PT3103784T - Preparação de uma emulsão óleo-em-água que compreende esqualeno - Google Patents

Preparação de uma emulsão óleo-em-água que compreende esqualeno

Info

Publication number
PT3103784T
PT3103784T PT16176832T PT16176832T PT3103784T PT 3103784 T PT3103784 T PT 3103784T PT 16176832 T PT16176832 T PT 16176832T PT 16176832 T PT16176832 T PT 16176832T PT 3103784 T PT3103784 T PT 3103784T
Authority
PT
Portugal
Prior art keywords
squalene
manufacture
oil
water emulsion
emulsion
Prior art date
Application number
PT16176832T
Other languages
English (en)
Inventor
Hora Maninder
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44358794&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT3103784(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PT3103784T publication Critical patent/PT3103784T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C11/00—Aliphatic unsaturated hydrocarbons
    • C07C11/21—Alkatrienes; Alkatetraenes; Other alkapolyenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/10—Vacuum distillation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/14—Fractional distillation or use of a fractionation or rectification column
    • B01D3/143—Fractional distillation or use of a fractionation or rectification column by two or more of a fractionation, separation or rectification step
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/10—Wash bottles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C7/00—Purification; Separation; Use of additives
    • C07C7/04—Purification; Separation; Use of additives by distillation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Water Supply & Treatment (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Clinical Laboratory Science (AREA)
  • Biophysics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
PT16176832T 2010-05-12 2011-05-12 Preparação de uma emulsão óleo-em-água que compreende esqualeno PT3103784T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39544810P 2010-05-12 2010-05-12

Publications (1)

Publication Number Publication Date
PT3103784T true PT3103784T (pt) 2019-05-20

Family

ID=44358794

Family Applications (3)

Application Number Title Priority Date Filing Date
PT191512326T PT3489211T (pt) 2010-05-12 2011-05-12 Métodos aperfeiçoados para preparar esqualeno
PT131647695T PT2620423T (pt) 2010-05-12 2011-05-12 Métodos aperfeiçoados para a preparação de esqualeno
PT16176832T PT3103784T (pt) 2010-05-12 2011-05-12 Preparação de uma emulsão óleo-em-água que compreende esqualeno

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PT191512326T PT3489211T (pt) 2010-05-12 2011-05-12 Métodos aperfeiçoados para preparar esqualeno
PT131647695T PT2620423T (pt) 2010-05-12 2011-05-12 Métodos aperfeiçoados para a preparação de esqualeno

Country Status (20)

Country Link
US (5) US9199897B2 (pt)
EP (4) EP2569267B2 (pt)
JP (2) JP5946188B2 (pt)
KR (1) KR101875894B1 (pt)
CN (2) CN105125488A (pt)
AU (1) AU2011251706B2 (pt)
BR (1) BR112012028711B1 (pt)
CA (1) CA2798924C (pt)
EA (1) EA027142B1 (pt)
ES (4) ES2817446T3 (pt)
IL (1) IL222855A (pt)
MX (1) MX352758B (pt)
NZ (1) NZ603918A (pt)
PL (4) PL3489211T3 (pt)
PT (3) PT3489211T (pt)
SG (2) SG10201503689TA (pt)
SI (1) SI2569267T1 (pt)
TR (1) TR201905021T4 (pt)
WO (1) WO2011141819A1 (pt)
ZA (1) ZA201208381B (pt)

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RU2015106930A (ru) 2012-09-06 2016-10-20 Новартис Аг Комбинированные вакцины с менингококком серогруппы в и к/д/с
BR112015008040A2 (pt) 2012-10-12 2017-07-04 Glaxosmithkline Biologicals Sa composição de vacina, vacina de combinação, e, processos para preparar um componente ap e para a fabricação de uma composição de vacina
EP2934574A1 (en) 2012-12-18 2015-10-28 GlaxoSmithKline Biologicals SA Conjugates for protecting against diphtheria and/or tetanus
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ES2721306T3 (es) 2014-12-02 2019-07-30 Novartis Ag Fabricación de composiciones que contienen tensioactivo
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WO2023056089A1 (en) 2021-10-03 2023-04-06 Eisai R&D Management Co., Ltd. Immunological adjuvant formulations comprising tlr4 agonist e6020
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WO2024126194A1 (en) 2022-12-12 2024-06-20 Evonik Operations Gmbh Process for obtaining plant-based squalene

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Also Published As

Publication number Publication date
SI2569267T1 (sl) 2014-03-31
EP2569267B2 (en) 2017-03-22
PT3489211T (pt) 2020-09-22
US11077186B2 (en) 2021-08-03
MX2012013027A (es) 2012-12-17
EP2620423A1 (en) 2013-07-31
EP3489211B1 (en) 2020-07-15
NZ603918A (en) 2015-04-24
AU2011251706B2 (en) 2015-10-22
IL222855A0 (en) 2012-12-31
PT2620423T (pt) 2016-09-23
US20160051670A1 (en) 2016-02-25
PL2569267T3 (pl) 2014-05-30
CN102892734B (zh) 2015-07-22
TR201905021T4 (tr) 2019-05-21
ES2453316T5 (es) 2017-07-18
IL222855A (en) 2015-11-30
PL2620423T3 (pl) 2017-09-29
EP2569267A1 (en) 2013-03-20
US9867877B2 (en) 2018-01-16
US9545440B2 (en) 2017-01-17
AU2011251706A1 (en) 2012-12-20
US20130209510A1 (en) 2013-08-15
BR112012028711B1 (pt) 2020-12-01
EP2620423B2 (en) 2019-07-31
ES2817446T3 (es) 2021-04-07
SG10201503689TA (en) 2015-06-29
JP5946188B2 (ja) 2016-07-05
PL2620423T5 (pl) 2019-12-31
EA027142B1 (ru) 2017-06-30
US9199897B2 (en) 2015-12-01
BR112012028711A2 (pt) 2017-03-21
US20200061187A1 (en) 2020-02-27
EP2569267B1 (en) 2013-12-25
EP3103784B1 (en) 2019-02-06
EP3489211A1 (en) 2019-05-29
PL3103784T3 (pl) 2019-07-31
ZA201208381B (en) 2014-04-30
ES2597158T3 (es) 2017-01-16
EA201291225A1 (ru) 2013-06-28
CN102892734A (zh) 2013-01-23
KR20130103668A (ko) 2013-09-24
JP2013530941A (ja) 2013-08-01
SG185419A1 (en) 2012-12-28
CA2798924A1 (en) 2011-11-17
ES2453316T3 (es) 2014-04-07
JP2015157858A (ja) 2015-09-03
CN105125488A (zh) 2015-12-09
US20170072053A1 (en) 2017-03-16
EP2620423B1 (en) 2016-07-20
ES2717266T3 (es) 2019-06-20
WO2011141819A1 (en) 2011-11-17
US10517947B2 (en) 2019-12-31
CA2798924C (en) 2014-05-06
KR101875894B1 (ko) 2018-08-02
ES2597158T5 (es) 2020-03-26
EP3103784A1 (en) 2016-12-14
US20180169225A1 (en) 2018-06-21
MX352758B (es) 2017-12-07
PL3489211T3 (pl) 2020-12-14
PL2569267T5 (pl) 2017-10-31

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