CN101130107B - 含羟基磷灰石纳米粒的壳聚糖/聚乙烯醇凝胶的制备方法 - Google Patents
含羟基磷灰石纳米粒的壳聚糖/聚乙烯醇凝胶的制备方法 Download PDFInfo
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- CN101130107B CN101130107B CN2007100530116A CN200710053011A CN101130107B CN 101130107 B CN101130107 B CN 101130107B CN 2007100530116 A CN2007100530116 A CN 2007100530116A CN 200710053011 A CN200710053011 A CN 200710053011A CN 101130107 B CN101130107 B CN 101130107B
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- 229920001661 Chitosan Polymers 0.000 title claims abstract description 82
- 239000004372 Polyvinyl alcohol Substances 0.000 title claims abstract description 73
- 229920002451 polyvinyl alcohol Polymers 0.000 title claims abstract description 73
- 229910052588 hydroxylapatite Inorganic materials 0.000 title claims abstract description 58
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 title claims abstract description 58
- 239000002105 nanoparticle Substances 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 239000000243 solution Substances 0.000 claims description 75
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 26
- 239000002253 acid Substances 0.000 claims description 20
- 150000001447 alkali salts Chemical class 0.000 claims description 17
- 238000003756 stirring Methods 0.000 claims description 15
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 12
- 239000001488 sodium phosphate Substances 0.000 claims description 12
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 12
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 12
- 239000001110 calcium chloride Substances 0.000 claims description 11
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 11
- 239000011259 mixed solution Substances 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 4
- 239000012153 distilled water Substances 0.000 claims description 3
- 239000011575 calcium Substances 0.000 claims description 2
- 229940068984 polyvinyl alcohol Drugs 0.000 claims 23
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims 23
- 235000015598 salt intake Nutrition 0.000 claims 1
- CRKADHVTAQCXRA-UHFFFAOYSA-K trisodium;phosphate;dihydrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]P([O-])([O-])=O CRKADHVTAQCXRA-UHFFFAOYSA-K 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 15
- 229940079593 drug Drugs 0.000 abstract description 15
- 239000002131 composite material Substances 0.000 abstract description 12
- 238000000034 method Methods 0.000 abstract description 12
- 238000013268 sustained release Methods 0.000 abstract description 12
- 239000012730 sustained-release form Substances 0.000 abstract description 12
- 238000011065 in-situ storage Methods 0.000 abstract description 7
- 210000001519 tissue Anatomy 0.000 abstract description 7
- 239000000463 material Substances 0.000 abstract description 6
- 238000004113 cell culture Methods 0.000 abstract description 5
- 239000003937 drug carrier Substances 0.000 abstract description 5
- 210000001188 articular cartilage Anatomy 0.000 abstract description 2
- 239000012567 medical material Substances 0.000 abstract description 2
- 229920001282 polysaccharide Polymers 0.000 abstract description 2
- 239000005017 polysaccharide Substances 0.000 abstract description 2
- 230000008439 repair process Effects 0.000 abstract description 2
- 150000004676 glycans Chemical class 0.000 abstract 1
- 239000000499 gel Substances 0.000 description 61
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 16
- 159000000011 group IA salts Chemical class 0.000 description 7
- 239000007788 liquid Substances 0.000 description 6
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 5
- 229940098773 bovine serum albumin Drugs 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000011173 biocomposite Substances 0.000 description 3
- 230000004071 biological effect Effects 0.000 description 3
- 230000036760 body temperature Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000000017 hydrogel Substances 0.000 description 3
- 239000003999 initiator Substances 0.000 description 3
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 238000010382 chemical cross-linking Methods 0.000 description 2
- 239000003431 cross linking reagent Substances 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005538 encapsulation Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 229910014497 Ca10(PO4)6(OH)2 Inorganic materials 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 239000000316 bone substitute Substances 0.000 description 1
- -1 cationic polysaccharide Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 210000001612 chondrocyte Anatomy 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 210000001243 pseudopodia Anatomy 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000035440 response to pH Effects 0.000 description 1
- 230000006903 response to temperature Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 230000002522 swelling effect Effects 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- ASTWEMOBIXQPPV-UHFFFAOYSA-K trisodium;phosphate;dodecahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[Na+].[O-]P([O-])([O-])=O ASTWEMOBIXQPPV-UHFFFAOYSA-K 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
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Abstract
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CN2007100530116A CN101130107B (zh) | 2007-08-22 | 2007-08-22 | 含羟基磷灰石纳米粒的壳聚糖/聚乙烯醇凝胶的制备方法 |
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CN2007100530116A CN101130107B (zh) | 2007-08-22 | 2007-08-22 | 含羟基磷灰石纳米粒的壳聚糖/聚乙烯醇凝胶的制备方法 |
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CN101130107A CN101130107A (zh) | 2008-02-27 |
CN101130107B true CN101130107B (zh) | 2010-04-14 |
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CN2007100530116A Active CN101130107B (zh) | 2007-08-22 | 2007-08-22 | 含羟基磷灰石纳米粒的壳聚糖/聚乙烯醇凝胶的制备方法 |
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Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101352585B (zh) * | 2008-07-31 | 2012-02-01 | 华南理工大学 | 颗粒定向排列的纳米羟基磷灰石/壳聚糖支架的制备方法 |
CN101376038B (zh) * | 2008-10-07 | 2011-12-21 | 浙江大学 | 壳聚糖和羟基磷灰石复合骨修复支架材料的制备方法 |
CN101480501B (zh) * | 2009-01-07 | 2012-10-24 | 四川大学 | 关节软骨修复的替代材料及制备方法 |
CN104086787A (zh) * | 2014-07-04 | 2014-10-08 | 武汉大学 | 玉米芯直链性半纤维素/壳聚糖或羧甲基壳聚糖/TiO2杂化材料及其制备方法和用途 |
CN104189960B (zh) * | 2014-09-15 | 2015-08-12 | 太原理工大学 | 一种复合水凝胶的制备方法 |
CN104906637B (zh) * | 2015-05-15 | 2018-01-12 | 武汉大学 | 一种可注射‑多孔‑载药的聚甲基丙烯酸甲酯基复合支架骨移植材料及其制备方法 |
CN107556499B (zh) * | 2017-07-27 | 2020-08-11 | 广西中烟工业有限责任公司 | 一种葡萄糖交联复合凝胶的制备方法及在卷烟中的应用 |
CN110292659A (zh) * | 2019-07-15 | 2019-10-01 | 四川大学华西医院 | 一种生物软骨组织修复替代材料及其制备方法 |
CN111166941A (zh) * | 2020-01-17 | 2020-05-19 | 上海贝奥路生物材料有限公司 | 组织缺陷修复剂及其制备方法和使用方法 |
CN112370571A (zh) * | 2020-11-26 | 2021-02-19 | 同济大学 | 治疗颌面部骨缺损的骨组织工程支架材料及其合成方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1169874A (zh) * | 1996-07-04 | 1998-01-14 | 卢贤元 | 速效戒毒剂 |
CN1389512A (zh) * | 2002-06-21 | 2003-01-08 | 华南理工大学 | 生物活性聚乙烯醇/羟基磷灰石纳米复合水凝胶及制备方法 |
CN1978498A (zh) * | 2006-11-30 | 2007-06-13 | 武汉大学 | 一种温度敏感型的壳聚糖/聚乙烯醇凝胶及其制备方法 |
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- 2007-08-22 CN CN2007100530116A patent/CN101130107B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1169874A (zh) * | 1996-07-04 | 1998-01-14 | 卢贤元 | 速效戒毒剂 |
CN1389512A (zh) * | 2002-06-21 | 2003-01-08 | 华南理工大学 | 生物活性聚乙烯醇/羟基磷灰石纳米复合水凝胶及制备方法 |
CN1978498A (zh) * | 2006-11-30 | 2007-06-13 | 武汉大学 | 一种温度敏感型的壳聚糖/聚乙烯醇凝胶及其制备方法 |
Non-Patent Citations (2)
Title |
---|
生瑜等.聚合物基无机纳米复合材料的制备方法Ⅰ原位生成法.高分子通报 第4期.2001,(第4期),9-14. |
生瑜等.聚合物基无机纳米复合材料的制备方法Ⅰ原位生成法.高分子通报 第4期.2001,(第4期),9-14. * |
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Denomination of invention: Preparation of chitosan/polyvinyl alcohol gel containing hydroxyapatite nanoparticle Effective date of registration: 20230509 Granted publication date: 20100414 Pledgee: Agricultural Bank of China Limited Qianjiang Branch Pledgor: HUA SHAN TECHNOLOGY CO.,LTD. Registration number: Y2023420000198 |
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