JP2009034115A5 - - Google Patents

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Publication number
JP2009034115A5
JP2009034115A5 JP2008287206A JP2008287206A JP2009034115A5 JP 2009034115 A5 JP2009034115 A5 JP 2009034115A5 JP 2008287206 A JP2008287206 A JP 2008287206A JP 2008287206 A JP2008287206 A JP 2008287206A JP 2009034115 A5 JP2009034115 A5 JP 2009034115A5
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Japan
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cells
process according
influenza virus
culture medium
virus
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JP2008287206A
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English (en)
Japanese (ja)
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JP2009034115A (ja
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Priority claimed from DE19612966A external-priority patent/DE19612966B4/de
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JP2008287206A 1996-04-01 2008-11-07 インフルエンザウイルスの複製のための動物細胞および方法 Withdrawn JP2009034115A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19612966A DE19612966B4 (de) 1996-04-01 1996-04-01 MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren

Related Parent Applications (1)

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JP2006147486A Division JP2006230415A (ja) 1996-04-01 2006-05-26 インフルエンザウイルスの複製のための動物細胞および方法

Related Child Applications (2)

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JP2011192118A Division JP2012005502A (ja) 1996-04-01 2011-09-02 インフルエンザウイルスの複製のための動物細胞および方法
JP2011224914A Division JP2012016358A (ja) 1996-04-01 2011-10-12 インフルエンザウイルスの複製のための動物細胞および方法

Publications (2)

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JP2009034115A JP2009034115A (ja) 2009-02-19
JP2009034115A5 true JP2009034115A5 (enExample) 2009-12-24

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ID=7790126

Family Applications (7)

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JP53508997A Expired - Fee Related JP4243349B2 (ja) 1996-04-01 1997-04-01 インフルエンザウイルスの複製のための動物細胞および方法
JP2004233905A Withdrawn JP2004331673A (ja) 1996-04-01 2004-08-10 インフルエンザウイルスの複製のための動物細胞および方法
JP2005108075A Withdrawn JP2005211080A (ja) 1996-04-01 2005-04-04 インフルエンザウイルスの複製のための動物細胞および方法
JP2006147486A Withdrawn JP2006230415A (ja) 1996-04-01 2006-05-26 インフルエンザウイルスの複製のための動物細胞および方法
JP2008287206A Withdrawn JP2009034115A (ja) 1996-04-01 2008-11-07 インフルエンザウイルスの複製のための動物細胞および方法
JP2011192118A Withdrawn JP2012005502A (ja) 1996-04-01 2011-09-02 インフルエンザウイルスの複製のための動物細胞および方法
JP2011224914A Withdrawn JP2012016358A (ja) 1996-04-01 2011-10-12 インフルエンザウイルスの複製のための動物細胞および方法

Family Applications Before (4)

Application Number Title Priority Date Filing Date
JP53508997A Expired - Fee Related JP4243349B2 (ja) 1996-04-01 1997-04-01 インフルエンザウイルスの複製のための動物細胞および方法
JP2004233905A Withdrawn JP2004331673A (ja) 1996-04-01 2004-08-10 インフルエンザウイルスの複製のための動物細胞および方法
JP2005108075A Withdrawn JP2005211080A (ja) 1996-04-01 2005-04-04 インフルエンザウイルスの複製のための動物細胞および方法
JP2006147486A Withdrawn JP2006230415A (ja) 1996-04-01 2006-05-26 インフルエンザウイルスの複製のための動物細胞および方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2011192118A Withdrawn JP2012005502A (ja) 1996-04-01 2011-09-02 インフルエンザウイルスの複製のための動物細胞および方法
JP2011224914A Withdrawn JP2012016358A (ja) 1996-04-01 2011-10-12 インフルエンザウイルスの複製のための動物細胞および方法

Country Status (9)

Country Link
US (4) US6455298B1 (enExample)
EP (2) EP2275535A1 (enExample)
JP (7) JP4243349B2 (enExample)
AT (1) ATE482267T1 (enExample)
DE (2) DE19612966B4 (enExample)
DK (1) DK0904351T3 (enExample)
ES (1) ES2352638T3 (enExample)
PT (1) PT904351E (enExample)
WO (1) WO1997037000A1 (enExample)

Families Citing this family (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19612967A1 (de) * 1996-04-01 1997-10-02 Behringwerke Ag Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren
DE19612966B4 (de) * 1996-04-01 2009-12-10 Novartis Vaccines And Diagnostics Gmbh & Co. Kg MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
ATE304048T1 (de) * 1997-10-25 2005-09-15 Roche Diagnostics Gmbh Suspensions-verpackungszellinien für retrovirusvektoren
SK285971B6 (sk) 1997-12-24 2007-12-06 Duphar International Research B. V. Spôsob prípravy buniek na výrobu biologických materiálov
DE60142506D1 (de) 2000-03-03 2010-08-19 Chemo Sero Therapeut Res Inst In serumfreier kultur verwendbare zelle, kultursuspension und verfahren zur virusproduktion als impfstoff unter verwendung der zelle
JP3547715B2 (ja) * 2001-03-06 2004-07-28 榮 新垣 ベクター精製用装置及び方法
DE10144903A1 (de) * 2001-09-12 2003-03-27 Chiron Behring Gmbh & Co Vermehrung von Viren in Zellkultur
DE10144906B4 (de) * 2001-09-12 2013-11-28 Novartis Vaccines And Diagnostics Gmbh Verfahren zur großtechnischen Herstellung von Impfstoffen
US20030078471A1 (en) * 2001-10-18 2003-04-24 Foley Frederick J. Manipulation of an organ
US6951752B2 (en) * 2001-12-10 2005-10-04 Bexter Healthcare S.A. Method for large scale production of virus antigen
CN103540613A (zh) 2002-04-26 2014-01-29 米迪缪尼有限公司 制备流感病毒的多质粒系统
US20050158342A1 (en) * 2003-12-23 2005-07-21 Medimmune, Inc. Multi plasmid system for the production of influenza virus
US7465456B2 (en) 2002-04-26 2008-12-16 Medimmune, Llc Multi plasmid system for the production of influenza virus
EP1597400B8 (en) * 2003-02-25 2013-10-09 MedImmune, LLC Methods of producing influenza vaccine compositions
US20060110406A1 (en) * 2003-02-25 2006-05-25 Medimmune Vaccines, Inc. Refrigerator-temperature stable influenza vaccine compositions
DE602004028736D1 (de) * 2003-06-20 2010-09-30 Microbix Biosystems Inc Verbesserungen bei der virusproduktion
WO2005026333A1 (ja) * 2003-09-09 2005-03-24 Japan Science And Technology Agency プロテアーゼを用いた接着性細胞の浮遊培養技術、及び該細胞を宿主として用いてウィルスを生産する方法
US20080254065A1 (en) 2004-03-09 2008-10-16 Chiron Corporation Influenza Virus Vaccines
BRPI0509493A (pt) * 2004-04-01 2007-09-11 Alza Corp aparelho e método para a liberação transdérmica de vacina da influenza
NZ551640A (en) * 2004-05-20 2010-05-28 Id Biomedical Corp Process for the production of an influenza vaccine
EP2578229B1 (en) 2004-09-09 2013-07-10 Novartis Vaccines and Diagnostics GmbH Decreasing potential iatrogenic risks associated with vaccine antigens
KR101346989B1 (ko) 2004-10-06 2014-02-06 메디뮨 엘엘씨 냉장 온도 안정성 인플루엔자 백신 조성물
DE102004049290A1 (de) * 2004-10-09 2006-04-20 Bayer Healthcare Ag Verfahren zur Herstellung von Virusmaterial
EP1807116B1 (en) 2004-11-03 2015-05-06 Novartis Vaccines and Diagnostics, Inc. Influenza vaccination
KR101316350B1 (ko) 2004-12-08 2013-10-15 메디뮨 엘엘씨 인플루엔자 백신 조성물의 제조 방법
CN101189326B (zh) * 2004-12-23 2013-06-12 米迪缪尼有限公司 用于病毒增殖的非致瘤性mdck细胞系
US7572620B2 (en) 2005-01-11 2009-08-11 Wisconsin Alumni Research Foundation H3 equine influenza A virus
FR2884255B1 (fr) 2005-04-11 2010-11-05 Vivalis Utilisation de lignees de cellules souches aviaires ebx pour la production de vaccin contre la grippe
US20070111309A1 (en) * 2005-10-04 2007-05-17 Daelli Marcelo G Vero cell line adapted to grow in suspension
CN101365480B (zh) 2005-11-01 2014-11-05 诺华疫苗和诊断有限两合公司 经由β-丙内酯处理的残留细胞DNA水平降低的细胞衍生病毒疫苗
HUE051122T2 (hu) 2005-11-04 2021-03-01 Seqirus Uk Ltd Sejttenyészetben növesztett influenzavírusból elõállított nemvirion anti-géneket tartalmazó adjuvált vakcinák
NZ592713A (en) 2005-11-04 2012-12-21 Novartis Vaccines & Diagnostic Adjuvanted influenza vaccines including a cytokine-inducing agents other than an agonist of Toll-Like Receptor 9
WO2007052058A1 (en) 2005-11-04 2007-05-10 Novartis Vaccines And Diagnostics Srl Influenza vaccines including combinations of particulate adjuvants and immunopotentiators
EA014028B1 (ru) 2005-11-04 2010-08-30 Новартис Вэксинс Энд Диагностикс Срл Эмульсии, содержащие свободное поверхностно-активное вещество в водной фазе в качестве адъюванта сплит вакцин против гриппа
AU2006310163B2 (en) 2005-11-04 2011-09-15 Seqirus UK Limited Influenza vaccine with reduced amount of oil-in-water emulsion as adjuvant
HUE049580T2 (hu) 2006-01-27 2020-09-28 Seqirus Uk Ltd Hemagglutinint és mátrixfehérjéket tartalmazó, influenza elleni oltóanyagok
CN101448523A (zh) 2006-03-24 2009-06-03 诺华疫苗和诊断有限两合公司 无需冷藏储存流感疫苗
WO2007126810A2 (en) 2006-03-31 2007-11-08 Warf - Wisconsin Alumni Research Foundation High titer recombinant influenza viruses for vaccines
EP2022849A4 (en) * 2006-05-11 2010-10-06 Chemo Sero Therapeut Res Inst METHOD FOR PROLIFERATION OF INFLUENZA VIRUS
GB0614460D0 (en) 2006-07-20 2006-08-30 Novartis Ag Vaccines
EP4585610A3 (en) * 2006-09-11 2025-09-24 Seqirus UK Limited Making influenza virus vaccines without using eggs
EP2069480B1 (en) * 2006-09-15 2014-03-19 MedImmune, LLC Mdck cell lines supporting viral growth to high titers and bioreactor process using the same
PL2121011T3 (pl) 2006-12-06 2014-10-31 Novartis Ag Szczepionki zawierające antygeny czterech szczepów wirusa grypy
JP5666905B2 (ja) 2007-06-18 2015-02-12 メディミューン,エルエルシー ヘマグルチニンポリペプチド中に変化を有するインフルエンザbウイルス
WO2008156778A2 (en) 2007-06-18 2008-12-24 Tokiko Watanabe Influenza m2 protein mutant viruses as live influenza attenuated vaccines
CN101784283A (zh) * 2007-06-27 2010-07-21 诺华有限公司 低添加流感疫苗
EP3327132A3 (en) * 2007-08-09 2018-07-18 Wyeth LLC Use of perfusion to enhance production of fed-batch cell culture in bioreactors
GB0810305D0 (en) 2008-06-05 2008-07-09 Novartis Ag Influenza vaccination
US8685654B2 (en) 2007-12-24 2014-04-01 Novartis Ag Assays for adsorbed influenza vaccines
US8506966B2 (en) 2008-02-22 2013-08-13 Novartis Ag Adjuvanted influenza vaccines for pediatric use
EA201071086A1 (ru) 2008-03-18 2011-04-29 Новартис Аг Усовершенствованный способ получения вакцинных антигенов вируса гриппа
TW201012930A (en) * 2008-06-16 2010-04-01 Intervet Int Bv Method of replicating viruses in suspension
MY172788A (en) 2008-08-01 2019-12-12 Gamma Vaccines Pty Ltd Influenza vaccines
JP5548207B2 (ja) 2008-09-24 2014-07-16 メディミューン,エルエルシー ウイルスの精製方法
CN103952376A (zh) 2008-09-24 2014-07-30 米迪缪尼有限公司 培养细胞、增殖和纯化病毒的方法
WO2010079081A1 (en) 2009-01-07 2010-07-15 Glaxosmithkline Biologicals S.A. Methods for recovering a virus or a viral antigen produced by cell culture
CA2750055A1 (en) 2009-02-06 2010-08-12 Glaxosmithkline Biologicals S.A. Method for purifying viruses using a density gradient
EP2396031A1 (en) 2009-02-10 2011-12-21 Novartis AG Influenza vaccines with increased amounts of h3 antigen
US20120093859A1 (en) 2009-02-10 2012-04-19 Novartis Ag Influenza vaccine regimens for pandemic-associated strains
EP3173097A3 (en) 2009-02-10 2017-07-12 Seqirus UK Limited Influenza vaccines with reduced amounts of squalene
CN102548577A (zh) 2009-04-27 2012-07-04 诺华有限公司 用于抵抗流感的佐剂疫苗
CN102803515A (zh) 2009-05-08 2012-11-28 诺华有限公司 用于流感病毒检测的通用测试
ES2394797T3 (es) 2009-05-21 2013-02-05 Novartis Ag Genética inversa usando promotores no endógenos de pol l
CN103764160A (zh) 2009-05-29 2014-04-30 诺华有限公司 流感病毒血凝素试验
AU2010277310B2 (en) 2009-07-31 2015-01-15 Seqirus UK Limited Reverse genetics systems
US20120237536A1 (en) 2009-09-10 2012-09-20 Novartis Combination vaccines against respiratory tract diseases
JP5871806B2 (ja) 2009-10-20 2016-03-01 ノバルティス アーゲー ウイルスレスキューのための改善された逆遺伝学
WO2011056591A1 (en) 2009-10-26 2011-05-12 Warf - Wisconsin Alumni Research Foundation High titer recombinant influenza viruses with enhanced replication in vero cells
DE102009056884B4 (de) 2009-12-03 2021-03-18 Novartis Ag Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
EA025622B1 (ru) 2009-12-03 2017-01-30 Новартис Аг Способ получения содержащей сквален эмульсии масла
DE102009056871A1 (de) 2009-12-03 2011-06-22 Novartis AG, 4056 Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
MX2012006216A (es) 2009-12-03 2012-07-12 Novartis Ag Circulacion de componentes durante la homogenizacion de emulsiones.
DE102009056883B4 (de) 2009-12-03 2012-08-16 Novartis Ag Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
SI2506833T1 (sl) 2009-12-03 2014-07-31 Novartis Ag Sklop interakcijske in protitlaäśne komore za mikrofluidiziranje
US20120309056A1 (en) 2010-02-04 2012-12-06 Leon Arnaud Fed-batch process using concentrated cell culture medium for the efficient production of biologics in eb66 cells
AU2011225748A1 (en) 2010-03-08 2012-09-13 Novartis Ag Methods of testing for intracellular pathogens
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
ES2562818T3 (es) 2010-05-03 2016-03-08 Glaxosmithkline Biologicals S.A. Procedimiento de inactivación del virus de la gripe
EP2566323A2 (en) 2010-05-06 2013-03-13 Novartis AG Organic peroxide compounds for microorganism inactivation
JP5946188B2 (ja) 2010-05-12 2016-07-05 ノバルティス アーゲー スクアレンを調製するための改良された方法
EP2571520B1 (en) 2010-05-21 2018-04-04 Seqirus UK Limited Influenza virus reassortment method
AU2011262312B2 (en) 2010-06-01 2015-05-28 Novartis Ag Concentration and lyophilization of influenza vaccine antigens
AU2011262309B2 (en) 2010-06-01 2015-08-13 Seqirus UK Limited Concentration of influenza vaccine antigens without lyophilization
MX337687B (es) * 2010-08-16 2016-03-15 Cevec Pharmaceuticals Gmbh Linea celular de amniocitos humanos permanente para la produccion de virus de influenza.
US9051361B2 (en) 2010-08-17 2015-06-09 National Health Research Institutes Immunogenic compositions and uses thereof
US9517205B2 (en) 2010-08-20 2016-12-13 Seqirus UK Limited Soluble needle arrays for delivery of influenza vaccines
EP3012330A1 (en) 2010-09-07 2016-04-27 Novartis AG Generic assays for detection of mammalian reovirus
US20140079732A1 (en) 2011-01-27 2014-03-20 Gamma Vaccines Pty Limited Combination vaccines
JP5999817B2 (ja) 2011-02-25 2016-10-05 ノバルティス アーゲー 外因性の内部陽性対照
JP2014527799A (ja) 2011-08-26 2014-10-23 ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション 変異型pb2遺伝子セグメントを有する弱毒化生ワクチンとしてのインフルエンザウイルス
GB201216121D0 (en) 2012-09-10 2012-10-24 Novartis Ag Sample quantification by disc centrifugation
WO2013057715A1 (en) 2011-10-20 2013-04-25 Novartis Ag Adjuvanted influenza b virus vaccines for pediatric priming
US20140335507A1 (en) 2011-12-12 2014-11-13 Novartis Ag Assays for influenza virus hemagglutinins
AU2014203051C1 (en) * 2012-03-02 2016-09-01 Seqirus UK Limited Influenza Virus Reassortment
ES2628301T3 (es) * 2012-03-02 2017-08-02 Seqirus UK Limited Recombinación de virus de gripe
CA2866465A1 (en) 2012-03-06 2013-09-12 Crucell Holland B.V. Improved vaccination against influenza
JP6152535B2 (ja) * 2012-04-16 2017-06-28 公益財団法人ヒューマンサイエンス振興財団 細胞培養組成物及びインフルエンザウイルスの生産方法
HK1208502A1 (en) 2012-06-04 2016-03-04 Novartis Ag Improved safety testing
GB201218195D0 (en) 2012-10-10 2012-11-21 Istituto Zooprofilattico Sperimentale Delle Venezie Composition
EP2925356A2 (en) 2012-12-03 2015-10-07 Novartis AG Reassortant influenza a viren
US10232031B2 (en) 2013-03-13 2019-03-19 Seqirus UK Limited Influenza virus reassortment
WO2014180999A1 (en) 2013-05-10 2014-11-13 Novartis Ag Avoiding narcolepsy risk in influenza vaccines
DE202013005130U1 (de) 2013-06-05 2013-09-10 Novartis Ag Influenza Virus Reassortierung
DE202013005100U1 (de) 2013-06-05 2013-08-26 Novartis Ag Influenza Virus Reassortierung
BR112015030582A2 (pt) 2013-06-06 2017-08-29 Novartis Ag Segmento de hemaglutinina da gripe quimérico e de neuraminidase quimérico, proteína de hemaglutinina quimérica, vírus da gripe rearranjado, métodos para preparação de um vírus da gripe rearranjado e para preparação de uma vacina e sistema de expressão
KR101370512B1 (ko) 2013-06-07 2014-03-06 재단법인 목암생명공학연구소 무단백 배지에서 부유 배양되는 mdck 유래 세포주 및 상기 세포주를 이용하여 바이러스를 증식시키는 방법
WO2015009743A1 (en) 2013-07-15 2015-01-22 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses with enhanced replication in mdck or vero cells or eggs
US10392603B2 (en) 2013-08-30 2019-08-27 The Chemo-Sero-Therapeutic Research Institute Method of viral purification
EP3068791B1 (en) 2013-11-15 2020-07-29 Novartis AG Removal of residual cell culture impurities
TWI743024B (zh) 2014-06-06 2021-10-21 美商健臻公司 灌注培養方法及其用途
TWI776235B (zh) * 2014-06-09 2022-09-01 美商健臻公司 種子罐培養法(seed train processes)及其用途
US10053671B2 (en) 2014-06-20 2018-08-21 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
AU2015252119A1 (en) 2014-11-07 2016-05-26 Takeda Vaccines, Inc. Hand, foot, and mouth vaccines and methods of manufacture and use thereof
MA40920A (fr) 2014-11-07 2017-09-12 Takeda Vaccines Inc Vaccins de la main, du pied et de la bouche, et procédés de fabrication et d'utilisation de ceux-ci
ES2861806T3 (es) 2014-12-02 2021-10-06 Novartis Ag Fabricación de composiciones que contienen tensioactivo
US10633422B2 (en) 2015-06-01 2020-04-28 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA
BR112017028011A2 (pt) 2015-06-26 2018-08-28 Seqirus Uk Ltd vacinas de gripe correspondentes antigenicamente
US9890363B2 (en) 2015-07-06 2018-02-13 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
CN108027371B (zh) 2015-07-07 2020-08-18 思齐乐 流感效力试验
WO2017072744A1 (en) * 2015-10-30 2017-05-04 National Institute Of Infectious Diseases And Vaccinology, National Health Research Institutes Mdck suspension cell lines in serum-free, chemically-defined media for vaccine production
WO2017143236A1 (en) 2016-02-19 2017-08-24 Yoshihiro Kawaoka Improved influenza b virus replication for vaccine development
AU2017244758B2 (en) 2016-03-29 2022-08-25 The Research Foundation For Microbial Diseases Of Osaka University Method for culturing MDCK cells
JP2017038622A (ja) * 2016-11-21 2017-02-23 ウィスコンシン アルムニ リサーチ ファンデイション H3型ウマa型インフルエンザウイルス
US11197926B2 (en) 2017-10-25 2021-12-14 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized HA for replication in eggs
US11648304B2 (en) 2017-11-03 2023-05-16 Takeda Vaccines, Inc. Zika vaccines and immunogenic compositions, and methods of using the same
JP7783047B2 (ja) 2018-08-07 2025-12-09 ウィスコンシン アルムニ リサーチ ファンデイション 組換えの生物学的に封じ込められたフィロウイルスワクチン
JP7655849B2 (ja) 2018-08-20 2025-04-02 ウィスコンシン アルムニ リサーチ ファンデイション ヘマグルチニン(ha)タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター
JP2022527235A (ja) 2019-01-23 2022-06-01 義裕 河岡 インフルエンザウイルスにおける付加的遺伝子に遺伝的安定性を付与する突然変異
EP3921413A1 (en) 2019-02-08 2021-12-15 Wisconsin Alumni Research Foundation (WARF) Humanized cell line
US11390649B2 (en) 2019-05-01 2022-07-19 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
CN113939311A (zh) 2019-05-08 2022-01-14 武田疫苗股份有限公司 灭活病毒组合物和寨卡疫苗制剂
US11807872B2 (en) 2019-08-27 2023-11-07 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized HA for replication in eggs
MX2022006005A (es) 2019-11-18 2022-10-27 Seqirus Pty Ltd Metodo para producir virus de la influenza reagrupados.
JP2023511444A (ja) 2020-01-24 2023-03-17 ウィスコンシン アルムニ リサーチ ファンデイション 安定化されたnaを有する組換えインフルエンザウイルス
WO2021195410A1 (en) 2020-03-25 2021-09-30 Wisconsin Alumni Research Foundation (Warf) Recombinant multivalent influenza viruses
US20230218526A1 (en) 2020-06-30 2023-07-13 Seqirus UK Limited Cold filtration of oil-in-water emulsion adjuvants
EP4476329A1 (en) 2022-02-09 2024-12-18 Takeda Vaccines, Inc. Zika vaccines and immunogenic compositions, and methods of using the same
CN116376810A (zh) * 2023-04-26 2023-07-04 上海奥浦迈生物科技股份有限公司 一种mdck细胞无血清贴壁培养驯化的方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1278075B (de) 1964-06-22 1968-09-19 Norden Lab Inc Verwendung von Gewebekulturen zur Zuechtung von Viren fuer die Gewinnung von Impfstoffen
US3616203A (en) * 1969-12-11 1971-10-26 Norden Lab Inc Virus culture and method
US4064232A (en) 1974-01-14 1977-12-20 Sandoz Ltd. Process for isolating the immunogenic components of influenza viruses
CA1122527A (en) 1979-05-15 1982-04-27 Karen K. Brown Influenza vaccine production in liquid cell culture
USRE33164E (en) * 1979-05-15 1990-02-13 Mobay Corporation Influenza vaccine production in liquid cell culture
US4500513A (en) * 1979-05-15 1985-02-19 Miles Laboratories, Inc. Influenza vaccine production in liquid cell culture
US5013663A (en) * 1983-06-15 1991-05-07 American Home Products Corporation Canine corona virus vaccine
US4783411A (en) 1984-10-22 1988-11-08 Janis Gabliks Influenza-A virus vaccine from fish cell cultures
EP0389925B1 (en) 1989-03-29 1995-12-27 The Research Foundation Of State University Of New York A method for purifying an outer membrane protein of Haemophilus influenzae
JP2827298B2 (ja) * 1989-07-10 1998-11-25 三菱化学株式会社 細胞培養担体
AT393277B (de) 1990-01-04 1991-09-25 Immuno Ag Verfahren zur herstellung von fruehsommer- meningoenzephalitis-virus (fsme-virus)-antigen
JPH0420284A (ja) * 1990-05-12 1992-01-23 Mitsubishi Kasei Corp 細胞培養用マイクロキャリア
JPH05207873A (ja) * 1992-01-27 1993-08-20 Mitsubishi Kasei Corp 付着性動物細胞の培養方法
US5762939A (en) * 1993-09-13 1998-06-09 Mg-Pmc, Llc Method for producing influenza hemagglutinin multivalent vaccines using baculovirus
US5753489A (en) * 1994-11-10 1998-05-19 Immuno Ag Method for producing viruses and vaccines in serum-free culture
ES2323490T3 (es) 1994-11-10 2009-07-17 Baxter Healthcare Sa Procedimiento de produccion de agentes biologicos en un medio de cultivo sin proteinas.
US5756341A (en) * 1994-11-10 1998-05-26 Immuno Ag Method for controlling the infectivity of viruses
AU694592B2 (en) 1994-11-16 1998-07-23 St. Jude Children's Research Hospital Novel replication process
US5646033A (en) * 1994-11-30 1997-07-08 Dyncorp African green monkey kidney cell lines useful for maintaining viruses and for preparation of viral vaccines
JPH11513372A (ja) 1995-09-22 1999-11-16 コノート ラボラトリーズ リミテッド パラインフルエンザウイルスの糖タンパクおよびワクチン
DE19612967A1 (de) 1996-04-01 1997-10-02 Behringwerke Ag Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren
DE19612966B4 (de) 1996-04-01 2009-12-10 Novartis Vaccines And Diagnostics Gmbh & Co. Kg MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
US6514502B1 (en) * 1999-01-26 2003-02-04 Schering-Plough Veterinary Corporation Propagation of bovine cononavirus in chinese hamster ovary cells

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