548203B (zh) | 一种富含胶原蛋白人工神经支架的制备方法 | |
| Ghobara et al. | Diatom nanostructured biosilica | |
| JP2015047076A (ja) | 細胞培養基材、並びにそれを用いた骨芽細胞分化誘導方法及び骨芽細胞製造方法 | |
| CA2987932C (en) | Oral delivery system for bioactive agents | |
| WO2009052998A2 (de) | Bioverbundmaterial für die kontrollierte freisetzung von wirkstoffen | |
| JP2005247967A (ja) | 高分子電解質複合体およびその製造方法 | |
| CN108047379A (zh) | 一种温敏水凝胶的制备方法 | |
| Prasad et al. | Alginate-based blends and nano/microbeads | |
| EP3253861B1 (fr) | Matrice sous forme de bille comme support cellulaire |