MX2012006216A - Circulacion de componentes durante la homogenizacion de emulsiones. - Google Patents

Circulacion de componentes durante la homogenizacion de emulsiones.

Info

Publication number
MX2012006216A
MX2012006216A MX2012006216A MX2012006216A MX2012006216A MX 2012006216 A MX2012006216 A MX 2012006216A MX 2012006216 A MX2012006216 A MX 2012006216A MX 2012006216 A MX2012006216 A MX 2012006216A MX 2012006216 A MX2012006216 A MX 2012006216A
Authority
MX
Mexico
Prior art keywords
circulation
emulsions
components during
during homogenization
container
Prior art date
Application number
MX2012006216A
Other languages
English (en)
Inventor
Harald Rueckl
Hanno Scheffczik
Barbara Santry
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43923723&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2012006216(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2012006216A publication Critical patent/MX2012006216A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/44—Mixers in which the components are pressed through slits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/27—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
    • B01F27/271—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator
    • B01F27/2711—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator provided with intermeshing elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
    • B01F33/811—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles in two or more consecutive, i.e. successive, mixing receptacles or being consecutively arranged
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Edible Oils And Fats (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Liquid Carbonaceous Fuels (AREA)
  • Display Devices Of Pinball Game Machines (AREA)

Abstract

La presente invención se refiere a un método mejorado para la manufactura de una emulsión de aceite en agua que involucra la circulación de los componentes de la emulsión entre un primer envase y un segundo envase por vía de un homogenizador y/o por vía de un dispositivo de microfluidización. Convenientemente, todos los componentes de la emulsión del primer envase son evacuados antes de ser regresados.
MX2012006216A 2009-12-03 2010-12-03 Circulacion de componentes durante la homogenizacion de emulsiones. MX2012006216A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28351809P 2009-12-03 2009-12-03
PCT/IB2010/003394 WO2011067673A2 (en) 2009-12-03 2010-12-03 Circulation of components during homogenization of emulsions

Publications (1)

Publication Number Publication Date
MX2012006216A true MX2012006216A (es) 2012-07-12

Family

ID=43923723

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2014014450A MX360299B (es) 2009-12-03 2010-12-03 Circulacion de componentes durante la homogenizacion de emulsiones.
MX2014014449A MX344381B (es) 2009-12-03 2010-12-03 Circulacion de componentes durante la homogenizacion de emulsiones.
MX2012006216A MX2012006216A (es) 2009-12-03 2010-12-03 Circulacion de componentes durante la homogenizacion de emulsiones.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
MX2014014450A MX360299B (es) 2009-12-03 2010-12-03 Circulacion de componentes durante la homogenizacion de emulsiones.
MX2014014449A MX344381B (es) 2009-12-03 2010-12-03 Circulacion de componentes durante la homogenizacion de emulsiones.

Country Status (25)

Country Link
US (6) US8895629B2 (es)
EP (4) EP2506834B1 (es)
JP (2) JP5820390B2 (es)
KR (1) KR101523215B1 (es)
CN (2) CN105055311A (es)
AU (1) AU2010325752B2 (es)
BR (1) BR112012013427B8 (es)
CA (1) CA2782511C (es)
DK (2) DK2638895T3 (es)
EA (1) EA024770B1 (es)
ES (3) ES2402569T3 (es)
FI (1) FI2638895T3 (es)
HK (2) HK1160396A1 (es)
HR (1) HRP20130398T1 (es)
HU (1) HUE066873T2 (es)
IL (1) IL219984B (es)
MX (3) MX360299B (es)
NZ (1) NZ600323A (es)
PL (1) PL2356983T3 (es)
PT (1) PT2356983E (es)
RS (1) RS52748B (es)
SG (2) SG10201501611QA (es)
SI (2) SI2356983T1 (es)
SM (1) SMT201300044B (es)
WO (1) WO2011067673A2 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11707520B2 (en) 2005-11-03 2023-07-25 Seqirus UK Limited Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture
JP2009514838A (ja) * 2005-11-04 2009-04-09 ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル 細胞培養物において増殖されたインフルエンザウイルスから調製された非ビリオン抗原を含むアジュバントワクチン
JP5642712B2 (ja) 2009-02-10 2014-12-17 ノバルティス アーゲー 少ない量のスクアレンを含むインフルエンザワクチン
DE102009056884B4 (de) 2009-12-03 2021-03-18 Novartis Ag Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
CN102858322B (zh) 2009-12-03 2015-04-29 诺华股份有限公司 疫苗佐剂制备中的亲水过滤
MX360299B (es) 2009-12-03 2018-10-29 Novartis Ag Circulacion de componentes durante la homogenizacion de emulsiones.
CL2012001399A1 (es) 2009-12-03 2013-03-08 Novartis Ag Metodo para fabricar adyuvante para vacuna (emulsion aceite/agua con escualeno, polisorbato 80 y trioleato de sorbitan), que comprende (i) formar primera emulsion en homogenizador desde un contendor a otro para formar segunda emulsion, (ii) y microfluidizar primera emulsion para formar segunda emulsion.
DE102009056883B4 (de) 2009-12-03 2012-08-16 Novartis Ag Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
PT3103784T (pt) 2010-05-12 2019-05-20 Novartis Ag Preparação de uma emulsão óleo-em-água que compreende esqualeno
AU2013229432A1 (en) 2012-03-08 2014-10-16 Novartis Ag Adjuvanted formulations of booster vaccines
CA2882619A1 (en) 2012-09-06 2014-03-13 Novartis Ag Combination vaccines with serogroup b meningococcus and d/t/p
AU2013328548A1 (en) 2012-10-12 2015-05-07 Glaxosmithkline Biologicals Sa Non-cross-linked acellular pertussis antigens for use in combination vaccines
WO2014095771A1 (en) 2012-12-18 2014-06-26 Novartis Ag Conjugates for protecting against diphtheria and/or tetanus
RU2550253C2 (ru) * 2013-06-25 2015-05-10 Татьяна Владимировна Шленская Устройство для получения гомогенного молочного продукта и способ гидратации полярных молекул аминокислот молочных белков в процессе приготовления гомогенного молочного продукта
US9127542B2 (en) 2014-01-28 2015-09-08 Lawrence O. Price Subterranean well treatment process
US20170304429A1 (en) 2014-09-26 2017-10-26 Seqirus UK Limited Vaccination of immunocompromised subjects
ES2927797T3 (es) 2014-09-26 2022-11-11 Seqirus Uk Ltd Vacunación de sujetos inmunocomprometidos
ES2861806T3 (es) 2014-12-02 2021-10-06 Novartis Ag Fabricación de composiciones que contienen tensioactivo
US9949915B2 (en) 2016-06-10 2018-04-24 Clarity Cosmetics Inc. Non-comedogenic and non-acnegenic hair and scalp care formulations and method for use
IT201800007790A1 (it) * 2018-08-02 2020-02-02 Gea Mech Equipment Italia Spa Omogeneizzatore ad alta pressione
CN111999489B (zh) * 2020-09-21 2024-08-09 上海科华生物工程股份有限公司 用于连续生产胶乳免疫比浊法的过滤分散设备和方法
WO2022112191A1 (en) * 2020-11-25 2022-06-02 Univerza V Ljubljani Liquid decontamination system comprising a cavitation device and method of decontamination of a liquid

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1876979U (de) 1963-06-14 1963-08-01 Rehau Plastiks Sickerleitungsrohr.
CA951238A (en) 1970-06-10 1974-07-16 Ralph R. Calaceto Abrasion resistant venturi scrubbers
US4060082A (en) 1976-08-16 1977-11-29 Mpl, Inc. Dual-ingredient medication dispenser
US4340482A (en) 1978-02-21 1982-07-20 Millipore Corporation Process for grafting amino acid molecules onto preformed polymer surfaces and products prepared thereby
US4473474A (en) 1980-10-27 1984-09-25 Amf Inc. Charge modified microporous membrane, process for charge modifying said membrane and process for filtration of fluid
US4673504A (en) 1980-10-27 1987-06-16 Cuno Inc. Charge modified microporous membrane
US4533254A (en) 1981-04-17 1985-08-06 Biotechnology Development Corporation Apparatus for forming emulsions
US4473475A (en) 1981-05-29 1984-09-25 Amf Inc. Charge modified microporous membrane, process for charge modifying said membrane, and process for filtration of fluids
US4432875A (en) 1981-05-29 1984-02-21 Brunswick Corporation Semi-permeable membranes and processes for making the same
US4413074A (en) 1982-01-25 1983-11-01 Brunswick Corporation Hydrophilic surfaces and process for making the same
NZ209308A (en) 1983-08-30 1991-08-27 Genentech Inc Vaccine against hsv involving a truncated membrane-free derivative of a membrane-bound protein
US4705753A (en) 1984-06-08 1987-11-10 Gregor Harry P Biologically active acrylonitrile-based copolymeric membrane
US4618533A (en) 1984-11-30 1986-10-21 Millipore Corporation Porous membrane having hydrophilic surface and process
US4794002A (en) 1985-11-01 1988-12-27 Monsanto Company Modified polymeric surfaces and process for preparing same
US4964990A (en) 1987-05-20 1990-10-23 Gelman Sciences, Inc. Filtration membranes and method of making the same
US4943374A (en) 1988-04-21 1990-07-24 Gessner & Co., Gmbh Use of a microporous membrane constructed of polyether sulfon and hydrophilization agent for the filtration of beer
ATE175681T1 (de) 1988-10-17 1999-01-15 Hemasure Inc Verfahren zur kovalenten oberflächen-modifikation hydrophober polymere und erzeugnisse daraus
CA2017507C (en) 1989-05-25 1996-11-12 Gary Van Nest Adjuvant formulation comprising a submicron oil droplet emulsion
DE69229703T2 (de) * 1991-05-08 2000-04-27 Schweiz Serum & Impfinst Wiederhergestellte Influenza-Virosomen mit immunostimulierenden und immunoverstärkenden Eigenschaften und diese enthaltende Impfstoffe
JPH0614756Y2 (ja) 1991-06-26 1994-04-20 株式会社アルテ 組み立て式の２室式容器兼用注射器
US5178765A (en) 1991-09-18 1993-01-12 Gelman Sciences Inc. Hydrophilic membranes prepared from polyethersulfone/poly-2-oxazoline/polyvinylpyrrolidone blend
EP0656779B1 (en) 1992-08-28 2000-04-12 Pharmos Corporation Submicron emulsions as ocular drug delivery vehicles
US5531893A (en) 1993-02-12 1996-07-02 Gelman Sciences Inc. Inter-penetrating network charge modified microporous membrane
US5277812A (en) 1993-02-12 1994-01-11 Gelman Sciences Inc. Inter-penetrating network charge modified microporous membrane
US6645463B1 (en) 1994-05-16 2003-11-11 The Board Of Regents Of The University Of Michigan Blood-pool selective carrier for lipophilic imaging agents
WO1995035157A1 (fr) 1994-06-20 1995-12-28 Nippon Shinyaku Co., Ltd. Procede de fabrication d'emulsion et emulsificateur
US5487965A (en) 1994-09-06 1996-01-30 Xerox Corporation Processes for the preparation of developer compositions
US5496284A (en) 1994-09-27 1996-03-05 Waldenburg; Ottfried Dual-chamber syringe & method
US5510118A (en) 1995-02-14 1996-04-23 Nanosystems Llc Process for preparing therapeutic compositions containing nanoparticles
DE19542499A1 (de) 1995-11-15 1997-05-22 Bayer Ag Verfahren und Vorrichtung zur Herstellung einer parenteralen Arzneistoffzubereitung
DE19612966B4 (de) 1996-04-01 2009-12-10 Novartis Vaccines And Diagnostics Gmbh & Co. Kg MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
WO1998001174A1 (fr) 1996-07-05 1998-01-15 Debiotech S.A. Seringue a chambre double permettant le melange de deux produits avant leur injection
US6168718B1 (en) 1996-11-08 2001-01-02 Pall Corporation Method for purifying blood plasma and apparatus suitable therefor
JP4451931B2 (ja) 1996-11-12 2010-04-14 ホアットマン，インコーポレーテッド 親水性のポリマー状の相転換メンブレン
US5971953A (en) 1998-01-09 1999-10-26 Bachynsky; Nicholas Dual chamber syringe apparatus
AU9785598A (en) 1997-10-03 1999-04-27 Texas Pharmaceuticals, Inc. Improved dual chamber syringe apparatus
US6039872A (en) 1997-10-27 2000-03-21 Pall Corporation Hydrophilic membrane
JP4117106B2 (ja) 1998-03-30 2008-07-16 株式会社荏原製作所 マンガン含有水の処理方法及び装置
GB9808689D0 (en) 1998-04-23 1998-06-24 Kalsep Ltd Improved membrane
JP3995830B2 (ja) 1999-01-13 2007-10-24 富士フイルム株式会社 熱現像画像記録材料
US6193077B1 (en) 1999-02-08 2001-02-27 Osmonics, Inc. Non-cracking hydrophilic polyethersulfone membranes
CA2363141C (en) 1999-02-26 2010-04-06 Chiron Corporation Microemulsions with adsorbed macromolecules and microparticles
KR100310234B1 (ko) 1999-08-20 2001-11-14 안복현 반도체 소자 ｃｍｐ용 금속산화물 슬러리의 제조방법
GB9923176D0 (en) 1999-09-30 1999-12-01 Smithkline Beecham Biolog Novel composition
DE10059430A1 (de) 2000-11-30 2002-06-06 Cognis Deutschland Gmbh Feinteilige Emulsionen
TWI228420B (en) 2001-05-30 2005-03-01 Smithkline Beecham Pharma Gmbh Novel vaccine composition
US20060148776A1 (en) 2003-03-13 2006-07-06 Conforma Therapeutics Corporation Drug formulations having long and medium chain triglycerides
US20040185068A1 (en) 2003-03-18 2004-09-23 Zhi-Jian Yu Self-emulsifying compositions, methods of use and preparation
KR100720213B1 (ko) 2003-04-04 2007-05-21 화이자 프로덕츠 인코포레이티드 미세 유동화된 수중 유적형 유화액 및 백신 조성물
US20050208083A1 (en) * 2003-06-04 2005-09-22 Nanobio Corporation Compositions for inactivating pathogenic microorganisms, methods of making the compositons, and methods of use thereof
EP1633322A2 (en) 2003-06-04 2006-03-15 Nanobio Corporation Compositions for inactivating pathogenic microorganisms, methods of making the compositions, and methods of use thereof
GB0406515D0 (en) * 2004-03-23 2004-04-28 Novartis Ag Organic compounds
CN1933862A (zh) 2004-03-23 2007-03-21 尼普洛株式会社 预充式注射器
RU2412686C2 (ru) * 2004-03-23 2011-02-27 Новартис Аг Фармацевтические композиции
BRPI0509606B1 (pt) 2004-04-05 2019-01-15 Pah Usa 15 Llc emulsões de óleo-em-água microfluidizadas e composições para vacinas
GB0411411D0 (en) * 2004-05-21 2004-06-23 Glaxosmithkline Biolog Sa Vaccines
DE102004031550A1 (de) 2004-06-29 2006-02-02 Cognis Ip Management Gmbh Hochkonzentrierte, selbstemulgierende Emulsionsgrundlagen zur Herstellung von Öl in Wasser Emulsionen
GB0416120D0 (en) 2004-07-19 2004-08-18 Health Prot Agency Stable compositions containing OMV's
CN101068612B (zh) 2004-10-13 2010-12-15 3M创新有限公司 制备亲水性聚醚砜膜的方法
TW200611880A (en) 2004-10-14 2006-04-16 Bi-Chang Li The microprocessor unit of bio-sludge-hydrolyzing equipment
DK1809238T3 (da) 2004-11-09 2010-01-25 Novagali Pharma Sa Ophthalmiske emulsioner indeholdende et immunosuppressivt middel
GB0427568D0 (en) 2004-12-16 2005-01-19 Resolution Chemicals Ltd Particle-size reduction apparatus, and the use thereof
CA2603180C (en) 2005-03-23 2015-10-13 Glaxosmithkline Biologicals S.A. Influenza vaccine compositions and method for immunization against influenza disease
US8703095B2 (en) 2005-07-07 2014-04-22 Sanofi Pasteur S.A. Immuno-adjuvant emulsion
US20070036831A1 (en) 2005-08-09 2007-02-15 Nanobio Corporation Nanoemulsion compositions having anti-inflammatory activity
WO2008048271A2 (en) 2005-10-24 2008-04-24 Magsense Life Sciences, Inc. Polymer coated microparticles
US7959931B2 (en) * 2005-11-04 2011-06-14 Novartis Ag Influenza vaccines extemporaneously adsorbed to aluminium adjuvants
AU2006310163B2 (en) 2005-11-04 2011-09-15 Seqirus UK Limited Influenza vaccine with reduced amount of oil-in-water emulsion as adjuvant
FR2896162B1 (fr) 2006-01-13 2008-02-15 Sanofi Pasteur Sa Emulsion huile dans eau thermoreversible
US20100226932A1 (en) * 2006-02-22 2010-09-09 Novavax, Inc. Adjuvant and Vaccine Compositions
EP1849452A1 (de) 2006-04-27 2007-10-31 Cognis IP Management GmbH Dispersionen, enthaltend Acylglutamate
PL2422810T3 (pl) 2006-07-17 2015-03-31 Glaxosmithkline Biologicals Sa Szczepionka przeciw grypie
GB0622282D0 (en) 2006-11-08 2006-12-20 Novartis Ag Quality control methods
EP2532362A1 (en) * 2006-12-06 2012-12-12 Novartis AG Vaccines including antigen from four strains of influenza virus
US8506966B2 (en) 2008-02-22 2013-08-13 Novartis Ag Adjuvanted influenza vaccines for pediatric use
AU2008354007A1 (en) 2008-04-04 2009-10-08 Robert Rodriguez Lipid-oil-water nanoemulsion delivery system for microtubule-interacting agents
US8187554B2 (en) 2008-04-23 2012-05-29 Microfluidics International Corporation Apparatus and methods for nanoparticle generation and process intensification of transport and reaction systems
EP2307021A4 (en) * 2008-06-19 2011-08-10 Neurosystec Corp FORMULATIONS
DE102009056871A1 (de) 2009-12-03 2011-06-22 Novartis AG, 4056 Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
DE102009056883B4 (de) * 2009-12-03 2012-08-16 Novartis Ag Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
DE102009056884B4 (de) 2009-12-03 2021-03-18 Novartis Ag Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
CN102858322B (zh) 2009-12-03 2015-04-29 诺华股份有限公司 疫苗佐剂制备中的亲水过滤
PL2380558T5 (pl) 2009-12-03 2020-10-05 Novartis Ag Wytwarzanie emulsji w układzie komory oddziaływań i komory przeciwciśnieniowej do mikrofluidyzacji
MX360299B (es) 2009-12-03 2018-10-29 Novartis Ag Circulacion de componentes durante la homogenizacion de emulsiones.
CL2012001399A1 (es) * 2009-12-03 2013-03-08 Novartis Ag Metodo para fabricar adyuvante para vacuna (emulsion aceite/agua con escualeno, polisorbato 80 y trioleato de sorbitan), que comprende (i) formar primera emulsion en homogenizador desde un contendor a otro para formar segunda emulsion, (ii) y microfluidizar primera emulsion para formar segunda emulsion.
US20120315308A1 (en) 2010-02-24 2012-12-13 Travers William A Methods and devices for controlling particle size and particle size distribution
GB201009671D0 (en) 2010-06-10 2010-07-21 Glaxosmithkline Biolog Sa Novel process

Also Published As

Publication number Publication date
HK1160396A1 (en) 2012-08-17
ES2975170T3 (es) 2024-07-03
CA2782511A1 (en) 2011-06-09
US10463615B2 (en) 2019-11-05
US11141376B2 (en) 2021-10-12
EA201290426A1 (ru) 2012-11-30
US20130142833A1 (en) 2013-06-06
EP2638895B1 (en) 2024-03-20
ES2573710T3 (es) 2016-06-09
CN102753149A (zh) 2012-10-24
SMT201300044B (it) 2013-07-09
US8895629B2 (en) 2014-11-25
KR101523215B1 (ko) 2015-05-27
USRE46441E1 (en) 2017-06-20
DK2638895T3 (da) 2024-06-17
SI2506834T1 (sl) 2016-04-29
RS52748B (en) 2013-08-30
IL219984B (en) 2018-06-28
ES2402569T3 (es) 2013-05-06
EP2506834B1 (en) 2016-03-02
PL2356983T3 (pl) 2013-08-30
BR112012013427B8 (pt) 2021-05-25
NZ600323A (en) 2013-12-20
HK1175404A1 (zh) 2013-07-05
BR112012013427A2 (pt) 2016-04-05
WO2011067673A2 (en) 2011-06-09
AU2010325752A1 (en) 2012-06-21
HRP20130398T1 (en) 2013-06-30
JP5820390B2 (ja) 2015-11-24
EP2356983A1 (en) 2011-08-17
US20160128937A1 (en) 2016-05-12
US20200268661A1 (en) 2020-08-27
IL219984A0 (en) 2012-07-31
FI2638895T3 (fi) 2024-06-20
EP2638895A2 (en) 2013-09-18
JP2013512892A (ja) 2013-04-18
SG10201501611QA (en) 2015-04-29
EP4410306A2 (en) 2024-08-07
MX360299B (es) 2018-10-29
EA024770B1 (ru) 2016-10-31
PT2356983E (pt) 2013-04-23
CN102753149B (zh) 2015-10-14
CA2782511C (en) 2013-11-12
EP2638895A3 (en) 2014-02-19
JP2015193656A (ja) 2015-11-05
KR20120099750A (ko) 2012-09-11
BR112012013427B1 (pt) 2021-03-30
SI2356983T1 (sl) 2013-05-31
US9750690B2 (en) 2017-09-05
EP4410306A3 (en) 2024-11-13
HUE066873T2 (hu) 2024-09-28
US20160113870A1 (en) 2016-04-28
EP2506834A2 (en) 2012-10-10
DK2356983T3 (da) 2013-03-11
WO2011067673A3 (en) 2012-05-10
CN105055311A (zh) 2015-11-18
US20180055769A1 (en) 2018-03-01
MX344381B (es) 2016-12-14
SG181096A1 (en) 2012-07-30
EP2356983B1 (en) 2013-02-20
AU2010325752B2 (en) 2013-12-19

Similar Documents

Publication Publication Date Title
MX2012006216A (es) Circulacion de componentes durante la homogenizacion de emulsiones.
EP3657327A4 (en) GAME RENDERING PROCESS, AS WELL AS METHOD, APPARATUS AND DEVICE FOR GENERATING A GAME RESOURCE FILE
EP2786714A3 (en) System for operating a surgical instrument
EP2911084A3 (en) Service authorization methods and apparatuses
EP3552495A4 (en) OIL-IN-WATER EMULSION COMPOSITION AND METHOD FOR PRODUCING THE OIL-IN-WATER EMULSION COMPOSITION
EP4235548A3 (en) Method and apparatus for providing calendar displaying work history of document
EP2634711A3 (en) System and method for structural analysis
EP3488918A4 (en) MICROBREW GENERATOR, METHOD FOR PRODUCING MICROBREWS, SUCTION DEVICE AND SUCTION SYSTEM
EP3428643C0 (en) SUBSTANCE MARKING PATCH AND METHOD AND DEVICE FOR TISSUE DIAGNOSIS THEREOF
MX2016009319A (es) Aparato de prueba de carton.
MX340045B (es) Metodo y aparato para registro ocular multi-nivel.
GB201600299D0 (en) Ultrasonic measuring system, means of transportation and method for operating an ultrasonic transmitter-receiver device
EP2763376A3 (en) Method and device for providing service
EP3347844A4 (en) METHOD AND SYSTEM FOR DIAGNOSIS OF DISEASES AND FOR THE PREPARATION OF TREATMENT RECOMMENDATIONS
EP3612998A4 (en) IDENTITY RECOGNITION METHOD, APPARATUS, SYSTEM AND SERVER FOR AN OFFICE PLATFORM
EP2962728A4 (en) FIREPLACE COMPENSATION METHOD AND ULTRASONIC MEDICAL APPARATUS FOR THIS METHOD
EP3106751A4 (en) Device for supplying emulsified fuel and method for supplying said fuel
EP3658901C0 (en) A METHOD FOR FIXING AND RETENTION OF EXTRACELLULAR VESICLES, FIXED EXTRACELLULAR VESICLES AND A METHOD FOR DIAGNOSING A DISEASE.
GB2547056B (en) A system for determining the condition of a fluid in a tank, an apparatus including the system and a method for managing the condition of the fluid
BR112015002558A2 (pt) bobina endorretal, aparelho cirúrgico endorretal, método de geração de imagem com uma bobina endorretal e bobina endorretal de próstata.
EP2747428A3 (en) Method and apparatus for rendering multi-view image
SG10201805841PA (en) Method and device for producing an electronic signed document
EP3526686A4 (en) METHOD AND SYSTEM FOR A DISTRIBUTION AND DISTRIBUTION PLATFORM OF ELECTRONIC STRUCTURED CONTENT
EP2674923A3 (en) Item validation
EP3093948A3 (en) Voltage regulation in wireless power receiver

Legal Events

Date Code Title Description
FG Grant or registration