PL3103784T3 - Wytwarzanie emulsji typu olej w wodzie zawierającej skwalen - Google Patents

Wytwarzanie emulsji typu olej w wodzie zawierającej skwalen

Info

Publication number
PL3103784T3
PL3103784T3 PL16176832T PL16176832T PL3103784T3 PL 3103784 T3 PL3103784 T3 PL 3103784T3 PL 16176832 T PL16176832 T PL 16176832T PL 16176832 T PL16176832 T PL 16176832T PL 3103784 T3 PL3103784 T3 PL 3103784T3
Authority
PL
Poland
Prior art keywords
squalene
manufacture
oil
water emulsion
emulsion
Prior art date
Application number
PL16176832T
Other languages
English (en)
Inventor
Maninder Hora
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44358794&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3103784(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PL3103784T3 publication Critical patent/PL3103784T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C11/00—Aliphatic unsaturated hydrocarbons
    • C07C11/21—Alkatrienes; Alkatetraenes; Other alkapolyenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/10—Vacuum distillation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/14—Fractional distillation or use of a fractionation or rectification column
    • B01D3/143—Fractional distillation or use of a fractionation or rectification column by two or more of a fractionation, separation or rectification step
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/10—Wash bottles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C7/00—Purification; Separation; Use of additives
    • C07C7/04—Purification; Separation; Use of additives by distillation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Water Supply & Treatment (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Clinical Laboratory Science (AREA)
  • Biophysics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
PL16176832T 2010-05-12 2011-05-12 Wytwarzanie emulsji typu olej w wodzie zawierającej skwalen PL3103784T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US39544810P 2010-05-12 2010-05-12
EP13164769.5A EP2620423B2 (en) 2010-05-12 2011-05-12 Improved methods for preparing squalene
EP11738802.5A EP2569267B2 (en) 2010-05-12 2011-05-12 Improved methods for preparing squalene
EP16176832.0A EP3103784B1 (en) 2010-05-12 2011-05-12 Manufacture of an oil-in-water emulsion comprising squalene
PCT/IB2011/001397 WO2011141819A1 (en) 2010-05-12 2011-05-12 Improved methods for preparing squalene

Publications (1)

Publication Number Publication Date
PL3103784T3 true PL3103784T3 (pl) 2019-07-31

Family

ID=44358794

Family Applications (4)

Application Number Title Priority Date Filing Date
PL19151232T PL3489211T3 (pl) 2010-05-12 2011-05-12 Ulepszone sposoby otrzymywania skwalenu
PL16176832T PL3103784T3 (pl) 2010-05-12 2011-05-12 Wytwarzanie emulsji typu olej w wodzie zawierającej skwalen
PL13164769T PL2620423T5 (pl) 2010-05-12 2011-05-12 Ulepszone sposoby otrzymywania skwalenu
PL11738802T PL2569267T5 (pl) 2010-05-12 2011-05-12 Ulepszone sposoby otrzymywania skwalenu

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL19151232T PL3489211T3 (pl) 2010-05-12 2011-05-12 Ulepszone sposoby otrzymywania skwalenu

Family Applications After (2)

Application Number Title Priority Date Filing Date
PL13164769T PL2620423T5 (pl) 2010-05-12 2011-05-12 Ulepszone sposoby otrzymywania skwalenu
PL11738802T PL2569267T5 (pl) 2010-05-12 2011-05-12 Ulepszone sposoby otrzymywania skwalenu

Country Status (20)

Country Link
US (5) US9199897B2 (pl)
EP (4) EP3103784B1 (pl)
JP (2) JP5946188B2 (pl)
KR (1) KR101875894B1 (pl)
CN (2) CN105125488A (pl)
AU (1) AU2011251706B2 (pl)
BR (1) BR112012028711B1 (pl)
CA (1) CA2798924C (pl)
EA (1) EA027142B1 (pl)
ES (4) ES2817446T3 (pl)
IL (1) IL222855A (pl)
MX (1) MX352758B (pl)
NZ (1) NZ603918A (pl)
PL (4) PL3489211T3 (pl)
PT (3) PT3489211T (pl)
SG (2) SG185419A1 (pl)
SI (1) SI2569267T1 (pl)
TR (1) TR201905021T4 (pl)
WO (1) WO2011141819A1 (pl)
ZA (1) ZA201208381B (pl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA027142B1 (ru) * 2010-05-12 2017-06-30 Новартис Аг Улучшенные способы получения сквалена
PL2575870T3 (pl) * 2010-06-04 2017-05-31 Wyeth Llc Preparaty szczepionek
AU2013229432A1 (en) 2012-03-08 2014-10-16 Novartis Ag Adjuvanted formulations of booster vaccines
JP6324961B2 (ja) 2012-09-06 2018-05-16 ノバルティス アーゲー 血清群ｂ髄膜炎菌とｄ／ｔ／ｐとの組み合わせワクチン
EP3620172A1 (en) 2012-10-12 2020-03-11 GlaxoSmithKline Biologicals SA Non-cross-linked acellular pertussis antigens for use in combination vaccines
WO2014095771A1 (en) 2012-12-18 2014-06-26 Novartis Ag Conjugates for protecting against diphtheria and/or tetanus
EP3052603B2 (en) * 2013-09-30 2023-08-09 AAK AB (publ) Enrichment of triterpene esters
ES2721306T3 (es) 2014-12-02 2019-07-30 Novartis Ag Fabricación de composiciones que contienen tensioactivo
AU2019281011A1 (en) * 2018-06-08 2021-01-28 Amyris, Inc. Synthesis of E,E-farnesol, farnesyl acetate and squalene from farnesene via farnesyl chloride
WO2020134682A1 (zh) 2018-12-24 2020-07-02 南京远大赛威信生物医药有限公司 用于治疗乙型肝炎的药物制剂及其制备方法和用途
WO2023056089A1 (en) 2021-10-03 2023-04-06 Eisai R&D Management Co., Ltd. Immunological adjuvant formulations comprising tlr4 agonist e6020
WO2023250129A1 (en) * 2022-06-24 2023-12-28 Amyris, Inc. Compositions and methods for the purification of squalene
WO2024126194A1 (en) 2022-12-12 2024-06-20 Evonik Operations Gmbh Process for obtaining plant-based squalene

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4060082A (en) 1976-08-16 1977-11-29 Mpl, Inc. Dual-ingredient medication dispenser
JPS57200142A (en) 1981-06-01 1982-12-08 Micron Kk Calculus removing tool
NZ209308A (en) 1983-08-30 1991-08-27 Genentech Inc Vaccine against hsv involving a truncated membrane-free derivative of a membrane-bound protein
ES8504584A1 (es) 1984-06-27 1985-05-01 Bendiberica Sa Mecanismo de direccion asistida compacto
JPH0348427A (ja) 1989-04-04 1991-03-01 Matsushita Electric Ind Co Ltd バイポーラ半導体装置とその製造方法
HU212924B (en) 1989-05-25 1996-12-30 Chiron Corp Adjuvant formulation comprising a submicron oil droplet emulsion
JPH0614756Y2 (ja) 1991-06-26 1994-04-20 株式会社アルテ 組み立て式の２室式容器兼用注射器
JPH06116171A (ja) * 1992-10-06 1994-04-26 Nippon Fine Chem Co Ltd 天然スクワレンの精製方法
JP3484227B2 (ja) † 1994-05-20 2004-01-06 日清オイリオ株式会社 油脂からのスクワラン精製方法
US5496284A (en) 1994-09-27 1996-03-05 Waldenburg; Ottfried Dual-chamber syringe & method
DE19612966B4 (de) 1996-04-01 2009-12-10 Novartis Vaccines And Diagnostics Gmbh & Co. Kg MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
WO1998001174A1 (fr) 1996-07-05 1998-01-15 Debiotech S.A. Seringue a chambre double permettant le melange de deux produits avant leur injection
US6090598A (en) * 1997-01-30 2000-07-18 Fuji Oil Company, Limited Enzymatic process for interesterification of fats and oils using distillation
GB9716578D0 (en) 1997-08-05 1997-10-08 Brf International Lipid removal
WO1999017820A1 (en) 1997-10-03 1999-04-15 Texas Pharmaceuticals, Inc. Improved dual chamber syringe apparatus
US5971953A (en) 1998-01-09 1999-10-26 Bachynsky; Nicholas Dual chamber syringe apparatus
US6165481A (en) * 1997-12-25 2000-12-26 Nippon Petrochemicals Company, Inc. Highly pure squalane, raw material for pharmaceuticals and cosmetics prepared by using the same and method for producing the same
DE19835749C1 (de) 1998-08-07 2000-02-03 Dieter Perthes Fertig-Spritze für nicht-stabile Arzneimittel
JP4282804B2 (ja) † 1998-12-24 2009-06-24 新日本石油株式会社 アジュバント組成物
GB9923176D0 (en) 1999-09-30 1999-12-01 Smithkline Beecham Biolog Novel composition
TWI228420B (en) 2001-05-30 2005-03-01 Smithkline Beecham Pharma Gmbh Novel vaccine composition
MY142319A (en) * 2002-08-20 2010-11-15 Malaysian Palm Oil Board Mpob Extraction of palm vitamin e, phytosterols and squalene from palm oil
US20070092525A1 (en) * 2005-02-07 2007-04-26 Institut National De La Sante Et De La Recherche Medicale (Inserm) Polypeptide derived from gp41, a vaccine composition comprising said polypeptide, and uses for treating an infection by an hiv virus in an individual
ES2318077T3 (es) * 2003-09-04 2009-05-01 Biomay Ag Polipeptidos hipoalergenicos basados en parvalbumina de peces.
US7208627B2 (en) * 2003-12-18 2007-04-24 Nippon Shokubai Co., Ltd Alkylborazine compound and production method for the same
JP5003155B2 (ja) 2004-03-23 2012-08-15 ニプロ株式会社 プレフィルドシリンジ
US8703095B2 (en) 2005-07-07 2014-04-22 Sanofi Pasteur S.A. Immuno-adjuvant emulsion
NZ567978A (en) 2005-11-04 2011-09-30 Novartis Vaccines & Diagnostic Influenza vaccine with reduced amount of oil-in-water emulsion as adjuvant
CA2628397C (en) * 2005-11-04 2013-08-20 Novartis Vaccines And Diagnostics S.R.L. Changing th1/th2 balance in split influenza vaccines with adjuvants
CN101365485A (zh) * 2005-11-04 2009-02-11 诺华疫苗和诊断有限公司 用于佐剂配制裂解流感疫苗的含游离水相表面活性剂的乳液
FR2896162B1 (fr) 2006-01-13 2008-02-15 Sanofi Pasteur Sa Emulsion huile dans eau thermoreversible
CN100376519C (zh) † 2006-02-23 2008-03-26 华南农业大学 一种制备角鲨烯的方法
PT2086582E (pt) 2006-10-12 2013-01-25 Glaxosmithkline Biolog Sa Vacina compreendendo uma emulsão adjuvante óleo em água
GB0622282D0 (en) * 2006-11-08 2006-12-20 Novartis Ag Quality control methods
ES2308924B1 (es) † 2007-05-18 2009-11-02 Pradomudo Investigacion Y Desarrollo, S.L(Titular El 50%) Procedimiento de obtencion de escualeno.
FR2933403B1 (fr) 2008-07-07 2010-08-27 Sophim Procede d'extration de squalene, de stereols et de vitamine e contenus dans des condensats de raffinage physique et/ou dans des distillats de desodorisation d'huiles vegetales
PL2268823T3 (pl) 2008-08-28 2012-03-30 Novartis Ag Wytwarzanie skwalenu z wykorzystaniem drożdży nadprodukujących skwalen
AU2010212550B2 (en) † 2009-02-10 2016-03-10 Seqirus UK Limited Influenza vaccines with reduced amounts of squalene
CN101597204B (zh) * 2009-07-09 2013-03-13 天津大学 以橄榄油为原料提取高纯度角鲨烯的方法
CN101697204B (zh) 2009-10-23 2013-02-20 北京派瑞根科技开发有限公司 电子签章
DE102009056884B4 (de) 2009-12-03 2021-03-18 Novartis Ag Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
KR101523215B1 (ko) 2009-12-03 2015-05-27 노파르티스 아게 에멀션 미세 액화 및/또는 균질화 동안 성분들의 순환
DE102009056883B4 (de) 2009-12-03 2012-08-16 Novartis Ag Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
DE102009056871A1 (de) 2009-12-03 2011-06-22 Novartis AG, 4056 Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
CN104688687A (zh) 2009-12-03 2015-06-10 诺华股份有限公司 疫苗佐剂制备中的亲水过滤
EA027142B1 (ru) * 2010-05-12 2017-06-30 Новартис Аг Улучшенные способы получения сквалена
CN101830770B (zh) † 2010-06-02 2013-06-05 天津大学 从植物油脱臭馏出物中提取角鲨烯的方法
JP6116171B2 (ja) 2012-09-24 2017-04-19 株式会社ダスキン 左右開閉型払拭体保持具、払拭体及び清掃用具

Also Published As

Publication number Publication date
ES2717266T3 (es) 2019-06-20
JP5946188B2 (ja) 2016-07-05
PL2620423T5 (pl) 2019-12-31
US9545440B2 (en) 2017-01-17
US20160051670A1 (en) 2016-02-25
EP3489211B1 (en) 2020-07-15
WO2011141819A1 (en) 2011-11-17
BR112012028711A2 (pt) 2017-03-21
ES2453316T5 (es) 2017-07-18
ZA201208381B (en) 2014-04-30
CN105125488A (zh) 2015-12-09
KR20130103668A (ko) 2013-09-24
ES2817446T3 (es) 2021-04-07
US9867877B2 (en) 2018-01-16
PL3489211T3 (pl) 2020-12-14
TR201905021T4 (tr) 2019-05-21
US11077186B2 (en) 2021-08-03
SG10201503689TA (en) 2015-06-29
EP2569267B2 (en) 2017-03-22
EP3103784B1 (en) 2019-02-06
JP2015157858A (ja) 2015-09-03
PT3103784T (pt) 2019-05-20
PL2620423T3 (pl) 2017-09-29
ES2453316T3 (es) 2014-04-07
PL2569267T3 (pl) 2014-05-30
US20200061187A1 (en) 2020-02-27
EP2620423B1 (en) 2016-07-20
NZ603918A (en) 2015-04-24
AU2011251706B2 (en) 2015-10-22
KR101875894B1 (ko) 2018-08-02
EP3489211A1 (en) 2019-05-29
JP2013530941A (ja) 2013-08-01
US9199897B2 (en) 2015-12-01
US20180169225A1 (en) 2018-06-21
US20130209510A1 (en) 2013-08-15
CA2798924C (en) 2014-05-06
MX352758B (es) 2017-12-07
AU2011251706A1 (en) 2012-12-20
EP2569267A1 (en) 2013-03-20
US20170072053A1 (en) 2017-03-16
EA027142B1 (ru) 2017-06-30
PT3489211T (pt) 2020-09-22
PT2620423T (pt) 2016-09-23
IL222855A0 (en) 2012-12-31
EP2620423B2 (en) 2019-07-31
BR112012028711B1 (pt) 2020-12-01
SI2569267T1 (sl) 2014-03-31
US10517947B2 (en) 2019-12-31
PL2569267T5 (pl) 2017-10-31
MX2012013027A (es) 2012-12-17
EP3103784A1 (en) 2016-12-14
ES2597158T5 (es) 2020-03-26
EP2620423A1 (en) 2013-07-31
ES2597158T3 (es) 2017-01-16
CN102892734B (zh) 2015-07-22
SG185419A1 (en) 2012-12-28
EA201291225A1 (ru) 2013-06-28
IL222855A (en) 2015-11-30
CN102892734A (zh) 2013-01-23
EP2569267B1 (en) 2013-12-25
CA2798924A1 (en) 2011-11-17

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