MX352758B - Metodos mejorados para preparar escualeno. - Google Patents

Metodos mejorados para preparar escualeno.

Info

Publication number
MX352758B
MX352758B MX2012013027A MX2012013027A MX352758B MX 352758 B MX352758 B MX 352758B MX 2012013027 A MX2012013027 A MX 2012013027A MX 2012013027 A MX2012013027 A MX 2012013027A MX 352758 B MX352758 B MX 352758B
Authority
MX
Mexico
Prior art keywords
squalene
improved methods
preparing squalene
preparing
steps
Prior art date
Application number
MX2012013027A
Other languages
English (en)
Other versions
MX2012013027A (es
Inventor
Hora Maninder
Original Assignee
Novartis Ag Star
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44358794&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX352758(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag Star filed Critical Novartis Ag Star
Publication of MX2012013027A publication Critical patent/MX2012013027A/es
Publication of MX352758B publication Critical patent/MX352758B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C11/00—Aliphatic unsaturated hydrocarbons
    • C07C11/21—Alkatrienes; Alkatetraenes; Other alkapolyenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/10—Vacuum distillation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/14—Fractional distillation or use of a fractionation or rectification column
    • B01D3/143—Fractional distillation or use of a fractionation or rectification column by two or more of a fractionation, separation or rectification step
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/10—Wash bottles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C7/00—Purification; Separation; Use of additives
    • C07C7/04—Purification; Separation; Use of additives by distillation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Water Supply & Treatment (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Clinical Laboratory Science (AREA)
  • Biophysics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se describe un método mejorado para preparar escualeno a partir de una composición que contiene escualeno, el método que comprende los pasos de (a) una destilación de purificación llevada a cabo a una temperatura Ti; (b) una destilación de desnaturalización llevada a cabo a una temperatura T2 en donde los pasos (a) y (b) se pueden realizar en cualquier orden; T1 y T2 son suficientes para provocar que hierva el escualeno; T2 > T1; y T2 = 200°C.
MX2012013027A 2010-05-12 2011-05-12 Metodos mejorados para preparar escualeno. MX352758B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39544810P 2010-05-12 2010-05-12
PCT/IB2011/001397 WO2011141819A1 (en) 2010-05-12 2011-05-12 Improved methods for preparing squalene

Publications (2)

Publication Number Publication Date
MX2012013027A MX2012013027A (es) 2012-12-17
MX352758B true MX352758B (es) 2017-12-07

Family

ID=44358794

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012013027A MX352758B (es) 2010-05-12 2011-05-12 Metodos mejorados para preparar escualeno.

Country Status (20)

Country Link
US (5) US9199897B2 (es)
EP (4) EP3103784B1 (es)
JP (2) JP5946188B2 (es)
KR (1) KR101875894B1 (es)
CN (2) CN105125488A (es)
AU (1) AU2011251706B2 (es)
BR (1) BR112012028711B1 (es)
CA (1) CA2798924C (es)
EA (1) EA027142B1 (es)
ES (4) ES2717266T3 (es)
IL (1) IL222855A (es)
MX (1) MX352758B (es)
NZ (1) NZ603918A (es)
PL (4) PL2620423T5 (es)
PT (3) PT3489211T (es)
SG (2) SG10201503689TA (es)
SI (1) SI2569267T1 (es)
TR (1) TR201905021T4 (es)
WO (1) WO2011141819A1 (es)
ZA (1) ZA201208381B (es)

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Publication number Publication date
PT3103784T (pt) 2019-05-20
EP2569267B2 (en) 2017-03-22
EA027142B1 (ru) 2017-06-30
EP3103784A1 (en) 2016-12-14
KR101875894B1 (ko) 2018-08-02
US20160051670A1 (en) 2016-02-25
US9199897B2 (en) 2015-12-01
CA2798924A1 (en) 2011-11-17
ES2453316T5 (es) 2017-07-18
US20200061187A1 (en) 2020-02-27
EP2620423A1 (en) 2013-07-31
CA2798924C (en) 2014-05-06
TR201905021T4 (tr) 2019-05-21
PL3103784T3 (pl) 2019-07-31
US11077186B2 (en) 2021-08-03
NZ603918A (en) 2015-04-24
ES2597158T5 (es) 2020-03-26
US20130209510A1 (en) 2013-08-15
IL222855A (en) 2015-11-30
US9545440B2 (en) 2017-01-17
ES2453316T3 (es) 2014-04-07
US9867877B2 (en) 2018-01-16
MX2012013027A (es) 2012-12-17
CN102892734B (zh) 2015-07-22
IL222855A0 (en) 2012-12-31
AU2011251706A1 (en) 2012-12-20
EP3489211A1 (en) 2019-05-29
PL3489211T3 (pl) 2020-12-14
AU2011251706B2 (en) 2015-10-22
ES2717266T3 (es) 2019-06-20
BR112012028711B1 (pt) 2020-12-01
ZA201208381B (en) 2014-04-30
KR20130103668A (ko) 2013-09-24
WO2011141819A1 (en) 2011-11-17
US10517947B2 (en) 2019-12-31
ES2597158T3 (es) 2017-01-16
JP5946188B2 (ja) 2016-07-05
PL2620423T5 (pl) 2019-12-31
PT3489211T (pt) 2020-09-22
US20170072053A1 (en) 2017-03-16
SG10201503689TA (en) 2015-06-29
SG185419A1 (en) 2012-12-28
PT2620423T (pt) 2016-09-23
EP3489211B1 (en) 2020-07-15
EP2569267A1 (en) 2013-03-20
EP2620423B1 (en) 2016-07-20
EP2569267B1 (en) 2013-12-25
CN102892734A (zh) 2013-01-23
SI2569267T1 (sl) 2014-03-31
JP2013530941A (ja) 2013-08-01
ES2817446T3 (es) 2021-04-07
EP3103784B1 (en) 2019-02-06
EP2620423B2 (en) 2019-07-31
CN105125488A (zh) 2015-12-09
PL2569267T3 (pl) 2014-05-30
US20180169225A1 (en) 2018-06-21
PL2569267T5 (pl) 2017-10-31
BR112012028711A2 (pt) 2017-03-21
EA201291225A1 (ru) 2013-06-28
PL2620423T3 (pl) 2017-09-29
JP2015157858A (ja) 2015-09-03

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